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| 1 | 2D titanium carbide(MXene) electrodes with lower-F surface for high performance lithium-ion batteries显示文摘MXene has shown distinctive advantages as anode materials of lithium-ion batteries. However, local surface chemistry, which was confirmed that can block ion transfer and limit redox reaction, has a significant effect on electrochemical performance. Herein, annealing MXene under hydrogen was employed for removing-F and turning-OH to-O terminations. We demonstrate that it improves the kinetics of Li-ion transport between the electrolyte and electrode. As a result, a lower interfacial charge transfer impedance was obtained. The electrochemical measurement exhibited that a nearly 2-fold increase of specific capacity was achieved for the annealed MXene. | Ming Lu Haojie Li Wenjuan Han Junnan Chen Wen Shi Jiaheng Wang Xiang-Min Meng Jingang Qi Haibo Li Bingsen Zhang Wei Zhang Weitao Zheng | 2019 | Journal of Energy Chemistry2019，28，4： | 8 |
| 2 | Comparison of alternative extraction methods for secretome profiling in human hepatocellular carcinoma cells显示文摘Secreted proteins are important sources for early detection and diagnosis of disease, and as such have received considerable attention. The extraction of low concentration proteins from large volumes of culture media, which are rich in salts and other compounds that interfere with most proteomics techniques, presents a problem for secretome studies. Ultrafiltration, precipitation, and dialysis are three major extraction methods that can be used to overcome this problem. The present study for the first time, compared the merits and shortcomings of these three methods, without bias. Centrifugal ultrafiltration provided the best extraction efficiency, and precipitation provided the highest number of identifiable proteins. The three methods yielded closely related, but different, information on the secretome; thus, they should be considered complementary or, at least, supplementary methods. Three hundred and sixty unique proteins were identified, including 211 potential secreted proteins. Compared with previous studies, this study also identified 42 new secreted proteins. The present study not only offers a reference for the selection of secretome extraction methods, but also expands the secretome database for the investigation of hepatocellular carcinoma. | CAO Jing SHEN ChengPin ZHANG Jun YAO Jun SHEN HuaLi LIU YinKun LU HaoJie YANG PengYuan | 2011 | Science China(Life Sciences)2011，54，1： | 8 |
| 3 | Protein expression and fucosylated glycans of the serum haptoglobin-β subunit in hepatitis B virus-based liver diseases显示文摘Glycosylation,调整 glycoproteins 的配置和功能,是最重要的 translational 以后修正。学习是在 glycan 和浆液 haptoglobin- 子单元(Hp-) 的蛋白质部分观察微分模式的这的目的与肝炎 B 从病人净化了病毒(HBV ) 感染,肝肝硬化(LC ) ,或 hepatocellular 癌(HCC ) 。2-D 胶化电气泳动和多路的 proteomics 染色技术被采用调查 Hp- glycan 水平是否与蛋白质水平成正比。Multi-lectin 污点,高效的液体层析(HPLC ) ,和西方的污点分析被执行识别 Hp- 份量上的 glycoform。我们的实验证明到 Hp- 的 glycosylated 形式的全部的浆液 Hp- 的比率与不同的肝疾病在病人之中变化了。全部的 Hp- 蛋白质表示水平比 LC 在 HCC 是高得多的,当 fucosylated Hp- 的一个增长比例也在 HBV 和健康控制与那相比在 LC 和 HCC 病人被观察时。微分 fucosylation 被 HPLC 和反人的 SialylLewis X 抗体进一步作为路易斯十世结构识别。在结论, Hp- glycan 和全部的蛋白质表示的异常引申可以是为早 hepatocarcinogenesis 的有希望的 biomarker。 | Hong Shu Shu Zhang Xiaonan Kang Shan Li Xue Qin Chun Sun Haojie Lu Yinkun Liu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 6 |
| 4 | Physical sensors for skin-inspired electronics显示文摘Skin,the largest organ in the human body,is sensitive to external stimuli.In recent years,an increasing number of skin-inspired electronics,including wearable electronics,implantable electronics,and electronic skin,have been developed because of their broad applications in healthcare and robotics.Physical sensors are one of the key building blocks of skin-inspired electronics.Typical physical sensors include mechanical sensors,temperature sensors,humidity sensors,electrophysiological sensors,and so on.In this review,we systematically review the latest advances of skin-inspired mechanical sensors,temperature sensors,and humidity sensors.The working mechanisms,key materials,device structures,and performance of various physical sensors are summarized and discussed in detail.Their applications in health monitoring,human disease diagnosis and treatment,and intelligent robots are reviewed.In addition,several novel properties of skin-inspired physical sensors such as versatility,self-healability,and implantability are introduced.Finally,the existing challenges and future perspectives of physical sensors for practical applications are discussed and proposed. | Shuo Li Yong Zhang Yiliang Wang Kailun Xia Zhe Yin Huimin Wang Mingchao Zhang Xiaoping Liang Haojie Lu Mengjia Zhu Haomin Wang Xinyi Shen Yingying Zhang | 2020 | InfoMat2020，2，1： | 5 |
| 5 | Employing MXene as a matrix for loading amorphous Si generated upon lithiation towards enhanced lithium-ion storage显示文摘Although Si-based nanomaterials provide incomparable lithium ion storage ability in theory, it suffers from low initial Coulombic efficiency, electrical disconnection, and fracture due to huge volume changes after extended cycles. As a result, it leads to a severe capacity fading and an increase in internal impedance. Herein, Ti-elemental MXene was employed as a matrix for the intermediate product of Si electrodes. The boundary between the inner core of pristine Si and its outer shell of amorphous Li x Si alloy was reconstructed. Smaller amorphous aggregates were observed in the MXene&Si hybrid electrode after 500 cycles by using transmission electron microscopy. Consequently, an enhanced specific capacity was achieved as MXene as a matrix enables loading amorphous Si. | Haojie Li Ming Lu Wenjuan Han Haibo Li Yucheng Wu Wei Zhang Jiaheng Wang Bingsen Zhang | 2019 | Journal of Energy Chemistry2019，28，11： | 4 |
| 6 | Quantitative analysis of site-specific N-glycans on sera haptoglobin βchain in liver diseases显示文摘在有临床的申请的潜力的 glycoproteins 的 N-glycans 的地点特定的描述是重要的。在我们的以前的报告,链被发现在肝疾病不同的 sera haptoglobin (Hp ) 的全面 N-glycans。Hp 链包含 N-glycosylation 的四个潜在的地点。在这研究,我们以一种地点特定的方式在 Hp 链上调查了 N-glycans 的潜在的变化。在象有肝炎 B 病毒( HBV )的病人一样的健康个人的 Sera Hp 链,肝肝硬化( LC )和 hepatocellular 癌( HCC )被净化,消化并且使遭到了到液体 chromatography-electrospray 电离高度精力碰撞分离团 spectrometry ,它允许鉴定和 glycopeptide 的结构决心,象在每 glycopeptide 上在场的 glycans 的相对 quantification 一样。量的结果表明 NLFLN207HSEN211ATAK 和 fucosylated 的 sialylation 根本组织在 HBV 病人和健康个人与那些相比在 LC 和 HCC 病人显著地增加的 glycopeptides。在各种各样的肝疾病的 Hp 链的一套不同 N-glycan 模式被决定了。因此, sialylated 和 Hp 链力量的 fucosylated glycoforms 与早 hepatocarcinogenesis 有关并且可能也作为为 LC 和 HCC 病人的新奇微分标记有用。 | Shu Zhang Kai Jiang Chun Sun Haojie Lu Yinkun Liu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 3 |
| 7 | Advancements in mass spectrometry-based glycoproteomics and glycomics显示文摘Protein N-glycosylation plays a crucial role in a considerable number of important biological processes.Research studies on glycoproteomes and glycomes have already characterized many glycoproteins and glycans associated with cell development, life cycle, and disease progression. Mass spectrometry(MS) is the most powerful tool for identifying biomolecules including glycoproteins and glycans, however, utilizing MS-based approaches to identify glycoproteomes and glycomes is challenging due to the technical difficulties associated with glycosylation analysis. In this review, we summarize the most recent developments in MS-based glycoproteomics and glycomics, including a discussion on the development of analytical methodologies and strategies used to explore the glycoproteome and glycome, as well as noteworthy biological discoveries made in glycoproteome and glycome research. This review places special emphasis on China, where scientists have made sizeable contributions to the literature, as advancements in glycoproteomics and glycomincs are occurring quite rapidly. | Haojie Lu Ying Zhang Pengyuan Yang | 2016 | National Science Review2016，3，3： | 3 |
| 8 | Nascent Proteome and Glycoproteome Reveal the Inhibition Role of ALG1 in Hepatocellular Carcinoma Cell Migration显示文摘Asparagine-linked glycosylation protein 1 homolog(ALG1)participates in the initial stage of protein N-glycosylation and N-glycosylation has been implicated in the process of hepatocellular carcinoma(HCC)progression.However,whether ALG1 plays a role in human HCC remains unknown.In this study,the expression profile of ALG1 in tumorous and corresponding adjacent non-tumor tissues was analyzed.The relationship of ALG1 expression with clinical features and prognosis of HCC patients was also evaluated using immuno-histochemical method.Here we found ALG1 decreased in HCC tissues compared with adjacent normal liver tissues,which predicted an unfavorable prognosis.Combined with RNA interference,nascent proteome and glycoproteome were determined systematically in Huh7 cell line.Bioinformatics analysis indicated that the differentially expressed proteins participating in the response of ALG1 knockdown were most significantly associated with cell-cell adhesion.Functional studies confirmed that knockdown of ALG1 reduced cell adhesion capacity,and promoted cell migration.Furthermore,down-regulation of H8N2(on N-glycosite N651)and H5N4S2F1(on N-glycosite N692)from N-cadherin was identified as a feature of ALG1 knockdown.Our findings revealed that ALG1 controlled the expression of glycosylated N-cadherin and played a role in HCC migration,with implications for prognosis. | Xinyi Cao Yuyin Shao Peiyi Meng Zhao Cao Guoquan Yan Jun Yao Xinwen Zhou Chao Liu Lei Zhang Hong Shu Haojie Lu | 2022 | Phenomics2022，2，4： | 2 |
| 9 | Ultra-sensitive and wide applicable strain sensor enabled by carbon nanofibers with dual alignment for human machine interfaces显示文摘Flexible strain sensors with high sensitivity,wide detection range,and low detection limit have continuously attracted great interest due to their tremendous application potential in areas such as health/medical-care,human-machine interface,as well as safety and security.While both of a high sensitivity and a wide working range are desired key parameters for a strain sensor,they are usually contrary to each other to be achieved on the same sensor due to the tightly structure dependence of both of them.Here,a flexible strain sensor with both high sensitivity and wide strain detection range is prepared based on the design of an integrated membrane containing both of parallel aligned and randomly aligned carbon nanofibers(CNFs).The parallel aligned CNF membrane(p-CNF)exhibits a low strain detection limit and high sensitivity,while the random aligned CNF membrane(r-CNF)exhibits a large strain detection range.Taking the advantages of both p-CNF and r-CNF,the strain sensor with stacked p-CNF and r-CNF(p/r-CNF)exhibits both high sensitivity and wide working range.Its gauge factor(GF)is 1,272 for strains under 0.5%and 2,266 for strain from 70%to 100%.At the same time,it can work in a wide strain range of 0.005%to 100%,fulfilling the requirements for accurately detecting full-range human motions.We demonstrated its applications in the recognition of facial expressions and joint movements.Furtherly,we constructed an intelligent lip-language recognition system,which can accurately track phonetic symbols and may help people with language disabilities,proving the potential of this strain sensor in health management and medical assistance.Besides,we foresee that the dual-alignment structure design of the p/r-CNF strain sensor may also be applied in the design of other high performance sensors. | Peng Bi Mingchao Zhang Shuo Li Haojie Lu Haomin Wang Xiaoping Liang Huarun Liang Yingying Zhang | 2023 | Nano Research2023，16，3： | 2 |
| 10 | Silkworm Silk Fibers with Multiple Reinforced Properties Obtained through Feeding Ag Nanowires显示文摘Silkworm silk fbers have been woven into textiles for thousands of years,because of their attractive luster,good mechanical properties,excellent biocompatibility,and large-scale production.With the development of human society,preparation of silk fbers with modifed or enhanced properties are highly desirable for potential applications in structural materials and smart textiles.Herein,we realized the reinforcement of multiple properties of silk fbers by feeding silkworms with Ag nanowire(Ag NW)modifed diets.The obtained silk fbers show obviously enhanced comprehensive mechanical properties,including improved tensile strength,elongation at break,tensile modulus,and toughness,which are increased by 37.2%,37.6%,68.3%,and 69.8%,respectively.Furthermore,compared with unmodifed silk,the electrical conductivity and thermal conductivity of modifed silk fbers are improved by 246.4%and 32.1%,respectively.The analysis on the components and structure shows that the incorporated Ag NWs lead to increased content of random coil/α-helix,improved orientation of crystallites,and increased content of Ag compared to pristine silk fbers,which may contribute to the enhanced mechanical,electrical,and thermal properties. | Haojie Lu Muqiang Jian Zhe Yin Kailun Xia Shaoyi Shi Mingchao Zhang Huimin Wang Xiaoping Liang Weigang Ma Xing Zhang Yingying Zhang | 2022 | Advanced Fiber Materials2022，4，3： | 2 |
| 11 | A natural variation of an SVP MADS-box transcription factor in Triticum petropavlovskyi leads to its ectopic expression and contributes to elongated glume显示文摘Dear Editor,Triticum petropavlovskyi,commonly known as Xinjiang rice wheat,is a unique hexaploidy wheat grown in the Xinjiang area.T.petropavlovskyi is marked by its elongated glume(Eg)trait,which is controlled by gene P1pet located on chromosome 7A(Wang et al.,2002;Watanabe and Imamura,2002).The origin of T.petropavlovskyi has been disputed.It is generally accepted that P1pet was introduced from tetraploid polish wheat(T.polonicum)via a hybridization with hexaploid common wheat(T.aestivum)(Akond et al.,2008;Chen et al.,2016). | Jin Xiao Yan Chen Yifan Lu Zhipeng Liu Dongmei Si Tao Xu Li Sun Zongkuan Wang Chunxia Yuan Haojie Sun Xu Zhang Mingxing Wen Luyang Wei Wenli Zhang Haiyan Wang Xiue Wang | 2021 | Molecular Plant2021，14，9： | 2 |
| 12 | A chromosome-scale genome assembly of Dasypyrum villosum provides insights into its application as a broad-spectrum disease resistance resource for wheat improvement显示文摘Dasypyrum villosum is one of the most valuable gene resources in wheat improvement,especially for disease resistance.The mining of favorable genes from D.villosum is frustrated by the lack of a whole genome sequence.In this study,we generated a doubled-haploid line,91C43^(DH),using microspore culture and obtained a 4.05-GB high-quality,chromosome-scale genome assembly for D.villosum.The assembly contains39727 high-confidence genes,and 85.31% of the sequences are repetitive.Two reciprocal translocation events were detected,and 7VS-4VL is a unique translocation in D.villosum.The prolamin seed storage protein-coding genes were found to be duplicated;in particular,the genes encoding low-molecular-weight glutenin at the Glu-V3 locus were significantly expanded.RNA sequencing(RNA-seq)analysis indicated that,after Blumeria graminearum f.sp tritici(Bgt)inoculation,there were more upregulated genes involved in the pattern-triggered immunity and effector-triggered immunity defense pathways in D.villosum than in Triticum urartu.MNase hypersensitive sequencing(MH-seq)identified two Bgt-inducible MH sites(MHSs),one in the promoter and one in the 3'terminal region of the powdery mildew resistance(Pm)gene NLR1-V.Each site had two subpeaks and they were termed MHS1(MHS1.1/1.2)and MHS2(MHS2.1/2.2).Bgt-inducible MHS2.2 was uniquely present in D.villosum,and MHS1.1 was more inducible in D.villosum than in wheat,suggesting that MHSs may be critical for regulation of NLR1-V expression and plant defense.In summary,this study provides a valuable genome resource for functional genomics studies and wheat-D.villosum introgression breeding.The identified regulatory mechanisms may also be exploited to develop new strategies for enhancing Pm resistance by optimizing gene expression in wheat. | Xu Zhang Haiyan Wang Haojie Sun Yingbo Li Yilong Feng Chengzhi Jiao Mengli Li Xinying Song Tong Wang Zongkuan Wang Chunxia Yuan Li Sun Ruju Lu Wenli Zhang Jin Xiao Xiue Wang | 2023 | Molecular Plant2023，16，2： | 1 |
| 13 | Mechanically Reinforced Silkworm Silk Fiber by Hot Stretching显示文摘Silkworm silk,which is obtained from domesticated Bombyx mori(B.mori),can be produced in a large scale.However,the mechanical properties of silkworm silk are inferior to its counterpart,spider dragline silk.Therefore,researchers are continuously exploring approaches to reinforce silkworm silk.Herein,we report a facile and scalable hot stretching process to reinforce natural silk fibers obtained from silkworm cocoons.Experimental results show that the obtained hot-stretched silk fibers(HSSFs)retain the chemical components of the original silk fibers while being endowed with increasedβ-sheet nanocrystal content and crystalline orientation,leading to enhanced mechanical properties.Significantly,the average modulus of the HSSFs reaches 21:6±2:8 GPa,which is about twice that of pristine silkworm silk fibers(11:0±1:7 GPa).Besides,the tensile strength of the HSSFs reaches 0:77±0:13 GPa,which is also obviously higher than that of the pristine silk(0:56±0:08 GPa).The results show that the hot stretching treatment is effective and efficient for producing superstiff,strong,and tough silkworm silk fibers.We anticipate this approach may be also effective for reinforcing other natural or artificial polymer fibers or films containing abundant hydrogen bonds. | Haojie Lu Kailun Xia Muqiang Jian Xiaoping Liang Zhe Yin Mingchao Zhang Huimin Wang Haomin Wang Shuo Li Yingying Zhang | 2022 | Research2022，，3： | 1 |
| 14 | New lysine-acetylated proteins screened by immunoaffinity and liquid chromatography-mass spectrometry显示文摘The lack of selective extraction specific for lysine-acetylated proteins has been a major problem in the field of acetylation biology,though acetylation plays a key role in many biological processes.In this paper,we report for the first time the proteomic screening of lysine-acetylated proteins from a mouse liver tissue,by a new approach of immunoaffinity purification of lysine-acetylated peptides combined with nano-HPLC/MS/MS analysis.We have found 20 lysine-acetylated proteins with 21 lysine-acetylated sites,among which 12 lysine-acetylated proteins and 16 lysine-acetylated sites have never been reported before.Notably,three acetyltransferases harboring in mitochondrion are newly discovered acetyltransferases responsible for the acetylation of nonhistone proteins.We have explored the significant patterns of residue preference by the hierarchical clustering analysis of amino acid residues surrounding acetylation sites,which could be helpful to the prediction of new sites of lysine acetylation.Our findings provide more candidates for studying the important roles played by acetylation in diverse cellular pathways and related human diseases. | ZHANG Bing ZHAO Chao LUO KaiXuan YAN GuoQuan YAO Jun WANG YingYin LU HaoJie FAN HuiZhi YANG PengYuan | 2010 | Science China Chemistry2010，53，1： | 1 |
| 15 | High-throughput site-specific N-glycoproteomics reveals glyco-signatures for liver disease diagnosis显示文摘The glycoproteome has emerged as a prominent target for screening biomarkers,as altered glycosylation is a hallmark of cancer cells.In this work,we incorporated tandem mass tag labeling into quantitative glycoproteomics by developing a chemical labeling-assisted complementary dissociation method for the multiplexed analysis of intact N-glycopeptides.Benefiting from the complementary nature of two different mass spectrometry dissociation methods for identification and multiplex labeling for quantification of intact N-glycopeptides,we conducted the most comprehensive site-specific and subclass-specific N-glycosylation profiling of human serum immunoglobulin G(IgG)to date.By analysing the serum of 90 human patients with varying severities of liver diseases,as well as healthy controls,we identified that the combination of IgG1-H3N5F1 and IgG4-H4N3 can be used for distinguishing between different stages of liver diseases.Finally,we used targeted parallel reaction monitoring to successfully validate the expression changes of glycosylation in liver diseases in a different sample cohort that included 45 serum samples. | Zhenyu Sun Bin Fu Guoli Wang Lei Zhang Ruofan Xu Ying Zhang Haojie Lu | 2023 | National Science Review2023，10，1： | 1 |
| 16 | Berberine promotes glucagon-like peptide-1(7-36)amide secretion in streptozotocin-induced diabetic rats显示文摘 | LU Shousi YU Yunli ZHU Haojie | 2009 | Journal of Endocrinology2009，200，2： | 1 |
| 17 | Heterointerface Engineering of β‑Chitin/Carbon Nano‑Onions/Ni-P Composites with Boosted Maxwell‑Wagner‑Sillars Effect for Highly Efficient Electromagnetic Wave Response and Thermal Management显示文摘The rational construction of microstructure and composition with enhanced Maxwell-Wagner-Sillars effect(MWSE)is still a challenging direction for reinforcing electromagnetic wave(EMW)absorption performance,and the related EMW attenuation mechanism has rarely been elucidated.Herein,MWSE boostedβ-chitin/carbon nano-onions/Ni–P composites is prepared according to the heterointerface engineering strategy via facile layer-by-layer electrostatic assembly and electroless plating techniques.The heterogeneous interface is reinforced from the aspect of porous skeleton,nanomaterials and multilayer construction.The composites exhibit competitive EMW response mechanism between the conductive loss and the polarization/magnetic loss,as describing like the story of“The Hare and the Tortoise”.As a result,the composites not only achieve a minimum reflection loss(RL_(min))of−50.83 dB and an effective bandwidth of 6.8 GHz,but also present remarkable EMW interference shielding effectiveness of 66.66 dB.In addition,diverse functions such as good thermal insulation,infrared shielding and photothermal performance were also achieved in the hybrid composites as a result of intrinsic morphology and chemicophysics properties.Therefore,we believe that the boosted MWSE open up a novel orientation toward developing multifunctional composites with high-efficient EMW response and thermal management. | Fei Pan Lei Cai Yuyang Shi Yanyan Dong Xiaojie Zhu Jie Cheng Haojie Jiang Xiao Wang Yifeng Jiang Wei Lu | 2022 | Nano-Micro Letters2022，14，5： | 1 |
| 18 | State of the art recent advances and perspectives in 2D MXenebased microwave absorbing materials:A review显示文摘Recently,great efforts have been made to explore high-performance microwave absorbing(MA)materials,which aim to reduce the booming electromagnetic wave(EMW)pollution caused by electronic devices.MXenes(i.e.,two-dimensional(2D)transition metal carbide/nitride),an emerging family of 2D nanomaterials,demonstrate superiority to conventional nanomaterials,such as tunable electrical conductivity,unique layer structure,abundant terminal groups,and great physico-chemical properties,becoming potential candidate materials for high-efficiency MA.By hybridizing MXenes with other lossy mediums and designing novel microstructures,MA properties can be further optimized and enhanced for practical applications.Furthermore,MXenebased materials,with smartly designed multi-functionality,become a research priority to develop new or advanced applications for the coming“intelligent era”.This review focuses on using MXenes to effectively absorb EMW energy.In the first part,the fabricating methods of MXenes are systematically introduced followed by a second part on the progress of MXene-based materials regarding the MA performances,as well as a summarization on their next-generation smart multifunctional materials.In the final part,opinions on the future perspectives and opportunities of MXene-based MA materials are presented.It is believed that this review will pave the way for further flourishing the development of MXene-based materials in MA field. | Hongtao Guo Xiao Wang Fei Pan Yuyang Shi Haojie Jiang Lei Cai Jie Cheng Xiang Zhang Yang Yang Lixin Li Zheng Xiu Dan Batalu Wei Lu | 2023 | Nano Research2023，16，7： | 1 |
| 19 | Selective adsorption and separation of dyes from an aqueous solution on organic- inorganic hybrid cyclomatrix polyphosphazene submicro spheres显示文摘 | Wei Wei Lu Rongjie Xie Haojie | 2015 | Journal of Materials Chemistry A2015，3，8： | 1 |
| 20 | Association between sex hormone-binding globulin and kidney function in men: results from the SPECT-China study显示文摘Background::The association between sex hormone-binding globulin(SHBG)and renal function has rarely been reported in men.We aimed to investigate the above association in a community-based Chinese population.Methods::A total of 5027 men were included from the survey on prevalence for metabolic diseases and risk factors,which is a population-based study conducted from 2014 to 2016 in Eastern China.The estimated glomerular filtration rate(eGFR)was calculated according to the chronic kidney disease Epidemiology Collaboration equation.Low eGFR was defined as eGFR<60 mL·min-1·1.73 m-2.Results::After adjusting for age,smoking,metabolic factors,and testosterone,through increasing quartiles of SHBG,a significantly positive association between SHBG quartiles and eGFR was detected in men(Q1 vs.Q4,β-2.53,95%confidence interval-3.89,-1.17,Ptrend<0.001).Compared with the highest quartile of SHBG,SHBG in the lowest quartile was associated with 96%higher odds of low eGFR(odds ratio 1.96,95%confidence interval 1.10,3.48)in the model after full adjustment.According to the stratified analyses,the associations between a 1-standard deviation increase in serum SHBG and the prevalence of low eGFR were significant in men aged≥60 years old,waist circumference<90 cm,diabetes(no),hypertension(yes),dyslipidemia(no),and nonalcoholic fatty liver disease(no).Conclusions::Lower serum SHBG levels were significantly associated with lower eGFR and a higher prevalence of low eGFR in Chinese men independent of demographics,lifestyle,metabolic-related risk factors,and testosterone.Large prospective cohort and basic mechanistic studies are warranted in the future. | Haojie Zhang Chi Chen Xuan Zhang Yuying Wang Heng Wan Yi Chen Wen Zhang Fangzhen Xia Yingli Lu Ningjian Wang | 2022 | Chinese Medical Journal2022，135，17： | 1 |
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