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| 1 | 血管性认知损害诊断的进一步规范化:血管性认知损害分类共识研究组指南显示文摘引言血管性认知损害(vascular cognitive impairment,VCI)诊断共识的缺乏(体现为多种不同评估方案的使用),妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究(Vascular Impairment of Cognition Classification Consensus Study,VICCCS),旨在就VCI的诊断原则(VICCCS-1)和诊断方案(VICCCS-2)达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲(Delphi)调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65~79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网(National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN)发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作. | Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂 徐俊 | 2018 | 国际脑血管病杂志2018，26，4： | 58 |
| 2 | 脑白质高信号与认知功能障碍:基于FLAIR高信号的定量研究显示文摘目的利用半自动化分析软件对脑白质疏松患者不同区域白质损伤进行定量,并对其与认知功能评分进行偏相关分析。方法 2011年1月-2017年1月在北京天坛医院进行健康体检的50~85岁社区'健康'人群63例,对其进行认知功能评价[简易精神状态量表(mini-mental state examination,MMSE)、蒙特利尔认知量表(Montreal cognitive assessment,Mo CA)]及影像学数据采集,基于液体衰减反转恢复序列定量计算全脑、侧脑室旁及深部皮层下脑白质受损体积,将认知功能评分与以上白质受损体积进行偏相关分析,探索白质受损在认知障碍发生发展过程中所起的作用。结果控制年龄、性别、文化程度后,全脑白质体积与MMSE评分、Mo CA评分有偏相关性(R’=-0.428,P=0.001)(R’=-0.539,P<0.001),尤其是侧脑室旁白质体积(R’=-0.427,P=0.001)(R’=-0.559,P<0.001),与深部皮层下白质也存在偏相关性(R’=-0.365,P=0.004)(R’=-0.447,P<0.001)。结论全脑、侧脑室旁、深部皮层下脑白质损伤体积增大,认知功能评分随之下降;MMSE评分、Mo CA评分与侧脑室旁白质损伤之间的相关性较深部皮层下白质损伤更大。 | 叶娜 Wei Wen 王金芳 石庆丽 李越秀 陈红燕 Perminder Sachdev 王拥军 张玉梅 | 2018 | 中国卒中杂志2018，13，8： | 5 |
| 3 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 4 | Risk Profiles for Mild Cognitive Impairment Vary by Age and Sex: The Sydney Memory and Ageing Study显示文摘 | Perminder S. Sachdev Darren M. Lipnicki John Crawford Simone Reppermund Nicole A. Kochan Julian N. Trollor Brian Draper Melissa J. Slavin Kristan Kang Ora Lux Karen A. Mather Henry Brodaty | 2012 | American Journal of Geriatric Psychiatry2012，，10： | 1 |
| 5 | Homoeysteine,cerebrovaseular disease and brain atrophy显示文摘 | | 2004 | Journal of the Neurolagical Sciences2004，226，： | 1 |
| 6 | Homocysteine and neuropsychiatric disorders显示文摘 | Perminder Sachdev | 2004 | Rev Bras Psiquiatr2004，26，1： | 1 |
| 7 | Arterial stiffness, the brain and cognition: A systematic review显示文摘 | Joel Singer Julian N. Trollor Bernhard T. Baune Perminder S. Sachdev Evelyn Smith | 2014 | Ageing Research Reviews2014，，： | 1 |
| 8 | Higher normal fasting plasma glucose is associated with hippocampal atrophy: The PATH Study显示文摘 | Nicolas Cherbuin Perminder Sachdev Kaarin J. Anstey | 2012 | Neurology2012，，10： | 1 |
| 9 | Homocysteine and neuropsychiatric disorders显示文摘 | Perminder Sachdev | 2004 | Rev Bras Psiquiatr2004，26，1： | 1 |
| 10 | Magnetic resonance spectroscopy in cognitive research显示文摘 | Amy J Ross Perminder S Sachdev | 2003 | Brain Research Reviews2003，，2： | 1 |
| 11 | Magnetic resonance spectroscopy in AD显示文摘 | Michael J. Valenzuela Perminder Sachdev | 2001 | Neurology2001，，5： | 1 |
| 12 | Deep Brain Stimulation of Anteromedial Globus Pallidus Interna for Severe Tourette’s Syndrome显示文摘 | Cannon Elisabeth Silburn Peter Coyne Terrence O’Maley Karen Crawford John D Sachdev Perminder S | 2012 | The American Journal of Psychiatry2012，，8： | 1 |
| 13 | Age-Specific Effects of Voluntary Exercise on Memory and the Older Brain显示文摘 | Joyce Siette R. Frederick Westbrook Carl Cotman Kuldip Sidhu Wanlin Zhu Perminder Sachdev Michael J. Valenzuela | 2012 | Biological Psychiatry2012，，： | 1 |
| 14 | APOE genotype and MRI markers of cerebrovascular disease: Systematic review and meta-analysis显示文摘 | Sabrina Schilling Anita L. DeStefano Perminder S. Sachdev Seung Hoan Choi Karen A. Mather Charles D. DeCarli Wei Wen Peter H?gh Naftali Raz Rhoda Au Alexa Beiser Philip A. Wolf José Rafael Romero Yi-Cheng Zhu Kathryn L. Lunetta Lindsay Farrer Carole Dufou | 2013 | Neurology2013，，3： | 1 |
| 15 | Bilateral deep brain stimulation of the nucleus accumbens for comorbid obsessive compulsive disorder and Tourette’s syndrome显示文摘 | Perminder Singh Sachdev Elisabeth Cannon Terry J Coyne Peter Silburn | 2012 | Case Reports (sep )2012，，122： | 1 |
| 16 | Association of Type 2 Diabetes With Depression, Brain Atrophy, and Reduced Fine Motor Speed in a 60- to 64-Year-Old Community Sample显示文摘 | Rajeev Kumar Kaarin J. Anstey Nicolas Cherbuin Wei Wen Perminder S. Sachdev | 2008 | American Journal of Geriatric Psychiatry2008，，12： | 1 |
| 17 | Risk Profiles for Mild Cognitive Impairment Vary by Age and Sex: The Sydney Memory and Ageing Study显示文摘 | Perminder S. Sachdev Darren M. Lipnicki John Crawford Simone Reppermund Nicole A. Kochan Julian N. Trollor Brian Draper Melissa J. Slavin Kristan Kang Ora Lux Karen A. Mather Henry Brodaty | 2012 | American Journal of Geriatric Psychiatry2012，，10： | 1 |
| 18 | Microstructural white matter changes in cognitively normal individuals at risk of amnestic MCI显示文摘 | Lin Zhuang Perminder S. Sachdev Julian N. Trollor Nicole A. Kochan Simone Reppermund Henry Brodaty Wei Wen | 2012 | Neurology2012，，8： | 1 |
| 19 | Homocysteine, cerebrovascular disease and brain atrophy显示文摘 | Perminder Sachdev | 2004 | Journal of the Neurological Sciences2004，，1： | 1 |
| 20 | The Sydney Centenarian Study: methodology and profile of centenarians and near-centenarians显示文摘 | Perminder S. Sachdev Charlene Levitan John Crawford Mamta Sidhu Melissa Slavin Robyn Richmond Nicole Kochan Henry Brodaty Wei Wen Kristan Kang Karen A. Mather | 2013 | International Psychogeriatrics2013，，6： | 1 |
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