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| 1 | Expression of MRP14 gene is frequently down-regulated in Chinese human esophageal cancer显示文摘Migration inhibitory factor-related protein 14 (MRP 14) is one of calcium-binding proteins,referred as S 100A9. The heterodimeric molecule formed by MRP 14 with its partner MRP8 (S 100A8) is the major fatty acid carrier in neutrophils.The MRP8/14 complex has been also implicated in the intracellular transport of arachidonic acid and its precursors in keratinocytes. We show here the involvement of MRP14 in human esophageal cancer. In an initial study,mRNA differential display - reverse transcription polymerase chain reaction (DD-PCR) was performed with two esophageal carcinomas,one esophageal adenocarcinoma and matched normal adjacent mucosa. DD-PCR with the arbitrary primer OPA3 showed that one cDNA band was highly expressed in normal tissues,but disappeared or substantially decreased in tumor counterparts. It was later identified to be the 3'-end of migration inhibitory factor-related protein 14 (MRP14).Northern blotting,RT-PCR and Western blotting corroborated the down-regulation of MRP14 in 58/64 squamous cell carcinomas and 2/2 adenocarcinomas as compared with adjacent normal epithelia of the esophagus. MRP14 was undetectable in 3/3 esophageal-carcinoma cell lines. Immunochemistry demonstrated that expression of MRP14 was restricted to normal esophageal epithelia. No mutation was found in the genomic DNA of the MRP14 gene by PCR and directed DNA sequencing. Our finding suggested that the reduction of MRP14 expression is a frequent event in Chinese human esophageal cancer. | JieWANG YanCAI HaoXU JunZHAO XinXU YaLingHAN ZhiXiongXU BaoShengCHEN HaiHU MinWU MingRongWANG | 2004 | Cell Research2004，14，1： | 17 |
| 2 | Efficacy of Atorvastatin combined with adipose-derived mesenchymal stem cell transplantation on cardiac function in rats with acute myocardial infarction显示文摘间充质的干细胞(MSC ) 广泛地被申请了在尖锐心肌的梗塞(AMI ) 以后的 cardiomyocytes 损失的恢复。然而,在 ischemic 心疾病的 MSC 的最佳的治疗学的功效被他们的差的幸存和低区分的率妨碍了。因此, MSC 幸存的改进和区分的率被保证并且为在 AMI 的 MSC 的功效批评。在这份报纸,从腹股沟的胖纸巾作为脂肪质导出被称为间充质的干细胞(ASC ) 的老鼠孤立的 MSC,和 ASC 的第四个段落被文化 co 在一个 transwell 系统与 cardiomyocytes 预先指定作为 co-ASCs 称为。十四天以后, GATA-4 (一个抄写因素) 和心脏的 troponin -- 我被细胞的 immunofluorescence 检测。Atorvastatin (Ator 组) 或车辆(控制组) 在老鼠在 AMI 生产以后为开始的 24 h 被管理。十四天以后,煽动性的参数和心脏的功能被评估。另外的幸存老鼠与 1 普物敭 ? 潴戠 ? 的一个总数被注射 ? 楤敲瑣琠牡敧 ? 敧敮漠 ? 業??? 祢攠桮湡散 ? 牧敥 ? 汦潵敲 ' 諟?牰瑯楥? 敲潰瑲牥攠灸牥浩湥吗? | Anping Cai Dongdan Zheng Yugang Dong Ruofeng Qiu Yuli Huang Yuanbin Song Zhigao Jiang Shaoqi Rao Xinxue Liao Jian Kuang Gang Dai Weiyi Mai | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 16 |
| 3 | Glial cell-derived neurotrophic factor mRNA expression in a rat model of spinal cord injury following bone marrow stromal cell transplantation显示文摘BACKGROUND: Several animal experiments utilizing bone marrow stromal cell (BMSC) transplantation for the treatment of spinal cord injury have proposed a hypothesis that BMSC transplantation effects are associated with increased glial cell-derived neurotrophic factor (GDNF) expression. OBJECTIVE: To confirm the effects of BMSC transplantation on GDNF mRNA expression in rats with spinal cord injury by reverse transcription-polymerase chain reaction (RT-PCR). DESIGN, TIME AND SETTING: The present molecular, cell biology experiment was performed at the Key Laboratory of Children's Congenital Malformation, Ministry of Health of China & Department of Developmental Biology, Basic Medical College, China Medical University between March 2006 and May 2007. MATERIALS: Sixty healthy Wistar rats aged 2-4-months and of either gender were included in this study. Spinal cord injury was induced in all rats by hemisection of T9 on the left side. RT-PCR kits were purchased from TaKaRa Company, China. Type 9600 RCR amplifier was provided by PerkinElmer Company, USA. METHODS: Three rats were selected for BMSC culture and subsequent transplantation (after three passages). Of the remaining 57 rats, nine were selected for sham-operation (sham-operated group), where only the T9 spinal cord was exposed without hemisection. A total of 48 rats were randomly and evenly divided into BMSC transplantation and model groups. In the BMSC transplantation group, following spinal cord injury induction, each rat was administered a BMSC suspension through two injection sites selected on the gray and white matter boundary caudally and cephalically, seperately and near to injury site in the spinal cord. The model group received an equal volume of PBS through the identical injection sites. MAIN OUTCOME MEASURES: At 24 and 72 hours, as well as at 7 days, following spinal cord injury, the spinal cord at the T 9 segment was removed. Eight rats were allocated to each time point in the BMSC transplantation and model groups, with three rats allocated to the sham-operated group. GDNF mRNA expression was semiquantitatively analyzed by RT-PCR. RESULTS: The sham-operated group exhibited extremely low GDNF mRNA expression. GDNF mRNA expression significantly increased at 24 hours after spinal cord injury, reached a peak level at 72 hours, and slowly decreased thereafter. However, it remained higher than normal levels at 7 days (P < 0.05). At all time points following spinal cord injury, GDNF mRNA expression was significantly greater in the BMSC transplantation group than in the model group (P < 0.05). CONCLUSION: Transplantation of BMSCs into the injured spinal cord up-regulated GDNF mRNA expression, thereby promoting repair of the injured spinal cord. | Lei Li Gang Lu Yanfeng Wang Hong Gao XinXu Lunhao Bai Lunhao Bai Huan Wang | 2008 | Neural Regeneration Research2008，3，10： | 13 |
| 4 | Singularity Analysis of a 3-RPS Parallel Manipulator Using Geometric Algebra显示文摘Singular configurations must be avoided in path planning and control of a parallel manipulator. However, most studies rarely focus on an overall singularity loci distribution of lower-mobility parallel mechanisms. Geometric algebra is employed in analysis of singularity of a 3-RPS parallel manipulator. Twist and wrench in screw theory are represented in geometric algebra. Linear dependency of twists and wrenches are described by outer product in geometric algebra. Reciprocity between twists and constraint wrenches are reflected by duality. To compute the positions of the three spherical joints of the 3-RPS parallel manipulator, Tilt-and-Torsion angles are used to describe the orientation of the moving platform. The outer product of twists and constraint wrenches is used as an index for closeness to singularity(ICS) of the 3-RPS parallel manipulator. An overall and thorough perspective of the singularity loci distribution of the 3-RPS parallel manipulator is disclosed, which is helpful to design, trajectory planning and control of this kind of parallel manipulator. | LI Qinchuan XIANG Ji'nan CHAI Xinxue WU Chuanyu | 2015 | Chinese Journal of Mechanical Engineering2015，28，6： | 12 |
| 5 | Comparison of thermal and light performance in two typical Chinese solar greenhouses in Beijing显示文摘Solar greenhouses have been used for producing vegetables in northern China during early spring,late autumn or over-winter.To improve the thermal performance of solar greenhouses,a traditional type and a retrofitted design were comparatively evaluated.In the retrofitted design,three adjustments were incorporated:the material and structure of the walls,south-facing roof angle,and structure of the north-facing back-roof.The results indicated that the thermal and light performance of the retrofitted greenhouse was much better than that of the traditional greenhouse.Specifically,the daily mean temperature,minimum air temperature,and soil temperature inside the greenhouses after retrofit ting were increased by 1.3,2.4,and 1.9℃,respectively,meanwhile,the daily total solar radiation and PAR were increased by 28.2%and 9.2%,respectively.The wall temperature and its daily variation range were reduced with increasing depth and height.The characteristic analysis of heat storage and release indicated that higher locations have longer heat storage,and shorter heat release time in vertical direction,as well as a lower ratio of heat release to storage.In horizontal direction,the western wall has the shortest heat storage time but the highest heat release flux density.Altogether,the heat storage time of the wall is 1.5 h less than that of the soil.The heat storage flux density of the wall is 1.5 times of that of the soil,but the heat release flux is only 61%of the soil’s value.The total wall heat storage is half of that of the soil in the greenhouse;the total wall heat release amount is only a quarter of that of the soil.Therefore,the thermal environment of solar greenhouses can be further improved by improving the thermal insulation properties of the wall. | Fan Xu Chao Shang Hongling Li Xuzhang Xue Weituo Sun Hong Chen Yinkun Li Zhenhe Zhang Xinxu Li Wenzhong Guo | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 4 |
| 6 | Randomized crossover study comparing efficacy of transnasal endoscopy with that of standard endoscopy to detect Barrett’s esophagus显示文摘 | M. Kareem Shariff Elizabeth L. Bird-Lieberman Maria O'Donovan Zarah Abdullahi Xinxue Liu Jane Blazeby Rebecca Fitzgerald | 2012 | Gastrointestinal Endoscopy2012，，5： | 2 |
| 7 | Changes of ECM and CAM gene expression profile in the cirrhotic liver after HCV infection: Analysis by cDNA expression array显示文摘AIM: We aimed to observe the expression of extracellular matrix (ECM) and cellular adhesion molecules (CAM) in cirrhotic liver tissues after hepatitis C virus (HCV) infection. METHODS: Twelve patients with post HCV inflammatory liver cirrhosis were selected to evaluate their liver function and other virological, pathological parameters. Then three specimens of cirrhotic patients whose health assessment results and laboratory data were similar and three normal liver specimens explanted from liver grafts prepared for liver transplantation were chosen for investigating gene expression of ECM and CAM using cDNA expression array. RESULTS: The cDNA array assay revealed 36.7% (36/96)of genes with changes, in which 26.3% (26/96) was up regulated and 10.1% (10/96) was down-regulated. Integrin (ITGA), collagen (COL), ADAMTS were identified as the characteristic changes of ECM and CAM gene expression levels. ITGA were demonstrated β1 and β2 sub-section changed in liver cirrhosis.CONCLUSION: ECM and CAM play an important role inthe progression of liver cirrhosis after HCV infection. The capital mechanism is related to the inflammatory cellsinfiltration, the activation and transformation of ECM producing cells and the imbalance between production and elimination of ECM. | XinXu Yi-MingLi HongJi Chong-ZhiHou Ying-BoCheng Fu-PingMa | 2005 | World Journal of Gastroenterology2005，11，14： | 2 |
| 8 | Exogenous hydrogen sulfide protects H9c2 cardiac cells against highglucose-induced injury by inhibiting the activities of the p38 MAPK and ERK1/2pathways显示文摘 | Wenming Xu Wen Wu Jingfu Chen Runmin Guo Jiancong Lin Xinxue Liao Jianqiang Feng | 2013 | International Journal of Molecular Medicine2013，，4： | 2 |
| 9 | Polyvinyl acetate/poly(amide-12-b-ethylene oxide) blend membranes for carbon dioxide separation显示文摘In this paper,blend membranes from polyvinyl acetate(PVAc)and block copolymer poly(amide-12-b-ethylene oxide)(Pebax1074)are prepared by solution casting and solvent evaporation method.Although they are homogeneous on a macro-scale,the observations from DSC and SEM indicate micro-phase separation for PVAc/Pebax1074 blend membranes.With the increase of Pebax1074 content,gas permeabilities of CO2,H2,N2and CH4all increase greatly.PVAc/Pebax1074 blend membranes with high PVAc content are appropriate for CO2/CH4separation.The temperature dependence of gas permeability is divided into rubbery region and glassy region.The activation energies of permeation in rubbery region are smaller than those in glassy region,and they all decrease with increasing Pebax1074 content.For N2,H2and CH4,their gas permeation properties are mainly influenced by the dual-mode sorption and hydrostatic pressure effect.But for CO2,its permeability increases with the increase of pressure due to CO2-induced plasticization effect,which is more obvious for PVAc/Pebax1074 blend membranes with high PVAc content. | Shichao Feng Jizhong Ren Hui Li Kaisheng Hua Xinxue Li Maicun Deng | 2013 | Journal of Energy Chemistry2013，22，6： | 1 |
| 10 | Strength Opti-mization Design of Box-shape Arms of a Scissor Lift Mecha-nism with Single Hydraulic Cylinder显示文摘 | ZHANG Wei WANG Xinxu WANG Liwen | | 0，，01： | 1 |
| 11 | Application of atomic force microscopy in blood research显示文摘AIM: To find suitable solutions having lesser granules and keeping erythrocytes in normal shapes under atomic force microscopy (AFM).METHODS: Eight kinds of solutions, 1% formaldehyde,PBS buffer (pH7.2), citrate buffer (pH6,0), 0.9% NaCl,5% dextrose, TAE, 1640 medium and 5% EDTA-K2, were selected from commonly used laboratory solutions, and venous blood from a healthy human volunteer was drawn and anticoagulated with EDTA-K2. Before scanned by AFM (NanoScopeⅢa SPM, Digital Instruments, Santa Barbara,CA), a kind of intermixture was deposited on freshly cleaved mica and then dried in the constant temperature cabinet (37 ℃).RESULTS: One percent formaldehyde, citrate buffer, 5%dextrose, TAE, were found to keep human erythrocytes in normal shape with few particles. Processed by these solutions, fine structures of human erythrocyte membrane were obtained.CONCLUSION: One percent formaldehyde, citrate buffer,5% dextrose and TAE may be applied to disposeerythrocytes in AFM. The results may offer meaningful data for clinical diagnosis of blood by AFM. | Xiao-LongJi Ya-MinMa TongYin Ming-ShiShen XinXu WeiGuan | 2005 | World Journal of Gastroenterology2005，11，11： | 1 |
| 12 | Randomized crossover study comparing efficacy of transnasal endoscopy with that of standard endoscopy to detect Barrett’s esophagus显示文摘 | M. Kareem Shariff Elizabeth L. Bird-Lieberman Maria O’Donovan Zarah Abdullahi Xinxue Liu Jane Blazeby Rebecca Fitzgerald | 2012 | Gastrointestinal Endoscopy2012，，： | 1 |
| 13 | Strength Opti- mization Design of Box-shape Arms of a Scissor Lift Mecha- nism with Single Hydraulic Cylinder显示文摘 | ZHANG Wei WANG Xinxu WANG Liwen | 2012 | Applied Mechan- ics and Materials2012，141，1： | 1 |
| 14 | An anti-freezing biomineral hydrogel of high strain sensitivity for artificial skin applications显示文摘Mineral hydrogels have caught a lot of attention for their strong competency as artificial skin-like materials.Nonetheless,it remains a great difficulty in fulfilling in one hydrogel system a range of key functionalities that are needed for practical artificial skin applications,i.e.,to be biocompatible,strain-sensitive,ion-conductive,elastic and robust,anti-swelling,and anti-freezing.Here we present a such type of versatile hydrogel that is not only capable to deliver all the above-mentioned key functionalities but also highly stable.This novel hydrogel is constructed by introducing a gelatinous and amorphous multi-ionic biomineral(denoted as Mg-ACCP,containing Mg^(2+),Ca^(2+),CO_(3)^(2−),and PO_(4)^(3−))into the network of biocompatible polyvinyl alcohol(PVA)and sodium alginate(SA).The presence of Mg^(2+)and PO_(4)^(3−)in this hydrogel helps prohibit the crystallization of the biominerals,leading to significantly improved stability.The hydrogel thus obtained delivers excellent mechanical performance due to the chelation between the mineral ions and the organic matrix,and high sensitivity even to subtle pressure and strain applied,such as slight finger bending and gentle tapping.Furthermore,the novel hydrogel features high ionic conductivity,high resistance to swelling,and extraordinary anti-freezing property,holding great promise for applications in different practical scenarios,particularly in aqueous or cold environments. | Junda Shen Peng Du Binbin Zhou Guobin Zhang Xinxue Tang Jie Pan Bo Li Jingyang Zhang Jian Lu Yang Yang Li | 2022 | Nano Research2022，15，7： | 1 |
| 15 | Relationship Between Syphilis and HIV Infections Among Men Who Have Sex With Men in Beijing, China显示文摘 | Yuhua Ruan Dongliang Li Xinxu Li Han-zhu Qian Wei Shi Xiaoxi Zhang Zhenkai Yang Xiaoyan Zhang Chen Wang Yingjie Liu Miao Yu Dong Xiao Chun Hao Hui Xing Kunxue Hong Yiming Shao | 2007 | Sexually Transmitted Diseases2007，，8： | 1 |
| 16 | A fast computational method for the landing footprints of space-to-ground vehicles显示文摘Fast computation of the landing footprint of a space-to-ground vehicle is a basic requirement for the deployment of parking orbits, as well as for enabling decision makers to develop real-time programs of transfer trajectories. In order to address the usually slow computational time for the determination of the landing footprint of a space-to-ground vehicle under finite thrust, this work proposes a method that uses polynomial equations to describe the boundaries of the landing footprint and uses back propagation(BP) neural networks to quickly determine the landing footprint of the space-to-ground vehicle. First, given orbital parameters and a manoeuvre moment, the solution model of the landing footprint of a space-to-ground vehicle under finite thrust is established. Second, given arbitrary orbital parameters and an arbitrary manoeuvre moment, a fast computational model for the landing footprint of a space-to-ground vehicle based on BP neural networks is provided.Finally, the simulation results demonstrate that under the premise of ensuring accuracy, the proposed method can quickly determine the landing footprint of a space-to-ground vehicle with arbitrary orbital parameters and arbitrary manoeuvre moments. The proposed fast computational method for determining a landing footprint lays a foundation for the parking-orbit configuration and supports the design of real-time transfer trajectories. | LIU Qingguo LIU Xinxue WU Jian LI Yaxiong | 2020 | Journal of Systems Engineering and Electronics2020，31，5： | 1 |
| 17 | An ILC scheme for a class of nonlinear continuous‐time systems with time‐iteration‐varying parameters subject to second‐order internal model显示文摘 | ChenkunYin Jian‐XinXu ZhongshengHou | 2011 | Asian Journal of Control2011，，1： | 1 |
| 18 | Syphilis Among Female Sex Workers in Southwestern China: Potential for HIV Transmission显示文摘 | Yuhua Ruan Xiaoyun Cao Han-Zhu Qian Li Zhang Guangming Qin Zhengqing Jiang Benli Song Wei Hu Shu Liang Kanglin Chen Ye Yang Xinxu Li Jun Wang Xi Chen Chun Hao Yanhui Song Hui Xing Ning Wang Yiming Shao | 2006 | Sexually Transmitted Diseases2006，，12： | 1 |
| 19 | Predictors of Unprotected Sex Among Men Who Have Sex With Men in Beijing 显示文摘 | Xinxu Li Wei Shi Dongliang Li | 2008 | Southeast Asian Journal of Tropical Medicine and Public Health2008，39，1： | 1 |
| 20 | Risk Factors for Syphilis and Prevalence of HIV, Hepatitis B and C among Men Who Have Sex with Men in Beijing, China: Implications for HIV Prevention显示文摘 | Yuhua Ruan Fengji Luo Yujiang Jia Xinxu Li Qingchun Li Hongyuan Liang Xiaoxi Zhang Dongliang Li Wei Shi Jennifer M. Freeman Sten H. Vermund Yiming Shao | 2009 | AIDS and Behavior2009，，： | 1 |
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