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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Palaeogeomorphology and its control on the development of sequence stratigraphy and depositional systems of the Early Silurian in the Tarim Basin显示文摘The Silurian in the Tarim Basin was deposited on the basement deformed by the Caledonian tectonic movements at the end of the Late Ordovician. The development and distribution of sedimentary sequences of the Early Silurian have been clearly controlled by the palaeogeomorphology of the Late Ordovician. Based on unconformity characteristics and distribution of erosion, several zones can be differentiated including a high uplifted erosion zone, a transitional slope zone and a depression zone. The central and west Tabei Uplift zones show high angular unconformity and intense erosion. The Tarim Basin in the late Ordovician shows characteristics of higher in the west, lower in the east while higher in the south, lower in the north. The Early Silurian mainly developed transgressive and highstand systems tracts on the whole, while the lowstand systems tract only developed partly below the slope break. The palaeogeomorphology controlled the clastic source supply and deposit distribution. Braided delta system and tidal flat–estuary system were deposited. The duration of uplifting of the Tazhong paleouplift was longer than that of the Tabei paleo-uplift, and deposition was later. This led to the lower and middle members of the Kepingtage Formation missing in that area. As a large-scale transgression occurred during the deposition period of the upper member of the Kepingtage Formation, sediment from the west of the basin was transported and deposited by tides and waves, forming tidal–marine debris systems above the uplift. Proximal alluvial fan and fan delta coarse clastic deposits developed in proximal uplift zone in the east and southeast of the basin, and braided delta put forward to the transitional zone between the edge of uplift and the sea. Large-scale tidal channel, sub-distributary channel and mouth bar of the delta front can form favorable reservoirs, and they are primary targets for oil and gas exploration. This research on sequence–depositional systems development and distribution controlled by palaeogeomorphology is significant in guiding the prediction of reservoir sandstones. | Liu Jingyan Lin Changsong Cai Zhenzhong Zhu Yongfeng Yang Yongheng Peng Li Si Baoling Huang Zhen Li Huanpu Xu Yingcai Su Zhenzhen | 2010 | Petroleum Science2010，7，3： | 13 |
| 3 | Effect of heat treatment on mechanical properties of heavily cold-rolled Fe-6.5wt%Si alloy sheet显示文摘Fe-6.5wt%Si alloy has excellent soft magnetic properties,but it is hard to be cold-rolled due to appearance of ordered phases in this alloy.In this paper we report that ultra thin Fe-6.5wt%Si sheet of 0.05 mm thick was obtained by heavily cold rolling.By means of optical microscope,micro-hardness indenter,instron,SEM and X-ray diffraction,the effect of heat treatment on mechanical properties of this alloy sheet was investigated.The heavily cold-rolled sheet exhibits some extent of ductility.The ultimate tensile strength reaches 1.93 GPa.After heat treatment,micro-hardness is decreased and the ductility is lost,especially at temperature above 650℃ when recrystallization takes place.The reason for decreasing the ductility lies in the ordered DO3 phase transformation. | LIANG YongFeng,YE Feng,LIN JunPin,WANG YanLi,ZHANG LaiQi & CHEN GuoLiang State Key Laboratory for Advanced Metals and Materials,University of Science and Technology Beijing,Beijing 100083,China | 2010 | Science China(Technological Sciences)2010，53，4： | 10 |
| 4 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
| 5 | Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis显示文摘 | Lin He Xinhua Liu Jianguo Yang Wanjin Li Shumeng Liu Xujun Liu Ziran Yang Jie Ren Yue Wang Lin Shan Chengjian Guan Fei Pei Liandi Lei Yu Zhang Xia Yi Xiaohan Yang Jing Liang Rong Liu Luyang Sun Yongfeng Shang | 2018 | Cell Research2018，28，9： | 5 |
| 6 | Aerodynamic characteristics of rigid coaxial rotor by wind tunnel test and numerical calculation显示文摘Focusing on aerodynamic characteristics of rigid coaxial rotor of a high-speed helicopter in hover and forward flight, a wind tunnel test is conducted in the 8 m ? 6 m low-speed straightflow wind tunnel of China Aerodynamics Research and Development Center. In the experiment,a 4 m diameter composite model rigid coaxial rotor is designed and manufactured, and firstorder flapping frequency ratio of the blade is 1.796 to ensure sufficient stiffness at the blade root.Rotor aerodynamic performance is measured under hovering and high advance ratio conditions.Also, the numerical method is used to calculate aerodynamic characteristics in typical states of the rigid coaxial rotor for analysis purpose. The rotor lift-drag ratio and lateral lift offset in the experiment are emphatically analyzed for the rigid coaxial rotor. The results indicate that in forward flight condition, the rotor lift-drag ratio first increases and then decreases with the increment of advance ratio and lift offset. When advance ratio remains constant, with the increment of lift offset, the lift-drag ratio of rigid coaxial rotor first increases and then decreases. | Jinghui DENG Feng FAN Ping'an LIU Shuilin HUANG Yongfeng LIN | 2019 | Chinese Journal of Aeronautics2019，32，3： | 5 |
| 7 | Experimental studies on interaction of water mist with class K fires显示文摘Interaction of water mist with cooking oil fires is studied experimentally and theoretically. A LDV/APV system is used to measure the velocity and diameter of water mist at different pressures in the experiments,and the effect of water mist velocity and diameter on fire extinguishment efficiency is investi-gated. The experimental results show that water mist has excellent surface cooling effect; it can control and extinguish cooking oil fires quickly without re-ignition. The critical temperature (Tfo) is calculated by energy balance equation,and the fire plume momentum is calculated and compared with that of water mist in order to determine the critical velocity (νwy) of fire extinguishment. This paper provides references for cooking oil fires extinguishment with water mist. | FANG Yudong ZHANG Yongfeng LIN Lin LIAO Guangxuan HUANG Xin CONG Beihua | 2006 | Chinese Science Bulletin2006，51，24： | 4 |
| 8 | The vertical structure of the atmospheric boundary layer over the central Arctic Ocean显示文摘The tropopause height and the atmospheric boundary layer(PBL)height as well as the variation of inversion layer above the floating ice surface are presented using GPS(global position system)radiosonde sounding data and relevant data obtained by China’s fourth arctic scientific expedition team over the central Arctic Ocean(86–88 N,144–170 W)during the summer of 2010.The tropopause height is from 9.8 to 10.5 km,with a temperature range between–52.2 and–54.1 C in the central Arctic Ocean.Two zones of maximum wind(over 12 m/s)are found in the wind profile,namely,low-and upper-level jets,located in the middle troposphere and the tropopause,respectively.The wind direction has a marked variation point in the two jets from the southeast to the southwest.The average PBL height determined by two methods is 341 and 453m respectively.These two methods can both be used when the inversion layer is very low,but the results vary significantly when the inversion layer is very high.A significant logarithmic relationship exists between the PBL height and the inversion intensity,with a correlation coefficient of 0.66,indicating that the more intense the temperature inversion is,the lower the boundary layer will be.The observation results obviously differ from those of the third arctic expedition zone(80–85 N).The PBL height and the inversion layer thickness are much lower than those at 87–88 N,but the inversion temperature is more intense,meaning a strong iceatmosphere interaction in the sea near the North Pole.The PBL structure is related to the weather system and the sea ice concentration,which affects the observation station. | BIAN Lingen MA Yongfeng LU Changgui LIN Xiang | 2013 | Acta Oceanologica Sinica2013，32，10： | 3 |
| 9 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 10 | Numerical Calculations of Aerodynamic and Acoustic Characteristics for Scissor Tail-Rotor in Forward Flight显示文摘The aerodynamic and aeroacoustic characteristics of a scissor tail-rotor in a forward flight are numerically calculated.A novel computational fluid dynamics(CFD)model based on Navier-Stokes(N-S)equations is presented to simulate the unsteady flowfield and the aerodynamic characteristics of a scissor tail-rotor in the forward flight.Then the Farassat Formulation 1 Aderived from the FW-H equation is coupled into the CFD model in order to compute the aeroacoustic characteristics of the scissor tail-rotor.In addition,two different scissor tail-rotor configurations,i.e.,the L-and U-configuration,are analyzed in details and compared with a conventional one.The influence of scissor angles on the aerodynamic and aeroacoustic characteristics of the scissor tail-rotor is also investigated.The simulation results demonstrate that the flowfield,aerodynamic force and aeroacoustic characteristics of a scissor tail-rotor are significantly different from the conventional one,and the aerodynamic interaction decreases with the increase of scissor angle,which leads to a reduction of amplitude variation of the tail-rotor thrust in the forward flight.The scissor angle has an important effect on the aerodynamics and aeroacoustics of the scissor tail-rotor. | Fan Feng Huang Shuilin Lin Yongfeng | 2016 | Transactions of Nanjing University of Aeronautics and Astronautics2016，33，3： | 3 |
| 11 | Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer显示文摘Lung adenocarcinoma(LUAD)and squamous carcinoma(LUSC)are two major subtypes of non-small cell lung cancer with distinct pathologic features and treatment paradigms.The heterogeneity can be attributed to genetic,transcriptional,and epigenetic parameters.Here,we established a multi-omics atlas,integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing.We investigated their differences in genetic amplification,cellular compositions,and expression modules.We revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells,and had distinct cellular composition modules associated with poor survival of lung cancer.Malignant and stage-specific gene analyses further uncovered critical transcription factors and genes in tumor progression.Moreover,we identified subclusters with proliferating and differentiating properties in AT2 and basal cells.Overexpression assays of ten genes,including sub-cluster markers AQP5 and KPNA2,further indicated their functional roles,providing potential targets for early diagnosis and treatment in lung cancer. | Li Zhang Yiming Zhang Chengdi Wang Ying Yang Yinyun Ni Zhoufeng Wang Tingting Song Menglin Yao Zhiqiang Liu Ningning Chao Yongfeng Yang Jun Shao Zhidan Li Ran Zhou Li Chen Dan Zhang Yuancun Zhao Wei Liu Yupeng Li Ping He Jing-wen Lin Yuan Wang Kang Zhang Lu Chen Weimin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 12 | Genetic diversity analysis of Sinojackia microcarpa, a rare tree species endemic in China, based on simple sequence repeat markers显示文摘Although most Sinojackia species are endangered, they contribute greatly to the biodiversity of local ecosystems. Sinojackia microcarpa, an endangered species, is distributed only in three provinces of eastern China. Determining the genetic diversity of S. microcarpa provides key information for germplasm evaluation and species conservation. Here we used simple sequence repeat (SSR) markers to investigate the genetic diversity of eight natural populations of S. microcarpa. Leaf samples were collected from 144 individuals in 8 wild populations. The 156 bands were generated from 14 pairs of informative SSR primers, with an average percentage of polymorphic bands of 45.67%. The average values of Nei’s genetic diversity (He) and Shannon’s diversity index (I) were 0.1007 and 0.1658, respectively. The total genetic variation of S. microcarpa existed mainly within the eight populations, rather than among populations, and reached 86.41%. A cluster analysis showed that the eight wild populations of S. microcarpa could be classified into four groups, at a threshold of 4.0, based on an analysis of the SSR genotypes. Furthermore, there was a significant association between the phylogenetic relationships and the geographic locations of the S. microcarpa populations. In particular, populations from Fuyang, Jiande, and Lin’an in Zhejiang Province had close phylogenetic relationships and geographic distances. In addition, these three populations had the highest genetic diversity and the most individuals, suggesting that these three locations may be the S.microcarpa distribution center. This study serves as a model for studying the genetic diversity of endangered plant species. | Tailin Zhong Guangwu Zhao Yongfeng Lou Xinchun Lin Xiaomin Guo | 2019 | Journal of Forestry Research2019，30，3： | 2 |
| 13 | Requirement and Development of Hydrogel Micromotors towards Biomedical Applications显示文摘With controllable size,biocompatibility,porosity,injectability,responsivity,diffusion time,reaction,separation,permeation,and release of molecular species,hydrogel microparticles achieve multiple advantages over bulk hydrogels for specific biomedical procedures.Moreover,so far studies mostly concentrate on local responses of hydrogels to chemical and/or external stimuli,which significantly limit the scope of their applications.Tetherless micromotors are autonomous microdevices capable of converting local chemical energy or the energy of external fields into motive forces for self-propelled or externally powered/controlled motion.If hydrogels can be integrated with micromotors,their applicability can be significantly extended and can lead to fully controllable responsive chemomechanical biomicromachines.However,to achieve these challenging goals,biocompatibility,biodegradability,and motive mechanisms of hydrogel micromotors need to be simultaneously integrated.This review summarizes recent achievements in the field of micromotors and hydrogels and proposes next steps required for the development of hydrogel micromotors,which become increasingly important for in vivo and in vitro bioapplications. | Xinyi Lin Borui Xu Hong Zhu Jinrun Liu Alexander Solovev Yongfeng Mei | 2020 | Research2020，，1： | 2 |
| 14 | Kinetics of methanol steam reforming over COPZr-2 catalyst显示文摘COPZr-2 催化剂,在我们的前期研究被准备,在改革反应的甲醇蒸气显示出好催化性能。在这篇文章,最好的被选择为一个例子学习在这类催化剂上改过的甲醇蒸气的反应动力学。首先,到插头公司的甲醇变换的效果 2 和甲醇变换到甲醇上的插头公司假接触时间 W/F MeOH 被调查。然后,由使用反应线路,直接改过的那甲醇(医生) 和甲醇分解(DE ) 在平行被执行,反应有力量功能类型的运动模型被建立。并且为模型的参数用计算了定义对象函数的加权的最少的广场的一个非线性的回归程序被估计。最后,运动模型通过了关联测试和 F-test。 | Yongfeng Li Weiming Lin Lin Yu Zhifeng Hao Rongjian Mai | 2008 | Journal of Natural Gas Chemistry2008，17，2： | 2 |
| 15 | Exploration on crystallization habit of rare earth fluoride crystal BaY2F8 显示文摘 | LIN Junyi RUAN Yongfeng WANG Jun | 2004 | J Rare Earth2004，22，12： | 1 |
| 16 | Research on output performance of tracking fiat-plate PV module 显示文摘 | Lin Juan Xu Yongfeng Li Ming | 2010 | Solar Energy2010，，10： | 1 |
| 17 | Temperature-dependent optical resonance in a thin-walled tubular oxide microcavity显示文摘This work proposes a temperature-response capability of optical resonance in tubular optical oxide microcavities. The thin wall thickness with a subwavelength scale enables these microcavities to interact with the environment effectively. By optimization of the geometries and materials, the tubular microcavities can be tuned into temperature-inert in vacuum, and the experiments support this design. The experiments prove the idea of utilizing them as temperature-inert microcavities. Contrary wavelength shifts from previous studies were observed, which can be explained with the theoretical model. Furthermore, the theoretical results of the present work suggest that novel rolled-up microtubes could act as an exceptional optical microcavity for the application in temperature response. | Yangfu Fang Xianyun Lin Shiwei Tang Borui Xu Jiao Wang Yongfeng Mei | 2017 | Progress in Natural Science:Materials International2017，27，4： | 1 |
| 18 | Exploration on Crystallization Habit of Rare Earth Fluoride Crystal BaY2F8显示文摘 | Lin Junyi Ruan Yongfeng Wang Jun Liu Jian Huan Boxian | 2004 | Journal of Rare Earth2004，22，3： | 1 |
| 19 | Dickkopf-1 autoantibody is a novel serological biomarker for non-small cell lung cancer显示文摘 | Xiao Yao Hua Jiang Cuizhen Zhang Huamao Wang Lin Yang Yongfeng Yu Junming Yu Bizhi Shi Zhijun Shen Huiping Gao Zhiwei Chen Shujun Tian Shun Lu Zonghai Li Jianren Gu | 2010 | Biomarkers2010，，2： | 1 |
| 20 | Pathogenicity and genomic characterization of a pseudorabies virus variant isolated from Bartha-K61-vaccinated swine population in China显示文摘 | Yuzi Luo Na Li Xin Cong Chun-Hua Wang Min Du Lin Li Bibo Zhao Jin Yuan Dan-Dan Liu Su Li Yongfeng Li Yuan Sun Hua-Ji Qiu | 2014 | Veterinary Microbiology2014，，： | 1 |
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