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| 1 | Why are Nitrogen Concentrations in Plant Tissues Lower under Elevated CO_2? A Critical Examination of the Hypotheses显示文摘Plants grown under elevated atmospheric CO2 typically have decreased tissue concentrations of N compared with plants grown under current ambient CO2.The physiological mechanisms responsible for this phenomenon have not been definitely established,although a considerable number of hypotheses have been advanced to account for it.In this review we discuss and critically evaluate these hypotheses.One contributing factor to the decreases in tissue N concentrations clearly is dilution of N by increased photosynthetic assimilation of C.In addition,studies on intact plants show strong evidence for a general decrease in the specific uptake rates (uptake per unit mass or length of root) of N by roots under elevated CO2.This decreased root uptake appears likely to be the result both of decreased N demand by shoots and of decreased ability of the soil-root system to supply N.The best-supported mechanism for decreased N supply is a decrease in transpiration-driven mass flow of N in soils due to decreased stomatal conductance at elevated CO2,although some evidence suggests that altered root system architecture may also play a role.There is also limited evidence suggesting that under elevated CO2,plants may exhibit increased rates of N loss through volatilization and/or root exudation,further contributing to lowering tissue N concentrations. | Daniel R. Taub Xianzhong Wang | 2008 | Journal of Integrative Plant Biology2008，50，11： | 22 |
| 2 | Grazing effects on herbage nutritive values depend on precipitation and growing season in Inner Mongolian grassland显示文摘Aims Grasslands are widely used for production of livestock,which depend on the nutritive value of herbage species.However,there are still large uncertainties as to how grazing,precipitation and growing season interactively affect herbage nutritive value.Methods Here,based on a grazing experiment with seven grazing intensities in an Inner Mongolian grassland since the year 2005,we analysed nutritive value of four dominant grass species from June to September in both a relatively wetter year(2008)and a drier year(2010).Herbage with high nutritive value is characterized by high concentration of crude protein,high concentration of cellulase digestible organic matter and low concentration of neutral detergent fibre.Important Findings We found that(i)grazing significantly increased the nutritive value of Leymus chinensis,Agropyron michnoi and Cleistogenes squarrosa but had minor effects on the nutritive value of Stipa grandis.(ii)For all species,nutritive values were greater in the wetter year than in the drier year and were greatest in the early growing season(June)and lowest at the end of the growing season(September).Inter-annual and inter-seasonal variations in nutritive value were much greater for L.chinensis and A.michnoi than for C.squarrosa and S.grandis,suggesting higher water use efficiency for the latter two species.(iii)Grazing significantly decreased the drought resistance of three species,but not of S.grandis.(iv)Grazing significantly increased inter-month variation in nutritive value for L.chinensis and A.michnoi but had relatively minor or no effects on that of C.squarrosa and S.grandis.Therefore,grazing effects on species nutritive values showed strong inter-annual and seasonal patterns,and species-specific responses might be related to species traits(i.e.water use efficiency,digestibility).Our results have important implications for ecosystem management of arid and semiarid grasslands under intense grazing and global climatic change. | Haiyan Ren Guodong Han Zhichun Lan Hongwei Wan Philipp Schönbach Martin Gierus Friedhelm Taube | 2016 | Journal of Plant Ecology2016，9，6： | 14 |
| 3 | 强制性使用运动疗法在脑卒中患者中的应用显示文摘强制性使用运动疗法(CIMT)是通过限制偏瘫患者的健肢活动的同时对患侧进行集中反复作业训练,诱使患肢的使用能力提高,从而提高患肢的运动功能和日常生活活动能力的一种新的康复治疗技术,被认为是能够成功地将偏瘫患者从康复治疗室学到的运动功能转移到日常生活环境中的一种有效的治疗方法。笔者结合在美国伯明翰阿拉巴马大学CIMT实验室学习CI-MT的体会,详细阐述CIMT的基本要素和独到之处。 | 李贞兰 David Morris Edward Taub | 2007 | 中国康复理论与实践2007，13，6： | 13 |
| 4 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 5 | Ultra-thin chips for high-performance flexible electronics显示文摘Flexible electronics has significantly advanced over the last few years,as devices and circuits from nanoscale structures to printed thin films have started to appear.Simultaneously,the demand for high-performance electronics has also increased because flexible and compact integrated circuits are needed to obtain fully flexible electronic systems.It is challenging to obtain flexible and compact integrated circuits as the silicon based CMOS electronics,which is currently the industry standard for high-performance,is planar and the brittle nature of silicon makes bendability difficult.For this reason,the ultra-thin chips from silicon is gaining interest.This review provides an in-depth analysis of various approaches for obtaining ultra-thin chips from rigid silicon wafer.The comprehensive study presented here includes analysis of ultra-thin chips properties such as the electrical,thermal,optical and mechanical properties,stress modelling,and packaging techniques.The underpinning advances in areas such as sensing,computing,data storage,and energy have been discussed along with several emerging applications(e.g.,wearable systems,m-Health,smart cities and Internet of Things etc.)they will enable.This paper is targeted to the readers working in the field of integrated circuits on thin and bendable silicon;but it can be of broad interest to everyone working in the field of flexible electronics. | Shoubhik Gupta William Taube Navaraj Leandro Lorenzelli Ravinder Dahiya | 2018 | npj Flexible Electronics2018，2，1： | 10 |
| 6 | 强制性使用运动疗法对脑卒中偏瘫患者上肢使用能力的恢复作用显示文摘目的:观察强制性使用运动疗法对脑卒中偏瘫患者上肢使用能力和运动功能的康复疗效。方法:恢复期脑卒中上肢偏瘫患者20例,随机分为强制性使用运动疗法组(简称CI组)10例,对照组10例,CI组进行强制性使用运动疗法,对照组进行反复作业疗法,每周5 d,每日连续3h,共治疗3周;治疗前、治疗后1周、治疗后6及12个月分别采用MAL指数评定法评定患侧肢体的使用能力,采用WMFT运动功能评定法评定患侧肢体运动功能。结果:治疗后1周2组的MAL指数均高于治疗前(P<0.01);CI组治疗后6及12个月的MAL指数较治疗前均显著提高(P<0.05或P<0.01),对照组治疗后6及12个月的MAL指数与治疗前比较差异均无显著性(P>0.05);2组的WMFT分数在治疗前、治疗后1周及12个月均无明显变化(P>0.05)。结论:强制性使用运动疗法对脑卒中偏瘫患者的上肢使用能力有较好的康复疗效,但对运动功能改善不明显。 | 李贞兰 赵节绪 TAUB E | 2008 | 吉林大学学报(医学版)2008，34，3： | 9 |
| 7 | DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection显示文摘 | Oertli Mathias Sundquist Malin Hitzler Iris Engler Daniela B Arnold Isabelle C Reuter Sebastian Maxeiner Joachim Hansson Malin Taube Christian Quiding-J?rbrink Marianne Müller Anne | 2012 | EN2012，，3： | 5 |
| 8 | Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells显示文摘 | Arnold Isabelle C Dehzad Nina Reuter Sebastian Martin Helen Becher Burkhard Taube Christian Müller Anne | 2011 | Journal of Clinical Investigation2011，，8： | 4 |
| 9 | Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol显示文摘AIM To analyse the risk factors and outcomes of delayed graft function(DGF) in patients receiving a steroid sparing protocol. METHODS Four hundred and twenty-seven recipients of deceased donor kidney transplants were studied of which 135(31.6%) experienced DGF. All patients received monoclonal antibody induction with a tacrolimus based, steroid sparing immunosuppression protocol.RESULTS Five year patient survival was 87.2% and 94.9% in the DGF and primary graft function(PGF) group respectively, P = 0.047. Allograft survival was 77.9% and 90.2% in the DGF and PGF group respectively, P < 0.001. Overall rejection free survival was no different between the DGF and PGF groups with a 1 and 5 year rejection free survival in the DGF group of 77.7% and 67.8% compared with 81.3% and 75.3% in the PGF group, P = 0.19. Patients with DGF who received IL2 receptor antibody induction were at significantly higher risk of rejection in the early post-transplant period than the group with DGF who received alemtuzumab induction. On multivariate analysis, risk factors for DGF were male recipients, recipients of black ethnicity, circulatory death donation, preformed DSA, increasing cold ischaemic time, older donor age and dialysis vintage.CONCLUSION Alemtuzumab induction may be of benefit in preventing early rejection episodes associated with DGF. Prospective trials are required to determine optimal immunotherapy protocols for patients at high risk of DGF. | Michelle Willicombe Anna Rizzello Dawn Goodall Vassilios Papalois Adam G Mc Lean David Taube | 2017 | World Journal of Transplantation2017，7，1： | 4 |
| 10 | 患者对书面知情同意的理解:问卷研究显示文摘目的检验患者对手术知情同意书的地位、作用、以及免除知情同意的理解。设计前瞻性问卷调查研究。问卷于术后一个月发给患者。答卷按频数和单变量分析。地点大型教学医院。参加者 732名已在妇产科接受手术超过6个月的患者。主要结果评价患者对知情同意书法律含义的认识,以及患者关于知情同意书的作用和免除书面知情同意的观点。结果患者对知情同意书法律地位的理解非常有限。将近一半的患者(46%,95%可信区间43%~50%)认为同意书的基本作用是保护医院,68%(65%~71%)的人认为同意书让医生行使控制权。只有41%(37%~44%)的患者认为同意书使医生了解患者的愿望。结论许多患者对他们签署或者不签署同意书的法律含义知之有限,他们也没有认识到同意书的基本作用是保护他们自己的利益。看来目前作为一种表达自主选择的方法,同意程序还不够充分,而且其伦理地位及可信区间令人质疑。 | Andrea Akkad Clare Jackson Sara Kenyon Mary Dixon-Woods Nick Taub Marwan Habiba 翟小梅(译) | 2007 | 英国医学杂志中文版2007，10，2： | 3 |
| 11 | Heterogeneous integration of contact-printed semiconductor nanowires for high-performance devices on large areas显示文摘In this work,we have developed a contact-printing system to efficiently transfer the bottom-up and top-down semiconductor nanowires(NWs),preserving their as-grown features with a good control over their electronic properties.In the close-loop configuration,the printing system is controlled with parameters such as contact pressure and sliding speed/stroke.Combined with the dry pre-treatment of the receiver substrate,the system prints electronic layers with high NW density(7 NWs/μm for bottom-up ZnO and 3 NWs/μm for top-down Si NWs),NW transfer yield and reproducibility.We observed compactly packed(~115 nm average diameters of NWs,with NW-to-NW spacing~165 nm)and well-aligned NWs(90%with respect to the printing direction).We have theoretically and experimentally analysed the role of contact force on NW print dynamics to investigate the heterogeneous integration of ZnO and Si NWs over pre-selected areas.Moreover,the contact-printing system was used to fabricate ZnO and Si NW-based ultraviolet(UV)photodetectors(PDs)with Wheatstone bridge(WB)configuration on rigid and flexible substrates.The UV PDs based on the printed ensemble of NWs demonstrate high efficiency,a high photocurrent to dark current ratio(>10^(4))and reduced thermal variations as a result of inherent self-compensation of WB arrangement.Due to statistically lesser dimensional variations in the ensemble of NWs,the UV PDs made from them have exhibited uniform response. | Carlos García Núñez Fengyuan Liu William Taube Navaraj Adamos Christou Dhayalan Shakthivel Ravinder Dahiya | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 12 | Mechanical valve obstruction:Review of diagnostic and treatment strategies显示文摘Prosthetic valve obstruction(PVO) is a rare but feared complication of mechanical valve replacement. Diagno-stic evaluation should focus on differentiating prosthetic valve thrombosis(PVT) from pannus formation,as their treatment options differ. History of sub-optimal anti-coagulation and post-op time course to development of PVO are useful clinical characteristics in differentiating thrombus from pannus formation. Treatment of PVT is influenced by the patient's symptoms,valve location,degree of obstruction and thrombus size and may include thrombolysis or surgical intervention. Alternatively,pannus formation requires surgical intervention. The purpose of this article is to review the pathophysiology,epidemiology,diagnostic approach and treatment options for aortic and mitral valve PVO. | Jason Salamon Jerson Munoz--Mendoza Jared J Liebelt Cynthia C Taub | 2015 | World Journal of Cardiology2015，7，12： | 2 |
| 13 | 唐代金属银线:技术分析与研究显示文摘 | 杨军昌 Paul Jett 赵西晨 Michelle Taube | 2007 | 考古与文物2007，，6： | 2 |
| 14 | Treatment-Induced Cortical Reorganization After Stroke in Humans显示文摘 | Joachim Liepert Heike Bauder Wolfgang H. R. Miltner Edward Taub Cornelius Weiller | 2000 | Stroke: Journal of the American Heart Association2000，，6： | 2 |
| 15 | Assessment of Scales of Disability and Handicap for Stroke Patients显示文摘 | C. D.A. Wolfe N. A. Taub E. J. Woodrow P. G.J. Burney | 1991 | Stroke1991，，10： | 2 |
| 16 | 膳食脂肪和心脏代谢健康:证据、争议和指导共识显示文摘Nita G Forouhi及其同事认为,尽管在营养研究和制定指南方面存在困难,但公众越来越能理解膳食脂肪和整体饮食的复杂性。 | Nita G Forouhi Ronald M Krauss Gary Taubes Walter Willett 仲琳(译) 王春筱(译) 杨军(校) | 2021 | 英国医学杂志中文版2021，24，3： | 2 |
| 17 | Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G-250 and R-250显示文摘 | Neuhoff V Arold N Taube D | 1988 | Electrophoresis1988，9，： | 2 |
| 18 | Blood pressure changes in spontaneously hypertensive rats correlate with aortic prostacyclin formation 显示文摘 | Forster W Taube C | 1983 | Br J Pharmacol1983，79，： | 1 |
| 19 | Trauma and PTSD Among Adolescents With Severe Emotional Disorders Involved in Multiple Service Systems显示文摘 | Kim T Mueser Jonas Taub | 2008 | Psychiatr Serv2008，59，： | 1 |
| 20 | Intestinal epithelial cells modulate PMN activation and apoptosis following bacterial and hypoxic challenges显示文摘 | Diebel LN Liberati DM Taub JS | 2005 | J Trauma2005，58，6： | 1 |
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