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| 1 | Diagnosis of alcoholic liver disease显示文摘Alcohol is a hepatotoxin that is commonly consumed worldwide and is associated with a spectrum of liver injury including simple steatosis or fatty liver, alcoholic hepatitis, fibrosis, and cirrhosis. Alcoholic liver disease(ALD) is a general term used to refer to this spectrum of alcohol-related liver injuries. Excessive or harmful alcohol use is ranked as one of the top five risk factors for death and disability globally and results in 2.5 million deaths and 69.4 million annual disability adjusted life years. All patients who present with clinical features of hepatitis or chronic liver disease or who have elevated serum elevated transaminase levels should be screened for an alcohol use disorder. The diagnosis of ALD can generally be made based on history, clinical and laboratory findings. However, the diagnosis of ALD can be clinically challenging as there is no single diagnostic test that confirms the diagnosis and patients may not be forthcoming about their degree of alcohol consumption. In addition, clinical findings may be absent or minimal in early ALD characterized by hepatic steatosis. Typical laboratory findings in ALD include transaminase levels with aspartate aminotransferase greater than alanine aminotransferase as well as increased mean cor-puscular volume, gamma-glutamyltranspeptidase, and IgA to IgG ratio. In unclear cases, the diagnosis can be supported by imaging and liver biopsy. The histological features of ALD can ultimately define the diagnosis according to the typical presence and distribution of hepatic steatosis, inflammation, and Mallory-Denk bodies. Because of the potential reversible nature of ALD with sobriety, regular screening of the general population and early diagnosis are essential. | Cara Torruellas Samuel W French Valentina Medici | 2014 | World Journal of Gastroenterology2014，20，33： | 26 |
| 2 | Refractive outcomes among glaucoma patients undergoing phacoemulsification cataract extraction with and without Kahook Dual Blade goniotomy显示文摘Background:Glaucoma patients undergoing phacoemulsification alone have a higher rate of refractive surprise compared to patients without glaucoma.This risk is further increased with combined filtering procedures.Indeed,there are few and conflicting reports on the effect of combined phacoemulsification and micro-invasive glaucoma surgery(MIGS).Here,we look at refractive outcomes of glaucoma patients undergoing phacoemulsification with and without Kahook Dual Blade(KDB)goniotomy.Methods:Retrospective chart review of 385 glaucomatous eyes of 281 patients,which underwent either phacoemulsification alone(n=309)or phacoemulsification with KDB goniotomy(n=76,phaco-KDB)at the University of Colorado.The main outcome was refractive surprise defined as the difference in target and postoperative refraction spherical equivalent greater than±0.5 Diopter(D).Results:Refractive surprise greater than±0.5 D occurred in 26.3%of eyes in the phaco-KDB group and 36.2%in the phacoemulsification group(p=0.11).Refractive surprise greater than±1.0 D occurred in 6.6%for the phacoKDB group and 9.7%for the phacoemulsification group(p=0.08).There was no significant difference in risk of refractive surprise when pre-operative IOP,axial length,keratometry or performance of KDB goniotomy were assessed in univariate analyses.Conclusion:There was no difference between refractive outcomes of glaucomatous patients undergoing phacoemulsification with or without KDB goniotomy. | Erin G.Sieck Cara E.Capitena Young Rebecca S.Epstein Jeffrey R.SooHoo Mina B.Pantcheva Jennifer L.Patnaik Anne M.Lynch Malik Y.Kahook Leonard K.Seibold | 2019 | Eye and Vision2019，6，1： | 7 |
| 3 | Role of human papillomavirus in oropharyngeal squamous cell carcinoma: A review显示文摘Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities. | Robbie SR Woods Esther M O'Regan Susan Kennedy Cara Martin John J O'Leary Conrad Timon | 2014 | World Journal of Clinical Cases2014，2，6： | 5 |
| 4 | Organic electrode materials for fast-rate,high-power battery applications显示文摘The development of new battery materials with fast charging/discharging capabilities is necessary to meet the growing demands of modern technologies.While counter ion transport in inorganic materials(generally by de/intercalation)currently limits charge/discharge rates in lithium-ion batteries,the weak intermolecular forces in organic materials result in flexible,spacious structures that offer improved ion transport capabilities.Herein,we present the principles which enable fast rate capabilities in organic electrode materials,accompanied by specific literature examples illustrating exceptional rate performances.We discuss approaches to material design which support electron and/or ion transport and the limitations associated with each approach.This review aims to highlight the unique characteristics of organic materials as high-power density electrodes and inspire continued work in the field. | Cara N.Gannett Luis Melecio-Zambrano Monica Jo Theibault Brian M.Peterson Brett P.Fors Hector D.Abruna | 2021 | Materials Reports(Energy)2021，1，1： | 4 |
| 5 | NASPGHAN Practice Guidelines: Diagnosis and Management of Hepatitis C Infection in Infants, Children, and Adolescents显示文摘 | Cara L. Mack Regino P. Gonzalez-Peralta Nitika Gupta Daniel Leung Michael R. Narkewicz Eve A. Roberts Philip Rosenthal Kathleen B. Schwarz | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，6： | 2 |
| 6 | Muscle adaptation prior to recovery following eccentric exercise显示文摘 | Cara B. Ebbeling Priscilla M. Clarkson | 1990 | European Journal of Applied Physiology and Occupational Physiology1990，，： | 2 |
| 7 | Assembly of Fibronectin Extracellular Matrix显示文摘 | Purva Singh Cara Carraher Jean E. Schwarzbauer | 2010 | Annual Review of Cell and Developmental Biology2010，，： | 2 |
| 8 | The consumer quest for authenticity: The multiplicity of meanings within the MG subculture of consumption显示文摘 | Thomas W. Leigh Cara Peters Jeremy Shelton | 2006 | Journal of the Academy of Marketing Science2006，，： | 2 |
| 9 | Iliac allograft used for sternal reconstruction after resection of a chondrosarcoma显示文摘 | Cara JA Lacl e riga AF Caoadell J | 1993 | Int Orthop1993，17，5： | 1 |
| 10 | Enhanced enzymatic hydrolysis of olive tree wood by steam explosion and alkaline peroxide delignification显示文摘 | Cristobal Cara Encamacion Ruiz Ignacio Ballesteros | 2006 | Process Biochemistry2006，41，2： | 1 |
| 11 | Expressional and functional analysis of the male-specific cluster mst36F during Drosophila spermatogenesis显示文摘 | Di Cara F Cavaliere D Galliero V | | 0，，06： | 1 |
| 12 | Cloning of decayaccelerating factor suggests novel use of splicing to generate two proteins 显示文摘 | Davitz MA Rhee L | 1987 | Nature1987，325，： | 1 |
| 13 | SMART-1: ananalysis of flight data 显示文摘 | DI CARA Davina M ESTUBLIER Denis | 2004 | Acta Astronautica2004，57，2： | 1 |
| 14 | Anaerobic co- digestion of primary sludge and the fruit and vegetable fraction of the municipal solid wastes conditions for mixing andevaluation ofthe organic loading rate显示文摘 | Gomez X Cuetos M J Cara J | 2006 | Renew Energy2006，31，12： | 1 |
| 15 | Insilicon pharmacology for a multidisciplinary drug discovery process 显示文摘 | Ortega SS Cara LC Salvador MK | 2012 | Drug Metabol Drug Interact2012，27，4： | 1 |
| 16 | Mi- croalgae to biofuels lifecycle assessment--multiple pathway evalua- tion 显示文摘 | Jason C Quinn Gordon T Smith Cara Meghan Downes | 2014 | Algal Research2014，4，4： | 1 |
| 17 | Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication显示文摘 | Kristoff Jan Haret-Richter George Ma Dongzhu Ribeiro Ruy M Xu Cuiling Cornell Elaine Stock Jennifer L He Tianyu Mobley Adam D Ross Samantha Trichel Anita Wilson Cara Tracy Russell Landay Alan Apetrei Cristian Pandrea Ivona | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 18 | Altered contribution of RhoA/Rho kinase signaling in contractile activity of myometrium in leptin receptor-deficient mice显示文摘 | Jeremy SH Cara CR Stephanie LP | 2011 | Am J Physiol Endocrinol Metab2011，301，2： | 1 |
| 19 | Field effect transistor sensitive to penieillin显示文摘 | Caras S Janata | 1980 | Anal chem1980，52，： | 1 |
| 20 | Removal of metaphyseal bone tumors with preservation of the epiphysis显示文摘 | Canadell J Forriol F Cara JA | 1994 | J Bone Joint Surg (Br)1994，76，1： | 1 |
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