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| 1 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 2 | The aqueous degradation of butylated hydroxyanisole by UV/S2O82-:Study of reaction mechanisms via dimerization and mineralization显示文摘 | Lan T K Chu W Graham N J D | 2007 | Environmental Science and Technology2007，41，2： | 1 |
| 3 | Development of a profit planning framework in an international hotel chain: A case study 显示文摘 | lan C G Graham I C Harris P J | 1999 | International Journal of Contemporary Hospitality Management1999，11，5： | 1 |
| 4 | Altered white matter microarchitecture in Parkinson’s disease:a voxel-based meta-analysis of diffusion tensor imaging studies显示文摘This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease(PD)reflected by fractional anisotropy(FA),addressing clinical profiles and methodology-related heterogeneity.Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusion tensor imaging studies comparing PD with healthy controls(HC)using the anisotropic effect size–signed differential mapping.A total of 808 patients with PD and 760 HC coming from 27 databases were finally included.Subgroup analyses were conducted considering heterogeneity with respect to medication status,disease stage,analysis methods,and the number of diffusion directions in acquisition.Compared with HC,patients with PD had decreased FA in the left middle cerebellar peduncle,corpus callosum(CC),left inferior fronto-occipital fasciculus,and right inferior longitudinal fasciculus.Most of the main results remained unchanged in subgroup metaanalyses of medicated patients,early stage patients,voxel-based analysis,and acquisition with˂30 diffusion directions.The subgroup meta-analysis of medication-free patients showed FA decrease in the right olfactory cortex.The cerebellum and CC,associated with typical motor impairment,showed the most consistent FA decreases in PD.Medication status,analysis approaches,and the number of diffusion directions have an important impact on the findings,needing careful evaluation in future meta-analyses. | Xueling Suo Du Lei Wenbin Li Lei Li Jing Dai Song Wang Nannan Li Lan Cheng Rong Peng Graham J Kemp Qiyong Gong | 2021 | Frontiers of Medicine2021，15，1： | 0 |
| 5 | 随钻地层评价新进展显示文摘准确及时地进行地层评价是石油勘探开发的一个重要方面。过去,作业者不得不在随钻测井仪实时测量的优势与电缆地层评价技术更加全面的优势之间寻求平衡。一种新型综合随钻测井仪结合功能强大的解释软件,建立了新的安全高效标准,而且降低了地层评价的不确定性。 | Bob Adolph Chris Stoller Mike Archer Daniel Codazzi Tamir el-Halawani Patrick Perciot Geoff Weller Mike Evans Jeff Grant Roger Griffiths Don Hartman Gerald Sirkin Makoto lchikawa Graham Scott lan Tribe David White | 2006 | 国外测井技术2006，21，4： | 0 |
| 6 | New Methods and Synthetic Applications of Asymmetric Nitrogen Transfer显示文摘N-alkoxycarbonyl- 和 N-carboxamidooxaziridines 的结构 / 反应关系被探索,并且条件为硫化物和主要的胺的有效胺化作用被发现。有链烯的这些 oxaziridines 的反应也被检验,并且导致有趣的新 heteroatom 转移反应产品。最后, 2-alkoxydihydropyrans 的 aminative 重新整理导致能经历合成操作给的 pyrrolidines 的有用 stereocontrolled 合成[2.2.1 ]- 并且[3.2.1 ]-azabicycles。 | ARMSTRONG, Alan EDMONDS, lan COOKE, Richard S. SHANAHAN, Stephen E. KNIGHT, Jamie D. CUMMING, Graham R. | 2005 | Chinese Journal of Chemistry2005，23，9： | 0 |
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