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| 1 | Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas显示文摘In gliomas, the canonical Wingless/Int(WNT)/b-catenin pathway is increased while peroxisome proliferator-activated receptor gamma(PPAR-c) is downregulated.The two systems act in an opposite manner. This review focuses on the interplay between WNT/b-catenin signaling and PPAR-c and their metabolic implications as potential therapeutic target in gliomas. Activation of the WNT/bcatenin pathway stimulates the transcription of genes involved in proliferation, invasion, nucleotide synthesis,tumor growth, and angiogenesis. Activation of PPAR-c agonists inhibits various signaling pathways such as the JAK/STAT, WNT/b-catenin, and PI3 K/Akt pathways,which reduces tumor growth, cell proliferation, cell invasiveness, and angiogenesis. Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin,and sulforaphane downregulate the WNT/b-catenin pathway through the upregulation of PPAR-c and thus appear to provide an interesting therapeutic approach for gliomas.Temozolomide(TMZ) is an antiangiogenic agent. The downstream action of this opposite interplay may explain the TMZ-resistance often reported in gliomas. | AlexANDre Vallée Yves Lecarpentier Rémy Guillevin Jean-Noёl Vallée | 2018 | Neuroscience Bulletin2018，34，3： | 7 |
| 2 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 3 | Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE)显示文摘 | Alicia Amigou Jérémie Rudant Laurent Orsi Stéphanie Goujon-Bellec Guy Leverger André Baruchel Yves Bertrand Brigitte Nelken Geneviève Plat Gérard Michel Stéphanie Haouy Pascal Chastagner Stéphane Ducassou Xavier Rialland Denis Hémon Jacqueline Clavel | 2012 | Cancer Causes & Control2012，，8： | 2 |
| 4 | Pancreatic fistula after a pancreaticoduodenectomy for ductal adenocarcinoma and its association with morbidity: a multicentre study of the F rench S urgical A ssociation显示文摘 | Pietro Addeo Jean Robert Delpero Francois Paye Elie Oussoultzoglou Pascal R Fuchshuber Alain Sauvanet Antonio Sa Cunha Yves Patrice Le Treut Mustapha Adham Jean‐Yves Mabrut Laurence Chiche Philippe Bachellier | 2014 | HPB2014，，1： | 2 |
| 5 | Hepatic Resection for Noncolorectal Nonendocrine Liver Metastases: Analysis of 1452 Patients and Development of a Prognostic Model显示文摘 | René Adam Laurence Chiche Thomas Aloia Dominique Elias Rémy Salmon Michel Rivoire Daniel Jaeck Jean Saric Yves Patrice Le Treut Jacques Belghiti Georges Mantion Gilles Mentha | 2006 | Annals of Surgery2006，，4： | 2 |
| 6 | Verifying remote dataintegrity inpeer-to-peer data storage:a comprehensivesurvey ofprotocols显示文摘 | NOUHA O JEAN L YVES R | 2011 | Peer-to-Peer Networking and Applications2011，5，3： | 1 |
| 7 | Scanning probe microscopy显示文摘 | Colton Richard J Baselt David R Dufrêne Yves F Green John-Bruce D Lee Gil U | 1997 | Chemical Biology1997，1，3： | 1 |
| 8 | Reproducibility of blood tests of liver fibrosis in clinical practice显示文摘 | Paul Calès Pascal Veillon Anselme Konaté Elisabeth Mathieu Catherine Ternisien Alain Chevailler Alban Godon Yves Gallois Fran?oise Joubaud Isabelle Hubert-Fouchard Frédéric Oberti Stéphane Réaud Gilles Hunault Fran?oise Mauriat Fran?oise Lunel-Fabiani | 2007 | Clinical Biochemistry2007，，1： | 1 |
| 9 | Medullary sponge kidney - part of a congenital syndrome显示文摘 | Denis R Yves P | 2001 | Nephrol Dial Tranplant2001，16，： | 1 |
| 10 | Steroid saponins from fenugreek seeds:extraction,purification,and pharmacological investigation on feeding behavior and plasma cholesterol显示文摘 | Pierre R P Yves D S Dominique M H | 1995 | Steroids1995，60，10： | 1 |
| 11 | Steroid saponins from fenugreek seeds:extraction,purification and pharmacological investigation on feeding behavior and plasma cholesterol显示文摘 | Pierre R Yves D Dominique M | 1995 | Steroids1995，60，： | 1 |
| 12 | 显示文摘 | Yves C Joris V D K Frits C R S | 2002 | Discrete Applied Mathematics2002，123，： | 1 |
| 13 | clinical efficacy of oxasliplatin monotherapy: phase I1 trials in advanced colorectal cancer 显示文摘 | Yves B Philippe R | 2003 | Semin Oncol2003，23，2： | 1 |
| 14 | The inverse {0,1 t-knapsack prob- lem : theory, algorithms and computational experiments 显示文摘 | Julien R Jose R F Yves D S | 2013 | Discrete Optimization2013，0，2： | 1 |
| 15 | Scanning probe microscopy显示文摘 | Richard J Colton^* David R Baselt Yves F Dufrkne John -Bruce D Greenand Gil U Lee | 1997 | Chemical Biology1997，1，： | 1 |
| 16 | Clinical efficacy of oxaliplatin monotherapy:Phase 2 trialsin advanced colorectal cancer显示文摘 | Yves B P Hilippe R | 1998 | Semin Oncol1998，25，5： | 1 |
| 17 | Doppler imaging based on radar target precession显示文摘 | Lammers Yve H W Marr R A | 1993 | IEEE Transactions on Aerospace and Electronic Systems1993，29，1： | 1 |
| 18 | TVT-O for the Treatment of female stress urinary incontinence:results of a prospective study after a 3-year minimum follow-Up显示文摘 | David W Yves G Olivier R | 2008 | European Urology2008，53，8： | 1 |
| 19 | Contention awareness and fault-tolerant scheduling for precedence consa'ained tasks in hetero- geneous systems显示文摘 | ANNE B MOURAD H YVES R | 2009 | Parallel Computing2009，35，2： | 1 |
| 20 | Simom and 'The Common Good':A Note on the Concept,'Ethics显示文摘 | Clarke Cochran 'Yves R | 1978 | 88(April 1978)1978，88，： | 1 |
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