|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Indocyanine Green Nanoparticles for Theranostic Applications显示文摘Theranostics is a concept that integrated imaging and therapy. As an emerging field, it embraces multiple techniques to arrive at an individualized treatment purpose. Indocyanine green(ICG) is a near infrared dye that has been approved by Food and Drug Administration(FDA) in USA for the use in indicator-dilution studies in humans. ICG nanoparticles(NPs) have attracted much attention for its potential applications in cancer theranostics. This review focuses on the preparation, application of ICG NPs for in vivo imaging(fluorescent imaging and photoacoustic imaging) and therapeutics(photothermal therapy, photodynamic therapy and photoacoustic therapy), and future directions based on recent developments in these areas. It is hoped that this review might provide new impetus to understand ICG NPs for cancer theranostics. | Zonghai Sheng Dehong Hu Miaomiao Xue Meng He Ping Gong Lintao Cai | 2013 | Nano-Micro Letters2013，5，3： | 11 |
| 2 | Highly Sensitive MoS_2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site显示文摘Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS_2–ICG hybrid with indocyanine green(ICG) conjugated to the surface of MoS_2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS_2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS_2–ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS_2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS_2–ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine. | Chengbo Liu Jingqin Chen Ying Zhu Xiaojing Gong Rongqin Zheng Ningbo Chen Dong Chen Huixiang Yan Peng Zhang Hairong Zheng Zonghai Sheng Liang Song | 2018 | Nano-Micro Letters2018，10，3： | 10 |
| 3 | Treatment of solid tumors with chimeric antigen receptor-engineered T cells: current status and future prospects显示文摘Chimeric antigen receptors(CARs) are artificial recombinant receptors that generally combine the antigen-recognition domain of a monoclonal antibody with T cell activation domains. Recent years have seen great success in clinical trials employing CD19-specific CAR-T cell therapy for B cell leukemia. Nevertheless, solid tumors remain a major challenge for CAR-T cell therapy. This review summarizes the preclinical and clinical studies on the treatment of solid tumors with CAR-T cells. The major hurdles for the success of CAR-T and the novel strategies to address these hurdles have also been described and discussed. | Shengmeng Di Zonghai Li | 2016 | Science China(Life Sciences)2016，59，4： | 10 |
| 4 | Grey systems for intelligent sensors and information processing显示文摘In a measurement system,new representation methods are necessary to maintain the uncertainty and to supply more powerful ability for reasoning and transformation between numerical system and symbolic system.A grey measurement system is discussed from the point of view of intelligent sensors and incomplete information processing compared with a numerical and symbolized measurement system.The methods of grey representation and information processing are proposed for data collection and reasoning.As a case study,multi-ultrasonic sensor systems are demonstrated to verify the effectiveness of the proposed methods. | Chen Chunlin Dong Daoyi Chen Zonghai Wang Haibo | 2008 | Journal of Systems Engineering and Electronics2008，19，4： | 7 |
| 5 | CD13/APN expression in peripheral blood lymphocytes and skin lesions in patients with advanced psoriasis vulgaris显示文摘Objective: To observe the expression of CD13/APN in peripheral blood lymphocytes and skin lesions of patients with advanced psoriasis vulgaris, and discuss its effect on the pathogenesis of psoriasis. Methods: CD13 expression in peripheral blood lymphocytes and skin lesions was detected by flow cytometry and immunohistochemical technique, respectively. Results were compared with those of healthy controls. Results: CD13 expression was significantly higher in peripheral blood lymphocytes of patients with advanced psoriasis vulgaris than in that of healthy controls, and in skin lesions than in healthy skin tissues. The expression was mainly in the suprabasal layers of skin lesions, and positively correlated to PASI (R=0.78029). Conclusion: The significantly higher expression of CD13 in peripheral blood lymphocytes and skin lesions of the patients with advanced psoriasis vulgaris probably is related to immunological abnormality, blood vessel abnormality and proliferation of keratinocyte in the pathogenic course of psoriasis. It may be a novel and effective way to treat psoriasis with specific CD13 inhibitors. | Liu Taihua Liu Defang Chen Yihua Hu Zonghai Chen Lu Luo Chen Xu Zhejuan | 2009 | Journal of Medical Colleges of PLA(China)2009，24，1： | 5 |
| 6 | Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic approaches显示文摘 | Min Yu Zonghai Li | 2017 | Frontiers of Medicine2017，11，4： | 5 |
| 7 | Multi-step evolution and measurement control of finite-dimensional quantum systems显示文摘For finite-dimensional quantum systems,we propose a quantum control scheme based on a multi-step unitary evolution and quantum projective measurements.The objective is to design a control law to steer the system to a target eigenstate of the measurement operator in the least number of steps.Within each control step,unitary evolution and quantum projective measurement are performed in turn until the system reaches the target state.The control process can be modeled as a finite-state Markov chain with an absorbing state.We prove that the controlled system will converge to the target eigenstate with probability one after a finite number of control steps and find a minimal-step-number condition that would steer the system to the target eigenstate in the least number of steps. | WenFeng Liu ChenBin Zhang ZongHai Chen | 2012 | Chinese Science Bulletin2012，57，18： | 4 |
| 8 | MATTER-ELEMENT MODELING OF PARALLEL STRUCTURE AND APPLICATION ABOUT EXTENSION PID CONTROL SYSTEM显示文摘这篇文章详细经由扩展描述一个新方法调节 extensionPID 控制器的参数的平行结构的事元素模型的可预言的算法。与比较模糊并且扩展 PID 控制器,当系统状态离开平衡,并且同时保留控制信号的更低的侧面时,建议扩展 PIDpredictable 控制器表演更高控制获得。因而,更好的控制性能被完成。通过建议调节公式, anextension 逻辑的 weighting 因素可预言的控制器能系统地根据控制植物被选择。通过工业域数据和地点工程师的一个试验性的例子是经验在模糊控制器上表明建议控制器的优异性能。 | Rongde LU Zonghai CHEN | 2006 | Journal of Systems Science & Complexity2006，19，2： | 3 |
| 9 | Identification and characterization of a novel peptide ligand of Tie2 for targeting gene therapy显示文摘有免疫球蛋白和表皮的生长因素相同 domain-2 (Tie2 ) 的酷氨酸 kinase 在稳固的肿瘤为基因治疗被看作了一个合理目标。以便为指向的基因治疗识别 Tie2 的新奇的肽 ligand,我们屏蔽了一个噬菌体显示肽图书馆并且识别了候选人肽 ligand NSLSNASEFRAPY (指明的 GA5 ) 。有约束力的试金和 Scatchard 分析表明 GA5 能明确地与 2.1 的一个分离常数绑在 Tie2 ?鷐 吗?? | Xianghua Wu Zonghai Li Ming Yao Huamao Wang Sumin Qu Xianlian Chen Jinjun Li Ye Sun Yuhong Xu Jianren Gu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，3： | 2 |
| 10 | Genetically engineered T cells for cancer immunotherapy显示文摘T cells in the immune system protect the human body from infection by pathogens and clear mutant cells through specific recognition by T cell receptors(TCRs).Cancer immunotherapy,by relying on this basic recognition method,boosts the antitumor efficacy of T cells by unleashing the inhibition of immune checkpoints and expands adaptive immunity by facilitating the adoptive transfer of genetically engineered T cells.T cells genetically equipped with chimeric antigen receptors(CARs)or TCRs have shown remarkable effectiveness in treating some hematological malignancies,although the efficacy of engineered T cells in treating solid tumors is far from satisfactory.In this review,we summarize the development of genetically engineered T cells,outline the most recent studies investigating genetically engineered T cells for cancer immunotherapy,and discuss strategies for improving the performance of these T cells in fighting cancers. | Dan Li Xue Li Wei-Lin Zhou Yong Huang Xiao Liang Lin Jiang Xiao Yang Jie Sun Zonghai Li Wei-Dong Han Wei Wang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 11 | Gel electrolyte for lithium-ion batteries显示文摘 | Chen Zonghai Zhang L Z West R | 2008 | Electrochimica Acta2008，53，： | 1 |
| 12 | Feature extension and matching for mobile robot global localization显示文摘This paper introduces an indoor global localization method by extending and matching features. In the proposed method, the environment is partitioned into convex subdivisions.Local extended maps of the subdivisions are then built by extending features to constitute the local extended map set. While the robot is moving in the environment, the local extended map of the current local environment is established and then matched with the local extended map set. Therefore, global localization in an indoor environment can be achieved by integrating the position and orientation matching rates. Both theoretical analysis and comparison experimental result are provided to verify the effectiveness of the proposed method for global localization. | Peng Wang Qibin Zhang Zonghai Chen | 2015 | Journal of Systems Engineering and Electronics2015，26，4： | 1 |
| 13 | One step growth of high luminescence CdTe quantum dots with low cytotoxicity in ambient atmospheric conditions显示文摘 | Sheng Zonghai Han Heyou Hu Xiaofeng | | 0，，： | 1 |
| 14 | Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates显示文摘Fluorescence probes with aggregation-induced emission(AIE)characteristics are of great importance in biomedical imaging with superior spatial and temporal resolution.However,the lack of toxicity studies and deep tissue imaging in nonhuman primates hinders their clinical translation.Here,we report the blood chemistry and histological analysis in nonhuman primates treated with AIE probes over tenfold of an intravenous dose of clinically used indocyanine green(ICG)during a study period of 36 days to demonstrate AIE probes are nontoxic.Furthermore,through bright and nontoxic AIE probes and fluorescence imaging in the second window(NIR-II,1,000-1,700 nm),we achieve an unprecedented 1.5-centimeter-deep vascular imaging in nonhuman primates,breaking the current limitation of millimeter-deep NIR-II fluorescence imaging.Our important findings,i.e.,nontoxic features of AIE probes and centimeter-deep NIR-II vascular imaging in nonhuman primates,may facilitate successful translation of AIE probes in clinical trials. | Zonghai Sheng Yaxi Li Dehong Hu Tianliang Min Duyang Gao Jen-Shyang Ni Pengfei Zhang Yuenan Wang Xin Liu Kai Li Hairong Zheng Ben Zhong Tang | 2020 | Research2020，，1： | 1 |
| 15 | Grey Qualitative Simulation显示文摘 | HUANG Yuanliang CHEN Zonghai GUI Wangshen | 2004 | The Journal of Grey System2004，16，1： | 1 |
| 16 | Adaptive control method for nonlinear time-delay processes显示文摘Two complex properties,varying time-delay and block-oriented nonlinearity,are very common in chemical engineering processes and not easy to be controlled by routine control methods.Aimed at these two complex properties,a novel adaptive control algorithm the basis of nonlinear OFS (orthonormal functional series) model is proposed.First,the hybrid model which combines OFS and Volterra series is introduced.Then,a stable state feedback strategy is used to construct a nonlinear adaptive control algorithm that can guarantee the closed-loop stability and can track the set point curve without steady-state errors.Finally,control simulations and experiments on a nonlinear process with varying time-delay are presented.A number of experimental results validate the efficiency and superiority of this algorithm. | Chen Zonghai Zhang Haitao Li Ming Xiang Wei | 2007 | Journal of Systems Engineering and Electronics2007，18，3： | 1 |
| 17 | Facile synthesis of fluorescent carbon dots using wa- termelon peel as a carbon source 显示文摘 | Zhou Jiaojiao Sheng Zonghai Han Heyou | 2012 | Matter Lett2012，66，1： | 1 |
| 18 | Dickkopf-1 autoantibody is a novel serological biomarker for non-small cell lung cancer显示文摘 | Xiao Yao Hua Jiang Cuizhen Zhang Huamao Wang Lin Yang Yongfeng Yu Junming Yu Bizhi Shi Zhijun Shen Huiping Gao Zhiwei Chen Shujun Tian Shun Lu Zonghai Li Jianren Gu | 2010 | Biomarkers2010，，2： | 1 |
| 19 | In vitro and in vivo assessment of an intelligent artificial anal sphincter in rabbits 显示文摘 | Huang Zonghai Shi Fujun Chert Fei | 2011 | ArtifOrgans2011，35，10： | 1 |
| 20 | Soft sensor based on relevance vector machines for microbiological fermentation显示文摘 | SUN Youxian | 2005 | Developments in Chemical Engineering and Mineral Processing2005，13，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员