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| 1 | Progress in Global Gas Hydrate Development and Production as a New Energy Resource显示文摘Natural gas hydrates have been hailed as a new and promising unconventional alternative energy,especially as fossil fuels approach depletion,energy consumption soars,and fossil fuel prices rise,owing to their extensive distribution,abundance,and high fuel efficiency.Gas hydrate reservoirs are similar to a storage cupboard in the global carbon cycle,containing most of the world's methane and accounting for a third of Earth's mobile organic carbon.We investigated gas hydrate stability zone burial depths from the viewpoint of conditions associated with stable existence of gas hydrates,such as temperature,pressure,and heat flow,based on related data collected by the global drilling programs.Hydrate-related areas are estimated using various biological,geochemical and geophysical tools.Based on a series of previous investigations,we cover the history and status of gas hydrate exploration in the USA,Japan,South Korea,India,Germany,the polar areas,and China.Then,we review the current techniques for hydrate exploration in a global scale.Additionally,we briefly review existing techniques for recovering methane from gas hydrates,including thermal stimulation,depressurization,chemical injection,and CH4-CO2 exchange,as well as corresponding global field trials in Russia,Japan,United States,Canada and China.In particular,unlike diagenetic gas hydrates in coarse sandy sediments in Japan and gravel sediments in the United States and Canada,most gas hydrates in the northem South China Sea are non-diagenetic and exist in fine-grained sediments with a vein-like morphology.Therefore,especially in terms of the offshore production test in gas hydrate reservoirs in the Shenhu area in the north slope of the South China Sea,Chinese scientists have proposed two unprecedented techniques that have been verified during the field trials:solid fluidization and formation fluid extraction.Herein,we introduce the two production techniques,as well as the so-called'fbur-in-one'environmental monitoring system employed during the Shenhu production test.Methane is not currently commercially produced from gas hydrates anywhere in the world;therefore,the objective of field trials is to prove whether existing techniques could be applied as feasible and economic production methods for gas hydrates in deep-water sediments and permafrost zones.Before achieving commercial methane recovery from gas hydrates,it should be necessary to measure the geologic properties of gas hydrate reservoirs to optimize and improve existing production techniques.Herein,we propose horizontal wells,multilateral wells,and cluster wells improved by the vertical and in dividual wells applied during existing field trials.It is noteworthy that relatively pure gas hydrates occur in seafloor mounds,within near-surface sediments,and in gas migration conduits.Their extensive distribution,high saturation,and easy access mean that these types of gas hydrate may attract considerable attention from academia and industry in the future.Herein,we also review the occurrence and development of concentrated shallow hydrate accumulations and briefly introduce exploration and production techniques.In the closing section,we discuss future research needs,key issues,and major challenges related to gas hydrate exploration and production.We believe this review article provides insight on past,present,and future gas hydrate exploration and production to provide guidelines and stimulate new work into the field of gas hydrates. | LIU Liping SUN Zhilei ZHANG Lei WU Nengyou Yichao Qin JIANG Zuzhou GENG Wei CAO Hong ZHANG Xilin ZHAI Bin XU Cuiling SHEN Zhicong JIA Yonggang | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 13 |
| 2 | Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death显示文摘Objective: Squamous esophageal carcinoma is highly prevalent in developing countries, especially in China. Tu Bei Mu (TBM), a traditional folk medicine, has been used to treat esophageal squamous cell carcinoma (ESCC) for a long term. tubeimoside I (TBMS1) is the main component of TBM, exhibiting great anticancer potential. In this study, we investigated the mechanism of TBMS1 cytotoxic effect on EC109 cells. Methods: Comparative nuclear proteomic approach was applied in the current study and we identified several altered protein spots. Further biochemical studies were carried out to detect the mitochondrial membrane potential, cell cycle and corresponding proteins' expression and location. Results: Subcellular proteomic study in the nucleus from EC109 cells revealed that altered proteins were associated with mitochondrial function and cell proliferation. Further biochemical studies showed that TBMS1-induced molecular events were related to mitochondria-induced intrinsic apoptosis and P21-cyclin B1/cdc2 complex-related G2/M cell cycle arrest. Conclusions: Considering the conventional application of TBM in esophageal cancer, TBMS1 therefore may have a great potential as a chemotherapeutic drug candidate for ESCC. | Yang Xu Guanghui Wang Quancheng Chen Ting Lin Zhiping Zeng Qiang Luo Jie Liu Cuiling Sun | 2013 | Chinese Journal of Cancer Research2013，25，3： | 12 |
| 3 | Analyzing Population Density Disparity in China with GIS-automated Regionalization: The Hu Line Revisited显示文摘The famous ’Hu Line’, proposed by Hu Huanyong in 1935, divided China into two regions(southeast and northwest) of comparable area size but drastically different in population. However, the classic Hu Line was derived manually in absence of reliable census data and computational technologies of modern days. It has been subject to criticism of lack of scientific rigor and accuracy. This research uses a GIS-automated regionalization method, termed REDCAP(Regionalization with Dynamically Constrained Agglomerative Clustering and Partitioning), to reconstruct the demarcation line based on the 2010 county-level census data in China. The results show that the logarithmic transformation of population density is a better measure of attributive homogeneity in derived regions than density itself, and produces two regions of nearly identical area size and greater contrast in population. Specifically, the revised Hu Line by Hu Huanyong in 1990 had the southeast region with 94.4% of total population and 42.9% of total land, and our delineation line yields a southeast region with 97.4% population and 50.8% land. Therefore, the population density ratio of the two regions is 27.1 by our line, much higher than the ratio of 22.4 by the Hu Line, and thus outperforms the Hu Line in deriving regions of maximum density contrast with comparable area size. Furthermore, more regions are delineated to further advance our understanding of population distribution disparity in China. | WANG Fahui LIU Cuiling XU Yaping | 2019 | Chinese Geographical Science2019，29，4： | 3 |
| 4 | The Character and Formation of Elongated Depressions on the Upper Bulgarian Slope显示文摘Seafloor elongated depressions are indicators of gas seepage or slope instability. Here we report a sequence of slopeparallel elongated depressions that link to headwalls of sediment slides on upper slope. The depressions of about 250 m in width and several kilometers in length are areas of focused gas discharge indicated by bubble-release into the water column and methane enriched pore waters. Sparker seismic profiles running perpendicular and parallel to the coast, show gas migration pathways and trapped gas underneath these depressions with bright spots and seismic blanking. The data indicate that upward gas migration is the initial reason for fracturing sedimentary layers. In the top sediment where two young stages of landslides can be detected, the slopeparallel sediment weakening lengthens and deepens the surficial fractures, creating the elongated depressions in the seafloor supported by sediment erosion due to slope-parallel water currents. | XU Cuiling GREINERT Jens HAECKEL Matthias BIALAS Jorg DIMITROV Lyubomir ZHAO Guangtao | 2018 | Journal of Ocean University of China2018，17，3： | 2 |
| 5 | Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication显示文摘 | Kristoff Jan Haret-Richter George Ma Dongzhu Ribeiro Ruy M Xu Cuiling Cornell Elaine Stock Jennifer L He Tianyu Mobley Adam D Ross Samantha Trichel Anita Wilson Cara Tracy Russell Landay Alan Apetrei Cristian Pandrea Ivona | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 6 | Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice显示文摘 | Rui-Hong Wang Kundan Sengupta Cuiling Li Hyun-Seok Kim Liu Cao Cuiying Xiao Sangsoo Kim Xiaoling Xu Yin Zheng Beverly Chilton Rong Jia Zhi-Ming Zheng Ettore Appella Xin Wei Wang Thomas Ried Chu-Xia Deng | 2008 | Cancer Cell2008，，4： | 1 |
| 7 | Electrochemicai detectin of parathionat glassy carbon electrode modified with hexadecane显示文摘 | Xu Cuiling Wu Kangbing Hu Shengshui | 2002 | Anal Bioanal Chem2002，373，： | 1 |
| 8 | Monitoring Avian In- fluenza A (H7Ng) Virus through National Influenza-like Illness Surveillance,China显示文摘 | Cuiling Xu Fiona Havers Lijie Wang | 2013 | EID2013，19，8： | 1 |
| 9 | Identifying areas with a high risk of human infection with the avi- an influenza A(HTNg) virus in East Asia 显示文摘 | FULLER T HAVERS F XU Cuiling | 2014 | J Infect2014，69，2： | 1 |
| 10 | The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice显示文摘 | Yang Xiao Li Cuiling Xu Xiaoling | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 11 | Identifying areas with a high risk of human infection with the avi- an influenza A(HTNg) virus in East Asia 显示文摘 | FULLER T HAVERS F XU Cuiling | 2014 | J Infect2014，69，2： | 1 |
| 12 | The Seroprevalence of Pandemic Influenza H1N1 (2009) Virus in China显示文摘 | Cuiling Xu Tian Bai A Panielle | | 0，，04： | 1 |
| 13 | Research Progress of Seafloor Pockmarks in Spatio-Temporal Distribution and Classification显示文摘Seafloor pockmarks are important indicators of submarine methane seepages and slope instabilities.In order to promote the understanding of submarine pockmarks and their relationship with sediment instabilities and climate changes,here we summarize the research results of pockmarks in the spatio-temporal distributions and shaping factors.Most of pockmarks occur along active or passive continental margins during the last 25 kyr B.P..Circular and ellipse are the most common forms of pockmarks,whereas pockmarks in a special crescent or elongated shape are indicators of slope instabilities,and ring-shape pockmarks are endemic to the gas hydrate zones.Further researches should be focused on the trigger mechanism of climate changes based on the pockmarks in the high latitudes formed during the deglaciation periods,and the role of gas hydrates in the seafloor evolution should be elucidated.In addition,the feature of pockmarks at their early stage(e.g.,developing gas chimneys and gas driving sedimentary doming)and the relations between pockmarks and mass movements,mud diapirs could be further studied to clarify the influences of rapid methane release from submarine sediments on the atmospheric carbon contents. | XU Cuiling XU Guoqiang XING Junhui SUN Zhilei WU Nengyou | 2020 | Journal of Ocean University of China2020，19，1： | 1 |
| 14 | Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice显示文摘 | Rui-Hong Wang Kundan Sengupta Cuiling Li Hyun-Seok Kim Liu Cao Cuiying Xiao Sangsoo Kim Xiaoling Xu Yin Zheng Beverly Chilton Rong Jia Zhi-Ming Zheng Ettore Appella Xin Wei Wang Thomas Ried Chu-Xia Deng | 2008 | Cancer Cell2008，，4： | 1 |
| 15 | ,Electrocatalytic reduction of dioxygen at the surface of glassy carbon electrodes modified by calixarene-methyl viologen显示文摘 | Hua Shengshui Xu Cuiling He Yongbing | 2000 | Microchemical Journal2000，65，3： | 1 |
| 16 | Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo显示文摘The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2)is a global crisis.Clinical candidates with high efficacy,ready availability,and that do not develop resistance are in urgent need.Despite that screening to repurpose clinically approved drugs has provided a variety of hits shown to be effective against SARS-CoV-2 infection in cell culture,there are few confirmed antiviral candidates in vivo.In this study,94 compounds showing high antiviral activity against SARS-CoV-2 in Vero E6 cells were identified from 2,580 FDA-approved small-molecule drugs.Among them,24 compounds with low cytotoxicity were selected,and of these,17 compounds also effectively suppressed SARS-CoV-2 infection in He La cells transduced with human ACE2.Six compounds disturb multiple processes of the SARSCoV-2 life cycle.Their prophylactic efficacies were determined in vivo using Syrian hamsters challenged with SARS-CoV-2infection.Seven compounds reduced weight loss and promoted weight regain of hamsters infected not only with the original strain but also the D614G variant.Except for cisatracurium,six compounds reduced hamster pulmonary viral load,and IL-6 and TNF-αm RNAwhen assayed at 4 d postinfection.In particular,sertraline,salinomycin,and gilteritinib showed similar protective effects as remdesivir in vivo and did not induce antiviral drug resistance after 10 serial passages of SARS-CoV-2 in vitro,suggesting promising application for COVID-19 treatment. | Haoran Peng Cuiling Ding Liangliang Jiang Wanda Tang Yan Liu Lanjuan Zhao Zhigang Yi Hao Ren Chong Li Yanhua He Xu Zheng Hailin Tang Zhihui Chen Zhongtian Qi Ping Zhao | 2022 | Science China(Life Sciences)2022，65，6： | 1 |
| 17 | Construction of PS/PNIPAM core-shell particles and hollow spheres by using hydrophobic interaction and thermosensitive phase separation显示文摘This paper reports an easy and effective way to fabricate polystyrene/poly(N-isopropylacrylamide)(PS/PNIPAM)core-shell particles and PNIPAM hollow spheres.The main point of the method is to take advantage of the hydrophobic interaction between initiator and PS particles.The hydrophobic azodiisobutyronitriles automatically concentrate around the PS particles and initiate polymerization of N-isopropylacrylamide(NIPAM)and the crosslinkermethylene bisacrylamide(MBA),which dissolve in the aqueous phase,at the surface of the PS nanoparticles.Then,PNIPAM adheres to the PS particles to form a coreshell structure as a result of their hydrophobic interaction.This interaction is due to the unique property of PNIPAM,namely,its ability to transition from hydrophilic to hydrophobic when the temperature rises to 32℃.Furthermore,the hollow PNIPAM spheres were obtained by etching the PS core with chloroform. | Dongmei ZHU Fei WANG Cuiling GAO Zheng XU | 2008 | Frontiers of Chemical Science and Engineering2008，2，3： | 1 |
| 18 | Entropy-driven self-assembly of tethered Janus nanoparticles on a sphere显示文摘Understanding the effect of curvature and topological frustration on self-assembly yields insight into the mechanistic details of the ordering of identical subunits in curved spaces,such as the assembly of viral capsids,growth of solid domains on vesicles,and the self-assembly of molecular monolayers.However,the self-assembly of nanoparticles with anisotropic surface topology and compartmentalization on curved surfaces remains elusive.By combining large-scale molecular simulations as well as theoretical analysis,we demonstrate here that the interplay among anisotropy,curvature,and chain conformation induces tethered Janus nanoparticles to self-assemble into diverse novel structures on a sphere,including binary nanocluster(C_(B)),trinary nanocluster(C_(T)),nanoribbon(R_(N))and hexagon with centered reverse(HR),which are mapped on a phase diagram related to the length asymmetry of tethered chains and Janus balance of the nanoparticles.The dynamical mechanism for the formation of these structure states is analyzed by examining the detailed kinetic pathways as well as free energy.We also show that the centered-reverse state is more prone to emerging around the topological defects,indicating the defect-enhanced entropy effect on a curved surface.Finally,the analytical model that rationalizes the regimes of these structure states is developed and fits simulations reasonably well,resulting in a mechanistic interpretation based on the order through entropy.Our findings shed light on curvature engineering as a versatile strategy to tailor the superstructures formed by anisotropic building blocks toward unique properties. | Guolong Zhu Yuming Wang Lijuan Gao Ziyang Xu Xuanyu Zhang Xiaobin Dai Lijun Dai Cuiling Hou Li-Tang Yan | 2021 | Fundamental Research2021，1，5： | 0 |
| 19 | Homogenizing the sulfonic acid distribution of DMF-modified PEDOT:PSS films and perovskite solar cells显示文摘Inverted perovskite solar cells using pristine PEDOT:PSS as the hole-transporting layer (HTL) have been widely studied for its less hysteresis and low-temperature preparation technologies. However, this device suffers from an inferior open-circuit voltage (VOC) and stability problems. Several attempts have made on film formation and interface engineering to improve the efficiency. Modification proved beneficial to decrease energy offset at the interface between the HTL layer and the adjacent perovskite layer. In this paper, modification PEDOT:PSS layers were realized with a dimethyl formamide (DMF) solvent. The sulfonic acid distribution was homogenized in the normal directi on after modification. The work function of the modified PEDOT:PSS layers increased from 4.71 to 5.07eV, and the conductivity of modified PEDOT:PSS increased from 3×10^-4 to 0.45 S/cm. The as-deposited perovskite films were more uniform with larger grain sizes and less pinholes, resulting in an improved VOC from 0.93 to 1.048 V, while the efficiency was increased from 11.5% to 16.8%. Solar cells without encapsulation under the 50 h and 50% humidity aging test showed 7% degradation of fill factor (FF) with 50 v/v% PEDOT:PSS layer, while the fill factor decreased 11.2% in the 0 v/v% PEDOT:PSS layer, respectively. | Hongliang Li Cuiling Zhang Yunping Ma Zhiqiang Li Ying Xu Yaohua Mai | 2019 | Journal of Energy Chemistry2019，28，5： | 0 |
| 20 | Mapping the glaucousness suppressor Iw1 from wild emmer wheat “PI 481521”显示文摘Many species of Triticeae display a glaucous phenotype. In wheat, glaucousness/waxiness on spikes, leaves and shoots is controlled by wax production genes(W loci) and epistatic inhibitors(Iw loci). In this study, a suppressor of glaucousness from wild emmer wheat(Triticum turgidum ssp. dicoccoides) accession 'PI 481521' was investigated in a pair of durum(T. turgidum ssp. durum cv. 'Langdon', LDN)—wild emmer wheat chromosome substitution lines, LDN and 'LDNDIC521-2B'. Genetic analysis revealed that the non-glaucous phenotype of LDNDIC521-2Bwas controlled by the dominant glaucous suppressor Iw1 on the short arm of chromosome 2B. In total, 371 2B-specific marker differences were identified between LDN and LDNDIC521-2B. The location of the Iw1 gene was mapped using an F2 population that stemmed from LDN and LDNDIC521-2B, generating a partial linkage map that included 19 simple sequence repeats(SSR) and ten gene-based markers. On the current map, the Iw1 gene was located within the Xgwm614–BE498111 interval, and cosegregated with BQ788707,CD893659, CD927782, CD938589, and Xbarc35. Mapping of Iw1 in LDNDIC521-2B, a publically accessible and widely distributed line, will provide valuable information for marker-assisted selection of the agronomically important trait of glaucousness. | Zongchang Xu Cuiling Yuan Jirui Wang Daolin Fu Jiajie Wu | 2015 | The Crop Journal2015，3，1： | 0 |
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