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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | SCC MECHANISM OF STAINLESS STEEL AISI 321 IN ACIDIC CHLORIDE SOLUTION显示文摘It is verified that stainless steel AISI 321 is in the active anodic dissolution state in 0.5mol/L HCll+0.5 mol/L NaCl solution at 55℃.The SCC of the steel in the solution cannot be reasonably explained by passive film rupture-nepasivation theory and by hydrogenembrittlement theory.There are evidences that the fracture stress at the tip of the cracksis reduced by anodic dissolution due to its role in relieving strain hardening layer at cracktip. | HUANG Yanliang CAO Chu’nan LIN Haichao LU Ming Corrosion Science Laboratory,Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang,China Ph D student,Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang 110015,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，12： | 3 |
| 3 | The Distribution and Variability of Simulated Chlorophyll Concentration over the Tropical Indian Ocean from Five CMIP5 Models显示文摘Performances of 5 models from the Coupled Model Intercomparison Project Phase 5 (CMIP5) in simulating the chloro-phyll concentration over the tropical Indian Ocean are evaluated. Results show that these models are able to capture the dominant spatial distribution of observed chlorophyll concentration and reproduce the maximum chlorophyll concentration over the western part of the Arabian Sea, around the tip of the Indian subcontinent, and in the southeast tropical Indian Ocean. The seasonal evolution of chlorophyll concentration over these regions is also reproduced with significant amplitude diversity among models. All of 5 mod-els is able to simulate the interannual variability of chlorophyll concentration. The maximum interannual variation occurs at the same regions where the maximum climatological chlorophyll concentration is located. Further analysis also reveals that the Indian Ocean Dipole events have great impact on chlorophyll concentration in the tropical Indian Ocean. In the general successful simulation of chlorophyll concentration, most of the CMIP5 models present higher than normal chlorophyll concentration in the eastern equatorial Indian Ocean. | LIU Lin FENG Lin YU Weidong WANG Huiwu LIU Yanliang SUN Shuangwen | 2013 | Journal of Ocean University of China2013，12，2： | 2 |
| 4 | Accelerated anaerobic corrosion of electroactive sulfate-reducing bacteria by electrochemical impedance spectroscopy and chronoamperometry显示文摘 | Lin Yu Jizhou Duan Xiangqian Du Yanliang Huang Baorong Hou | 2013 | Electrochemistry Communications2013，，： | 1 |
| 5 | Enhanced stability of Pt/Al_(2)O_(3) modified by Zn promoter for catalytic dehydrogenation of ethane显示文摘Catalytic ethane dehydrogenation(EDH) to ethylene over Pt-based catalysts has received increasing interests in recent years as it is a potential alternative route to conventional steam cracking. However, the catalysts used in this reaction often suffer from rapid deactivation due to serious coke deposition and metal sintering. Herein, we reported the effects of Zn modification on the stability of Pt/Al2 O3 for EDH.The Zn-modified sample(PtZn2/Al2 O3) exhibits stable ethane conversion(20%) with over 95% ethylene selectivity. More importantly, it exhibits a significantly low deactivation rate of only 0.003 h-1 at 600 °C for70 h, which surpasses most of previously reported catalysts. Detailed characterizations including in situ FT-IR, ethylene adsorption microcalorimetry, and HAADF-STEM etc. reveal that Zn modifier reduces the number of Lewis acid sites on the catalyst surface. Moreover, it could modify Pt sites and preferentially cover the step sites, which decrease surface energy and retard the sintering of Pt particle, then prohibiting the further dehydrogenation of ethylene to ethylidyne. Consequently, the good stability is realized due to anti-sintering and the decrease of coke formation on the Pt Zn2/Al2 O3 catalyst. | Xiaoyu Li Yanliang Zhou Botao Qiao Xiaoli Pan Chaojie Wang Liru Cao Lin Li Jian Lin Xiaodong Wang | 2020 | Journal of Energy Chemistry2020，29，12： | 1 |
| 6 | Boosting Efficient Ammonia Synthesis over Atomically Dispersed Co-Based Catalyst via the Modulation of Geometric and Electronic Structures显示文摘Ammonia(NH_(3))synthesis at mild conditions is of great significance,while the significant bottleneck of this process is the activation of N_(2) to realize the desired NH_(3) synthesis performance,which requires deep insight and rational design of active sites at the atomic level.Here,were synthesized atomically dispersed Co-based catalysts with different Co-N coordination numbers(CNs)to explore the coordination-sensitive NH_(3) synthesis reaction for the first time.Our studies showed that Co-based catalysts increased the NH_(3) synthesis rate gradually with a decrease in CN.The Co-N_(2) catalyst exhibited the highest NH_(3) synthesis rate of 85.3 mmol gCo^(−1) h^(−1) at 300℃ and 1 MPa,which outperformed most of the previously reported Co-based catalysts.Various characterizations and theoretical calculations demonstrated that atomically dispersed Co catalyst with low CN could generate more unoccupied Co 3d charges and tetrahedral cobalt(Ⅱ)sites.The unoccupied Co 3d charge,in turn,promoted the electron donation from the Co active center to the antibonding π-orbital(π*)of N_(2) and expedites N_(2) hydrogenation.Furthermore,the Co-N_(2) catalyst with more tetrahedral cobalt(II)sites could effectively facilitate the desorption of N-containing intermediate species(such as*NH_(3) and*N_(2)H_(4))to obtain a high NH_(3) synthesis rate. | Yanliang Zhou Congying Wang Xuanbei Peng Tianhua Zhang Xiuyun Wang Yafei Jiang Haifeng Qi Lirong Zheng Jianxin Lin Lilong Jiang | 2022 | CCS Chemistry2022，4，5： | 1 |
| 7 | Identification of ions present in LiF-DyF_3 melts and the mechanism of Dy_2O_3 dissolution therein显示文摘Herein, the present paper were attempted to identify ions in LiF-DyF_3 melts according to the law of decreasing primary crystallization temperature and model analysis. Specifically.the primary crystallization temperatures of LiF-DyF_3 and LiF-DyF_3-Dy_2O_3 melts with various DyF_3 and Dy_2O_3 contents were determined by differential scanning calorimetry(DSC), and reactions occurring in the above melts were investigated using ideal dilute solution(Temkin and Flood) models. Moreover, crystal phases produced by rapid solidification of LiF-DyF_3, LiF-Dy_2O_3, DyF_3-Dy_2O_3, and LiF-DyF_3-Dy_2O_3 melts were identified by X-ray diffraction(XRD) analysis. The primary crystallization temperature of LiF-DyF_3 melts exhibits an approximately linear decrease with increasing molar fraction of DyF_3, and the general formula of complex ions in these melts is expressed as DyF_x^((3-x)),e.g., DyF_4^-. Finally, we investigated the dissolution of Dy_2O_3 in LiF-DyF_3 melts, showing that it was chemical in nature and afforded Dy_(1+x)O_(3x)F_(3-3x) and DyOF. | Chunfa Liao Shumei Chen Xu Wang Boqing Cai Jueyuan Lin Yunfen Jiao Yanliang Zeng | 2019 | Journal of Rare Earths2019，37，2： | 1 |
| 8 | Potential Response Analysis of Exponentially Decaying Polarizing Current of Electrode and its Use in the Study of Stress Corrosion Cracking(SCC)of Stainless Steel显示文摘A study on the potential response of exponentially decaying polarizing current of electrode was car-ried out.The appearance of critical point of the potential-time response of exponentially decayingcurrent was ensured from theoretical analysis,and this is the theoretical foundation of the criticalpoint method for the measurement of corrosion current of metals.The comparison of the corrosioncurrents measured by the critical point and static methods for the system of 321 stainless steel in0.5N HCI+0.5N NaCI solution at static state shows that the results agree very well.Finally.the tran-sient corrosion currents of 321 stainless steel in 0.5N HCI+0.5N NaCl solution at different strain levelare listed. | Yanliang HUANG Ming LU Chunan CAO Haichao LIN Ming LU Corrosion Science Laboratory,Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang,110015,China | 1993 | Journal of Materials Science & Technology1993，9，3： | 0 |
| 9 | Study of Local Structural Changes on Air Cooling at the End of Rotor Windings for Variable Speed Pumped Storage Generator-Motor显示文摘The shrink fit retaining ring is currently the easiest to install and the most widely used end fixed for structure AC excitation variable speed generator-motor rotor end windings.However,the current research on the effect of high strength sealing on the ventilation and heat dissipation performance of the end is not enough.In this paper,based on the actual structural parameters and periodic symmetry simplification,the three-dimensional coupled calculation model of fluid field and temperature field is established.After solving the fluid and thermal equations,the influence of the length of rotor support block,the height of rotor support block,and the number of rotor support block on the fluid flow and temperature distribution in the rotor end region of generator-motor is studied using the finite volume method.The rheological characteristics of the air in the rotor domain,such as velocity and inter-winding flow,are analyzed.The law of temperature variation with local structure in the computational domain is studied.The variation law of cooling medium performance inside the large variable speed power generator motor is revealed. | Yanliang Qiu Bin Xiong Zhe Hou Lin Luo | 2022 | Energy Engineering2022，119，6： | 0 |
| 10 | A theoretical study of electronic excited states of photosynthetic reaction center in Rhodopseudomonas viridis显示文摘The electronic singlet vertical excited states of photosynthetic reaction center (PSRC) in Rhodopseudomonas (Rps.) viridis were investigated by ZINDO and INDO/S methods. The effects of the interactions of pigment-pigment and pigment-protein on the electronic excitations were examined. The calculation results showed that the interactions of pigment-pigment and pigment-protein play an important role in reasonably assigning the experimental absorption and circular dichroism (CD) spec-tra of PSRC in Rps. virids. By comparing the theoretically computed excited states with the experi-mental absorption and CD spectra, satisfactory assignments of the experimental spectroscopic peaks were achieved. | REN Yanliang CHENG Lin WAN Jian LI Yongjian LIU Junjun YANG Guangfu ZHANG Lihua YANG Song | 2006 | Science China Chemistry2006，49，1： | 0 |
| 11 | Highly efficient subnanometer Ru-based catalyst for ammonia synthesis via an associative mechanism显示文摘The industrial manufacture of ammonia(NH_(3))using Fe-based catalyst works under rigorous conditions.For the goal of carbon-neutrality,it is highly desired to develop advanced catalyst for NH_(3)synthesis at mild conditions to reduce energy consumption and CO_(2)emissions.However,the main challenge of NH_(3)synthesis at mild conditions lies in the dissociation of steady N≡N triple bond.In this work,we report the design of subnanometer Ru clusters(0.8 nm)anchored on the hollow N-doped carbon spheres catalyst(Ru-SNCs),which effectively promotes the NH_(3)synthesis at mild conditions via an associative route.The NH_(3)synthesis rate over Ru-SNCs(0.49%(mass)Ru)reaches up to 11.7 mmol NH_(3)·(g cat)^(-1)·h^(-1) at 400℃ and 3 MPa,which is superior to that of 8.3 mmol NH_(3)·(g cat)^(-1)·h^(-1) over Ru nanoparticle catalyst(1.20%(mass)Ru).Various characterizations show that the N_(2)H_(4)species are the main intermediates for NH_(3)synthesis on Ru-SNCs catalyst.It demonstrates that Ru-SNCs catalyst can follow an associative route for N_(2)activation,which circumvents the direct dissociation of N_(2)and results in highly efficient NH_(3)synthesis at mild conditions. | Yanliang Zhou Qianjin Sai Zhenni Tan Congying Wang Xiuyun Wang Bingyu Lin Jun Ni Jianxin Lin Lilong Jiang | 2022 | Chinese Journal of Chemical Engineering2022，35，3： | 0 |
| 12 | Extreme Sea Level Rise off the Northwest Coast of the South China Sea in 2012显示文摘Tide gauge data are used to investigate sea level variability off the northwest coast of the South China Sea(SCS) in 2012,and a significant sea level elevation with a magnitude approaching 79 mm is observed.Analysis suggests that an abnormal sea surface heat flux and freshwater flux may have contributed to this abnormal rise in sea level,together with the remote influence of an ENSO event.Further investigation shows that the event was dominated by the positive freshwater flux,where large volumes of water entered the ocean,and a maximum is centered to the south of Guangdong province,China.Simultaneously,a positive anomalous heat flux occurred in the northwestern part of the SCS,which is considered to have made a positive contribution to the high local sea level elevation.In addition to the heat flux,the ENSO event also had a significant effect on the event,where the La Ni?a-induced northwest Pacific cyclone contributed to sea level rise over the northwestern SCS through dynamic and thermodynamic interactions. | LIU Lin LI Juan TAN Wei WU Yue LIU Yanliang WANG Huiwu | 2018 | Journal of Ocean University of China2018，17，5： | 0 |
| 13 | Early Imaging Features and Differential Diagnosis of Novel Coronavirus Pneumonia显示文摘Objective:To discuss the early imaging features of novel coronary pneumonia(NCP)and its differential diagnosis with common pneumonia for the clinical Provide relatively correct imaging diagnosis.Methods:A review of 10 cases of novel coronavirus pneumonia diagnosed in our hospital and surrounding counties was collected,and our hospital's 2019-2020 Common pneumonia such as influenza A and B virus pneumonia,lobar pneumonia and adenovirus confirmed by laboratory tests and abnormal chest radiographs Ten patients each with pneumonia,a total of 40 patients,were collected and their imaging features were analyzed.Results:In 10 patients with neo-coronary pneumonia,there were 30 lesions on chest CT,with typical characteristic lesions containing bronchograms within their Angiographic thickening;located in the subpleura,with grinding glass-like or combined solid changes,referred to as'extratubular halo',with multifocal and multifocal distribution.Morphology or unilobular large lamellar foci without lymph node enlargement and pleural effusion;10 cases of influenza A and B virus pneumonia in chest CT performance In nine patients,the lesions were distributed in the subpleural or along the perimeter of the bronchial vessels in the form of an analogous circular ground-glass shadow,some of which was a small piece of solid shadow,1 The case involved a single lobe of the lung and showed a large mixed ground glass image,and the CT in 10 cases of lobar pneumonia showed that they all had a single large solid lobe The variegated shadow or patchy cloud with blurred margins was triangularly altered with the tip pointing to the lung portal,and there were five cases of air-containing bronchograms.Adenoviral pneumonia is more common in infants and young children,and CT showed single or multiple grinded glass images in both lungs with patchy solid variegated shadows and lobar distribution.Conclusion:NCP and common pneumonia have certain imaging features that,in combination with laboratory tests and epidemiologic history,allow a preliminary diagnosis to be made.It has certain directions and help for clinical diagnosis. | Xiaofeng Jiang Xuyang Ma Tao Zhang Yanliang Kong Lei Cai Lin Lv Yanli Shao Jiangtao Bai Lianfeng Liu | 2020 | Journal of Clinical and Nursing Research2020，4，5： | 0 |
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