|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 2 | Expression of ipt gene driven by tomato fruit specific promoter and its effects on fruit development of tomato显示文摘Fruit specific promoter (2A12) from Lycopersi-com esculentum and cDNA of isopentenyl-transferase (ipt) from Ti plasmid of Agrobacterium tumerfaciens C58 were cloned by PCR procedure respectively. Two plant expression vectors with 2A12/gus or 2A12/ipt were respectively constructed. These two chimeric genes were transferred into tomato by Agrobacterium mediated procedure. The results of Southern hybridization showed that the fusion genes had been integrated into tomatoes. The result of gus histochemi-cal staining showed that 2A12 had high fruit specific expressive capability in transgenic tomato. The ipt expression resulted in accumulation of high level of cytokinins (CTKs) in fruit lead to developmental changes in fruits and seeds. The fruit of ipt transformed tomato had the hyperplastic placenta with very few seeds or even seedless. The shelf life of transgenic fruits elongated for 1-2 weeks. The ratio of fruit set, the dry weight of fruit and the crude protein content in fruit were increased, while | Zichao Mao Qiuju Yu Wei Zhen Junyi Guo Yuanlei Hu Yin Gao Zhongping Lin | 2002 | Chinese Science Bulletin2002，47，11： | 6 |
| 3 | Self-powered electrochromic devices with tunable infrared intensity显示文摘Triboelectric nanogenerator(TENG) is an efficient way to convert ambient mechanical energy into electricity to power up portable electronics.In this work,a flexible infrared electrochromical device(IR-ECD)with stable performances was assembled with a TENG for building self-powered infrared detector with tunable intensity.As driven by TENG,the electrochromic device could be operated in the mid-IR region due to the reversible electrochromic reactions.An average infrared reflectance contrast of 46% was achieved in 8–14 lm regions and as well a clear thermal image change can be observed.This work indicates that the TENG-driven infrared electrochromical device has potential for use in self-powered camouflage and thermal control. | Jiangman sun xiong pu Chunyan Jiang Chunhua Du Mengmeng Liu Yang Zhang Zhitian Liu Junyi Zhai Weiguo Hu Zhong Lin Wang | 2018 | Science Bulletin2018，63，12： | 6 |
| 4 | Enhanced NO_2 gas sensing of a single-layer MoS_2 by photogating and piezo-phototronic effects显示文摘NO_2 sensors with ultrahigh sensitivity are demanded for future electronic sensing systems. However,traditional sensors are considerably limited by the relative low sensitivity, high cost and complicated process. Here, we report a simply and reliable flexible NO_2 sensor based on single-layer MoS_2. The flexible sensor exhibits high sensitivity to NO_2 gas due to ultra-large specific surface area and the nature of two-dimensional(2 D) semiconductor. When the NO_2 is 400 ppb(parts per billion), compared with the dark and strain-free conditions, the sensitivity of the single-layer sensor is enhanced to 671% with a625 nm red light-emitting diode(LED) illumination of 4 mW/cm^2 power under 0.67% tensile strain.More important, the response time is dramatically reduced to $16 s and it only needs $65 s to complete90% recovery. A theoretical model is proposed to discuss the microscopic mechanisms. We find that the remarkable sensing characteristics are the result of coupling among piezoelectricity, photoelectricity and adsorption-desorption induced charges transfer in the single-layer MoS_2 Schottky junction based device.Our work opens up the way to further enhancements in the sensitivity of gas sensor based on single-layer MoS_2 by introducing photogating and piezo-phototronic effects in mesoscopic systems. | Junmeng Guo Rongmei Wen Junyi Zhai Zhong Lin Wang | 2019 | Science Bulletin2019，64，2： | 5 |
| 5 | Magnetostratigraphy of a Loess-Paleosol Sequence from Higher Terrace of the Daduhe River in the Eastern Margin of the Tibetan Plateau and Its Geological Significance显示文摘The eolian deposits distributed in the river valleys in the eastern margin of the Tibetan Plateau(TP)are very useful in neotectonic and paleoclimatic studies.Firstly,the climate in the eastern margin of the TP is mainly controlled by the Indian summer monsoon,and detailed studies on the loess-paleosol sequences in this region can provide valuable terrestrial evidence of past changes in the Indian summer monsoon.Secondly,the river terraces in the eastern margin of the TP are considered to be a sensitive recorder of neotectonism to reflect the timing and amplitude of the TP uplift.The formation ages of | QIAO Yansong WANG Yan YAO Haitao QI Lin HE Ze Xin CHENG Yu PENG Shasha GE Junyi | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 5 |
| 6 | Self-powered acoustic source Iocator in underwater environment based on organic film triboelectric nano-generator显示文摘 | Aifang Yu Ming Song Yan Zhang Yang Zhang Libo Chen Junyi Zhai Zhong Lin Wang | 2015 | Nano Research2015，8，3： | 4 |
| 7 | Preliminary experimental results by the prototype of Sanya Incoherent Scatter Radar显示文摘In the past decades,the Incoherent Scatter Radar(ISR)has been demonstrated to be one of the most powerful instruments for ionosphere monitoring.The Institute of Geology and Geophysics at the Chinese Academy of Sciences was founded to build a state-ofthe-art phased-array ISR at Sanya(18.3°N,109.6°E),a low-latitude station on Hainan Island,named the Sanya ISR(SYISR).As a first step,a prototype radar system consisting of eight subarrays(SYISR-8)was built to reduce the technical risk of producing the entire large array.In this work,we have summarized the preliminary experimental results based on the SYISR-8.The amplitude and phase among 256 channels were first calibrated through an embedded internal monitoring network.The mean oscillation of the amplitude and phase after calibration were about 1 dB and 5°,respectively,which met the basic requirements.The beam directivity was confirmed by crossing screen of the International Space Station.The SYISR-8 was further used to detect the tropospheric wind profile and meteors.The derived winds were evaluated by comparison with independent radiosonde and balloon-based GPS measurements.The SYISR-8 was able to observe several typical meteor echoes,such as the meteor head echo,range-spread trail echo,and specular trail echo.These results confirmed the validity and reliability of the SYISR-8 system,thereby reducing the technical risk of producing the entire large array of the SYISR to some extent. | XinAn Yue WeiXing Wan Han Xiao LingQi Zeng ChangHai Ke BaiQi Ning Feng Ding BiQiang Zhao Lin Jin Chen Li MingYuan Li JunYi Wang HongLian Hao Ning Zhang | 2020 | Earth and Planetary Physics2020，4，6： | 3 |
| 8 | Multiple periodic oscillations in the radio light curves of NRAO 530显示文摘In this paper,the time series analysis method CLEANest is employed to search for characteristic periodicities in the radio light curves of the blazar NRAO 530 at 4.8,8.0 and 14.5 GHz over a time baseline of three decades.Two prominent periodicities on time scales of ~6.3 and ~9.5 a are identified at all three frequencies,in agreement with previous results derived from different numerical techniques,confirming the multiplicity of the periodicities in NRAO 530.In addition to these two significant periods,there is also evidence of shorter-timescale periodicities of ~5.0,~4.2,~3.4 and ~2.8 a showing lower amplitude in the periodograms.The physical mechanisms responsible for the radio quasi-periodic oscillations and the multiplicity of the periods are discussed. | XIE MingJie WANG JunYi AN Tao ZHENG Lin HAN Xu | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，9： | 2 |
| 9 | Generation of human hepatocytes from extended pluripotent stem cells显示文摘Dear Editor,Human pluripotent stem cells have great potential for application in regenerative medicine,as they permit the generation of different lineages of functional cell types via directed differentiation.1 However,application of conventional human pluripotent stem cells is limited due to several factors,including heterogeneity in pluripotency,differentiation bias,relatively slow proliferation,and poor single-cell survival.2 Toovercome these problems. | Qiming Wang Da Sun Zhen Liang Junyi Wang Xinxing Zhong Yulin Lyu Junning Cao Zhongqing Lin Yuanyuan Du Zhenchuan Miao Shichun Lu Cheng Li Jun Xu Yan Shi Hongkui Deng | 2020 | Cell Research2020，30，9： | 1 |
| 10 | 1-Pbps orbital angular momentum fibre-optic transmission显示文摘Space-division multiplexing(SDM),as a main candidate for future ultra-high capacity fibre-optic communications,needs to address limitations to its scalability imposed by computation-intensive multi-input multi-output(MIMO)digital signal processing(DSP)required to eliminate the crosstalk caused by optical coupling between multiplexed spatial channels.By exploiting the unique propagation characteristics of orbital angular momentum(OAM)modes in ring core fibres(RCFs),a system that combines SDM and C+L band dense wavelength-division multiplexing(DWDM)in a 34 km 7-core RCF is demonstrated to transport a total of 24960 channels with a raw(net)capacity of 1.223(1.02)Peta-bit s−1(Pbps)and a spectral efficiency of 156.8(130.7)bit s−1 Hz−1.Remarkably for such a high channel count,the system only uses fixed-size 4×4 MIMO DSP modules with no more than 25 time-domain taps.Such ultra-low MIMO complexity is enabled by the simultaneous weak coupling among fibre cores and amongst non-degenerate OAM mode groups within each core that have a fixed number of 4 modes.These results take the capacity of OAM-based fibre-optic communications links over the 1 Pbps milestone for the first time.They also simultaneously represent the lowest MIMO complexity and the 2nd smallest fibre cladding diameter amongst reported few-mode multicore-fibre(FM-MCF)SDM systems of>1 Pbps capacity.We believe these results represent a major step forward in SDM transmission,as they manifest the significant potentials for further up-scaling the capacity per optical fibre whilst keeping MIMO processing to an ultra-low complexity level and in a modularly expandable fashion. | Junyi Liu Jingxing Zhang Jie Liu Zhenrui Lin Zhenhua Li Zhongzheng Lin Junwei Zhang Cong Huang Shuqi Mo Lei Shen Shuqing Lin Yujie Chen Ran Gao Lei Zhang Xiaobo Lan Xinlun Cai Zhaohui Li Siyuan Yu | 2022 | Light(Science & Applications)2022，11，8： | 1 |
| 11 | The draftgenome of a diploid cotton gossypium raimondii 显示文摘 | Kunbo Wang Zhiwen Wang Fuguang Li Wuwei Ye Junyi Wang Guoli Song Zhen Yue Lin Cong Haihong Shang Shilin Zhu Changsong Zou Qin Li Youlu Yuan Cairui Lu Hengling Wei Caiyun Gou Zequn Zheng Ye Yin Xueyan Zhang Kun Liu Bo Wang Chi Song Nan Shi Russell J Kohel Richard G Percy John Z Yu Yu-xian Zhu Jun Wang Shuxun Yu | 2012 | Nat Genet2012，，44： | 1 |
| 12 | Exploration on crystallization habit of rare earth fluoride crystal BaY2F8 显示文摘 | LIN Junyi RUAN Yongfeng WANG Jun | 2004 | J Rare Earth2004，22，12： | 1 |
| 13 | The effect of temperature on gonad,embryonic development and survival rate of juvenile seahorses,Hippocampus kuda Bleeker显示文摘 | LIN Qiang LU Junyi GAO Yongli | 2006 | Aquaculture2006，254，： | 1 |
| 14 | Expression and regulation of genes involved in the reserve starch biosynthesis pathway in hexaploid wheat (Triticum aestivum L.)显示文摘Reserve starch of cereal crop accounts for about 70%of grain endosperm and acts as an important human carbohydrate resource worldwide.Wheat reserve starch is synthesized by enzymatic machinery in endosperm cells.To identify genes involved in starch biosynthesis,we constructed 30 RNA-Seq libraries of 10 endosperm-development periods and performed expression and localization analyses.Of 166 endosperm-expressed homologs of starch biosynthesis-related genes,74 showed expression correlated with reserve starch accumulation,including 26 with expected subcellular distribution and higher expression than their isoforms.The key proteins SUS3,UGP1,cAGPase,and Bt1-3 formed the main metabolic pathway and contributed the major substrates for starch processing in amyloplasts.Important isoforms,key pathway proteins,and the main carbon flux toward starch formation in the reserve starch biosynthesis pathway were identified.Based on a coexpression analysis,a library of 425 transcription factors was produced to screen for common regulators.TaMYB44 had features of transcription factors and bound to TaSUT1,TaSSIIIa,TaBEIIa,TaISA1,and TaBEIIb promoters in yeast,suggesting that the gene is a pathway regulator.This study sheds light on understanding the mechanism of reserve starch biosynthesis and will be helpful for increasing starch content in wheat endosperm via biotechnological strategies. | Yunsong Gu Shichen Han Lin Chen Junyi Mu Luning Duan Yaxuan Li Yueming Yan Xiaohui Li | 2021 | The Crop Journal2021，9，2： | 1 |
| 15 | A study of long-term sea level variability in the East China Sea显示文摘From the analyses of the satellite altimeter Maps of Sea Level Anomaly(MSLA) data, tidal gauge sea level data and historical sea level data, this paper investigates the long-term sea level variability in the East China Sea(ECS).Based on the correlation analysis, we calculate the correlation coefficient between tidal gauge and the closest MSLA grid point, then generate the map of correlation coefficient of the entire ECS. The results show that the satellite altimeter MSLA data is effective to observe coastal sea level variability. An important finding is that from map of correlation coefficient we can identify the Kuroshio. The existence of Kuroshio decreases the correlation between coastal and the Pacific sea level. Kurishio likes a barrier or a wall, which blocks the effect of the Pacific and the global change. Moreover, coastal sea level in the ECS is mainly associated with local systems rather than global change. In order to calculate the long-term sea level variability trend, the empirical mode decomposition(EMD) method is applied to derive the trend on each MSLA grid point in the entire ECS. According to the 2-D distribution of the trend and rising rate, the sea level on the right side of the axis of Kuroshio rise faster than in its left side. This result supports the barrier effect of Kuroshio in the ECS. For the entire ECS, the average sea level rose 45.0 mm between 1993 and 2010, with a rising rate of(2.5±0.4) mm/a which is slower than global average.The relatively slower sea level rising rate further proves that sea level rise in the ECS has less response to global change due to its own local system effect. | XU Ying LIN Mingsen ZHENG Quanan YE Xiaomin LI Junyi ZHU Benlu | 2015 | Acta Oceanologica Sinica2015，34，11： | 1 |
| 16 | Exploration on Crystallization Habit of Rare Earth Fluoride Crystal BaY2F8显示文摘 | Lin Junyi Ruan Yongfeng Wang Jun Liu Jian Huan Boxian | 2004 | Journal of Rare Earth2004，22，3： | 1 |
| 17 | Giant magnetoelectric effect in multiferroic laminated composites 显示文摘 | Yuanhua Lin Ning Cai Junyi Zhai | 2005 | Phys Rev B2005，72，01： | 1 |
| 18 | Giant magnetoelectrie effect in multiferroic laminated com- posites显示文摘 | LIN Yuanhua CAI Ning ZHAI Junyi | 2005 | PhysiCal Review B2005，72，1： | 1 |
| 19 | Exploration on Crystallization Habit of Rare Earth Fluoride Crystal BaY2F8显示文摘 | Lin Junyi Ruan Yongfeng Wang Jun Liu Jian Huan Boxian | 2004 | Journal of Rare Earth2004，22，： | 1 |
| 20 | Graph Laplacian Matrix Learning from Smooth Time-Vertex Signal显示文摘In this paper,we focus on inferring graph Laplacian matrix from the spatiotemporal signal which is defined as“time-vertex signal”.To realize this,we first represent the signals on a joint graph which is the Cartesian product graph of the time-and vertex-graphs.By assuming the signals follow a Gaussian prior distribution on the joint graph,a meaningful representation that promotes the smoothness property of the joint graph signal is derived.Furthermore,by decoupling the joint graph,the graph learning framework is formulated as a joint optimization problem which includes signal denoising,timeand vertex-graphs learning together.Specifically,two algorithms are proposed to solve the optimization problem,where the discrete second-order difference operator with reversed sign(DSODO)in the time domain is used as the time-graph Laplacian operator to recover the signal and infer a vertex-graph in the first algorithm,and the time-graph,as well as the vertex-graph,is estimated by the other algorithm.Experiments on both synthetic and real-world datasets demonstrate that the proposed algorithms can effectively infer meaningful time-and vertex-graphs from noisy and incomplete data. | Ran Li Junyi Wang Wenjun Xu Jiming Lin Hongbing Qiu | 2021 | China Communications2021，18，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员