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| 1 | Recent advances in small-scale hydrogel-based robots for adaptive biomedical applications显示文摘Small-scale robots,ranging in size from micrometers to centimeters,have gained significant attention in the biomedical field.However,conventional small-scale robots made of rigid materials encounter challenges in adapting themselves to the soft tissues and complicated environments of human body.Compared to the rigid counterpart,small-scale hydrogel-based robots hold great promises due to their tissue-like low modulus,outstanding biocompatibility and accessible stimuli-responsive capabilities.These attributes offer small-scale hydrogel-based robots with multimodal locomotion and reinforced functions,further enhancing the adaptability in manipulation and tasks execution for various biomedical applications.In this review,we present recent advances in small-scale hydrogel-based robots.We first summarize the design principles of small-scale hydrogel-based robots including materials,fabrication techniques and manipulation strategies,then highlighting their upgraded functions and adaptive biomedical applications.Finally,we discuss existing challenges and future perspectives for small-scale hydrogel-based robots. | Mingzhe Nie Qilong Zhao Xuemin Du | 2024 | Nano Research2024，17，2： | 1 |
| 2 | Nanozyme-Triggered Cascade Reactions from Cup-Shaped Nanomotors Promote Active Cellular Targeting显示文摘Self-propelled nanomotors have shown enormous potential in biomedical applications.Herein,we report on a nanozymepowered cup-shaped nanomotor for active cellular targeting and synergistic photodynamic/thermal therapy under nearinfrared(NIR)laser irradiation.The nanomotor is constructed by the asymmetric decoration of platinum nanoparticles(PtNPs)at the bottom of gold nanocups(GNCs).PtNPs with robust peroxidase-(POD-)like activity are employed not only as propelling elements for nanomotors but also as continuous O_(2)generators to promote photodynamic therapy via catalyzing endogenous H_(2)O_(2)decomposition.Owing to the Janus structure,asymmetric propulsion force is generated to trigger the shortranged directional diffusion,facilitating broader diffusion areas and more efficient cellular searching and uptake.This cascade strategy combines key capabilities,i.e.,endogenous substrate-based self-propulsion,active cellular targeting,and enhanced dual-modal therapy,in one multifunctional nanomotor,which is crucial in advancing self-propelled nanomotors towards eventual therapeutic agents. | Xin Wang Zhongju Ye Shen Lin Lin Wei Lehui Xiao | 2022 | Research2022，，3： | 0 |
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