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| 1 | 脑缺氧是影响严重颅脑创伤患者短期预后的独立危险因素(英文)显示文摘Background:Brain hypoxia(BH)can aggravate outcome after severe traumatic brain injury(TBI).Whether BH or reduced brain oxygen(Pbto2)is an independent outcome predictor or a marker of disease severity is not fully elucidated.Objective To analyze the relationship between Pbto2,intracranial pressure(ICP),and cerebral perfusion pressure(CPP)and to examine whether BH correlates with worse outcome independently of ICP and CPP.Methods We studied103patients | Oddo M Levine JM Mackenzie L Frangos S Feihl F Kasner SE Katsnelson M Pukenas B Macmurtrie E Maloney-Wilensky E Kofke WA Leroux PD | 2011 | 中华神经外科疾病研究杂志2011，10，5： | 21 |
| 2 | Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients显示文摘Our previous work showed that the cartilage proteoglycan aggrecan could induce an erosive polyarthritis and spondylitis in BALB/c mice and the GI globular domain of the aggrecan (GI) contained the arthritogenic region. To elucidate whether autoreactive T cells to G1 are expressed in rheumatoid arthritis patients, we analyzed the frequency of human G1-specific T cells in the peripheral blood of five rheumatoid arthritis patients and tried to establish G1-reactive T cell lines from these rheumatoid arthritis patients. The results showed that the G1-specific T cells in PBL were detectable at the range of 4.97 ±0.5 ×10-6 in peripheral blood lymphocytes. We have also generated 15 G1-specific T lymphocyte lines from these pateints with a standard split-well method. All these cells expressed fine specificity to human recombinant G1, but not to unrelated antigen. All the 15 lines expressed a panT cell marker and 13 of them selectively used the αβ T cell receptor. Two of them used rye T cell receptor. The 13 of these T cell lines was CD4 positive. One line expressed CD8. One line expressed both CD4 and CD8. Moreover, 14 out of 15 lines expressed the Th-1 cytokine profile, characterized by interferon-γpositivity and IL-4 negativity. No Th-2 type cell line was generated. These data provide strong evidence in favor of the presence of autoreactive T cells in the rheumatoid arthritis pateints. What is the mechanism(s) that these autoreactive T cells attack self-target and whether these G1-specific, Th-1 type T cell lines can induce arthritis in immune deficiency mice are currently under investigation. | LI NING LI DONG QING ZHANG KUANG YAN ZHOU ANNIE CARTMAN JEAN YVES LEROUX A ROBIN POOLE YI PING ZHANG ( Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China)(Joint Diseases Laboratory, Shriners Hospital, Dep | 2000 | Cell Research2000，10，1： | 7 |
| 3 | RECENT ADVANCES IN RESEARCH AND FORECASTING OF TROPICAL CYCLONE TRACK, INTENSITY, AND STRUCTURE AT LANDFALL显示文摘This review prepared for the fourth International Workshop on Tropical Cyclone Landfall Processes(IWTCLP-4) summarizes the most recent(2015-2017) theoretical and practical knowledge in the field of tropical cyclone(TC) track, intensity, and structure rapid changes at or near landfall. Although the focus of IWTCLPIV was on landfall, this summary necessarily embraces the characteristics of storms during their course over the ocean prior to and leading up to landfall. In the past few years, extremely valuable observational datasets have been collected for TC forecasting guidance and research studies using both aircraft reconnaissance and new geostationary or low-earth orbiting satellites at high temporal and spatial resolution. Track deflections for systems near complex topography such as that of Taiwan and La Réunion have been further investigated, and advanced numerical models with high spatial resolution necessary to predict the interaction of the TC circulation with steep island topography have been developed. An analog technique has been designed to meet the need for longer range landfall intensity forecast guidance that will provide more time for emergency preparedness. Probabilistic track and intensity forecasts have also been developed to better communicate on forecast uncertainty. Operational practices of several TC forecast centers are described herein and some challenges regarding forecasts and warnings for TCs making landfall are identified. This review concludes with insights from both researchers and forecasters regarding future directions to improve predictions of TC track, intensity, and structure at landfall. | MARIE-DOMINIQUE LEROUX KIMBERLY WOOD RUSSELL L.ELSBERRY ESPERANZA O.CAYANAN ERIC HENDRICKS MATTHEW KUCAS PETER OTTO ROBERT ROGERS BUCK SAMPSON ZIFENG YU | 2018 | Tropical Cyclone Research and Review2018，7，2： | 4 |
| 4 | RECENT PROGRESS IN STORM SURGE FORECASTING显示文摘This report briefly summarizes recent progress in storm surge forecasts, one of topics discussed during the fourth International Workshop on Tropical Cyclone Landfall Process(IWTCLP 4) held during 5-8 December, 2017. In the workshop, improvement of storm surge forecasting system was mainly discussed with relevance to the problem of estimating the impacts of tropical cyclone landfall.To deal with storm surges, accurate TC condition(predictions and forecasts) as input, reasonable storm surge predictions(with forecasting systems), and effective advisories/warnings(i.e. useful information products) are necessary. Therefore, we need to improve storm surge related matters systematically: input, prediction system, and ef fective information.This report tries to highlight recent progress in the field of storm surges in relation to three key points: improvement in storm surge forecasting models/system, TC conditions as input for storm surge predictions, and informative products for end users. | NADAO KOHNO SHISHIR K.DUBE MIKHAIL ENTEL S.H.M.FAKHRUDDIN DIANA GREENSLADE MARIE-DOMINIQUE LEROUX JAMIE RHOME NGUYEN BA THUY | 2018 | Tropical Cyclone Research and Review2018，7，2： | 4 |
| 5 | 10 PW peak power femtosecond laser pulses at ELI-NP显示文摘We report on the generation and delivery of 10.2 PW peak power laser pulses,using the High Power Laser System at the Extreme Laser Infrastructure–Nuclear Physics facility.In this work we demonstrate for the first time,to the best of our knowledge,the compression and propagation of full energy,full aperture,laser pulses that reach a power level of more than 10 PW. | Christophe Radier Olivier Chalus Mathilde Charbonneau Shanjuhan Thambirajah Guillaume Deschamps Stephane David Julien Barbe Eric Etter Guillaume Matras Sandrine Ricaud Vincent Leroux Caroline Richard François Lureau Andrei Baleanu Romeo Banici Andrei Gradinariu Constantin Caldararu Cristian Capiteanu Andrei Naziru Bogdan Diaconescu Vicentiu Iancu Razvan Dabu Daniel Ursescu Ioan Dancus Calin Alexandru Ur Kazuo ATanaka Nicolae Victor Zamfir | 2022 | High Power Laser Science and Engineering2022，10，3： | 2 |
| 6 | Polymeric micelles for oral drug delivery显示文摘 | Geneviève Gaucher Prashant Satturwar Marie-Christine Jones Alexandra Furtos Jean-Christophe Leroux | 2010 | European Journal of Pharmaceutics and Biopharmaceutics2010，，2： | 2 |
| 7 | Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3′-UTR sequence arising from a single exon显示文摘 | Laurence Bernard Christine Leroux Hélène Hayes Mathieu Gautier Yves Chilliard Patrice Martin | 2001 | Gene2001，，1： | 2 |
| 8 | In situ-forming hydrogels-review of temperature-sensitive system显示文摘 | Gariepy E R Leroux J C | 2004 | European Journal of Pharmaecuties and Biopharmaeeuties2004，58，2： | 1 |
| 9 | Uptake of lithium by layered molybdenum oxide and its tin exchanged derivatives: high volumetric capacity materials显示文摘 | Leroux F Nazar L F | 2000 | Solid State Ionics2000，133，： | 1 |
| 10 | An experi- mental study of imsteady partial cavitation显示文摘 | LEROUX J B ASTOLFI J A BILLARD Y | 2004 | Journal of Fluids Engineering2004，126，2： | 1 |
| 11 | An experimental study of unsteady partial cavitation显示文摘 | LEROUX J B ASTOLFI J A BILIARD J Y | 2004 | Journal of Fluids Engineering2004，126，2： | 1 |
| 12 | Synthesis and Poly(thiophene)/Vanadium Oxide Interleaved Nanocomposite Aerogels 显示文摘 | Dave B C Dunn B Leroux F | 1998 | J Mater Chem1998，8，： | 1 |
| 13 | Role of tissue - plasminogen activator in a mouse model of neonatal white matter lesions : Interaction with plasmin inhibitors and anti - inflammatory drugs 显示文摘 | Leroux P Hennebert O Legros H | 2007 | Neuroscience2007，146，2： | 1 |
| 14 | Field strains of Stemphylium vesicarium with a resistance to dicarboximide fungicides correlated with changes in a two-component histidine kinase 显示文摘 | Alberoni G Collina M Lanen C Leroux P Brunelli A | 2010 | Eur J Plant Pathol2010，128，： | 1 |
| 15 | Quan- tum confined stark effect due to built-in internal polari zation fields in (A1GaN)/GaN quantum wells显示文摘 | LEROUX M GRANDJEAN N LAUGT M | 1998 | Physi cal Review B1998，58，13： | 1 |
| 16 | Experimental and bipha- sic FEN determinations of the material properties and hyd- raulic permeability of the meniscus in tension 显示文摘 | LeRoux Michelle A Setton | 2002 | Journal of Biomechanical Engineering2002，124，3： | 1 |
| 17 | Structure-function studies on small heat shock protein oligomeric assembly and interaction with unfoldedpolypeptides显示文摘 | Leroux MR Melki R Gordon B | 1997 | J Biol Chem1997，272，24： | 1 |
| 18 | Isokinetic evealuation of rotational strength in normal shouler and shoulders with impingment syndrome 显示文摘 | Leroux J1 Codine P Thomas E | 1994 | Clin Orthop Relat Res1994，30，4： | 1 |
| 19 | Poly(pyrrole) and Poly(thiophene)/Vanadium Oxide Interleaved Nanocomposites:Positive Electrodes for Lithium Batteries显示文摘 | Leroux F Nazar L F Goward G R | 1998 | Electrochim Acta1998，43，： | 1 |
| 20 | Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3'-UTR sequence arising from a single exon显示文摘 | BERNARD L LEROUX C HAYES H | 2001 | Gene2001，281，： | 1 |
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