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| 1 | A chromosome-scale genome assembly of Isatis indigotica,an important medicinal plant used in traditional Chinese medicine显示文摘Isatis indigotica(2n=14)is an important medicinal plant in China.Its dried leaves and roots(called Isatidis Folium and Isatidis Radix,respectively)are broadly used in traditional Chinese medicine for curing diseases caused by bacteria and viruses such as influenza and viral pneumonia.Various classes of compounds isolated from this species have been identified as effective ingredients.Previous studies based on transcriptomes revealed only a few candidate genes for the biosynthesis of these active compounds in this medicinal plant.Here,we report a high-quality chromosome-scale genome assembly of I.indigotica with a total size of 293.88 Mb and scaffold N50=36.16 Mb using single-molecule real-time long reads and high-throughput chromosome conformation capture techniques.We annotated 30,323 highconfidence protein-coding genes.Based on homolog searching and functional annotations,we identified many candidate genes involved in the biosynthesis of main active components such as indoles,terpenoids,and phenylpropanoids.In addition,we found that some key enzyme-coding gene families related to the biosynthesis of these components were expanded due to tandem duplications,which likely drove the production of these major active compounds and explained why I.indigotica has excellent antibacterial and antiviral activities.Our results highlighted the importance of genome sequencing in identifying candidate genes for metabolite synthesis in medicinal plants. | Minghui Kang Haolin Wu Qiao Yang Li Huang Quanjun Hu Tao Ma Zaiyun Li Jianquan Liu | 2020 | Horticulture Research2020，7，1： | 9 |
| 2 | MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells显示文摘MicroRNA-132(miR-132), a small RNA that regulates gene expression, is known to promote neurogenesis in the embryonic nervous system and adult brain.Although exposure to psychoactive substances can increase miR-132 expression in cultured neural stem cells(NSCs)and the adult brain of rodents, little is known about its role in opioid addiction. So, we set out to determine the effect of miR-132 on differentiation of the NSCs and whether this effect is involved in opioid addiction using the rat morphine self-administration(MSA) model. We found that miR-132 overexpression enhanced the differentiation of NSCs in vivo and in vitro. Similarly, speci?c overexpression of miR-132 in NSCs of the adult hippocampal dentate gyrus(DG) during the acquisition stage of MSA potentiated morphine-seeking behavior. These ?ndings indicate that miR-132 is involved in opioid addiction,probably by promoting the differentiation of NSCs in the adult DG. | Meng Jia Xuewei Wang Haolin Zhang Can Ye Hui Ma Mingda Yang Yijing Li Cailian Cui | 2019 | Neuroscience Bulletin2019，35，3： | 6 |
| 3 | Relationships Between Community Structure and Environmental Factors in Xixiakou Artificial Reef Area显示文摘The construction of artificial reefs has unparallelly developed for a few decades in China.Artificial reefs can be used to manage and conserve commercially exploited fish and crustacea.However,their suitability as ecological niche is poorly characterized.Therefore,in this study,we detected the seasonal variation of community biodiversity and the corresponding driving environmental factors.We also explored the relationships between dominant species and environmental factors to identify appropriate ecological niche areas.Different statistical analysis methods were used to assess species distribution within an artificial reef area in Xixiakou during nine sampling events in four seasons between 2017 and 2018.Non-metric multidimensional scaling(NMDS)and cluster analysis results indicated that the components of community can be divided into two clusters.Complexity of community,which is exhibited by species number,biodiversity,and catch per unit effort(CPUE),was significantly higher in summer than in other seasons.Generalized additive model(GAMs)results revealed the significant effects of temperature and chlorophyll a on the community structure.Sebastes schlegelii,Hexagrammos otakii,Conger myriaster and Charybdis japonica were the dominant species in four seasons.GAMs results indicated that temperature,dissolved oxygen(DO),pH and chlorophyll a affect the CPUE of dominant species significantly.The distinct suitable ecological niche for each dominant species was found in this study.For example,Charybdis japonica preferred to live in the area with 20.7–22.1℃,dissolved oxygen 7.07–7.15 mg L−1 and salinity 31.8–31.9.The results of this study are beneficial to resource conservation and fishery management. | YU Haolin YANG Wenzhao LIU Changdong TANG Yanli SONG Xiefa FANG Guangjie | 2020 | Journal of Ocean University of China2020，19，4： | 4 |
| 4 | Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury显示文摘 | Yumiko Imai Keiji Kuba G. Greg Neely Rubina Yaghubian-Malhami Thomas Perkmann Geert van Loo Maria Ermolaeva Ruud Veldhuizen Y.H. Connie Leung Hongliang Wang Haolin Liu Yang Sun Manolis Pasparakis Manfred Kopf Christin Mech Sina Bavari J.S. Malik Peiris Ar | 2008 | Cell2008，，2： | 4 |
| 5 | Lamellar hafnium ditelluride as an ultrasensitive surface-enhanced Raman scattering platform for label-free detection of uric acid显示文摘The development of two-dimensional(2D)transition metal dichalcogenides has been in a rapid growth phase for the utilization in surface-enhanced Raman scattering(SERS)analysis.Here,we report a promising 2D transition metal tellurides(TMTs)material,hafnium ditelluride(HfTe2),as an ultrasensitive platform for Raman identification of trace molecules,which demonstrates extraordinary SERS activity in sensitivity,uniformity,and reproducibility.The highest Raman enhancement factor of 2.32×10^(6)is attained for a rhodamine 6G molecule through the highly efficient charge transfer process at the interface between the HfTe2 layered structure and the adsorbed molecules.At the same time,we provide an effective route for large-scale preparation of SERS substrates in practical applications via a facile stripping strategy.Further application of the nanosheets for reliable,rapid,and label-free SERS fingerprint analysis of uric acid molecules,one of the biomarkers associated with gout disease,is performed,which indicates arresting SERS signals with the limits of detection as low as 0.1 mmol/L.The study based on this type of 2D SERS substrate not only reveals the feasibility of applying TMTs to SERS analysis,but also paves the way for nanodiagnostics,especially early marker detection. | YANG LI HAOLIN CHEN YANXIAN GUO KANGKANG WANG YUE ZHANG PEILIN LAN JINHAO GUO WEN ZHANG HUIQING ZHONG ZHOUYI GUO ZHENGFEI ZHUANG ZHIMING LIU | 2021 | Photonics Research2021，9，6： | 2 |
| 6 | Effect of surgical factors on the augmentation of cementinjectable cannulated pedicle screw fixation by a novel calcium phosphate-based nanocomposite显示文摘Bone cement-augmented pedicle screw system demonstrates great efficacy in spinal disease treatments. However, the intrinsic drawbacks associated with clinically used polymethylmethacrylate (PMMA) cement demands for new bone cement formulations. On the basis of our previous studies, a novel injectable and biodegradable calcium phosphate-based nanocomposite (CPN) for the augmentation of pedicle screw fixation was systematically evaluated for its surgical feasibility and biomechanical performance by simulated and animal osteoporotic bone models, and the results were compared with those of clinical PMMA cement. ASTM-standard solid foam and open-cell foam models and decalcified sheep vertebra models were employed to evaluate the augmentation effects of CPN on bone tissue and on the cement-injected cannulated pedicle screws (CICPs) placed in osteoporotic bone. Surgical factors in CICPs application, such as injection force, tapping technique, screw diameter, and pedicle screw loosening scenarios, were studied in comparison with those in PMMA. When directly injected to the solid foam model, CPN revealed an identical augmentation effect to that of PMMA, as shown by the similar compressive strengths (0.73 ± 0.04 MPa for CPN group vs. 0.79 ± 0.02 MPa for PMMA group). The average injection force of CPN at approximately 40-50 N was higher than that of PMMA at approximately 20 N. Although both values are acceptable to surgeons, CPN revealed a more consistent injection force pattern than did PMMA. The dispersing and anti-pullout ability of CPN were not affected by the surgical factors of tapping technique and screw diameter. The axial pullout strength of CPN evaluated by the decalcified sheep vertebra model revealed a similar augmentation level as that of PMMA (1351.6 ± 324.2 N for CPN vs. 1459.7 ± 304.4 N for PMMA). The promising results of CPN clearly suggest its potential for replacing PMMA in CICPs augmentation application and the benefits of further study and development for clinical uses. | Haolin Sun Chun Liu Shunlun Chen Yanjie Bai Huilin Yang Chunde Li Lei Yang | 2019 | Frontiers of Medicine2019，13，5： | 2 |
| 7 | A framework for the fusion of visual and tactile modalities for improving robot perception显示文摘Robots should ideally perceive objects using human-like multi-modal sensing such as vision, tactile feedback, smell, and hearing. However, the features presentations are different for each modal sensor. Moreover,the extracted feature methods for each modal are not the same. Some modal features such as vision, which presents a spatial property, are static while features such as tactile feedback, which presents temporal pattern,are dynamic. It is difficult to fuse these data at the feature level for robot perception. In this study, we propose a framework for the fusion of visual and tactile modal features, which includes the extraction of features, feature vector normalization and generation based on bag-of-system(BoS), and coding by robust multi-modal joint sparse representation(RM-JSR) and classification, thereby enabling robot perception to solve the problem of diverse modal data fusion at the feature level. Finally, comparative experiments are carried out to demonstrate the performance of this framework. | Wenchang ZHANG Fuchun SUN Hang WU Haolin YANG | 2017 | Science China(Information Sciences)2017，60，1： | 2 |
| 8 | Pervasive hybridization during evolutionary radiation of Rhododendron subgenus Hymenanthes in mountains of southwest China显示文摘Radiations are especially important for generating species biodiversity in mountainous ecosystems.The contribution of hybridization to such radiations has rarely been examined.Here,we use extensive genomic data to test whether hybridization was involved in evolutionary radiation within Rhododendron subgenus Hymenanthes,whose members show strong geographic isolation in the mountains of southwest China.We sequenced genomes for 143 species of this subgenus and 93 species of four other subgenera,and found that Hymenanthes was monophyletic and radiated during the late Oligocene to middle Miocene.Widespread hybridization events were inferred within and between the identified clades and subclades.This suggests that hybridization occurred both early and late during diversification of subgenus Hymenan thes,although the extent to which hybridization,speciation through mixing-isolation-mixing or hybrid speciation,accelerated the diversification needs further exploration.Cycles of isolation and contact in such and other montane ecosystems may have together promoted species radiation through hybridization between diverging populations and species.Similar radiation processes may apply to other montane floras in this region and elsewhere. | Yazhen Ma Xingxing Mao Ji Wang Lei Zhang Yuanzhong Jiang Yuying Geng Tao Ma Liming Cai Shuangquan Huang Pete Hollingsworth Kangshan Mao Minghui Kang Yiling Li Wenlu Yang Haolin Wu Yang Chen Charles C.Davis Nawal Shrestha Richard H.Ree Zhenxiang Xi Quanjun Hu Richard I.Milne Jianquan Liu | 2022 | National Science Review2022，9，12： | 1 |
| 9 | Filtration combus- tion of methane in high-porosity micro fibrous media 显示文摘 | Yang Haolin Minaev S Geynce E | 2009 | Combustion science and technology2009，181，： | 1 |
| 10 | General modeling and numerical simulation of the burning characteristics of porous chars显示文摘 | Wang Xiaohan Zeng Xiaojun Yang Haolin | | 0，，07： | 1 |
| 11 | The basis of a more contagious 501Y.V1 variant of SARS-CoV-2显示文摘Dear Editor,The SARS-CoV-2 virus has infected over one hundred million people(COVID-19 patients)and caused more than two million deaths to date.The number of infected people continues to grow quickly,emphasizing the need for rapid use of effective vaccines.Although two mRNA vaccines based on Spike protein(produced by Pfizer-BioNTech and MODERNA)have been approved for emergency use in the US,1,2 the increasing Spike variants that have appeared around the world raise concerns about the continued efficacy of the vaccines.3 Monoclonal antibodies,developed by Regeneron and Eli Lilly,specifically targeting the native form of Spike have been approved by the FDA for emergency use.4,5 An N501Y variant(Y501)of the Spike protein of SARS-CoV-2(B.1.1.7,20I/501Y.V1),first emerged in UK and has now spread to the rest of the world.This variant appears to be much more contagious than the original N501 version.3 Furthermore,Y501 mutation is also found in a variant(B.1.351,20H/501Y.V2)from South Africa and a variant(P1,20J/501Y.V3)from Brazil.3 Unfortunately,this mutation is located at the interaction surface between the RBD and human Angiotensin Converting Enzyme 2(ACE2).6 Thus,the Y501 variation present in B.1.1.7,20I/501Y.V1 might affect the binding ability of the RBD to bind ACE2.We therefore compared the binding affinity of N501 and Y501 RBD for ACE2,uncovering that the affinity for ACE2 of the Y501-RBD was~10 fold higher than that of the N501 version.This may account,at least in part,for the greater infectivity of SARS-CoV-2 with this mutation.Structural modeling data showed that Y501-RBD can form an additional aromatic ring–ring interaction and an additional hydrogen bond with ACE2 by comparison with the RBD of the wild type.In spite of this,sera from individuals immunized with the Pfizer-BioNTech vaccine still efficiently block ACE2 binding to Y501-RBD.Furthermore,Bamlanivimab,the recently FDA approved therapeutic antibody drug for treatment of COVID-19 patients4 still binds the variant Y501-RBD as efficiently as it binds the N501-RBD,giving hope that treatment with the existing monoclonal antibodies may still help COVID-19 patients. | Haolin Liu Qianqian Zhang Pengcheng Wei Zhongzhou Chen Katja Aviszus John Yang Walter Downing Chengyu Jiang Bo Liang Lyndon Reynoso Gregory PDowney Stephen KFrankel John Kappler Philippa Marrack Gongyi Zhang | 2021 | Cell Research2021，31，6： | 1 |
| 12 | Overcoming Mycobacterium tuberculosis through small molecule inhibitors to break down cell wall synthesis显示文摘Mycobacterium tuberculosis(MTB) utilizes multiple mechanisms to obtain antibiotic resistance during the treatment of infections. In addition, the biofilms, secreted by MTB, can further protect the latter from the contact with drug molecules and immune cells. These self-defending mechanisms lay a formidable challenge to develop effective therapeutic agents against chronic and recurring antibiotictolerant MTB infections. Although several inexpensive and effective drugs(isoniazid, rifampicin, pyrazinamide and ethambutol) have been discovered for the treatment regimen, MTB continues to cause considerable morbidity and mortality worldwide. Antibiotic resistance and tolerance remain major global issues, and innovative therapeutic strategies are urgently needed to address the challenges associated with pathogenic bacteria. Gratifyingly, the cell wall synthesis of tubercle bacilli requires the participation of many enzymes which exclusively exist in prokaryotic organisms. These enzymes, absent in human hepatocytes, are recognized as promising targets to develop anti-tuberculosis drug. In this paper, we discussed the critical roles of potential drug targets in regulating cell wall synthesis of MTB. And also, we systematically reviewed the advanced development of novel bioactive compounds or drug leads for inhibition of cell wall synthesis, including their discovery, chemical modification, in vitro and in vivo evaluation. | Wenbin Kuang Haolin Zhang Xiao Wang Peng Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 1 |
| 13 | Characterization of frozen soil-cement mixture for berm construction in cold regions显示文摘Lagoon berms in western Alaska are difficult to design and build due to limited resources, high cost of construction and materials, and warm permafrost conditions. This paper explores methods to treat locally available frozen materials and use them for berm construction. The goal is to find an optimized mix ratio for cement and additives that can be effective in increasing the strength and decreasing the thaw settlement of an ice-rich frozen silty soil. Soil of similar type and ice content to the permafrost found at a project site in Eek, Alaska is prepared in a cold room. The frozen soil is pulverized and cement, additives and fibers are added to the samples for enhancing shear strength and controlling thaw settlement. Thaw settlement and direct shear tests are performed to assess strength and settlement characteristics. This paper presents a sample preparation method, data from thaw settlement and direct shear tests, and analyses of the test results and preliminary conclusions. | HaoLin Yu XinLei Na ZhaoHui Joey Yang | 2015 | Research in Cold and Arid Regions2015，7，4： | 1 |
| 14 | A universal hydrochloric acid-assistant powder-to-powder strategy for quick and mass preparation of lead-free perovskite microcrystals显示文摘Lead-free halide perovskite materials possess low toxicity,broadband luminescence and robust stability compared with conventional lead-based perovskites,thus holding great promise for eyes-friendly white light LEDs.However,the traditionally used preparation methods with a long period and limited product yield have curtailed the commercialization of these materials.Here we introduce a universal hydrochloric acid-assistant powder-to-powder strategy which can accomplish the goals of thermal-,pressure-free,eco-friendliness,short time,low cost and high product yield,simultaneously.The obtained Cs_(2)Na_(0.9)Ag_(0.1)In_(0.95)Bi_(0.05)Cl_(6)microcrystals exhibit bright self-trapped excitons emission with quantum yield of(98.3±3.8)%,which could retain(90.5±1.3)%and(96.8±0.8)%after continuous heating or ultraviolet-irradiation for 1000 h,respectively.The phosphor converted-LED exhibited near-unity conversion efficiency from ultraviolet chip to self-trapped excitons emission at~200 mA.Various ions doping(such as Cs_(2)Na_(0.9)Ag_(0.1)InCl_(6):Ln^(3+))and other derived lead-free perovskite materials(such as Cs_(2)ZrCl_(6)and Cs_(4)MnBi_(2)Cl_(12))with high luminous performance are all realized by our proposed strategy,which has shown excellent availability towards commercialization. | Huanxin Yang Xiangxiang Chen Yiyue Chu Changjiu Sun Haolin Lu Mingjian Yuan Yuhai Zhang Guankui Long Libing Zhang Xiyan Li | 2023 | Light(Science & Applications)2023，12，4： | 0 |
| 15 | Electrode design for multimode suppression of aluminum nitride tuning fork resonators显示文摘This paper is focused on electrode design for piezoelectric tuning fork resonators.The relationship between the performance and electrode pattern of aluminum nitride piezoelectric tuning fork resonators vibrating in the in-plane flexural mode is investigated based on a set of resonators with different electrode lengths,widths,and ratios.Experimental and simulation results show that the electrode design impacts greatly the multimode effect induced from torsional modes but has little influence on other loss mechanisms.Optimizing the electrode design suppresses the torsional mode successfully,thereby increasing the ratio of impedance at parallel and series resonant frequencies(R_(p)/R_(s))by more than 80%and achieving a quality factor(Q)of 7753,an effective electromechanical coupling coefficient(kt_(eff)^(2))of 0.066%,and an impedance at series resonant frequency(R_(m))of 23.6 kΩ.The proposed approach shows great potential for high-performance piezoelectric resonators,which are likely to be fundamental building blocks for sensors with high sensitivity and low noise and power consumption. | Yi Yuan Qingrui Yang Haolin Li Shuai Shi Pengfei Niu Chongling Sun Bohua Liu Menglun Zhang Wei Pang | 2023 | Nanotechnology and Precision Engineering2023，6，4： | 0 |
| 16 | Polysaccharides from Chinese herbal medicine:a review on the hepatoprotective and molecular mechanism显示文摘Polysaccharides,predominantly extracted from traditional Chinese medicinal herbs such as Lycium barbarum,Angelica sinensis,Astragalus membranaceus,Dendrobium officinale,Ganoderma lucidum,and Poria cocos,represent principal bioactive constituents extensively utilized in Chinese medicine.These compounds have demonstrated significant anti-inflammatory capabilities,especially anti-liver injury activities,while exhibiting minimal adverse effects.This review summarized recent studies to elucidate the hepatoprotective efficacy and underlying molecular mechanisms of these herbal polysaccharides.It underscored the role of these polysaccharides in regulating hepatic function,enhancing immunological responses,and improving antioxidant capacities,thus contributing to the attenuation of hepatocyte apoptosis and liver protection.Analyses of molecular pathways in these studies revealed the intricate and indispensable functions of traditional Chinese herbal polysaccharides in liver injury management.Therefore,this review provides a thorough examination of the hepatoprotective attributes and molecular mechanisms of these medicinal polysaccharides,thereby offering valuable insights for the advancement of polysaccharide-based therapeutic research and their potential clinical applications in liver disease treatment. | LI Jifeng GUO Haolin DONG Ying YUAN Shuo WEI Xiaotong ZHANG Yuxin DONG Lu WANG Fei BAI Ting YANG Yong | 2024 | Chinese Journal of Natural Medicines2024，22，1： | 0 |
| 17 | Mechanism of capture section affecting an intake for atmosphere-breathing electric propulsion显示文摘Atmosphere-Breathing Electric Propulsion(ABEP)can compensate for lost momentum of spacecraft operating in Very Low Earth Orbit(VLEO)which has been widely concerned due to its excellent commercial potential.It is a key technology to improve the capture efficiency of intakes,which collect and compress the atmosphere for ABEP.In this paper,the mechanism of the capture section affecting capture efficiency is investigated by Test Particle Monte Carlo(TPMC)simulations with 3D intake models.The inner surface smoothness and average collision number are determined to be key factors affecting capture efficiency,and a negative effect growth model is accordingly established.When the inner surface smoothness is less than 0.2,the highest capture efficiency and its corresponding average collision number interval are independent of the capture section’s geometry and its mesh size.When the inner surface smoothness is higher than 0.2,the capture efficiency will decrease by installing any capture section.Based on the present results,the manufacturing process and material selection are suggested to be prioritized during the intake geometry design in engineering projects.Then,the highest capture efficiency can be achieved by adjusting the length and mesh size of the capture section. | Siyuan ZHANG Jinyuan YANG Cheng LI Haolin LI Liwei ZHANG Liang DING Anbang SUN | 2024 | Chinese Journal of Aeronautics2024，37，1： | 0 |
| 18 | Analysis on Ecological Personality Right--In the Perspective of Environmental Personality Right显示文摘This essay focuses on expanding the traditional theory of personality right and referring to the outside legislative cases in order to promote environmental information disclosure,the purpose,therefore is to realize the ecological personality right. | Wang Xinming Gong Jinping Wan Haolin Cao Huanlu Yang Zhiwei Shi Xinfeng | 2017 | Meteorological and Environmental Research2017，8，2： | 0 |
| 19 | Heteroatom tuning in agarose derived carbon aerogel for enhanced potassium ion multiple energy storage显示文摘The incorporation of heteroatoms into carbon aerogels(CAs)can lead to structural distortions and changes in active sites due to their smaller size and electronegativity compared to pure carbon.However,the evolution of the electronic structure from single-atom doping to heteroatom codoping in CAs has not yet been thoroughly investigated,and the impact of codoping on potassium ion(K+)storage and diffusion pathways as electrode material remains unclear.In this study,experimental and theoretical simulations were conducted to demonstrate that heteroatom codoping,composed of multiple heteroatoms(O/N/B)with different properties,has the potential to improve the electrical properties and stability of CAs compared to single-atom doping.Electronic states near the Fermi level have revealed that doping with O/N/B generates a greater number of active centers on adjacent carbon atoms than doping with O and O/N atoms.As a result of synergy with enhanced wetting ability(contact angle of 9.26°)derived from amino groups and hierarchical porous structure,ON-CA has the most optimized adsorption capacity(−1.62 eV)and diffusion barrier(0.12 eV)of K^(+).The optimal pathway of K^(+)in ON-CA is along the carbon ring with N or O doping.As K^(+)storage material for supercapacitors and ion batteries,it shows an outstanding specific capacity and capacitance,electrochemical stability,and rate performance.Especially,the assembled symmetrical K^(+)supercapacitor demonstrates an energy density of 51.8 Wh kg^(−1),an ultrahigh power density of 443Wkg^(−1),and outstanding cycling stability(maintaining 83.3%after 10,000 cycles in 1M KPF6 organic electrolyte).This research provides valuable insights into the design of highperformance potassium ion storage materials. | Kaijun Xie Xin Liu Haolin Li Long Fang Kai Xia Dongjiang Yang Yihui Zou Xiaodong Zhang | 2024 | Carbon Energy2024，6，3： | 0 |
| 20 | Epigallocatechin-3-gallate/mineralization precursors co-delivery hollow mesoporous nanosystem for synergistic manipulation of dentin exposure显示文摘As a global public health focus,oral health plays a vital role in facilitating overall health.Defected teeth characterized by exposure of dentin generally increase the risk of aggravating oral diseases.The exposed dentinal tubules provide channels for irritants and bacterial invasion,leading to dentin hypersensitivity and even pulp inflammation.Cariogenic bacterial adhesion and biofilm formation on dentin are responsible for tooth demineralization and caries.It remains a clinical challenge to achieve the integration of tubule occlusion,collagen mineralization,and antibiofilm functions for managing exposed dentin.To address this issue,an epigallocatechin-3-gallate(EGCG)and poly(allylamine)-stabilized amorphous calcium phosphate(PAH-ACP)co-delivery hollow mesoporous silica(HMS)nanosystem(E/PA@HMS)was herein developed.The application of E/PA@HMS effectively occluded the dentinal tubules with acid-and abrasion-resistant stability and inhibited the biofilm formation of Streptococcus mutans.Intrafibrillar mineralization of collagen fibrils and remineralization of demineralized dentin were induced by E/PA@HMS.The odontogenic differentiation and mineralization of dental pulp cells with high biocompatibility were also promoted.Animal experiments showed that E/PA@HMS durably sealed the tubules and inhibited biofilm growth up to 14 days.Thus,the development of the E/PA@HMS nanosystem provides promising benefits for protecting exposed dentin through the coordinated manipulation of dentin caries and hypersensitivity. | Jian Yu Haolin Bian Yaning Zhao Jingmei Guo Chenmin Yao He Liu Ya Shen Hongye Yang Cui Huang | 2023 | Bioactive Materials2023，，5： | 0 |
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