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| 1 | Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury显示文摘 | Yumiko Imai Keiji Kuba G. Greg Neely Rubina Yaghubian-Malhami Thomas Perkmann Geert van Loo Maria Ermolaeva Ruud Veldhuizen Y.H. Connie Leung Hongliang Wang Haolin Liu Yang Sun Manolis Pasparakis Manfred Kopf Christin Mech Sina Bavari J.S. Malik Peiris Ar | 2008 | Cell2008，，2： | 4 |
| 2 | Effect of surgical factors on the augmentation of cementinjectable cannulated pedicle screw fixation by a novel calcium phosphate-based nanocomposite显示文摘Bone cement-augmented pedicle screw system demonstrates great efficacy in spinal disease treatments. However, the intrinsic drawbacks associated with clinically used polymethylmethacrylate (PMMA) cement demands for new bone cement formulations. On the basis of our previous studies, a novel injectable and biodegradable calcium phosphate-based nanocomposite (CPN) for the augmentation of pedicle screw fixation was systematically evaluated for its surgical feasibility and biomechanical performance by simulated and animal osteoporotic bone models, and the results were compared with those of clinical PMMA cement. ASTM-standard solid foam and open-cell foam models and decalcified sheep vertebra models were employed to evaluate the augmentation effects of CPN on bone tissue and on the cement-injected cannulated pedicle screws (CICPs) placed in osteoporotic bone. Surgical factors in CICPs application, such as injection force, tapping technique, screw diameter, and pedicle screw loosening scenarios, were studied in comparison with those in PMMA. When directly injected to the solid foam model, CPN revealed an identical augmentation effect to that of PMMA, as shown by the similar compressive strengths (0.73 ± 0.04 MPa for CPN group vs. 0.79 ± 0.02 MPa for PMMA group). The average injection force of CPN at approximately 40-50 N was higher than that of PMMA at approximately 20 N. Although both values are acceptable to surgeons, CPN revealed a more consistent injection force pattern than did PMMA. The dispersing and anti-pullout ability of CPN were not affected by the surgical factors of tapping technique and screw diameter. The axial pullout strength of CPN evaluated by the decalcified sheep vertebra model revealed a similar augmentation level as that of PMMA (1351.6 ± 324.2 N for CPN vs. 1459.7 ± 304.4 N for PMMA). The promising results of CPN clearly suggest its potential for replacing PMMA in CICPs augmentation application and the benefits of further study and development for clinical uses. | Haolin Sun Chun Liu Shunlun Chen Yanjie Bai Huilin Yang Chunde Li Lei Yang | 2019 | Frontiers of Medicine2019，13，5： | 2 |
| 3 | A framework for the fusion of visual and tactile modalities for improving robot perception显示文摘Robots should ideally perceive objects using human-like multi-modal sensing such as vision, tactile feedback, smell, and hearing. However, the features presentations are different for each modal sensor. Moreover,the extracted feature methods for each modal are not the same. Some modal features such as vision, which presents a spatial property, are static while features such as tactile feedback, which presents temporal pattern,are dynamic. It is difficult to fuse these data at the feature level for robot perception. In this study, we propose a framework for the fusion of visual and tactile modal features, which includes the extraction of features, feature vector normalization and generation based on bag-of-system(BoS), and coding by robust multi-modal joint sparse representation(RM-JSR) and classification, thereby enabling robot perception to solve the problem of diverse modal data fusion at the feature level. Finally, comparative experiments are carried out to demonstrate the performance of this framework. | Wenchang ZHANG Fuchun SUN Hang WU Haolin YANG | 2017 | Science China(Information Sciences)2017，60，1： | 2 |
| 4 | DRP1 deficiency induces mitochondrial dysfunction and oxidative stress-mediated apoptosis during porcine oocyte maturation显示文摘Background: Environmental pollution induces oxidative stress and apoptosis in mammalian oocytes, which can cause defects in reproduction;however, the molecular regulation of oxidative stress in oocytes is still largely unknown. In the present study, we identified that dynamin-related protein 1(DRP1) is an important molecule regulating oocyte mitochondrial function and preventing oxidative stress/apoptosis. DRP1 is a member of the dynamin GTPase superfamily localized at the mitochondrial-endoplasmic reticulum interaction site, where it regulates the fission of mitochondria and other related cellular processes.Results: Our results show that DRP1 was stably expressed during different stages of porcine oocyte meiosis, and might have a potential relationship with mitochondria as it exhibited similar localization. Loss of DRP1 activity caused failed porcine oocyte maturation and cumulus cell expansion, as well as defects in polar body extrusion.Further analysis indicated that a DRP1 deficiency caused mitochondrial dysfunction and induced oxidative stress,which was confirmed by increased reactive oxygen species levels. Moreover, the incidence of early apoptosis increased as detected by positive Annexin-V signaling.Conclusions: Taken together, our results indicate that DRP1 is essential for porcine oocyte maturation and that a DRP1 deficiency could induce mitochondrial dysfunction, oxidative stress, and apoptosis. | Haolin Zhang Zhennan Pan Jiaqian Ju Chunhua Xing Xiaohan Li Mengmeng Shan Shaochen Sun | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 1 |
| 5 | A universal hydrochloric acid-assistant powder-to-powder strategy for quick and mass preparation of lead-free perovskite microcrystals显示文摘Lead-free halide perovskite materials possess low toxicity,broadband luminescence and robust stability compared with conventional lead-based perovskites,thus holding great promise for eyes-friendly white light LEDs.However,the traditionally used preparation methods with a long period and limited product yield have curtailed the commercialization of these materials.Here we introduce a universal hydrochloric acid-assistant powder-to-powder strategy which can accomplish the goals of thermal-,pressure-free,eco-friendliness,short time,low cost and high product yield,simultaneously.The obtained Cs_(2)Na_(0.9)Ag_(0.1)In_(0.95)Bi_(0.05)Cl_(6)microcrystals exhibit bright self-trapped excitons emission with quantum yield of(98.3±3.8)%,which could retain(90.5±1.3)%and(96.8±0.8)%after continuous heating or ultraviolet-irradiation for 1000 h,respectively.The phosphor converted-LED exhibited near-unity conversion efficiency from ultraviolet chip to self-trapped excitons emission at~200 mA.Various ions doping(such as Cs_(2)Na_(0.9)Ag_(0.1)InCl_(6):Ln^(3+))and other derived lead-free perovskite materials(such as Cs_(2)ZrCl_(6)and Cs_(4)MnBi_(2)Cl_(12))with high luminous performance are all realized by our proposed strategy,which has shown excellent availability towards commercialization. | Huanxin Yang Xiangxiang Chen Yiyue Chu Changjiu Sun Haolin Lu Mingjian Yuan Yuhai Zhang Guankui Long Libing Zhang Xiyan Li | 2023 | Light(Science & Applications)2023，12，4： | 0 |
| 6 | Electrode design for multimode suppression of aluminum nitride tuning fork resonators显示文摘This paper is focused on electrode design for piezoelectric tuning fork resonators.The relationship between the performance and electrode pattern of aluminum nitride piezoelectric tuning fork resonators vibrating in the in-plane flexural mode is investigated based on a set of resonators with different electrode lengths,widths,and ratios.Experimental and simulation results show that the electrode design impacts greatly the multimode effect induced from torsional modes but has little influence on other loss mechanisms.Optimizing the electrode design suppresses the torsional mode successfully,thereby increasing the ratio of impedance at parallel and series resonant frequencies(R_(p)/R_(s))by more than 80%and achieving a quality factor(Q)of 7753,an effective electromechanical coupling coefficient(kt_(eff)^(2))of 0.066%,and an impedance at series resonant frequency(R_(m))of 23.6 kΩ.The proposed approach shows great potential for high-performance piezoelectric resonators,which are likely to be fundamental building blocks for sensors with high sensitivity and low noise and power consumption. | Yi Yuan Qingrui Yang Haolin Li Shuai Shi Pengfei Niu Chongling Sun Bohua Liu Menglun Zhang Wei Pang | 2023 | Nanotechnology and Precision Engineering2023，6，4： | 0 |
| 7 | Comparative study on Photobiomodulation between 630 nm and 810 nm LED in diabetic wound healing both in vitro and in vivo显示文摘Photobiomodulation(PBM)promoting wound healing has been demonstrated by many studies.Currently,630 nm and 810 nm light-emitting diodes(LEDs),as light sources,are frequently used in the treatment of diabetic foot ulcers(DFUs)in clinics.However,the dose-effect relationship of LED-mediated PBM is not fully understood.Furthermore,among the 630 nm and 810 nm LEDs,which one gets a better effect on accelerating the wound healing of diabetic ulcers is not clear.The aim of this study is to evaluate and compare the effects of 630 nm and 810 nm LED-mediated PBM in wound healing both in vitro and in vivo.Our results showed that both 630 nm and 810 nm LED irradiation significantly promoted the proliferation of mouse fibroblast cells(L929)at different light irradiances(1,5,and 10 mW/cm^(2)).The cell proliferation rate increased with the extension of irradiation time(100,200,and 500 s),but it decreased when the irradiation time was over 500 s.Both 630 nm and 810nm LED irradiation(5 mW/cm^(2))significantly improved the migration capability of L929 cells.No difference between 630 nm and 810 nm LED-mediated PBM in promoting cell proliferation and migration was detected.In vivo results presented that both 630 nm and 810 nm LED irradiation promoted the wound healing and the expression of the vascular endothelial growth factor(VEGF)and transforming growth factor(TGF)in the wounded skin of type 2 diabetic mice.Overall,these results suggested that LED-mediated PBM promotes wound healing of diabetic mice through promoting fibroblast cell proliferation,migration,and the expression of growth factors in the wounded skin.LEDs(630 nm and 810 nm)have a similar outcome in promoting wound healing of type 2 diabetic mice. | Hongyou Zhao Tengda Ji Tianzhen Sun Haolin Liu Yidi Liu Defu Chen Ying Wang Yizhou Tan Jing Zeng Haixia Qiu Ying Gu | 2022 | Journal of Innovative Optical Health Sciences2022，15，2： | 0 |
| 8 | Mechanism of capture section affecting an intake for atmosphere-breathing electric propulsion显示文摘Atmosphere-Breathing Electric Propulsion(ABEP)can compensate for lost momentum of spacecraft operating in Very Low Earth Orbit(VLEO)which has been widely concerned due to its excellent commercial potential.It is a key technology to improve the capture efficiency of intakes,which collect and compress the atmosphere for ABEP.In this paper,the mechanism of the capture section affecting capture efficiency is investigated by Test Particle Monte Carlo(TPMC)simulations with 3D intake models.The inner surface smoothness and average collision number are determined to be key factors affecting capture efficiency,and a negative effect growth model is accordingly established.When the inner surface smoothness is less than 0.2,the highest capture efficiency and its corresponding average collision number interval are independent of the capture section’s geometry and its mesh size.When the inner surface smoothness is higher than 0.2,the capture efficiency will decrease by installing any capture section.Based on the present results,the manufacturing process and material selection are suggested to be prioritized during the intake geometry design in engineering projects.Then,the highest capture efficiency can be achieved by adjusting the length and mesh size of the capture section. | Siyuan ZHANG Jinyuan YANG Cheng LI Haolin LI Liwei ZHANG Liang DING Anbang SUN | 2024 | Chinese Journal of Aeronautics2024，37，1： | 0 |
| 9 | Fast-response,high-sensitivity multi-modal tactile sensors based on PPy/Ti_(3)C_(2)T_(x) films for multifunctional applications显示文摘In recent years,multi-modal flexible tactile sensors have become an important direction in the development of electronic skin because of their excellent sensitivity,flexibility and wearable properties.In this work,a humidity-pressure multi-modal flexible sensor based on polypyrrole(PPy)/Ti_(3)C_(2)T_(x) sensitive film packaged with porous polydimethylsiloxane(PDMS)is investigated by combining the sensitive structure generation mechanism of in situ polymerization to achieve the simultaneous detection of humidity and pressure,which has a sensitivity of 89,113.4Ω/%RH in a large humidity range of 0%-97%RH,and response/recovery time of 2.5/1.9 s.The tactile pressure sensing has a high sensitivity,a fast response of 67/52 ms,and a wide detection limit.The device also has excellent performance in terms of stability and repeatability,making it promising for respiratory pattern and motion detection.This work provides a new solution to address the construction of multi-modal tactile sensors with potential applications in the fields of medical health,epidemic prevention. | Guangshuai Xi Dongzhi Zhang Mingcong Tang Hao Zhang Yuehang Sun Yubiao Zhang Haolin Cai Hui Xia Dandi Zhou | 2024 | Nano Research2024，17，5： | 0 |
| 10 | Research on the Characteristics of the Coda Q Value in the Jiangsu Area显示文摘In this paper,research is conducted on the characteristics of coda Q values of the Jiangsu area,based on the Aki single backscattering model with the waveforms recorded by the Jiangsu digital seismic network. The results show that the Jiangsu area is a high Q value area as a whole,but the Q value differs obviously between different regions,characterized generally as high in the south and low in the north. This study focuses on 4 sub-regions where the stations are relatively dense,the tectonic features are distinguishing,and the calculation results of coda Q0 are fairly concentrated,and obtains the characteristic relationship between the Q value and frequency of the 4 regions. The region from south Jiangsu to the Yangtze River estuary and that around the Maoshan fault zone are the high Q value areas in Jiangsu; the region from central Jiangsu to the waterfront area is the low Q value area in Jiangsu Province,and the Lianyungang region in northern Jiangsu is the moderate Q value area. Comparing the tectonic activity and seismicity of the 4 different Q value sub-regions,there is a certain correlation between Q value,crustal movement and seismicity. | Sun Yejun Huang Yun Wang Bin Wang Jun Li Feng Jiang Haolin | 2014 | Earthquake Research in China2014，28，2： | 0 |
| 11 | Recent Advances in Rare-Earth Polypnictides显示文摘The polypnictide complexes of rare earth cations have drawn the attention of the scientific community for their uncommon bonding modes and potential applications.Herein,we present a systematic and comprehensive summary on recent advances in the field of rare earth polypnictides,focusing on their synthesis,structures,and reactivities.The structural stbilizing effects imposed by the electropositive rare earth cations as well as the reducing capability of rare earth precursors in the synthesis of these polypnictide complexes are described in this review.We also disscuss in detail the bonding interactions and coordination modes between rare earth cations and polypnictide clusters as well as the similarities and the peculiarity of some structures. | Lei Qiao Chao Zhang Xiang Wen Zhang Zi-Chuan Wang Haolin Yin Zhong Ming Sun | 2020 | Chinese Journal of Chemistry2020，38，3： | 0 |
| 12 | Analysis of Space-time Characteristics of Energy Field of Seismicity in Jiangsu and Its Neighboring Areas显示文摘The paper analyzes the variation characteristics of energy fields of seismicity 2.1≤M L ≤4.5 in Jiangsu and its neighboring areas during the period between January 1970 and December 2007.It also analyzes the variations of time 'weight' coefficients of the major typical energy fields,using random function theory with seismic energy fields as a space-time random function field based on Empirical Orthogonal Function (EOF) expansion methods.The results show that the expansion accuracy of the first seven typical fields is 0.9244.The strength of seismic energy varies remarkably in different tectonic blocks in the study area.High value areas are in middle and southern Jiangsu,and the south Yellow Sea.The distribution of the typical fields also shows that it is an area that affects most significantly the seismic energy fields of the study region.The time 'weight' coefficients of the first six typical fields vary with time,and the amplitude of the variations has strong temporal correlations with moderate-strong earthquakes in the region. | Wang Jun Sun Yejun Zhan Xiaoyan Zheng Jiangrong Jiang Haolin Huo Zhuqing | 2010 | Earthquake Research in China2010，24，4： | 0 |
| 13 | Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents显示文摘Programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1)have emerged as one of the most promising immune checkpoint targets for cancer immunotherapy.Despite the inherent advantages of small-molecule inhibitors over antibodies,the discovery of small-molecule inhibitors has fallen behind that of antibody drugs.Based on docking studies between small molecule inhibitor and PD-L1 protein,changing the chemical linker of inhibitor from a flexible chain to an aromatic ring may improve its binding capacity to PD-L1 protein,which was not reported before.A series of novel phthalimide derivatives from structure-based rational design was synthesized.P39 was identified as the best inhibitor with promising activity,which not only inhibited PD-1/PD-L1 interaction(IC_(50)=8.9 nmol/L),but also enhanced killing efficacy of immune cells on cancer cells.Co-crystal data demonstrated that P39 induced the dimerization of PD-L1 proteins,thereby blocking the binding of PD-1/PD-L1.Moreover,P39 exhibited a favorable safety profile with a LD_(50)>5000 mg/kg and showed significant in vivo antitumor activity through promoting CD8^(+)T cell activation.All these data suggest that P39 acts as a promising small chemical inhibitor against the PD-1/PD-L1 axis and has the potential to improve the immunotherapy efficacy of T-cells. | Chengliang Sun Yao Cheng Xiaojia Liu Gefei Wang Wenjian Min Xiao Wang Kai Yuan Yi Hou Jiaxing Li Haolin Zhang Haojie Dong Liping Wang Chenguang Lou Yanze Sun Xinmiao Yu Hongbin Deng Yibei Xiao Peng Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 0 |
| 14 | Investigation of high-quality-factor aluminum nitride MEMS cantilever resonators显示文摘This paper presents the design,fabrication,and characterization of cantilever-type resonators with a novel stacked structure.Aluminum nitride is adopted as the material for both the structural layer and the piezoelectric layer;this simplifies the fabrication process and improves the quality factor of the resonator.Both in-plane and out-of-planeflexural modes were investigated.The effect of the structural dimensions and electrode patterns on the resonator’s performance were also studied.Finite-element simulations and experiments examining anchor loss and thermoelastic damping,which are the main loss mechanisms affecting the quality factor of these resonators,were carried out.The optimal structural dimensions and electrode patterns of the cantilever-type resonators are presented.A quality factor of 7922 with a motional impedance of 88.52 kΩand a quality factor of 8851 with a motional impedance of 67.03 kΩwere achieved for the in-plane and out-of-planeflexural-mode resonators,respectively.The proposed resonator design will contribute to the development of high-performance devices such as accelerometers,gyroscopes,and pressure sensors. | Shuai Shi Qingrui Yang Yi Yuan Haolin Li Pengfei Niu Wenlan Guo Chen Sun Wei Pang | 2024 | Nanotechnology and Precision Engineering2024，7，1： | 0 |
| 15 | Metal organic frameworks as advanced extraction adsorbents for separation and analysis in proteomics and environmental research显示文摘Human health is always under global spotlight, but now it suffers from severe environmental issue and various diseases.Developing highly selective and effective extraction technique for environmental pollutant removal and target protein/peptide molecules conduces to the solution of environmental contamination and early disease detection, which will promise human health to a great degree. Metal-organic frameworks(MOFs) are typical porous nanomaterials featuring rigid structure, large specific surface area, thermal and chemical stability, numerous active sites and easy functionalization. Moreover, multitudinous combination of metal centers and organic ligands often endows MOFs with structure and function diversity. Owing to such splendid merits, MOFs are able to act as advanced adsorbents for sample-pretreatment in proteomics and environmental field,which indicates great efficiency, reproducibility, convenience and cost-effectiveness. In this review, the novel design of MOFs and their applications in proteomics and environmental research are roughly summarized. We first introduce the representative researches of functional MOFs in protein post-translational modifications including glycosylation and phosphorylation, mainly focusing on hydrophilic interaction liquid chromatography(HILIC) or metal-oxide affinity chromatography(MOAC). The important role of MOFs in enzyme immobilization is also covered. Then MOF-based adsorptive removal of diverse environmental contaminants embracing plasticizers, pesticides and varied water pollutants(pharmaceutical and personal care products,organic dyes and heavy metals), in which multiple chemical and non-chemical interactions play a vital role, is emphatically discussed. Finally, we analyze the existing problems and challenges in the way of wider practical applications and put forward prospective anticipation. | Yonglei Wu Haolin Chen Yijie Chen Nianrong Sun Chunhui Deng | 2022 | Science China Chemistry2022，65，4： | 0 |
| 16 | Mixed ion-electron conducting Li_(3)P for efficient cathode prelithiation of all-solid-state Li-ion batteries显示文摘All-solid-state batteries(ASSBs)using sulfide electrolytes hold promise for next-generation battery technology.Although using a pure Li metal anode is believed to maximize battery energy density,numerous recent studies have implicated that Li-ion anodes(e.g.,graphite and Si)are more realistic candidates due to their interfacial compatibility with sulfide electrolytes.However,those Li-ion ASSBs suffer from an issue similar to liquid Li-ion batteries,which is a loss of active Li inventory owing to interfacial side reactions between electrode components,resulting in reduced available capacities and shortened cycle life.Herein,for the first time,we explore the potential of Li_(3)P for cathode prelithiation of Li-ion ASSBs.We identify that the crystallized Li_(3)P(c-Li_(3)P)has room-temperature ionic and electronic conductivities of both over 1o-4 s/cm.Such a mixed ion-electron conduct-ing feature ensures that the neat c-LisP affords a high Li+-releasing capacity of 983 mAh/g in ASSBs during the first charging.Moreover,the electro-chemical delithiation of c-LisP takes place below 2 V versus Li+/Li,while its lithiation dominates below 1 V versus Lit/Li.Once used as a cathode prelithiation regent for ASSBs,c-Li_(3)P only functions as a Li+donor without lithiation activity and can adequately compensate for the Li loss with minimal dosage added.Besides mitigating first-cycle Li loss,c-LisP prelithiation can also improve the battery cyclability by sustained release of low-dosage Li+ions in subsequent cycles,which have been embodied in several full ASSBs by coupling a LiCoO2 cathode with various types of anodes(including graphite,in foil,Sb,and Si anode).Our work provides a universal cathode prelithiation strategy for high-efficiency Li-ion AsSBs. | Jing Li Dan Liu Han Sun Deyu Qu Zhizhong Xie Haolin Tang Jinping Liu | 2023 | SmartMat2023，4，5： | 0 |
| 17 | Distribution and Controlling Factors of Dissolved Gaseous Mercury and Reactive Mercury in Seawater Near Yangtze River Estuary显示文摘Complex hydrocultural conditions in the estuary affect the migration and transformation of mercury.Using two voyages in July and October 2018,Dissolved Gaseous Mercury(DGM)and Reactive Mercury(RHg)were determined to explore the source,transformation and influence of DGM content in the adjacent waters of Yangtze River Estuary in summer and autumn.The results showed the contents of DGM and RHg in summer were higher than those in autumn,and both of them were higher than those in open sea.In summer and autumn,the Yangtze River brought a higher concentration of DGM,and different flow direction and runoff resulted in differences in the high value region of the surface.The emergence of low-oxygen zones in summer was conducive to the production of DGM.In autumn,windy weather allowed seawater disturbances to promote the release of mercury from the underlying sediments,especially in shallow sea in northwest.RHg showed a higher concentration in the offshore than in the open sea in summer,but there was no such trend in autumn,reflecting the influence of less runoff input.DGM is the main product of RHg reduction,and there was a significant positive correlation between DGM and RHg in summer(r=0.356,P<0.05),while the correlation between DGM and RHg was not significant in autumn due to the influence of light intensity,wind speed and nutrients.The exchange flux of mercury in the adjacent waters of the Yangtze River Estuary was higher than that in the open sea.There was no significant difference of the release flux of mercury in summer and autumn.This article highlighted that the input of mercury from the Yangtze River runoff promotes the release of mercury in seawater,and the hypoxic zone caused by eutrophication is conducive to the production of DGM. | YIN Pingping ZHENG Wen WANG Yan LIU Ruhai HE Xin SUN Haolin LI Dou | 2023 | Journal of Ocean University of China2023，22，5： | 0 |
| 18 | Diagnosis and subtype classification on serum peptide fingerprints by mesoporous polydopamine with built-in metal-organic framework显示文摘Crohn's disease(CD)as a big issue to public health needs an accurate diagnosis urgently that is the common challenge among internal diseases.Herein,we design a mesoporous polydopamine with builtin metal-organic frameworks(dubbed MMP-b-MOFs)to combine with high-throughput mass spectrometry to extract serum peptide fingerprints from CD and healthy controls(HC).Benefitting by the sizeexclusion and strong hydrophilicity of MMP-b-MOFs,the extracted peptide fingerprints present extremely high quality.CD and HC are explicitly discriminated with orthogonal partial least squares discriminant analysis(OPLS-DA),the corresponding area under the curve(AUC)value is 1.000.Moreover,eight peptides with clear identity are screened out and achieve the accurate diagnosis and subtype classification of CD,with all AUC values up to 1.000.Moreover,the unsupervised model is also established to precisely classify HC and CD based on these eight clearly identified peptides.This work brings great benefits for clinical detection especially internal medicine. | Zixing Xu Haolin Chen Huimin Chu Xizhong Shen Chunhui Deng Nianrong Sun Hao Wu | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 19 | Specific enrichment of urinary exosomes and exosomal glycopeptides by coefficient affinity of integrated L-cysteine and titania显示文摘Exosome and inclusive cargoes have manifested significant function in different biological events. In particular, glycopeptides in exosome are closely associated with occurrence and development of various diseases. Developing advanced tools is highly desired to enrich glycopeptides from exosomes, and enrich exosomes from complex biological samples as well. In this work, integration of L-cysteine and titania onto the surface of magnetic nanoparticles is designed to realize the coefficient affinity towards exosomes and inclusive glycopeptides. Benefiting from the synergistic affinity, we separate exosomes from human urine concentrate directly, which was proved by the detection of three typical antigen markers of exosomes. Furthermore, hardly any exosomes remained on materials after ultrasonication, which confirmed the good capture performance of Fe_(3)O_(4)@TiO_(2)@L-Cys and high release effect of direct lysis.Moreover, 146 glycopeptides corresponding to 77 glycoproteins were successfully identified from captured exosomes. These satisfactory results will inspire more efforts to be devoted to this field and will be extremely helpful to in-depth information excavation of biological markers, especially disease-related ones, through exosomes and inclusive glycopeptides. | Yijie Chen Haolin Chen Chenjie Yang Yonglei Wu Chunhui Deng Nianrong Sun | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
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