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| 1 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 2 | Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication显示文摘Hepatitis B virus(HBV)can cause chronic hepatitis B,which may lead to cirrhosis and liver cancer.Type I interferon(IFN)is an approved drug for the treatment of chronic hepatitis B.However,the fundamental mechanisms of antiviral action by type I IFN and the downstream signaling pathway are unclear.TRIM25 is an IFN-stimulated gene(ISG)that has an important role in RIG-I ubiquitination and activation.Whether TRIM25 is induced in liver cells by type I IFN to mediate anti-HBV function remains unclear.Here we report that interleukin-27(IL-27)has a critical role in IFN-induced TRIM25 upregulation.TRIM25 induction requires both STAT1 and STAT3.In TRIM25 knockout HepG2 cells,type I IFN production was consistently attenuated and HBV replication was increased,whereas overexpression of TRIM25 in HepG2 cells resulted in elevated IFN production and reduced HBV replication.More interestingly,we found that TRIM25 expression was downregulated in HBV patients and the addition of serum samples from HBV patients could inhibit TRIM25 expression in HepG2 cells,suggesting that HBV might have involved a mechanism to inhibit antiviral ISG expression and induce IFN resistance.Collectively,our results demonstrate that type I IFN-induced TRIM25 is an important factor in inhibiting HBV replication,and the IFN-IL-27-TRIM25 axis may represent a new target for treating HBV infection. | Guangyun Tan Qingfei Xiao Hongxiao Song Feng Ma Fengchao Xu Di Peng Na Li Xiaosong Wang Junqi Niu Pujun Gao F Xiao-Feng Qin Genhong Cheng | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 3 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 4 | Investigate of in situ sludge reduction in sequencing batch biofilm reactor:Performances,mechanisms and comparison of different carriers显示文摘Biofilm is an effective simultaneous denitrification and in situ sludge reduction system,and the characteristics of different biofilm carrier have important implications for biofilm growth and in situ sludge reduction.In this study,the performance and mechanism of in situ sludge reduction were compared between FSC-SBBR and SC-SBBR with constructed by composite floating spherical carriers(FSC)and multi-faceted polyethylene suspension carriers(SC),respectively.The variation of EPS concentration indicated that the biofilm formation of FSC was faster than SC.Compared with SCSBBR,the FSC-SBBR yielded 0.16 g MLSS/g COD,almost 27.27%less sludge.The average removal rates of COD and NH_(4)^(+)-N were 93.39% and 96.66%,respectively,which were 5.21% and 1.43% higher than the average removal rate of SC-SBBR.Investigation of the mechanisms of sludge reduction revealed that,energy uncoupling metabolism and sludge decay were the main factors for sludge reduction inducing 43.13%and 49.65%less sludge,respectively,in FSC-SBBR.EEM fluorescence spectroscopy and SUVA analysis showed that the hydrolytic capacity of biofilm attached in FSC was stronger than those of SC,and the hydrolysis of EPS released more DOM contributed to lysis-cryptic growth metabolism.In additional,Bacteroidetes and Mizugakiibacter associated with sludge reduction were the dominant phylum and genus in FCS-SBBR.Thus,the effect of simultaneous in situ sludge reduction and pollutant removal in FSC-SBBR was better. | Yonglei Wang Baozhen Liu Kefeng Zhang Yongjian Liu Xuexin Xu Junqi Jia | 2018 | Frontiers of Environmental Science & Engineering2018，12，5： | 7 |
| 5 | Degradation of simulated organic wastewater by advanced oxidation with oxidants generated from oxygen reduction显示文摘The degradation capacity of advanced oxidants generated from oxygen reduction was investigated in model effluent containing chlorobenzene, aniline and benzene through the advanced oxidation processes(AOPs). Intermediate products of the degradation process were determined by GC–MS, and they contributed to specify the degradation pathways of monoaromatic compounds. The study particularly focused on the influence of the dosage of the oxidant, pH and the initial concentration of organic compounds on the degradation effectiveness.When the dosage of oxidant was 4 wt% and the pH was 7, the maximum degradation rates of 74.83% chlorobenzene, 70.32% aniline and 37.69% benzene were achieved. Furthermore, microwave was applied to intensify the oxidation process under optimal operation conditions, and the degradation rates were increased to 87.85% chlorobenzene, 89.11% aniline and 39.03% benzene, respectively. | Yi Ouyang Qing Xu Yang Xiang Wei Liu Junqi Du | 2019 | Chinese Journal of Chemical Engineering2019，27，4： | 5 |
| 6 | Facile synthesis of nanoceria by a molten hydroxide method and its photocatalytic properties显示文摘Ceria nanoparticles were facilely synthesized by a molten NaOH-KOH hydroxide flux method with the precursor of Ce(NO3)3·6H2O under different conditions in alumina crucibles or Teflon-lined stainless steel autoclave.The XRD patterns and TEM images show that both the crystal and particle sizes of synthesized nanoceria are around 10 nm.XPS results reveal that the nanoceria obtained in alumina crucible has a Ce3+fraction of 17.1%which is higher than that of ceria synthesized in the Teflon vessel,the FTIR spectra of nanoceria prepared in alumina crucible show a stronger intensity of O-H stretching mode.UV-DRS and PL spectra results show that the nanoceria synthesized in alumina crucible with a calculated band gap of 2.9 eV has a wider responding light wavelength and a lower photogene rated electron-hole recombination rate,due to a higher concentration of oxygen vacancies(Ce^3+%).The photocatalytic results show that the degradation ratio and rate of the Rhodamine B(RhB)solution with the nanoceria synthesized in alumina crucible are 98.39%and 0.02919 min-1,both of which are larger than those of the ceria obtained from Teflon vessel.This method proves to be a simple and scalable way to synthesize nanoceria with rich oxygen vacancies and high photocatalytic activity. | Xuewen Xia Yuanpei Lan Junqi Li Chaoyi Chen Benjun Xu Xian Luo Xisong Mao | 2020 | Journal of Rare Earths2020，38，9： | 4 |
| 7 | Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation显示文摘Although monkeys and pigs can be infected with SARS-Co V-2,they generally have a long growth cycle and a large size that is difficult to handle in large quantities.However,the readily available rats and mice are not susceptible to SARSCo V-2 because of differences in ACE2(angiotensin-converting enzyme 2),the receptor mediating cell entry of SARSCo V-2[1].Thus,the key to establishing a mouse model of COVID-19 is to make the mice express human ACE2 protein,and therefore become SARS-Co V-2 susceptible.Recently reported COVID-19 mouse models using a random insertion transgene approach[2,3]or adenoviral approach to express h ACE2[4],lack the tissue-specificity of h ACE2 expression and might not replicate COVID-19 precisely,limiting their applications in certain studies. | Feng-Liang Liu Kaixin Wu Jiaoyang Sun Zilei Duan Xiongzhi Quan Junqi Kuang Shilong Chu Wei Pang Han Gao Ling Xu Ying-Chang Li Hai-Lin Zhang Xue-Hui ang Rong-Hua Luo Xiao-Li Feng Hans RScholer Xinwen Chen Duanqing Pei Guangming Wu Yong-Tang Zheng Jiekai Chen | 2021 | National Science Review2021，8，2： | 3 |
| 8 | InAs-based interband cascade lasers at 4.0 μm operating at room temperature显示文摘InAs-based interband cascade lasers(ICLs) with InAs plasmon waveguides or InAs/AlSb superlattice(SL) waveguides were demonstrated at emission wavelengths below 4.1 μm. The threshold current densities of the lasers with SL waveguides were 37 A/cm^2 at 77 K in continuous wave mode. The operation temperature of these lasers reached room temperature in pulsed mode. Compared with the thick InAs n++ plasmon cladding layer, the InAs/AlSb superlattice cladding layers have greater advantages for ICLs with wavelengths less than 4 μm even in InAs based ICLs because in the short-wavelength region they have a higher confinement factor than InAs plasmon waveguides. | Tian Yu Shuman Liu Jinchuan Zhang Bo Xu Lijun Wang Junqi Liu Ning Zhuo Shenqiang Zhai Xiaoling Ye Yonghai Chen Fengqi Liu Zhanguo Wang | 2018 | Journal of Semiconductors2018，39，11： | 3 |
| 9 | Diamond & Related Materials显示文摘 | Xu Junqi Fan Huiqing Liu Weiguo | 2008 | 17(2):1942008，17，2： | 1 |
| 10 | Diamond & Related Materials显示文摘 | Xu Junqi Fan Huiqing Kousaka Hiroyuki | 2007 | 16(1):1612007，16，1： | 1 |
| 11 | Optimisation of diamondlike carbon films by unbalanced magnetron sputtering for infrared transmission enhancement 显示文摘 | Hang Lingxia Y Yin Xu Junqi | 2006 | Thin Solid Films2006，515，1： | 1 |
| 12 | Surface & Coating Technology显示文摘 | Xu Junqi Fan Huiqing Kousaka Hiroyuki | 2007 | 201(15):66312007，201，15： | 1 |
| 13 | Construction of hybrid constructed wetlands for phosphorus chemical industry tailwater treatment in the middle Yangtze river basin:Responses of plant growth and root-associated microbial communities显示文摘Constructed wetlands are commonly utilized to treat industrial wastewater due to their effectiveness,affordability,and environmental benefits.Many phosphorus chemical enterprises in the middle Yangtze River basin are facing high pollution load challenges and efforts are needed to improve removal efficiency of pollutants.This work was the first to use constructed wetlands for phosphorus chemical industry tailwater(PCITW)treatment.The new hybrid constructed wetlands(CWs)proposed were the aeration horizontal subsurface flow constructed wetland(AHSCW)and the integrated vertical flow constructed wetland(IVCW),which were constructed on a pilot scale.Here,the effectiveness of pollutant removal along hybrid CWs,wetland plant growth,and rootassociated microbial community responses to the PCITW were investigated.The results showed that there was spatial variation in removal of carbon,nitrogen,and phosphorus in the hybrid CWs,and that the AHSCW and the IVCW played synergistic roles in the removal of pollutants.Compared with influent,the toxic effect of effluent to embryos of a rare minnow(Gobiocypris rarus)was alleviated.Exposure to the effluent resulted in no malformation or death for embryos.Plants and microorganisms in the wetland system of the phosphate chemical tailwater were then compared with the control system of municipal tailwater.Plants in the former system had lower root density,and higher average root diameter,root shoot ratio,specific root length,and specific surface area.Plant roots also had decreased NH_(4)^(+)uptake ability but increased Ca^(2+)uptake to adapt to the high load and complex pollution stress.Unlike the control system,stochastic mechanisms had a more important role than deterministic processes in shaping the microbial community assembly associated with the PCITW.Meanwhile,analysis of microbial network-level topological characteristics demonstrated substantial reduction in network interactions complexity and microbiome stability in the treatment system.Findings from this study suggest wetlands will be helpful for efficient purification of phosphorus chemical industry wastewater in the Yangtze River basin. | Qianzheng Li Yao Guo Junqi Yu Lu Yao Shun Liu Yahua Li Disong Chen Fei Peng Dong Xu Zhenbin Wu Qiaohong Zhou | 2023 | Water Biology and Security2023，2，3： | 1 |
| 14 | Antiviral Treatment Alters the Frequency of Activating and Inhibitory Receptor-Expressing Natural Killer Cells in Chronic Hepatitis B Virus Infected Patients显示文摘 | Juan Lv Qinglong Jin Haibo Sun Xiumei Chi Xiaoli Hu Hongqing Yan Yu Pan Weihua Xiao Zhigang Tian Jinlin Hou Damo Xu Zhengkun Tu Junqi Niu Alex Kleinjan | 2012 | Mediators of Inflammation2012，，： | 1 |
| 15 | Impeller inlet geometry effect on performance improvement for centrifugal pumps显示文摘 | Xianwu Luo Yao Zhang Junqi Peng Hongyuan Xu Weiping Yu | 2008 | Journal of Mechanical Science and Technology2008，，10： | 1 |
| 16 | Optimisation of Diamondlike Carbon Films by Unbalanced Magnetron Spuering for Infrared Transmission Enhancement显示文摘 | Hang Lingxia Yin Y Xu Junqi | 2006 | Thin Solid Films2006，515，： | 1 |
| 17 | The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function显示文摘 | Xinglu Huang Xu Teng Dong Chen Fangqiong Tang Junqi He | 2009 | Biomaterials2009，，3： | 1 |
| 18 | Impeller inlet geometry effect on performance improvement for centrifugal pumps显示文摘 | Xianwu Luo Yao Zhang Junqi Peng Hongyuan Xu Weiping Yu | 2008 | Journal of Mechanical Science and Technology2008，，10： | 1 |
| 19 | Th1 and Th2 Immune Response in Chronic Hepatitis B Patients during a Long-Term Treatment with Adefovir Dipivoxil显示文摘 | Yanfang Jiang Zhenhua Ma Guijie Xin Hongqing Yan Wanyu Li Huining Xu Chunhai Hao Junqi Niu Pingwei Zhao Dennis Daniel Taub | 2010 | Mediators of Inflammation2010，，： | 1 |
| 20 | Optimisation of diamond-like carbon films by unbalanced magnetronsputtering for infrared transmission enhancement 显示文摘 | Hang Lingxia Yin Y Xu Junqi | 2006 | Thin Solid Films2006，515，： | 1 |
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