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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Lycium barbarum polysaccharide-glycoprotein preventative treatment ameliorates aversive stimuli-induced depression显示文摘Previous studies have shown that Lycium barbarum polysaccharide,the main active component of Lycium barbarum,exhibits antiinflammatory and antioxidant effects in treating neurological diseases.However,the therapeutic action of Lycium barbarum polysaccharide on depression has not been studied.In this investigation,we established mouse models of depression using aversive stimuli including exposure to fox urine,air puff and foot shock and physical restraint.Concurrently,we administered 5 mg/kg per day Lycium barbarum polysaccharide-glycoprotein to each mouse intragastrically for the 28 days.Our results showed that long-term exposure to aversive stimuli significantly enhanced depressive-like behavior evaluated by the sucrose preference test and the forced swimming test and increased anxietylike behaviors evaluated using the open field test.In addition,aversive stimuli-induced depressed mice exhibited aberrant neuronal activity in the lateral habenula.Importantly,concurrent Lycium barbarum polysaccharide-glycoprotein treatment significantly reduced these changes.These findings suggest that Lycium barbarum polysaccharide-glycoprotein is a potential preventative intervention for depression and may act by preventing aberrant neuronal activity and microglial activation in the lateral habenula.The study was approved by the Jinan University Institutional Animal Care and Use Committee(approval No.20170301003)on March 1,2017. | Yun-Wei Fu Yan-Fang Peng Xiao-Dan Huang Yan Yang Lu Huang Yue Xi Zheng-Fang Hu Song Lin Kwok-Fai So Chao-Ran Ren | 2021 | Neural Regeneration Research2021，16，3： | 8 |
| 3 | Treadmill Exercise Relieves Chronic Restraint Stress-induced Cognitive Impairments in Mice Via Activating Protein Phosphatase 2A显示文摘Dear Editor,Aerobic exercise is well known to improve cognitive functions including hippocampus-dependent spatial memory[1]and object recognition[2].Regarding the molecular mechanisms,the indispensable role of brain-derived neurotrophic factor(BDNF)in governing exercise-induced neural plasticity has been demonstrated for the improvement of learning and memory[3].Our recent study further demonstrated the activation of mechanistic target of rapamycin pathways downstream of BDNF to drive synaptic protein synthesis upon persistent exercise[4],but leaving the effect of exercise on the post-translational modification of proteins largely unknown. | Wenjing Zhang Haining Ou Borui Zhang Meifeng Zheng Lan Yan Yang Chen Kwok-Fai So Li Zhang | 2021 | Neuroscience Bulletin2021，37，10： | 2 |
| 4 | An eight-year study of epidemiologic features of enterovims 71 infection in Taiwan显示文摘 | Chen SO Chang HL Yan TB | 2007 | Am J Trop Med Hyg2007，77，1： | 1 |
| 5 | DNA hypermethylation is a mechanism for loss of expression of the HLA class I genes in human esophageal squamous cell carcinomas显示文摘 | Yan Nie Guang-yu Yang Yunlong Song Xin Zhao Chi So Jie Liao Li-Dong Wang | 2001 | Carcinogenesis2001，，： | 1 |
| 6 | Brassiere wearing and breast cancer risk:A systematic review and meta-analysis显示文摘AIM:To evaluate existing evidence for the association between different type of brassiere exposures and the risk of breast cancer.METHODS:Ovid Medline,CINAHL,Cochrane Data Base of Systematic Reviews,Pubmed,Scopus,Proquest,Sciencedirect,Wiley Online Library,WanF ang Data,Hong Kong Index to Chinese Periodicals,China Journal Net,Chinese Medical Current Contents,Chinese Biomedical Literature Database,China Academic Journals FullText database,Taiwan Electronic Periodical Services and HyR ead; reference lists of published studies; original research studies published in English or Chinese examining the association between type and duration of brassiere-wearing and breast cancer risk.Data were abstracted by a first reviewer and verified by a second.Study quality was rated according to predefined criteria.'Fair' or 'good' quality studies were included.Results were summarised by meta-analysis whenever adequate material was available.RESULTS:Twelve case-control studies were included in the review.Meta-analysis showed brassiere wearing during sleep was associated with a 1.3 times of increased risk.The odd ratio for more than 12 h of daily brassiere use in relation to breast cancer risk was 1.08(95%CI:1.01-1.14).CONCLUSION:The present review demonstrates insufficient evidence to establish a positive association between the duration and type of brassiere wearing and breast cancer.Further research is essential; specifically,a large-scale epidemiological study of a better design is needed to examine the association between various forms of brassiere exposure in detail and breast cancer risk,with adequate control of confounding variables. | Winnie KW So Dorothy NS Chan Yan Lou Kai-Chow Choi Carmen WH Chan Kristina Shin Ava Kwong Diana TF Lee | 2015 | World Journal of Meta-Analysis2015，3，4： | 1 |
| 7 | Ex vivo comparative study using the Endolifter ? as a traction device for enhancing submucosal visualization during endoscopic submucosal dissection显示文摘 | Anthony Yuen Bun Teoh Philip Wai Yan Chiu So Fei Hon Tony Wing Chung Mak Enders Kwok Wai Ng James Yun Wong Lau | 2013 | Surgical Endoscopy2013，，4： | 1 |
| 8 | Endoscopic submucosal dissection of gastric lesions by using a Master and Slave Transluminal Endoscopic Robot (MASTER)显示文摘 | Khek-Yu Ho Soo Jay Phee Asim Shabbir Soon Chiang Low Van An Huynh Andy Prima Kencana Kai Yang Davide Lomanto Bok Yan Jimmy So Y.Y. Jennie Wong S.C. Sydney Chung | 2010 | Gastrointestinal Endoscopy2010，，3： | 1 |
| 9 | Aldosterone Receptor Antagonism Induces Reverse Remodeling When Added to Angiotensin Receptor Blockade in Chronic Heart Failure显示文摘 | Anna K.Y. Chan John E. Sanderson Tian Wang Wynnie Lam Gabriel Yip Mei Wang Yat-Yin Lam Yan Zhang Leata Yeung Eugene B. Wu Wilson W.M. Chan John T.H. Wong Nina So Cheuk-Man Yu | 2007 | Journal of the American College of Cardiology2007，，7： | 1 |
| 10 | Long-term effect of chemical fertilizer, straw, and manure on soil chemical and biological properties in northwest China显示文摘 | Enke Liu Changrong Yan Xurong Mei Wenqing He So Hwat Bing Linping Ding Qin Liu Shuang Liu Tinglu Fan | 2010 | Geoderma2010，，3： | 1 |
| 11 | Long-term effect of chemical fertilizer, straw, and manure on soil chemical and biological properties in northwest China显示文摘 | Enke Liu Changrong Yan Xurong Mei Wenqing He So Hwat Bing Linping Ding Qin Liu Shuang Liu Tinglu Fan | 2010 | Geoderma2010，，3： | 1 |
| 12 | Contributions of artificial lighting sources on light pollution in Hong Kong measured through a night sky brightness monitoring network 显示文摘 | Chun Shing Jason Pun Chu Wing So Wai Yan Leung Chung Fai Wong | 2014 | Journal of Quantitative Spectroscopy & Radiative Transfer2014，，139： | 1 |
| 13 | Effect of Ginseng Mixture on Osteoporosis in Ovariectomized Rats显示文摘 | Hyung-Ryong Kim Yan Cui Su-Jung Hong Sook-Jeong Shin Do-Sung Kim Na-Mi Kim Seung-Ho So Seong-Kye Lee Eun-Cheol Kim Soo-Wan Chae Han-Jung Chae | 2008 | Immunopharmacology and Immunotoxicology2008，，2： | 1 |
| 14 | Failure mode analy-sis in adrenal vein sampling: a single-center experience显示文摘 | Trerotola SO Asmar M Yan Y | 2014 | J Vase Interv Radiol2014，25，10： | 1 |
| 15 | Laparoscopic appendectomy by residents: evaluating outcomes and learning curve显示文摘 | Yap Yan Lin Asim Shabbir Jimmy B. Y. So | 2010 | Surgical Endoscopy2010，，1： | 1 |
| 16 | Activation of receptor for a: a mechanism for chronic vascular dysfunction in disbetes vasculopathy and atherosderosis显示文摘 | Schmit AM Yan SO Wantier JL | 1999 | Circ Res1999，84，： | 1 |
| 17 | Functional expression of P2U receptors in rat spermatogenic cells: dual modulation of a Ca2+-activated K+ channel显示文摘 | Wu WL So SC Sun YP Chung YW Grima J Wong PY Yan YC Chan HC | | 0，，： | 1 |
| 18 | LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer显示文摘Prostate cancer(PCa)is the most commonly diagnosed genital cancer in men worldwide.Around 80%of the patients who developed advanced PCa suffered from bone metastasis,with a sharp drop in the survival rate.Despite great efforts,the detailed mechanisms underlying castration-resistant PCa(CRPC)remain unclear.Sirtuin 5(SIRT5),an NAD+-dependent desuccinylase,is hypothesized to be a key regulator of various cancers.However,compared to other SIRTs,the role of SIRT5 in cancer has not been extensively studied.Here,we revealed significantly decreased SIRT5 levels in aggressive PCa cells relative to the PCa stages.The correlation between the decrease in the SIRT5 level and the patient’s reduced survival rate was also confirmed.Using quantitative global succinylome analysis,we characterized a significant increase in the succinylation at lysine 118(K118su)of lactate dehydrogenase A(LDHA),which plays a role in increasing LDH activity.As a substrate of SIRT5,LDHA-K118su significantly increased the migration and invasion of PCa cells and LDH activity in PCa patients.This study reveals the reduction of SIRT5 protein expression and LDHA-K118su as a novel mechanism involved in PCa progression,which could serve as a new target to prevent CPRC progression for PCa treatment. | Oh Kwang Kwon In Hyuk Bang So Young Choi Ju Mi Jeon Ann-Yae Na Yan Gao Sam Seok Cho Sung Hwan Ki Youngshik Choe Jun Nyung Lee Yun-Sok Ha Eun Ju Bae Tae Gyun Kwon Byung-Hyun Park Sangkyu Lee | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 0 |
| 19 | Neuromodulation-Based Stem Cell Therapy in Brain Repair:Recent Advances and Future Perspectives显示文摘Stem cell transplantation holds a promising future for central nervous system repair. Current challenges, however, include spatially and temporally defined cell differentiation and maturation, plus the integration of transplanted neural cells into host circuits. Here we discuss the potential advantages of neuromodulation-based stem cell therapy, which can improve the viability and proliferation of stem cells, guide migration to the repair site,orchestrate the differentiation process, and promote the integration of neural circuitry for functional rehabilitation.All these advantages of neuromodulation make it one potentially valuable tool for further improving the efficiency of stem cell transplantation. | Ti-Fei Yuan Yi Dong Li Zhang Jieyu Qi Chun Yao Yongjun Wang Renjie Chai Yan Liu Kwok-Fai So | 2021 | Neuroscience Bulletin2021，37，5： | 0 |
| 20 | 缰核相关神经通路可介导光疗的抗抑郁作用显示文摘文章简介视网膜所感知的光信息可调节抑郁情绪在内的多种非成像功能。虽然临床研究表明光疗可显著改善抑郁症状,但光疗抗抑郁作用产生的神经通路机制尚不明确。在本研究中,研究人员通过采用神经环路示踪技术发现在小鼠中存有一条连接视网膜(Retina)与外侧缰核(LHb)的跨双突触神经通路。 | 黄鲁 席月 黄晓丹 Yan Yang Xiaodan Huang Yunwei Fu Qian Tao Jia Xiao Tifei Yuan Kai An Huan Zhao Mingliang Pu Fuqiang Xu Tian Xue Minmin Luo Kwok-Fai So 任超然 苏国辉 | 2020 | 科学新闻2020，，2： | 0 |
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