|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Progress in Global Gas Hydrate Development and Production as a New Energy Resource显示文摘Natural gas hydrates have been hailed as a new and promising unconventional alternative energy,especially as fossil fuels approach depletion,energy consumption soars,and fossil fuel prices rise,owing to their extensive distribution,abundance,and high fuel efficiency.Gas hydrate reservoirs are similar to a storage cupboard in the global carbon cycle,containing most of the world's methane and accounting for a third of Earth's mobile organic carbon.We investigated gas hydrate stability zone burial depths from the viewpoint of conditions associated with stable existence of gas hydrates,such as temperature,pressure,and heat flow,based on related data collected by the global drilling programs.Hydrate-related areas are estimated using various biological,geochemical and geophysical tools.Based on a series of previous investigations,we cover the history and status of gas hydrate exploration in the USA,Japan,South Korea,India,Germany,the polar areas,and China.Then,we review the current techniques for hydrate exploration in a global scale.Additionally,we briefly review existing techniques for recovering methane from gas hydrates,including thermal stimulation,depressurization,chemical injection,and CH4-CO2 exchange,as well as corresponding global field trials in Russia,Japan,United States,Canada and China.In particular,unlike diagenetic gas hydrates in coarse sandy sediments in Japan and gravel sediments in the United States and Canada,most gas hydrates in the northem South China Sea are non-diagenetic and exist in fine-grained sediments with a vein-like morphology.Therefore,especially in terms of the offshore production test in gas hydrate reservoirs in the Shenhu area in the north slope of the South China Sea,Chinese scientists have proposed two unprecedented techniques that have been verified during the field trials:solid fluidization and formation fluid extraction.Herein,we introduce the two production techniques,as well as the so-called'fbur-in-one'environmental monitoring system employed during the Shenhu production test.Methane is not currently commercially produced from gas hydrates anywhere in the world;therefore,the objective of field trials is to prove whether existing techniques could be applied as feasible and economic production methods for gas hydrates in deep-water sediments and permafrost zones.Before achieving commercial methane recovery from gas hydrates,it should be necessary to measure the geologic properties of gas hydrate reservoirs to optimize and improve existing production techniques.Herein,we propose horizontal wells,multilateral wells,and cluster wells improved by the vertical and in dividual wells applied during existing field trials.It is noteworthy that relatively pure gas hydrates occur in seafloor mounds,within near-surface sediments,and in gas migration conduits.Their extensive distribution,high saturation,and easy access mean that these types of gas hydrate may attract considerable attention from academia and industry in the future.Herein,we also review the occurrence and development of concentrated shallow hydrate accumulations and briefly introduce exploration and production techniques.In the closing section,we discuss future research needs,key issues,and major challenges related to gas hydrate exploration and production.We believe this review article provides insight on past,present,and future gas hydrate exploration and production to provide guidelines and stimulate new work into the field of gas hydrates. | LIU Liping SUN Zhilei ZHANG Lei WU Nengyou Yichao Qin JIANG Zuzhou GENG Wei CAO Hong ZHANG Xilin ZHAI Bin XU Cuiling SHEN Zhicong JIA Yonggang | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 13 |
| 2 | Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death显示文摘Objective: Squamous esophageal carcinoma is highly prevalent in developing countries, especially in China. Tu Bei Mu (TBM), a traditional folk medicine, has been used to treat esophageal squamous cell carcinoma (ESCC) for a long term. tubeimoside I (TBMS1) is the main component of TBM, exhibiting great anticancer potential. In this study, we investigated the mechanism of TBMS1 cytotoxic effect on EC109 cells. Methods: Comparative nuclear proteomic approach was applied in the current study and we identified several altered protein spots. Further biochemical studies were carried out to detect the mitochondrial membrane potential, cell cycle and corresponding proteins' expression and location. Results: Subcellular proteomic study in the nucleus from EC109 cells revealed that altered proteins were associated with mitochondrial function and cell proliferation. Further biochemical studies showed that TBMS1-induced molecular events were related to mitochondria-induced intrinsic apoptosis and P21-cyclin B1/cdc2 complex-related G2/M cell cycle arrest. Conclusions: Considering the conventional application of TBM in esophageal cancer, TBMS1 therefore may have a great potential as a chemotherapeutic drug candidate for ESCC. | Yang Xu Guanghui Wang Quancheng Chen Ting Lin Zhiping Zeng Qiang Luo Jie Liu Cuiling Sun | 2013 | Chinese Journal of Cancer Research2013，25，3： | 12 |
| 3 | Enhanced Photocatalytic Activity of Nanoparticle-Aggregated Ag–AgX(X=Cl, Br)@TiO_2 Microspheres Under Visible Light显示文摘Ag–AgX(X = Cl, Br)@TiO_2 nanoparticle-aggregated spheres with different mass ratio of R = TiO2/Ag(X) from 35:1 to 5:1 were synthesized by a facile sol–gel technique with post-photoreduction. The photocatalytic activities of both Ag–Ag Cl@TiO_2 and Ag–Ag Br@TiO_2 under visible light are effectively improved by ~3 times relative to TiO_2 NPAS under the simulated sunlight for the decomposition of methyl orange(MO). Ag–AgBr@TiO_2 showed 30% improvement and less stable in photocatalytic activity than that of AgCl@TiO_2. The role of Ag and Ag X nanoparticles on the surface of Ag–Ag X(X = Cl,Br)@TiO_2 was discussed. Ag on these samples not onlycan efficiently harvest visible light especially for Ag Cl, but also efficiently separate excited electrons and holes via the fast electron transfer from Ag X(X = Cl, Br) to metal Ag nanoparticles and then to TiO_2-aggregated spheres on the surface of heterostructure. On the basis of their efficient and stable photocatalytic activities under visible-light irradiation, these photocatalysts could be widely used for degradation of organic pollutants in aqueous solution. | Cuiling Zhang Hao Hua Jianlin Liu Xiangyu Han Qipeng Liu Zidong Wei Chengbin Shao Chenguo Hu | 2017 | Nano-Micro Letters2017，9，4： | 5 |
| 4 | Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury显示文摘 | Yuhua Wang Yanlong Liu Irina Kirpich Zhenhua Ma Cuiling Wang Min Zhang Jill Suttles Craig McClain Wenke Feng | 2013 | The Journal of Nutritional Biochemistry2013，，： | 4 |
| 5 | Advances in preimplantation genetic diagnosis/screening显示文摘Preimplantation genetic diagnosis(PGD)gives couples who have a high risk of transmitting genetic disorders to their baby the chance to have a healthy offspring through embryo genetic analysis and selection.Preimplantation genetic screening(PGS)is an effective method to select euploid embryos that may prevent repeated implantation failure or miscarriage.However,how and to whom PGS should be provided is a controversial topic.The first successful case of PGD of a human being was reported in 1990,and there have been tremendous improvements in this technology since then.Both embryo biopsy and genetic technologies have been improved dramatically,which increase the accuracy and expand the indications of PGD/PGS. | YAN LiYing WEI Yuan HUANG Jin ZHU XiaoHui SHI XiaoDan XIA Xi YAN Jie LU CuiLing LIAN Ying LI Rong LIU Ping QIAO Jie | 2014 | Science China(Life Sciences)2014，57，7： | 3 |
| 6 | Granulosa cell proliferation differentiation and its role in follicular development显示文摘Granulosa cells (GCs) are the most important cells in the ovary that undergo serious changes morphologi- cally and physiologically during the processes of follicular proliferation, differentiation, ovulation, lutenization and atresia. Oocyte (OC) directs GC proliferation and differen- tiation, while GCs influence OC maturation. Many ovarian factors are involved in the regulation of these processes via different molecular mechanisms and signal pathways. P38 MAPK can selectively regulate steroidogenesis in GCs con- trolled by FSH; Transcript factors LRH-1 and DAX-1 play an important role in this process; FSH induces GC prolifera- tion and differentiation by stimulating PCNA and StAR ex- pression and steroidogenesis. Activated ERK1/2 signal pathway may be involved in the FSH-regulated GC prolif- eration and differentiation. Therefore,GC is an ideal model for studying cell proliferation, differentiation and interaction as well as signal transduction. This review briefly summa- rizes the latest data in the literature, including the results achieved in our laboratory. | LU Cuiling YANG Wei HU Zhaoyuan LIU Yixun | 2005 | Chinese Science Bulletin2005，50，23： | 3 |
| 7 | Statin therapy improves response to interferon alfa and ribavirin in chronic hepatitis C: A systematic review and meta-analysis显示文摘 | Qianqian Zhu Na Li Qunying Han Pingping Zhang Cuiling Yang Xiaoyan Zeng Yanping Chen Yi Lv Xi Liu Zhengwen Liu | 2013 | Antiviral Research2013，，3： | 3 |
| 8 | Analyzing Population Density Disparity in China with GIS-automated Regionalization: The Hu Line Revisited显示文摘The famous ’Hu Line’, proposed by Hu Huanyong in 1935, divided China into two regions(southeast and northwest) of comparable area size but drastically different in population. However, the classic Hu Line was derived manually in absence of reliable census data and computational technologies of modern days. It has been subject to criticism of lack of scientific rigor and accuracy. This research uses a GIS-automated regionalization method, termed REDCAP(Regionalization with Dynamically Constrained Agglomerative Clustering and Partitioning), to reconstruct the demarcation line based on the 2010 county-level census data in China. The results show that the logarithmic transformation of population density is a better measure of attributive homogeneity in derived regions than density itself, and produces two regions of nearly identical area size and greater contrast in population. Specifically, the revised Hu Line by Hu Huanyong in 1990 had the southeast region with 94.4% of total population and 42.9% of total land, and our delineation line yields a southeast region with 97.4% population and 50.8% land. Therefore, the population density ratio of the two regions is 27.1 by our line, much higher than the ratio of 22.4 by the Hu Line, and thus outperforms the Hu Line in deriving regions of maximum density contrast with comparable area size. Furthermore, more regions are delineated to further advance our understanding of population distribution disparity in China. | WANG Fahui LIU Cuiling XU Yaping | 2019 | Chinese Geographical Science2019，29，4： | 3 |
| 9 | 'Green' synthesis of starch capped CdSe nanoparticles at room temperature 显示文摘 | Li Jinhua Ren Cuiling Liu Xiaoyan | 2007 | Materials Seience and Engineering A2007，458，： | 1 |
| 10 | Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice显示文摘 | Rui-Hong Wang Kundan Sengupta Cuiling Li Hyun-Seok Kim Liu Cao Cuiying Xiao Sangsoo Kim Xiaoling Xu Yin Zheng Beverly Chilton Rong Jia Zhi-Ming Zheng Ettore Appella Xin Wei Wang Thomas Ried Chu-Xia Deng | 2008 | Cancer Cell2008，，4： | 1 |
| 11 | NAC1 regulates root ground tissue maturation by coordinating with the SCR/SHR-CYCD6;1 module in Arabidopsis显示文摘Precise spatiotemporal control of the timing and extent of asymmetric cell divisions(AcDs)is essential for plant development.In the Arabidopsis root,ground tissue maturation involves an additional AcD of the endo-dermis that maintains the inner cell layer as the endodermis and generates the middle cortex to the outside.Through regulation of the cell cycle regulator CYCLIND6;1(CYCD6;1),the transcription factors SCARECROW(SCR)and SHORT-ROOT(SHR)play critical roles in this process.In the present study,we found that loss of function of NAC1,a NAC transcription factor family gene,causes markedly increased periclinal cell divisions in the root endodermis.Importantly,NAC1 directly represses the transcription of CYCD6;1 by recruiting the co-repressor TOPLESS(TPL),creating a fine-tuned mechanism to maintain proper root ground tissue patterning by limiting production of middle cortex cells.Biochemical and genetic analyses further showed that NAC1 physically interacts with SCR and SHR to restrict excessive periclinal cell divisions in the endo-dermis during root middle cortex formation.Although NAC1-TPL is recruited to the CYCD6;1 promoter and represses its transcription in an SCR-dependent manner,NAC1 and SHR antagonize each other to regu-late the expression of CYCD6;1.Collectively,our study provides mechanistic insights into how the NAC1-TPL module integrates with the master transcriptional regulators SCR and SHR to control root ground tissue patterning by fine-tuning spatiotemporal expression of CYCD6;1 in Arabidopsis. | Chuantian Xie Cuiling Li Fengxia Wang Feng Zhang Jiajia Liu Junxia Wang Xiansheng Zhang Xiangpei Kong Zhaojun Ding | 2023 | Molecular Plant2023，16，4： | 1 |
| 12 | IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgE levels in patients with chronic hepatitis B virus infection显示文摘 | Na Li Qianqian Zhu Zhu Li Qunying Han Jinghong Chen Yi Lv Yawen Wang Xiaoyan Zeng Yanping Chen Cuiling Yang Zhengwen Liu | 2013 | Human Immunology2013，，： | 1 |
| 13 | Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury显示文摘 | Yuhua Wang Yanlong Liu Irina Kirpich Zhenhua Ma Cuiling Wang Min Zhang Jill Suttles Craig McClain Wenke Feng | 2013 | The Journal of Nutritional Biochemistry2013，，： | 1 |
| 14 | Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes显示文摘It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient outcome.Here,we report that osteosarcoma Rab22a-NeoF1 fusion protein,together with its binding partner PYK2,is sorted into exosomes by HSP90 via its KFERQ-like motif(RVLFLN^(142)).The exosomal Rab22a-NeoF1 fusion protein facilitates the pulmonary pre-metastatic niche formation by recruiting bone marrow-derived macrophages.The exosomal PYK2 activates RhoA in its negative recipient osteosarcoma cells and induces signal transducer and activator of transcription 3 activation in its recipient macrophages to increase M2 phenotype.Consequently,lung metastases of its recipient osteosarcoma cells are promoted by this exosomal Rab22a-NeoF1 fusion protein,and this event can be targeted by disrupting its interaction with PYK2 using a designed internalizing RGD peptide. | Li Zhong Dan Liao Jingjing Li Wenqiang Liu Jingxuan Wang Cuiling Zeng Xin Wang Zhiliang Cao Ruhua Zhang Miao Li Kuntai Jiang Yi-Xin Zeng Jianhua Sui Tiebang Kang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 15 | Genetic variations of PD1 and TIM3 are differentially and interactively associated with the development of cirrhosis and HCC in patients with chronic HBV infection显示文摘 | Zhu Li Na Li Qianqian Zhu Guoyu Zhang Qunying Han Pingping Zhang Meng Xun Yawen Wang Xiaoyan Zeng Cuiling Yang Zhengwen Liu | 2013 | Infection, Genetics and Evolution2013，，： | 1 |
| 16 | Development and application of a universal Taqman real-time PCR for quantitation of duck hepatitis B virus DNA显示文摘 | Yawen Wang Yiping Li Cuiling Yang Lingyun Hui Qunying Han Lieting Ma Quanying Wang Guangxiao Yang Zhengwen Liu | 2013 | Journal of Virological Methods2013，，1： | 1 |
| 17 | Multi-point and multi- interval availabilities 显示文摘 | CuIL R Du S J LIU B L | 2013 | IEEE Transactions on Relia- bility2013，62，4： | 1 |
| 18 | Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice显示文摘 | Rui-Hong Wang Kundan Sengupta Cuiling Li Hyun-Seok Kim Liu Cao Cuiying Xiao Sangsoo Kim Xiaoling Xu Yin Zheng Beverly Chilton Rong Jia Zhi-Ming Zheng Ettore Appella Xin Wei Wang Thomas Ried Chu-Xia Deng | 2008 | Cancer Cell2008，，4： | 1 |
| 19 | Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo显示文摘The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2)is a global crisis.Clinical candidates with high efficacy,ready availability,and that do not develop resistance are in urgent need.Despite that screening to repurpose clinically approved drugs has provided a variety of hits shown to be effective against SARS-CoV-2 infection in cell culture,there are few confirmed antiviral candidates in vivo.In this study,94 compounds showing high antiviral activity against SARS-CoV-2 in Vero E6 cells were identified from 2,580 FDA-approved small-molecule drugs.Among them,24 compounds with low cytotoxicity were selected,and of these,17 compounds also effectively suppressed SARS-CoV-2 infection in He La cells transduced with human ACE2.Six compounds disturb multiple processes of the SARSCoV-2 life cycle.Their prophylactic efficacies were determined in vivo using Syrian hamsters challenged with SARS-CoV-2infection.Seven compounds reduced weight loss and promoted weight regain of hamsters infected not only with the original strain but also the D614G variant.Except for cisatracurium,six compounds reduced hamster pulmonary viral load,and IL-6 and TNF-αm RNAwhen assayed at 4 d postinfection.In particular,sertraline,salinomycin,and gilteritinib showed similar protective effects as remdesivir in vivo and did not induce antiviral drug resistance after 10 serial passages of SARS-CoV-2 in vitro,suggesting promising application for COVID-19 treatment. | Haoran Peng Cuiling Ding Liangliang Jiang Wanda Tang Yan Liu Lanjuan Zhao Zhigang Yi Hao Ren Chong Li Yanhua He Xu Zheng Hailin Tang Zhihui Chen Zhongtian Qi Ping Zhao | 2022 | Science China(Life Sciences)2022，65，6： | 1 |
| 20 | Experimentationof detecting the chlorpyrifos content in solution by near infraredspectroscopy显示文摘 | LIU Cuiling SUI Shuxia WU Jingzhu | 2009 | Trans Chin Soc Agric Mach2009，40，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员