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| 1 | Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy显示文摘AIM: To evaluate the implication of substitutions in the hepatitis C virus (HCV) non-structural 5A (NS5A) protein in the resistance of HCV during mono-interferon (IFN) or combined IFN-ribavirin (IFN-R) therapy. Although NS5A has been reported to interact with the HCV RNA- dependent RNA polymerase, NS5B, as well as with many cellular proteins, the function of NS5A in the life cycle of HCV remains unclear. METHODS: HCV quasispecies were studied by clon- ing and sequencing of sequential isolates from patients infected by HCV genotype 1b. Patients were treated by IFN-α2b for 3 mo followed by IFN-α2b alone or com- bined IFN-R therapy for 9 additional months. Patients were categorized intro two groups based on their re- sponse to the treatments: 7 with sustained virological re- sponse (SVR) (quasispecies = 150) and 3 non-respond- ers (NR) to IFN-R (quasispecies = 106). RESULTS: Prior to treatment, SVR patients displayed a lower complexity of quasispecies than NR patients. Most patients had a decrease in the complexity of quasispe- cies during therapy. Analysis of amino acids substitu- tions showed that the degree of the complexity of the interferon sensitivity-determining region (ISDR) and the V3 domain of NS5A protein was able to discriminate thetwo groups of patients. Moreover, SVR patients displayed more variability in the NS5A region than NR patients. CONCLUSION: These results suggest that detailed mo- lecular analysis of the NS5A region may be important for understanding its function in IFN response during HCV 1b infection. | Pascal Veillon Christopher Payan Hélène Le Guillou-Guillemette Catherine Gaudy Franoise Lunel | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Digestion and extraction of biological materials for zinc stable isotope determination by inductively coupled plasma mass spectrometry显示文摘 | Veillon C Patterson KY Moser-Veillon PB | 1996 | J Anal Atom Spectrom1996，11，： | 1 |
| 3 | Comparative evaluation of the total hepatitis C virus core antigen, branched-DNA, and amplicor monitor assays in determining viremia for patients with chronic hepatitis C during interferon plus ribavirin combination therapy 显示文摘 | VEILLON P PAYAN C PICCHIO G | 2003 | J Clin Microbiol2003，41，： | 1 |
| 4 | Urinary tract infection in percutaneous surgery for renal calculi显示文摘 | CHARTON M VALLANCIEN G VEILLON B | 1986 | J Urol1986，135，1： | 1 |
| 5 | Reproducibility of blood tests of liver fibrosis in clinical practice显示文摘 | Paul Calès Pascal Veillon Anselme Konaté Elisabeth Mathieu Catherine Ternisien Alain Chevailler Alban Godon Yves Gallois Fran?oise Joubaud Isabelle Hubert-Fouchard Frédéric Oberti Stéphane Réaud Gilles Hunault Fran?oise Mauriat Fran?oise Lunel-Fabiani | 2007 | Clinical Biochemistry2007，，1： | 1 |
| 6 | Comparative evaluation of the total hepatitis C:virus core antigen,branched DNA,and amplicor monitor assays in determining viremia for patients with chronic hepatitis C during interferon plus ribavirin combination therapy显示文摘 | Veillon P Payan C Picchio G | 2003 | J Clin Microbiol2003，41，7： | 1 |
| 7 | History- or ultrasound-based cerclage placement and adverse per- inataloutcomes显示文摘 | Brown JA Pearson AW Veillon EW | 2011 | J Reprod Med2011，56，910： | 1 |
| 8 | Imaging of the fa- cial nerve显示文摘 | Veillon F Ramos-Taboada L Abu-Eid M | 2010 | Eur J Radiol2010，74，： | 1 |
| 9 | 'Little' littoral cell angioma of the spleen显示文摘 | Veillon DM Williams RB Sardenga LI | 2000 | Am J Surg Pathol2000，24，2： | 1 |
| 10 | ‘Little'littoral cell angioma of the spleen显示文摘 | Veillon D M Williams R B Sardenga L J | 2000 | Am J Surg Pathol2000，24，2： | 1 |
| 11 | 'Little' littoral cell angioma of the spleen 显示文摘 | Veillon DM Williams RB Sardenga LJ | 2000 | Am J Surg Pathol2000，24，2： | 1 |
| 12 | Value of CT in allergic fungal sinusitis(AFS) 显示文摘 | Braun JJ Riehm S Veillon F | 2008 | J Radiol2008，89，4： | 1 |
| 13 | Antiviral effect of ribavirin in early non-responders to interferon monotherapy assessed by kinetics of hepatitis C virus RNA and hepatitis C virus core antigen显示文摘 | Lunel F Veillon P Fouchard-Hubert I | 2003 | J Hepatol2003，39，5： | 1 |
| 14 | Focused, extracorporeal pyrotherapy: feasibility study in man显示文摘 | Vallancien G Harouni M Veillon B | 1992 | Endourol1992，6，： | 1 |
| 15 | Systematic prostatic biopsies in 100 men with no suspicion of cancer on digital rectal examination显示文摘 | Prapotnich D Veillon B | 1991 | J Urol1991，146，5： | 1 |
| 16 | CT appearances of ossieular injuries显示文摘 | MERIOT P VEILLON F | 1997 | Radiographics1997，17，： | 1 |
| 17 | A single 60-rag Iron dose decreases zinc absorption in lactating women 显示文摘 | CAROLYN SC NAGEY D A CLAUDE VEILLON | 2002 | Nutri2002，132，： | 1 |
| 18 | Littoral cell angioma of the spleen显示文摘 | Veillon DM Williams RB Sardenga LJ | 2000 | Am J SurgPathol2000，24，2： | 1 |
| 19 | Imaging of the facial nerve显示文摘 | F. Veillon L. Ramos-Taboada M. Abu-Eid A. Charpiot S. Riehm | 2010 | European Journal of Radiology2010，，2： | 1 |
| 20 | Assessment of new hyalumnic acid assays and their impact no fibre meter scores显示文摘 | Veillon P Gallois Y Moal V | 2011 | Clin Chemica Ac- ta2011，412，34： | 1 |
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