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| 1 | Distribution,Frequency and Variation of Stripe Rust Resistance Loci Yr10,Lr34/Yr18 and Yr36 in Chinese Wheat Cultivars显示文摘Wheat stripe rust is a devastating disease in many regions of the world.In wheat,49 resistance genes for stripe rust have been officially documented,but only three genes are cloned,including the race-specific resistance Yr10 candidate gene(Yr10_(CG)) and slow-rusting genes Lr34/Yr18(hereafter designated as Yr18) and Yr36.In this study,we developed gene-specific markers for these genes and used them to screen a collection of 659 wheat accessions,including 485 Chinese cultivars.Thirteen percent and eleven percent of the tested Chinese cultivars were positive for the markers for Yr10_(CG) and Yr18_(RH)(the resistant haplotype of Yr18),respectively,but none were positive for the Yr36 marker.Since there is a limited use of the Yr10 gene in Chinese wheat,the relatively high frequency of wheat varieties with the Yr10_(CG) marker suggests that the identity of the Yr10 gene is unknown.With regards to the Yr18 gene,29%of the tested cultivars that are used in the Middle and Lower Yangtze Valleys' winter wheat zone were positive for Yr18_(RH) markers.A non-functional allele of Yr18_(RH) was identified in 'Mingxian 169',a commonly used susceptible check for studying stripe rust.The data presented here will provide useful information for marker-assisted selection for wheat stripe rust resistance. | Cuiling Yuan Hui Jiang Honggang Wang Kun Li Heng Tang Xianbin Li Daolin Fu | 2012 | Journal of Genetics and Genomics2012，39，11： | 12 |
| 2 | Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody显示文摘肝炎 E 病毒(HEV ) ,一个非包的、积极感觉的、搁浅单人赛的 RNA 病毒,是伤寒肝炎的一个主要原因。分类进家庭 Hepeviridae, HEV 包括四遗传型(遗传型 1-4 ) ,它属于单个 serotype。我们描述 monoclonal 抗体(mAb ) ,有 ~ 2.53-3.45 nM 的 8G12,同等地认出 HEV 的所有四遗传型,有约束力的亲密关系。mAb 8G12 有一保护,抵销能力,它能显著地在主人房间堵住病毒感染。动物与 1, 3 和 4 证实了跨遗传型的抵销的遗传型学习 8G12 和它肝炎 E 疾病的有效预防的能力。有丰富的遗传型的 HEV E2s 领域(病毒衣壳的最耸出的区域) 的 8G12 的复杂水晶结构 1 和 4 在 4.0 和 2.3 Å 被决定;分辨率分别地。这些结构表明 8G12 在 E2s dimerization 区域通过 epitopes 认出两遗传型。有像病毒的粒子的基于结构的 mutagenesis 和房间模型试金识别了为 8G12 中立化是必要的几保存残余(Glu549, Lys554 和 Gly591 ) 。而且, 8G12 的 epitope 作为涉及病毒主人相互作用的关键 epitope 被识别。这些调查结果将帮助为 HEV 感染的最丰富的形式的预防开发普通策略。 | Ying Gu Xuhua Tang Xiao Zhang Cuiling Song Minghua Zheng Kaihang Wang Jun Zhang Mun-Hon Ng Choy-Leong Hew Shaowei Li Ningshao Xia J. Sivaraman | 2015 | Cell Research2015，25，5： | 3 |
| 3 | Advances in preimplantation genetic diagnosis/screening显示文摘Preimplantation genetic diagnosis(PGD)gives couples who have a high risk of transmitting genetic disorders to their baby the chance to have a healthy offspring through embryo genetic analysis and selection.Preimplantation genetic screening(PGS)is an effective method to select euploid embryos that may prevent repeated implantation failure or miscarriage.However,how and to whom PGS should be provided is a controversial topic.The first successful case of PGD of a human being was reported in 1990,and there have been tremendous improvements in this technology since then.Both embryo biopsy and genetic technologies have been improved dramatically,which increase the accuracy and expand the indications of PGD/PGS. | YAN LiYing WEI Yuan HUANG Jin ZHU XiaoHui SHI XiaoDan XIA Xi YAN Jie LU CuiLing LIAN Ying LI Rong LIU Ping QIAO Jie | 2014 | Science China(Life Sciences)2014，57，7： | 3 |
| 4 | Statin therapy improves response to interferon alfa and ribavirin in chronic hepatitis C: A systematic review and meta-analysis显示文摘 | Qianqian Zhu Na Li Qunying Han Pingping Zhang Cuiling Yang Xiaoyan Zeng Yanping Chen Yi Lv Xi Liu Zhengwen Liu | 2013 | Antiviral Research2013，，3： | 3 |
| 5 | 'Green' synthesis of starch capped CdSe nanoparticles at room temperature 显示文摘 | Li Jinhua Ren Cuiling Liu Xiaoyan | 2007 | Materials Seience and Engineering A2007，458，： | 1 |
| 6 | Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice显示文摘 | Rui-Hong Wang Kundan Sengupta Cuiling Li Hyun-Seok Kim Liu Cao Cuiying Xiao Sangsoo Kim Xiaoling Xu Yin Zheng Beverly Chilton Rong Jia Zhi-Ming Zheng Ettore Appella Xin Wei Wang Thomas Ried Chu-Xia Deng | 2008 | Cancer Cell2008，，4： | 1 |
| 7 | Develop-ment and application of a universal TaqMan real-time PCR for quantitation of duck hepatitis B virus DNA显示文摘 | WANG Yawen LI Yiping YANG Cuiling | | 0，，1： | 1 |
| 8 | NAC1 regulates root ground tissue maturation by coordinating with the SCR/SHR-CYCD6;1 module in Arabidopsis显示文摘Precise spatiotemporal control of the timing and extent of asymmetric cell divisions(AcDs)is essential for plant development.In the Arabidopsis root,ground tissue maturation involves an additional AcD of the endo-dermis that maintains the inner cell layer as the endodermis and generates the middle cortex to the outside.Through regulation of the cell cycle regulator CYCLIND6;1(CYCD6;1),the transcription factors SCARECROW(SCR)and SHORT-ROOT(SHR)play critical roles in this process.In the present study,we found that loss of function of NAC1,a NAC transcription factor family gene,causes markedly increased periclinal cell divisions in the root endodermis.Importantly,NAC1 directly represses the transcription of CYCD6;1 by recruiting the co-repressor TOPLESS(TPL),creating a fine-tuned mechanism to maintain proper root ground tissue patterning by limiting production of middle cortex cells.Biochemical and genetic analyses further showed that NAC1 physically interacts with SCR and SHR to restrict excessive periclinal cell divisions in the endo-dermis during root middle cortex formation.Although NAC1-TPL is recruited to the CYCD6;1 promoter and represses its transcription in an SCR-dependent manner,NAC1 and SHR antagonize each other to regu-late the expression of CYCD6;1.Collectively,our study provides mechanistic insights into how the NAC1-TPL module integrates with the master transcriptional regulators SCR and SHR to control root ground tissue patterning by fine-tuning spatiotemporal expression of CYCD6;1 in Arabidopsis. | Chuantian Xie Cuiling Li Fengxia Wang Feng Zhang Jiajia Liu Junxia Wang Xiansheng Zhang Xiangpei Kong Zhaojun Ding | 2023 | Molecular Plant2023，16，4： | 1 |
| 9 | 3DRGO-NiFe2O4/NiO nanoparticles for fast and simple detection of organophosphorus pesticides显示文摘The residues of organophosphorus pesticide(OPs)on fruits and vegetables pose a threat to human health,so it is very meaningful to explore simple and fast detect methods for OPs residual.In this work,nickel ferrite/nickel oxide nanoparticles co-loaded three-dimensional reduced graphene oxide(3DRGONiFe2O4/NiO NPs),as a new low cost nanocomposite,was prepared.Based on its high performance mimetic peroxidase activity,a colorimetric method for the detection of OPs has been developed.Dichlorvos was chosen as model compounds to evaluate the detection performance.The detection linear range for dichlorvos is from 50μg/mL to 2.5×10^4μg/mL with a detection limit of 10μg/mL.Furthermore,a test paper can be developed based on the 3 DRGO-NiFe2O4/NiO NPs for visual detection of dichlorvos,and the image information of the paper sensor can be converted into digital signal and quantitative detection by a smartphone.Notably,this method can also be used to detect dichlorvos in real samples,including vegetables and fruits.Thus,the developed naked assay holds great potential in simple,inexpensive and rapid detection of OPs in fruit and vegetable samples. | Zhenni Wei Huiqing Li Jing Wu Yalei Dong Hongyi Zhang Hongli Chen Cuiling Ren | 2020 | Chinese Chemical Letters2020，31，1： | 1 |
| 10 | DNA Functionalized Fluorescent Quantum Dots for Bioanalytical Applications显示文摘作为一最新发展了荧光灯探查,有唯一的光性质的 DNA functionalized 量点(QD ) 在 bioanalytical 应用程序起一个关键作用。现在的评论在 DNA 的变化形式技术上提供概述给 QD,包括静电的吸引力,共有原子价附件,特定的效果和直接合成。另外,我们在 bioapplications 在 DNA functionalized QD 上总结最近的进展,例如指向 nucleic 酸,离子,小分子和蛋白质察觉,房间成像和疾病诊断。最后,我们在 DNA functionalized 上有关当前的挑战想象方面荧光灯 QD。 | Cuiling Zhang Caiping Ding Dongshan Xiang Li Li Xinghu Ji Zhike He Yuezhong Xian | 2016 | Chinese Journal of Chemistry2016，34，3： | 1 |
| 11 | IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgE levels in patients with chronic hepatitis B virus infection显示文摘 | Na Li Qianqian Zhu Zhu Li Qunying Han Jinghong Chen Yi Lv Yawen Wang Xiaoyan Zeng Yanping Chen Cuiling Yang Zhengwen Liu | 2013 | Human Immunology2013，，： | 1 |
| 12 | The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice显示文摘 | Yang Xiao Li Cuiling Xu Xiaoling | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 13 | Study and Application of High Property Die Casting Al Alloy显示文摘 | Jinsong Rao Huaji Li Cuiling Wang et at | 2005 | Journal of Chongqing University(Natural Science Edition)2005，28，10： | 1 |
| 14 | Microwave absorption and mechanical properties of La (NO3)3-doped muhi-walled carbon nanotube/polyvinyl chloride compos- ites 显示文摘 | Cuiling Hou Tiehu Li Tingkai Zhao | 2012 | Mater Lett2012，67，： | 1 |
| 15 | Electromag- netic wave absorbing properties of carbon nanotubes doped rare metal/pure carbon nanotubes double-layer polymer composites 显示文摘 | Cuiling Hou Tiehu Li Tingkai Zhao | 2012 | Materials and Design2012，33，： | 1 |
| 16 | Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes显示文摘It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient outcome.Here,we report that osteosarcoma Rab22a-NeoF1 fusion protein,together with its binding partner PYK2,is sorted into exosomes by HSP90 via its KFERQ-like motif(RVLFLN^(142)).The exosomal Rab22a-NeoF1 fusion protein facilitates the pulmonary pre-metastatic niche formation by recruiting bone marrow-derived macrophages.The exosomal PYK2 activates RhoA in its negative recipient osteosarcoma cells and induces signal transducer and activator of transcription 3 activation in its recipient macrophages to increase M2 phenotype.Consequently,lung metastases of its recipient osteosarcoma cells are promoted by this exosomal Rab22a-NeoF1 fusion protein,and this event can be targeted by disrupting its interaction with PYK2 using a designed internalizing RGD peptide. | Li Zhong Dan Liao Jingjing Li Wenqiang Liu Jingxuan Wang Cuiling Zeng Xin Wang Zhiliang Cao Ruhua Zhang Miao Li Kuntai Jiang Yi-Xin Zeng Jianhua Sui Tiebang Kang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 17 | Genetic variations of PD1 and TIM3 are differentially and interactively associated with the development of cirrhosis and HCC in patients with chronic HBV infection显示文摘 | Zhu Li Na Li Qianqian Zhu Guoyu Zhang Qunying Han Pingping Zhang Meng Xun Yawen Wang Xiaoyan Zeng Cuiling Yang Zhengwen Liu | 2013 | Infection, Genetics and Evolution2013，，： | 1 |
| 18 | Development and application of a universal Taqman real-time PCR for quantitation of duck hepatitis B virus DNA显示文摘 | Yawen Wang Yiping Li Cuiling Yang Lingyun Hui Qunying Han Lieting Ma Quanying Wang Guangxiao Yang Zhengwen Liu | 2013 | Journal of Virological Methods2013，，1： | 1 |
| 19 | Relationship between the free and total chloride diffusivity in concrete 显示文摘 | Lu Xinying Li Cuiling Zhang Haixia | 2002 | Cement and Concrete Research2002，32，2： | 1 |
| 20 | Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice显示文摘 | Rui-Hong Wang Kundan Sengupta Cuiling Li Hyun-Seok Kim Liu Cao Cuiying Xiao Sangsoo Kim Xiaoling Xu Yin Zheng Beverly Chilton Rong Jia Zhi-Ming Zheng Ettore Appella Xin Wei Wang Thomas Ried Chu-Xia Deng | 2008 | Cancer Cell2008，，4： | 1 |
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