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| 1 | Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers显示文摘 | Kaichao Feng Yang Liu Yelei Guo Jingdan Qiu Zhiqiang Wu Hanren Dai Qingming Yang Yao Wang Weidong Han1,3 | 2018 | Protein & Cell2018，9，10： | 37 |
| 2 | Soil water depletion depth by planted vegetation on the Loess Plateau显示文摘Evapotranspiration of much planted vegetation exceeds precipitation, and this can deplete soil water and cause a deep dry layer in the soil profile, which is a serious obstacle to sustainable land use on the Loess Plateau, China. This study aimed to determine water depletion depth of planted grassland, shrub, and forest in a semiarid area on the Loess Plateau. Soil moisture of five vegetation types was measured to >20 m in depth. The vegetation types were crop, natural grasse, seven-year-old planted alfalfa (Medicago sativa L.), 23-year-old planted caragana (Caragana microphylla Lam.) shrub, and 23-year-old planted pine (Pinus tabulaeformis L) forest land. Through comparing moisture of planted alfalfa grass, caragana shrub, and pine forest to crop and natural grassland, the depth and amount of soil water consumed by grassland, caragana brush and pine forest was determined. The depth of soil water depleted by alfalfa, caragana brush, and pine forest reached 15.5, 22.4 and 21.5 m, respectively. | WANG ZhiQiang LIU BaoYuan LIU Gang ZHANG YongXuan | 2009 | Science China Earth Sciences2009，52，6： | 29 |
| 3 | Effects of clay and calcium ions on coal flotation显示文摘The microflotation of three single minerals,mixed coal–kaolinite and mixed coal–montmorillonite were examined to study the effects of clay and calcium ions on coal flotation.The results show that the ash content of flotation concentrate increases by 3%in the presence of clay minerals,and the ash content would further increase by 3%in co-presence of clay minerals and high concentration of Ca2+.Scanning electron microscope(SEM)images and elemental spectrum analysis indicate that fne clay particles that coat on the coal surface,which is called slime coating,can affect the coal flotation.The slime coating would be induced much more easily in the presence of Ca2+. | Zhang Zhijun Liu Jiongtian Xu Zhiqiang Ma Liqiang | 2013 | International Journal of Mining Science and Technology2013，23，5： | 24 |
| 4 | Impacts of LUCC processes on potential land productivity in China in the 1990s显示文摘Using meteorological data and RS dynamic land-use observation data set, the po-tential land productivity that is limited by solar radiation and temperature is estimated and the impacts of recent LUCC processes on it are analyzed in this paper. The results show that the influence of LUCC processes on potential land productivity change has extensive and unbal-anced characteristics. It generally reduces the productivity in South China and increases it in North China, and the overall effect is increasing the total productivity by 26.22 million tons. The farmland reclamation and original farmlands losses are the primary causes that led potential land productivity to change. The reclamation mostly distributed in arable-pasture and arable-forest transitional zones and oasises in northwestern China has made total productivity increase by 83.35 million tons, accounting for 3.50% of the overall output. The losses of original farmlands driven by built-up areas invading and occupying arable land are mostly distributed in the regions which have rapid economic development, e.g. Huang-Huai-Hai plain, Yangtze River delta, Zhu-jiang delta, central part of Gansu, southeast coastal region, southeast of Sichuan Basin and Urumqi-Shihezi. It has led the total productivity to decrease 57.13 million tons, which is 2.40% of the overall output. | LIU Jiyuan XU Xinliang ZHUANG Dafang GAO Zhiqiang | 2005 | Science China Earth Sciences2005，48，8： | 22 |
| 5 | Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription显示文摘为 histone crotonylation 的酶和读者蛋白质上的最近的研究在抄写支持 histone crotonylation 的功能。然而,为 histone decrotonylation (HDCR ) 负责的酶仍然保持糟糕定义。而且,如果 histone crotonylation 从生理地重要、机能上地不同或对 histone acetylation 冗余,它尚待坚定。这里我们一级 histone deacetylases (HDAC ) 而非 sirtuin 家庭 deacetylases (SIRT ) 是主要 histone decrotonylases 的现在的证据,和那 histone crotonylation 象在哺乳动物的房间的 histone acetylation 一样动态。尤其是,我们与损害 HDAC 产生了新奇 HDAC1 和 HDAC3 异种但是未经触动的 HDCR 活动。用这些异种,我们证明在哺乳动物的房间的选择 HDCR 与宽广 transcriptional 压抑和 crotonylation 然而并非 acetylation 读者蛋白质的减少的倡导者协会相关。而且,我们证明那 histone crotonylation 被充实在并且为老鼠的自强要求了胚胎的干细胞。 | Wei Wei Xiaoguang Liu Jiwei Chen Shennan Gao Lu Lu Huifang Zhang Guangjin Ding Zhiqiang Wang Zhongzhou Chen Tieliu Shi Jiwen Li Jianjun Yu Jiemin Wong | 2017 | Cell Research2017，27，7： | 18 |
| 6 | Arabidopsis AtBECLIN 1/AtAtg6/AtVps30 is essential for pollen germination and plant development显示文摘兼容丑恶纸巾的表面上的花粉萌芽是为植物授精的必要的步。这里,我们报导 Arabidopsis 变异的 bcl1 是由于花粉萌芽的失败不育的男性。我们证明 bcl1 异种等位基因不能被男配偶体播送,没有同型结合的 bcl1 异种被获得。花粉发育阶段的分析显示 bcl1 变化影响花粉萌芽然而并非花粉成熟。分子的分析证明花粉萌芽的失败被 AtBECLIN 1 的混乱引起。AtBECLIN 1 在成熟花粉主要被表示并且与重要相同编码蛋白质到在酵母为 autophagyand vacuolar 蛋白质排序的过程(VPS ) 要求的 Beclin1/Atg6/Vps30。我们也证明 AtBECLIN 1 为正常被要求植物开发,和那与 autophagy, VPS 和 glycosylphosphatidylinositolanchor 系统有关的基因,被 AtBECLIN 1 的缺乏影响。 | Genji Qin Zhiqiang Ma Li Zhang Shufan Xing Xianhui Hou Jie Deng Jingjing Liu Zhangliang Chen Li-Jia Qu Hongya Gu | 2007 | Cell Research2007，17，3： | 17 |
| 7 | Simulation study of China's net primary production显示文摘Spatial and temporal distribution of vegetation net primary production(NPP)in China was studied us-ing three light-use efficiency models(CASA,GLOPEM and GEOLUE)and two mechanistic ecological process models(CEVSA,GEOPRO).Based on spatial and temporal analysis(e.g.monthly,seasonally and annually)of simulated results from ecological process mechanism models of CASA,GLOPEM and CEVSA,the following conclusions could be made:(1)during the last 20 years,NPP change in China followed closely the seasonal change of climate affected by monsoon with an overall trend of increas-ing;(2)simulated average seasonal NPP was:0.571±0.2 GtC in spring,1.573±0.4 GtC in summer,0.6±0.2 GtC in autumn,and 0.12±0.1 GtC in winter.Average annual NPP in China was 2.864±1 GtC.All the five models were able to simulate seasonal and spatial features of biomass for different ecological types in China.This paper provides a baseline for China's total biomass production.It also offers a means of estimating the NPP change due to afforestation,reforestation,conservation and other human activities and could aid people in using for-mentioned carbon sinks to fulfill China's commitment of reducing greenhouse gases. | GAO ZhiQiang LIU JiYuan | 2008 | Chinese Science Bulletin2008，53，3： | 17 |
| 8 | Design and integration of flexible planar micro- supercapacitors显示文摘作为精力存储设备的有希望的候选人,因为他们的唯一的特征, supercapacitors (SC ) 吸引了可观的注意,例如他们的高力量密度,突出的率能力,优秀骑车表演,和安全。在便携式的电子设备的最近的吊杆要求灵活的高效的 SC,简化,薄、综合。巨大的努力被各种各样的方法基于不同活跃电极材料向平面 micro-SCs (MSC ) 的设计和集成指导了。这评论与另外的电子设备在灵活平面 MSC 和他们的集成的设备设计加亮最近的开发。为灵活 MSC 的发展的当前的挑战和未来前景也被讨论。 | Lili Liu Zhiqiang Niu Jun Chen | 2017 | Nano Research2017，10，5： | 16 |
| 9 | A long-term Global LAnd Surface Satellite(GLASS)data-set for environmental studies显示文摘Recently,five Global LAnd Surface Satellite(GLASS)products have been released:leaf area index(LAI),shortwave broadband albedo,longwave broadband emissivity,incident short radiation,and photosynthetically active radiation(PAR).The first three products cover the years 19822012(LAI)and 19812010(albedo and emissivity)at 15 km and 8-day resolutions,and the last two radiation products span the period 20082010 at 5 km and 3-h resolutions.These products have been evaluated and validated,and the preliminary results indicate that they are of higher quality and accuracy than the existing products.In particular,the first three products have much longer time series,and are therefore highly suitable for various environmental studies.This paper outlines the algorithms,product characteristics,preliminary validation results,potential applications and some examples of initial analysis of these products. | Shunlin Liang Xiang Zhao Suhong Liu Wenping Yuan Xiao Cheng Zhiqiang Xiao Xiaotong Zhang Qiang Liu Jie Cheng Hairong Tang Yonghua Qu Yancheng Bo Ying Qu Huazhong Ren Kai Yu John Townshend | 2013 | International Journal of Digital Earth2013，6，S01： | 16 |
| 10 | Impacts of land-use and climate changes on ecosystem productivity and carbon cycle in the cropping-grazing transitional zone in China显示文摘The impact of land-use/land-cover and climate changes on ecosystem productivity and carbon cycle is one of the most important issues in global change studies. In the past 20 years, the climate and land-use in China have changed significantly and have had important ecological consequences, especially in ecologically sensitive regions, e.g. the cropping-grazing transition zone (CGTZ). Here we present a study that used a process-based ecosystem model and data of land-use changes based on remote sensing and of climate change at high spatial and temporal resolution to estimate the impacts of land-use and climate changes on net primary productivity (NPP), vegetation carbon storage, soil heterotrophic respiration (HR), carbon storage and net ecosystem productivity (NEP) in the CGTZ of China. The results show that the warming and decreases in precipitation in CGTZ reduced NPP by 3.4%, increased HR by 4.3%, and re- duced annual mean total NEP by 33.7Tg from the 1980s to the 1990s. Although carbon storage in vegetation and soil was increasing because the mean NPP for the period was higher than HR, the decreasing NEP indicate that climate change reduced the carbon uptake rate. However, land-use changes in this zone caused increases in NPP by 3.8%, vegetation carbon storage by 2.4%, and annual total NEP by 0.59Tg. The land-use changes enhanced ecosystem carbon up- take, but not enough to offset the negative effect of the climate change. The climate change had greater impacts than the land-use change for the whole CGTZ zone, but had smaller impacts than the land-use change in the regions where it occurred. | GAO Zhiqiang LIU Jiyuan CAO Mingkui LI Kerang TAO Bo | 2005 | Science China Earth Sciences2005，48，9： | 16 |
| 11 | Numerical analysis for cooling effect of open boundary ripped-rock embankment on Qinghai-Tibetan railway显示文摘The heat convection of fluid inside the ballast layer and ripped-rock layer, which are re- garded as porous media in railway embankment, is a process of heat and mass transfer. At present, the ripped-rock embankment, as a new type of embankment structure, has widely been used in the construction of Qinghai-Tibetan railway. However, because its ripped-rock layer is almost open in two bilateral boundaries and closed at top and bottom, and air can flow into/out of the ballast layer and ripped-rock layer, the convection and transfer heat patterns are very complicated in the embankment. Therefore, based on the temperature and geology conditions of the Qinghai-Tibetan Plateau, a nu- merical approach of the unsteady two-dimensional continuity, momentum (non-Darcy flow) and en- ergy equations of heat convection for incompressible fluid in porous media is provided to analyze the velocity and temperature characteristics of the ripped-rock embankment with different embankment heights under open boundary condition for the coming 50 years in this paper. The calculated results indicate that, due to the influence of the outside wind, the convective heat transfer mainly relies on the forced convection in the open ripped-rock embankment. Even if the air temperature will be warmed up by 2.6℃ in the coming 50 years, it still has a better cooling effect on the underlying soils and a low temperature frozen-soil core is formed in the permafrost below it if the embankment is constructed in the regions whose present mean annual air temperature is ?4.0℃. Furthermore, the cooling effect of high ripped-rock embankment is better than that of low embankment. This is because the wider bot- tom of high embankment has a more influence dimension on the underlying frozen soil. However, cardinal winds on the Qinghai-Tibetan Plateau disturb its convection pattern, so that an asymmetric temperature distribution occurs under high embankment and it is possible to induce a transverse un- even deformation of embankment, but no similar situation occurs under low embankment. This asymmetric temperature field problem should be considered when ripped-rock embankment is de- signed and constructed. | LAI Yuanming ZHANG Mingyi LIU Zhiqiang YU Wenbing | 2006 | Science China Earth Sciences2006，49，7： | 15 |
| 12 | Characteristics and recent trends of sulfur dioxide at urban,rural,and background sites in North China:Effectiveness of control measures显示文摘SO 2 measurements made in recent years at sites in Beijing and its surrounding areas are performed to study the variations and trends of surface SO 2 at different types of sites in Northern China.The overall average concentrations of SO 2 are (16.8±13.1) ppb,(14.8±9.4) ppb,and (7.5±4.0) ppb at China Meteorological Administration (CMA,Beijing urban area),Gucheng (GCH,relatively polluted rural area,110 km to the southwest of Beijing urban area),and Shangdianzi (SDZ,clean background area,100 km to the northeast of Beijing urban area),respectively.The SO 2 levels in winter (heating season) are 4-6 folds higher than those in summer.There are highly significant correlations among the daily means of SO 2 at different sites,indicating regional characteristics of SO 2 pollution.Diurnal patterns of surface SO 2 at all sites have a common feature with a daytime peak,which is probably caused by the downward mixing and/or the advection transport of SO 2 -richer air over the North China Plain.The concentrations of SO 2 at CMA and GCH show highly significant downward trends (-4.4 ppb/yr for CMA and -2.4 ppb/yr for GCH),while a less significant trend (-0.3 ppb/yr) is identified in the data from SDZ,reflecting the character of SDZ as a regional atmospheric background site in North China.The SO 2 concentrations of all three sites show a significant decrease from period before to after the control measures for the 2008 Olympic Games,suggesting that the SO 2 pollution control has long-term effectiveness and benefits.In the post-Olympics period,the mean concentrations of SO 2 at CMA,GCH,and SDZ are (14.3±11.0) ppb,(12.1±7.7) ppb,and (7.5±4.0) ppb,respectively,with reductions of 26%,36%,and 13%,respectively,compared to the levels before.Detailed analysis shows that the differences of temperature,relative humidity,wind speed,and wind direction were not the dominant factors for the significant differences of SO 2 between the pre-Olympics and post-Olympics periods.By extracting the data being more representative of local or regional characteristics,a reduction of up to 40% for SO 2 in polluted areas and a reduction of 20% for regional SO 2 are obtained for the effect of control measures implemented for the Olympic Games. | Weili Lin Xiaobin XU Zhiqiang Ma Huarong Zhao Xiwen Liu Ying Wang | 2012 | Journal of Environmental Sciences2012，24，1： | 15 |
| 13 | Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes显示文摘Being infected by SARS-CoV-2 may cause damage to multiple organs in patients, such as the lung, liver and heart. Angiotensin-converting enzyme 2(ACE2), reported as a SARS-CoV-2 receptor, is also expressed in human male testes. This suggests a potential risk in human male reproductive system. However, the characteristics of ACE2-positive cells and the expression of other SARS-CoV-2 process-related genes are still worthy of further investigation. Here, we performed singlecell RNA seq(scRNA-seq) analysis on 853 male embryo primordial germ cells(PGCs) and 2,854 normal testis cells to assess the effects of the SARS-CoV-2 virus on the male reproductive system from embryonic stage to adulthood. We also collected and constructed the scRNA-seq library on 228 Sertoli cells from three non-obstructive azoospermia(NOA) patients to assess the effects at disease state. We found that ACE2 expressing cells existed in almost all testis cell types and Sertoli cells had highest expression level and positive cells ratio. Moreover, ACE2 was also expressed in human male PGCs. In adulthood, the level of ACE2 expression decreased with the increase of age. We also found that ACE2 positive cells had high expressions of stress response and immune activation-related genes. Interestingly, some potential SARS-CoV-2 process-related genes such as TMPRSS2, BSG, CTSL and CTSB had different expression patterns in the same cell type. Furthermore, ACE2 expression level in NOA donors’ Sertoli cells was significantly decreased. Our work would help to assess the risk of SARS-CoV-2 infection in the male reproductive system. | Xixi Liu Yidong Chen Wenhao Tang Li Zhang Wei Chen Zhiqiang Yan Peng Yuan Ming Yang Siming Kong Liying Yan Jie Qiao | 2020 | Science China(Life Sciences)2020，63，7： | 14 |
| 14 | Functional electrical stimulation-facilitated proliferation and regeneration of neural precursor cells in the brains of rats with cerebral infarction显示文摘Previous studies have shown that proliferation of endogenous neural precursor cells cannot alone compensate for the damage to neurons and axons. From the perspective of neural plasticity, we observed the effects of functional electrical stimulation treatment on endogenous neural precursor cell proliferation and expression of basic fibroblast growth factor and epidermal growth factor in the rat brain on the infarct side. Functional electrical stimulation was performed in rat models of acute middle cerebral artery occlusion. Simultaneously, we set up a placebo stimulation group and a sham-operated group. Immunohistochemical staining showed that, at 7 and 14 days, compared with the placebo group, the numbers of nestin(a neural precursor cell marker)-positive cells in the subgranular zone and subventricular zone were increased in the functional electrical stimulation treatment group. Western blot assays and reverse-transcription PCR showed that total protein levels and gene expression of epidermal growth factor and basic fibroblast growth factor were also upregulated on the infarct side. Prehensile traction test results showed that, at 14 days, prehension function of rats in the functional electrical stimulation group was significantly better than in the placebo group. These results suggest that functional electrical stimulation can promote endogenous neural precursor cell proliferation in the brains of acute cerebral infarction rats, enhance expression of basic fibroblast growth factor and epidermal growth factor, and improve the motor function of rats. | Yun Xiang Huihua Liu Tiebin Yan Zhiqiang Zhuang Dongmei Jin Yuan Peng | 2014 | Neural Regeneration Research2014，9，3： | 13 |
| 15 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 16 | Oxidized low-density lipoprotein activates adipophilin through ERK1/2 signal pathway in RAW264.7 cells显示文摘它被报导了那氧化低密度的脂蛋白(Ox-LDL ) 能增加 adipophilin 的表示。然而,详细机制充分没被理解。这研究的目的是在 adipophilin 表示和细胞内部的类脂化合物微滴累积上调查 Ox-LDL 的机制。一个鼠标像巨噬细胞的房间线, RAW264.7,全部被使用,并且 Ox-LDL 以一种剂量依赖者方式导致了 adipophilin 表示,这被发现。而且, Ox-LDL 导致了 peroxisome 激活 proliferator 的受体 --(PPAR ) 表示和 PPAR 特定的禁止者 T0070907 没废除 Ox-LDL-induced adipophilin 表示,而是特定的收缩筋 GW1929。而且, Ox-LDL 导致了 ERK1/2 的 phosphorylation,并且由 PD98059 的 ERK1/2-specific 抑制压制了 Ox-LDL-induced PPAR 和 adipophilin 表示。结果显示出那 ERK1/2 或 PPAR 特定的抑制减少了细胞内部的类脂化合物微滴的数量。同时, PPAR 特定的收缩筋增加了细胞内部的类脂化合物微滴。这些结果建议 Ox-LDL-induced 经由 ERK1/2 激活在 adipophilin 水平增加是在 RAW264.7 房间导致细胞内部的类脂化合物微滴的更大的数量的机制之一,它显示 adipophilin 涉及动脉粥样硬化患者前进。 | Qingnan Liu Zhibing Dai Zhiqiang Liu Xiaohui Liu Chaoke Tang Zuo Wang Guanghui Yi Lushan Liu Zhisheng Jiang Yongzong Yang Zhonghua Yuan | 2010 | Acta Biochimica et Biophysica Sinica2010，42，9： | 13 |
| 17 | Marine Yeasts and Their Applications in Mariculture显示文摘The terrestrial yeasts have been receiving great attention in science and industry for over one hundred years because they can produce many kinds of bioactive substances. However, little is known about the bioactive substances of marine yeasts. In recent years, it has been found that marine yeasts have wide applications in mariculture and other fields. Therefore,marine yeasts, the bioactive substances from them and the applications of marine yeasts themselves and the bioactive substances they produced are reviewed in this paper. | CHI Zhenming LIU Zhiqiang GAO Lingmei GONG Fang MA Chunling WANG Xianghong LI Haifeng | 2006 | Journal of Ocean University of China2006，5，3： | 12 |
| 18 | Relative position determination of a lunar rover using the biased differential phase delay of same-beam VLBI显示文摘When only data transmission signals with a bandwidth of 1 MHz exist in the rover, the position can be obtained using the differential group delay data of the same-beam very long baseline interferometry (VLBI). The relative position between a lunar rover and a lander can be determined with an error of several hundreds of meters. When the guidance information of the rover is used to determine relative position, the rover's wheel skid behavior and integral movement may influence the accuracy of the determined position. This paper proposes a new method for accurately determining relative position. The differential group delay and biased differential phase delay are obtained from the same-beam VLBI observation, while the modified biased differential phase delay is obtained using the statistic mean value of the differential group delay and the biased phase delay as basis. The small bias in the modified biased phase delay is estimated together with other parameters when the relative position of the rover is calculated. The effectiveness of the proposed method is confirmed using the same-beam VLBI observation data of SELENE. The radio sources onboard the rover and the lander are designed for same-beam VLBI observations. The results of the simulations of the differential delay of the same-beam VLBI observation between the rover and the lander show that the differential delay is sensitive to relative position. An approach to solving the relative position and a strategy for tracking are also introduced. When the lunar topography data near the rover are used and the observations are scheduled properly, the determined relative position of the rover may be nearly as accurate as that solved using differential phase delay data. | CHEN Ming LIU QingHui WU YaJun ZHAO RongBing DAI ZhiQiang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，12： | 12 |
| 19 | An efficient rendering method for large vector data on large terrain models显示文摘This paper presents an efficient way to render large-scale vector maps on level-of-detail(LOD) digital elevation models(DEMs).By using the frame buffer and Voronoi diagram,we achieve a rapid simplification of large-scale vector maps while keeping their original topological relationships.With the simplified maps,we establish level-of-detail vector map models.In the detailed level,we use the stencil shadow volume approach to render the map accurately,and in the coarse level we use substitute techniques to render the map approximately yet more quickly.The method proposed in this paper is universally applicable to rendering vector maps on various LOD terrain models,and the overlaying performance is independent of the complexity of underlying terrain surfaces.By use of the view frustum culling and sub-region index techniques,the impact of complexity of vector maps is reduced,and the rendering time is restricted to a certain scope.Thereby,we can achieve seamless and rapid rendering of large-scale vector maps on LOD terrain surfaces. | YANG Ling ZHANG LiQiang KANG ZhiZhong XIAO ZhiQiang PENG JunHuan ZHANG XingMing LIU Liu | 2010 | Science China(Information Sciences)2010，53，6： | 11 |
| 20 | Neddylation of PTEN regulates its nuclear import and promotes tumor development显示文摘PTEN tumor suppressor opposes the PI3K/Akt signaling pathway in the cytoplasm and maintains chromosomal integrity in the nucleus.Nucleus–cytoplasm shuttling of PTEN is regulated by ubiquitylation,SUMOylation and phosphorylation,and nuclear PTEN has been proposed to exhibit tumor-suppressive functions.Here we show that PTEN is conjugated by Nedd8 under high glucose conditions,which induces PTEN nuclear import without effects on PTEN stability.PTEN neddylation is promoted by the XIAP ligase and removed by the NEDP1 deneddylase.We identify Lys197 and Lys402 as major neddylation sites on PTEN.Neddylated PTEN accumulates predominantly in the nucleus and promotes rather than suppresses cell proliferation and metabolism.The nuclear neddylated PTEN dephosphorylates the fatty acid synthase(FASN)protein,inhibits the TRIM21-mediated ubiquitylation and degradation of FASN,and then promotes de novo fatty acid synthesis.In human breast cancer tissues,neddylated PTEN correlates with tumor progression and poor prognosis.Therefore,we demonstrate a previously unidentified pool of nuclear PTEN in the Nedd8-conjugated form and an unexpected tumor-promoting role of neddylated PTEN. | Ping Xie Zhiqiang Peng Yujiao Chen Hongchang Li Mengge Du Yawen Tan Xin Zhang Zhe Lu Chun-Ping Cui Cui Hua Liu Fuchu He Lingqiang Zhang | 2021 | Cell Research2021，31，3： | 11 |
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