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| 1 | 孟河医家新探显示文摘明末至近代 ,江苏孟河名医辈出 ,逐渐形成以费、马、巢、丁四大家族为主的孟河医派。以四大家为核心的孟河医派 ,以其高深的学术造诣 ,丰富的临床经验 ,对中国医学的发展作出了卓越的功绩。广泛收集的资料涉及中国各大图书馆及欧洲、美国、港台图书馆馆藏的有关孟河医学的著作、方志、家谱百十余种 ,采访孟河医家的子孙、传人、学生或门徒 2 0 0余人。由此说明 ,孟河医派似一颗灿烂的明星 ,照耀在清代末年、民国初年的医坛上 ,学术相传 ,至今未衰。 | Volker Scheid 缪卫群 SOAS | 2004 | 中华医史杂志2004，34，2： | 18 |
| 2 | Argon reduces microglial activation and inflammatory cytokine expression in retinal ischemia/reperfusion injury显示文摘We previously found that argon exerts its neuroprotective effect in part by inhibition of the toll-like receptors(TLR)2 and 4.The downstream transcription factors signal transducer and activator of transcription 3(STAT3)and nuclear factor kappa B(NF-κB)are also affected by argon and may play a role in neuroprotection.It also has been demonstrated that argon treatment could mitigate brain damage,reduce excessive microglial activation,and subsequently attenuate brain inflammation.Despite intensive research,the further exact mechanism remains unclear.In this study,human neuroblastoma cells were damaged in vitro with rotenone over a period of 4 hours(to mimic cerebral ischemia and reperfusion damage),followed by a 2-hour post-conditioning with argon(75%).In a separate in vivo experiment,retinal ischemia/reperfusion injury was induced in rats by increasing intraocular pressure for 1 hour.Upon reperfusion,argon was administered by inhalation for 2 hours.Argon reduced the binding of the transcription factors signal transducer and activator of transcription 3,nuclear factor kappa B,activator protein 1,and nuclear factor erythroid 2-related factor 2,which are involved in regulation of neuronal damage.Flow cytometry analysis showed that argon downregulated the Fas ligand.Some transcription factors were regulated by toll-like receptors;therefore,their effects could be eliminated,at least in part,by the TLR2 and TLR4 inhibitor oxidized phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine(OxPAPC).Argon treatment reduced microglial activation after retinal ischemia/reperfusion injury.Subsequent quantitative polymerase chain reaction analysis revealed a reduction in the pro-inflammatory cytokines interleukin(IL-1α),IL-1β,IL-6,tumor necrosis factorα,and inducible nitric oxide synthase.Our results suggest that argon reduced the extent of inflammation in retinal neurons after ischemia/reperfusion injury by suppression of transcription factors crucial for microglial activation.Argon has no known side effects or narcotic properties;therefore,therapeutic use of this noble gas appears ideal for treatment of patients with neuronal damage in retinal ischemia/reperfusion injury.The animal experiments were approved by the Commission for Animal Care of the University of Freiburg(approval No.35-9185.81/G14-122)on October 19,2012. | Ulrich Goebel Stefanie Scheid Sashko Spassov Nils Schallner Jakob Wollborn Hartmut Buerkle Felix Ulbrich | 2021 | Neural Regeneration Research2021，16，1： | 8 |
| 3 | Correlation between β-decay Energies of Superheavy Nuclei Involving Effects of Symmetry Energy显示文摘 | Dong Jianmin Zuo Wei Werner Scheid | 2011 | IMP & HIRFL Annual Report2011，，1： | 5 |
| 4 | 欧洲的中医药发展史、现状及存在的问题显示文摘1994年5月,作者应邀在中国中医研究院中医药信息研究所做了有关欧洲中医药发展情况的专题报告。报告介绍了中医药在欧洲一些国家的传播和发展,并分析了其政治、历史、文化背景。针对中医药学在欧洲的观状,提出了存在的问题和今后发展中应当注意的方向。 | Volker Scheid 李春梅 | 1994 | 国外医学(中医中药分册)1994，16，4： | 3 |
| 5 | New Approach for a-Decay Half-lives of Superheavy Nuclei and Applicability of WKB Approximation显示文摘 | Dong Jianmin Zuo Wei Werner Scheid | 2011 | IMP & HIRFL Annual Report2011，，1： | 3 |
| 6 | Change in ploidy can modify epigenetic silencing显示文摘 | Scheid O M Jakovleva L Afsar K Maluszynska J Paszkowski J A | 1996 | Proc Natl Acad Sci USA1996，93，71： | 2 |
| 7 | Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect显示文摘The noble gas argon has the potential to protect neuronal cells from cell death.So far,this effect has been studied in treatment after acute damage.Preconditioning using argon has not yet been investigated.In this study,human neuroblastoma SH-SY5Y cells were treated with different concentrations of argon(25%,50%,and 74%;21%O_(2),5%CO_(2),balance nitrogen)at different time intervals before inflicting damage with rotenone(20μM,4 hours).Apoptosis was determined by flow cytometry after annexin V and propidium iodide staining.Surface expressions of Toll-like receptors 2 and 4 were also examined.Cells were also processed for analysis by western blot and qPCR to determine the expression of apoptotic and inflammatory proteins,such as extracellular-signal regulated kinase(ERK1/2),nuclear transcription factor-κB(NF-κB),protein kinase B(Akt),caspase-3,Bax,Bcl-2,interleukin-8,and heat shock proteins.Immunohistochemical staining was performed for TLR2 and 4 and interleukin-8.Cells were also pretreated with OxPAPC,an antagonist of TLR2 and 4 to elucidate the molecular mechanism.Results showed that argon preconditioning before rotenone application caused a dose-dependent but not a time-dependent reduction in the number of apoptotic cells.Preconditioning with 74%argon for 2 hours was used for further experiments showing the most promising results.Argon decreased the surface expression of TLR2 and 4,whereas OxPAPC treatment partially abolished the protective effect of argon.Argon increased phosphorylation of ERK1/2 but decreased NF-κB and Akt.Preconditioning inhibited mitochondrial apoptosis and the heat shock response.Argon also suppressed the expression of the pro-inflammatory cytokine interleukin-8.Immunohistochemistry confirmed the alteration of TLRs and interleukin-8.OxPAPC reversed the argon effect on ERK1/2,Bax,Bcl-2,caspase-3,and interleukin-8 expression,but not on NF-κB and the heat shock proteins.Taken together,argon preconditioning protects against apoptosis of neuronal cells and mediates its action via Toll-like receptors.Argon may represent a promising therapeutic alternative in various clinical settings,such as the treatment of stroke. | Stefanie Scheid Adrien Lejarre Jakob Wollborn Hartmut Buerkle Ulrich Goebel Felix Ulbrich | 2023 | Neural Regeneration Research2023，18，6： | 2 |
| 8 | 妊娠期耳鼻咽喉科处方用药指南显示文摘由于妊娠期母体生理功能的改变,药物更易于通过胎盘进入胎儿体内。妊娠期用药不当可导致胎儿畸形或死亡。本文就耳鼻咽喉科常用的几类药物在妊娠期的应用指征做一编译,以供同道们参考。 | Ambro BT Scheid SC . Pribitkin EA 张革化(译) 李源(译) | 2006 | 国际耳鼻咽喉头颈外科杂志2006，30，2： | 2 |
| 9 | Cytosine methylation at CG and CNG sites is not a prerequisite for the initiation of transcriptional gene silencing in plants,but it is required for its maintenance显示文摘 | DIEGUEZ M J VAUCHERET H PASZKOWSKI J SCHEID O M | 1998 | Molecular & General Genetics1998，259，2： | 1 |
| 10 | Leucine-derived cyanogenic gluco- sides in the Rosaceae-Spiraeoideae 显示文摘 | Nahrstedt A Scheid H | 1981 | Phytochemistry1981，20，6： | 1 |
| 11 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 12 | Inflammation in cystic fibrosis airways:relationship to increased bacterial adherence显示文摘 | Scheid P Kempster L Griesenbach U | 2001 | Eur Respir J2001，17，1： | 1 |
| 13 | Determining ectopic pregnancy risk using progesterone levels显示文摘 | Scheid DC Ramakrishnan K | 2006 | Am Faro Physieian2006，73，10： | 1 |
| 14 | Evidence for specific selenium target tissues and new biologically important selenoproteins显示文摘 | Behne D Hilmert H Scheid | 1988 | Biochem Biophys Acta1988，966，： | 1 |
| 15 | The effect of exercise and estro- gen on osteoprotegerin in premenopausal women 显示文摘 | West SL Scheid JL Souza MJ | 2009 | Bone2009，44，1： | 1 |
| 16 | Gas exchange in the domestic fowl during spontaneous breathing and artificial ventilation 显示文摘 | PIIPER J DREES F SCHEID P | 1970 | Respiration Physiology1970，9，2： | 1 |
| 17 | Characterization of cerebral microang/opathy using 3 Tesla MRI: correlation with neurological impairment and vascular risk factors 显示文摘 | Hund - Georgiadis M Ballaschke O Scheid R | 2002 | J Magn Reson Imaging2002，15，： | 1 |
| 18 | Downstream signalling events regulated by phosphatidylinositol 3-kinase activity 显示文摘 | Duronio V Scheid MP Ettinger S | 1998 | Cell Signalling1998，10，： | 1 |
| 19 | Hypoxia -regula- ted gene expression in fetal wound regeneration and adult wound repair显示文摘 | Scheid A Wenger RH Christina H | 2000 | Pediatr Surg Int2000，16，4： | 1 |
| 20 | An investigation of the kinetics of cellulose degradation under non - isothermal conditions 显示文摘 | Stephen W Bigger Scheid J | 1998 | Pol- ymer Degmiation and Stability1998，62，1： | 1 |
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