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| 1 | Promoter hypermethylation of CDH1, FHIT, MTAP and PLAGL1 in gastric adenocarcinoma in individuals from Northern Brazil显示文摘AIM: To evaluate the methylation status of CDH1, FHIT, MTAP and PLAGL1 promoters and the association of these findings with clinico-pathological characteristics. METHODS: Methylation-specific PCR (MSP) assay was performed in 13 nonneoplastic gastric adenocarcinoma, 30 intestinal-type gastric adenocarcinoma and 35 diffuse- type gastric adenocarcinoma samples from individuals in Northern Brazil. Statistical analyses were performed using the chi-square or Fisher’s exact test to assess associations between methylation status and clinico- pathological characteristics. RESULTS: Hypermethylation frequencies of CDH1, FHIT, MTAP and PLAGL1 promoter were 98.7%, 53.9%, 23.1% and 29.5%, respectively. Hypermethylation of three or four genes revealed a significant association with diffuse-type gastric cancer compared with nonneoplastic cancer. A higher hypermethylation frequency wassignificantly associated with H pylori infection in gastric cancers, especially with diffuse-type. Cancer samples without lymph node metastasis showed a higher FHIT hypermethylation frequency. MTAP hypermethylation was associated with H pylori in gastric cancer samples, as well as with diffuse-type compared with intestinal-type. In diffuse-type, MTAP hypermethylation was associated with female gender. CONCLUSION: Our findings show differential gene methylation in tumoral tissue, which allows us to conclude that hypermethylation is associated with gastric carcinogenesis. MTAP promoter hypermethylation can be characterized as a marker of diffuse-type gastric cancer, especially in women and may help in diagnosis, prognosis and therapies. The H pylori infectious agent was present in 44.9% of the samples. This infection may be correlated with the carcinogenic process through the gene promoter hypermethylation, especially the MTAP promoter in diffuse-type. A higher H pylori infection in diffuse-type may be due to greater genetic predisposition. | Mariana Ferreira Leal Eleonidas Moura Lima Patrícia Natália Oliveira Silva Paulo Pimentel Assumpo Danielle Queiroz Calcagno Spencer Luiz Marques Payo Rommel Rodríguez Burbano Marília de Arruda Cardoso Smith | 2007 | World Journal of Gastroenterology2007，13，18： | 24 |
| 2 | Serrated polyposis syndrome:Molecular,pathological and clinical aspects显示文摘Hyperplastic polyps have traditionally been considered not to have malignant potential.New pathological classification of serrated polyps and recent discoveries about the serrated pathway of carcinogenesis have revolutionized the concepts and revitalized the research in this area.Until recently,it has been thought that most colorectal cancers arise from conventional adenomas via the traditional tumor suppressor pathway initiated by a mutation of the APC gene,but it has been found thatthis pathway accounts for only approximately 70%-80% of colorectal cancer(CRC)cases.The majority of the remaining colorectal cancer cases follow an alternative pathway leading to CpG island methylator phenotype carcinoma with BRAF mutation and with or without microsatellite instability.The mechanism of carcinomas arising from this alternative pathway seems to begin with an activating mutation of the BRAF oncogene.Serrated polyposis syndrome is a relatively rare condition characterized by multiple and/or large serrated polyps of the colon.Clinical characteristics,etiology and relationship of serrated polyposis syndrome to CRC have not been clarified yet.Patients with this syndrome show a high risk of CRC and both sporadic and hereditary cases have been described.Clinical criteria have been used for diagnosis and frequent colonoscopy surveillance should be performed in order to prevent colorectal cancer.In this review,we try to gather new insights into the molecular pathogenesis of serrated polyps in order to understand their possible clinical implications and to make an approach to the management of this syndrome. | Carla Guarinos Cristina Sánchez-Fortún María Rodríguez-Soler Cristina Alenda Artemio Payá Rodrigo Jover | 2012 | World Journal of Gastroenterology2012，18，20： | 8 |
| 3 | New Development of China-Russia-India Triangle显示文摘Since 2001, positive improvement has occurred in the trianglerelationship between China, Russia and India. The foreignministers of the three nations met in Russia recently, symbolizingthe launching of substantive triangular cooperation. | Ma Jiali is Research Professor at CICIR. He specializes in South Asian security, especially in India’s foreign policy. He is the author of three books, such as Pay Close Attention to India: A Rising Power which is very influential. He was one of the delegates for Track Two Dialogue between China and India for all of four rounds and a delegate for Track Two Dialogue between China, Russia and India. He is also a member of Eminent Persons Group Forum between China and India. | 2005 | Contemporary International Relations2005，15，7： | 4 |
| 4 | Palliative surgery for unresectable pancreatic and periampullary cancer: a reappraisal显示文摘 | Mickael Lesurtel M.D. Nidal Dehni M.D. Emmanuel Tiret M.D. Rolland Parc M.D. Fran?ois Paye M.D. Ph.D | 2006 | Journal of Gastrointestinal Surgery2006，，2： | 3 |
| 5 | Para‐aortic lymph node sampling in pancreatic head adenocarcinoma显示文摘 | L. Schwarz R. M. Lupinacci M. Svrcek M. Lesurtel M. Bubenheim H. Vuarnesson P. Balladur F. Paye | 2014 | Br J Surg2014，，5： | 2 |
| 6 | Impact of five annual rounds of mass drug administration with ivermectin on onchocerciasis in Sierra Leone显示文摘Background:Onchocerciasis is endemic in 12 of the 14 health districts of Sierra Leone.Good treatment coverage of community-directed treatment with ivermectin was achieved between 2005 and 2009 after the 11-year civil conflict.Sentinel site surveys were conducted in 2010 to evaluate the impact of five annual rounds of ivermectin distribution.Methods:In total,39 sentinel villages from hyper-and meso-endemic areas across the 12 endemic districts were surveyed using skin snips in 2010.Results were analyzed and compared with the baseline data from the same 39 villages.Results:The average microfilaridermia(MF)prevalence across 39 sentinel villages was 53.10%at baseline.The MF prevalence was higher in older age groups,with the lowest in the age group of 1-9 years(11.00%)and the highest in the age group of 40-49 years(82.31%).Overall mean MF density among the positives was 28.87 microfilariae(mf)/snip,increasing with age with the lowest in the age group of 1-9 years and the highest in the age group of 40-49 years.Males had higher MF prevalence and density than females.In 2010 after five rounds of mass drug administration,the overall MF prevalence decreased by 60.26%from 53.10%to 21.10%;the overall mean MF density among the positives decreased by 71.29%from 28.87 mf/snip to 8.29 mf/snip;and the overall mean MF density among all persons examined decreased by 88.58%from 15.33 mf/snip to 1.75 mf/snip.Ten of 12 endemic districts had>50%reduction in MF prevalence.Eleven of 12 districts had≥50%reduction in mean MF density among the positives.Conclusions:A significant reduction of onchocerciasis MF prevalence and mean density was recorded in all 12 districts of Sierra Leone after five annual MDAs with effective treatment coverage.The results suggested that the onchocerciasis elimination programme in Sierra Leone was on course to reach the objective of eliminating onchocerciasis in the country by the year 2025.Annual MDA with ivermectin should continue in all 12 districts and further evaluations are needed across the country to assist the NTDP with programme decision making. | Joseph B.Koroma Santigie Sesay Abdul Conteh Benjamin Koudou Jusufu Paye Mohamed Bah Mustapha Sonnie Mary H.Hodges Yaobi Zhang Moses J.Bockarie | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 7 | Pancreatic fistula after a pancreaticoduodenectomy for ductal adenocarcinoma and its association with morbidity: a multicentre study of the F rench S urgical A ssociation显示文摘 | Pietro Addeo Jean Robert Delpero Francois Paye Elie Oussoultzoglou Pascal R Fuchshuber Alain Sauvanet Antonio Sa Cunha Yves Patrice Le Treut Mustapha Adham Jean‐Yves Mabrut Laurence Chiche Philippe Bachellier | 2014 | HPB2014，，1： | 2 |
| 8 | Donor selection-matching for mismatches显示文摘 | Perez-Rodriguez M Madrigal JA | 1999 | Heematologica1999，84，： | 1 |
| 9 | A multicenter study of patients with adult-onset Still's disease compared with systemic juvenile idiopathic arthritis 显示文摘 | PAY S TURKCAPAR N KALYONCU M | 2006 | Clinical Rheumatology2006，25，5： | 1 |
| 10 | Intensive systemic chemotherapy combined with surgery for metastatic colorectal cancer : results of a phase Ⅱ study 显示文摘 | Taieb J Artru P Paye F | 2005 | J Clin Oncol2005，23，3： | 1 |
| 11 | Prothrombotic gene expression profile in vascular smooth muscle cells of human saphenous vein, but not internal mammary artery 显示文摘 | Payeli SK Latini R Gebhard C | 2008 | Arterioscler Thromb Vasc Biol2008，28，4： | 1 |
| 12 | Characterization of a transcription terminator of the procyclin PARP A unit of Trypanosoma brucei显示文摘 | Berberof M Pays A Lips S | | 0，，03： | 1 |
| 13 | Analysis of the strain transfer in a new FBG sensor for structural health monitoring显示文摘 | Torres B Payá-Zaforteza I Calderón P A | 2011 | Engineering Structures2011，33，2： | 1 |
| 14 | Incidence and reversibility of organ failure in the course of sterile or infected necrotizing pancreatitis显示文摘 | Le Mée J Paye F Sauvanet A | 2001 | Arch Surg2001，136，12： | 1 |
| 15 | Alzhei-mer's disease can be accurately diagnosed in verymildly impaired individuals 显示文摘 | Salmon DP Thomas RG Pay MM | 2002 | Neurology2002，59，： | 1 |
| 16 | Pancreatic fistula after a pancreaticoduodenectomy for ductal adenocarcinoma and its association with morbidity: a multicentre study of the French Surgical Association 显示文摘 | Addeo P Delpero JR Paye F | 2014 | HPB2014，16，1： | 1 |
| 17 | Detection of BRAF V600E Mutation in Colorectal Cancer显示文摘 | Susana Benlloch Artemio Payá Cristina Alenda Xavier Bessa Montserrat Andreu Rodrigo Jover Antoni Castells Xavier Llor F. Ignacio Aranda Bartomeu Massutí | 2006 | The Journal of Molecular Diagnostics2006，，5： | 1 |
| 18 | New Diagnostic criteria for multiple sclerosis, Guide lines for reseasch protocols 显示文摘 | Poser CM Pay DW Scheinberg L | 1983 | Ann Neurol1983，，3： | 1 |
| 19 | A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease显示文摘 | Tuszynski M H Thal L Pay M | | 0，，05： | 1 |
| 20 | The MsK family of alfalfa protein kinase genes encodes homologues of shaggy/glycogen synthase kinase-3 and shows differential expression patterns in plant organs and development显示文摘 | Pay A Jonak C Bogre L | | 0，，06： | 1 |
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