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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 3 | 世界家庭医生组织(WONCA)研究论文摘要汇编——如何改进欧洲国家的全科医学/家庭医学发展状况:来自30个欧洲国家专家的建议显示文摘背景对全科医学/家庭医学(GP/FM)的管理、GP/FM医务人员能力、GP/FM服务开展状况、GP/FM学术发展及地位在欧洲各国存在很大的差异。世界卫生组织鼓励各国政府为其国民提供高质量的GP/FM服务,因为这是实现'人人健康'目标的必要条件。本研究旨在调查欧洲家庭医师组织协会(EURACT)成员就如何改进其所在国家的GP/FM的地位而提出建议。方法本研究使用了混合方法及探索性序列设计方案。来自32个欧洲国家的EURACT成员首次参加了在欧洲举行的如何改进GP/FM发展状况的头脑风暴活动。随后,由来自37个欧洲国家的代表使用利克特量表(9个条目)就EURACT代表提出的建议在其所在国家是否可行进行评分并加权计算,同时对其所在国家的GP/FM发展状况以4个维度来进行评价。结果有来自30个欧洲国家的代表完成了所有调查。研究对象一致认为,不管GP/FM在其国家目前发展状况如何,非常有必要确保将GP/FM建立一门在教学和科研方面并举发展的学科。来自将GP/FM视为非常重要或重要的国家的研究对象认为,将GP/FM现有发展水平提高到其他学科同等水平,此举非常重要。来自不重视GP/FM的国家代表称,已强调了设立共同学习目标并规定了参考书目。结论为了改进欧洲的GP/FM发展状况,EURACT及其他专业机构必须设立共同目标,欧洲各国应共享GP/FM专业知识。此外,让决策者了解GP/FM服务体系的成本效益也非常重要。 | ZARBAILOV N WILM S TANDETER H 本刊编辑部 | 2017 | 中国全科医学2017，20，29： | 7 |
| 4 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 5 | Single-operator cholangioscopy for biliary complications in liver transplant recipients显示文摘AIM To evaluate cholangioscopy in addition to endoscopic retrograde cholangiopancreatography(ERCP) for management of biliary complications after liver transplantation(LT).METHODS Twenty-six LT recipients with duct-to-duct biliary reconstruction who underwent ERCP for suspected biliary complications between April and December2016 at the university hospital of Muenster were consecutively enrolled in this observational study. After evaluating bile ducts using fluoroscopy, cholangioscopy using a modern digital single-operator cholangioscopy s y s t e m(S py G la s s D S ?) wa s pe r fo r me d dur ing the same procedure with patients under conscious sedation. All patients received peri-interventional antibiotic prophylaxis and bile was collected during the intervention for microbial analysis and for antibiotic susceptibility testing.RESULTS Thirty-three biliary complications were found in a total of 22 patients, whereas four patients showed normal bile ducts. Anastomotic strictures were evident in 14(53.8%) patients, non-anastomotic strictures in seven(26.9%), biliary cast in three(11.5%), and stones in six(23.1%). A benefit of cholangioscopy was seen in 12(46.2%) patients. In four of them, cholangioscopy was crucial for selective guidewire placement prior to planned intervention. In six patients, biliary cast and/or stones failed to be diagnosed by ERCP and were only detectable through cholangioscopy. In one case, a bile duct ulcer due to fungal infection was diagnosed by cholangioscopy. In another case, signs of bile duct inflammation caused by acute cholangitis were evident. One patient developed post-interventional cholangitis. No further procedure-related complications occurred. Thirty-seven isolates were found in bile. Sixteen of these were gram-positive(43.2%), 12(32.4%) were gram-negative bacteria, and Candida species accounted for 24.3% of all isolated microorganisms. Interestingly, only 48.6% of specimens were sensitive to prophylactic antibiotics.CONCLUSION Single-operator cholangioscopy can provide important diagnostic information, helping endoscopists to plan and perform interventional procedures in LT-related biliary complications. | Anna Hüsing-Kabar Hauke Sebastian Heinzow Hartmut Hans-Jürgen Schmidt Carina Stenger Hans Ulrich Gerth Michele Pohlen Gerold Tholking Christian Wilms Iyad Kabar | 2017 | World Journal of Gastroenterology2017，23，22： | 4 |
| 6 | A comparison of Kneipp hydrotherapy with conventional physiotherapy in the treatment of osteoarthritis: a pilot trial显示文摘BACKGROUND: An increasingly aging population implies an increasing prevalence of osteoarthritis (OA) of hip or knee. It has been ascertained that unspecific hydrotherapy of OA according to Sebastian Kneipp not only improves the range of mobility but also reduces pain significantly and increases the quality of life of the patients affected. OBJECTIVE: The main aim of this pilot study was to determine the effects of hydrotherapy in comparison to conventional physiotherapy, and to analyze the feasibility of the study design under clinical circumstances. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: The study design is a prospective randomized controlled three-arm clinical pilot trial, carried out at a specialist clinic for integrative medicine. Thirty patients diagnosed with symptomatic OA of hip or knee and radiologic findings were randomly assigned to one of two intervention groups and a control group: hydrotherapy (group 1), physiotherapy (group 2), and both physiotherapy and hydrotherapy (group 3, control group) of the affected joint. MAIN OUTCOME MEASURES: Primary outcome: pain intensity of the affected joint in the course of inpatient treatment; secondary outcome: health-related quality of life, joint-specific pain and mobility in the course of the study. RESULTS: Concerning the main outcome, intervention group 1 showed most beneficial effects in the course of inpatient treatment, followed by groups 3 and 2, and also the indirect flexion ability of hip or knee together with the general patient mobility through the 'timed up and go' test were mainly improved within group 1 followed by groups 3 and 2. CONCLUSION: The results of this pilot study demonstrate beneficial effects of hydrotherapy. The study design is feasible. For statistically significant evidence and a robust conclusion of efficacy of Kneipp's hydrotherapy, a larger sample size is necessary. | Martin Schencking Stefan Wilm Marcus Redaelli | 2013 | Journal of Integrative Medicine2013，11，1： | 4 |
| 7 | Paclitaxel-eluting balloon dilation of biliary anastomotic stricture after liver transplantation显示文摘AIM:To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon(PEB) for biliary anastomotic stricture(AS) after liver transplantation(LT).METHODS:This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT at the University Hospital of Münster between January 2011 and March 2014.The patients were treated by endoscopic therapy with a PEB and followed up every 8 wk by endoscopic retrograde cholangiopancreatography(ERCP).In cases of re-stenosis,further balloon dilation with a PEB was performed.Follow-up was continued until 24 mo after the last intervention.RESULTS:Initial technical feasibility,defined as successful balloon dilation with a PEB during the initial ERCP procedure,was achieved in 100% of cases.Long-term clinical success(LTCS),defined as no need for further endoscopic intervention for at least 24 mo,was achieved in 12 of the 13 patients(92.3%).The mean number of endoscopic interventions required to achieve LTCS was only 1.7 ± 1.1.Treatment failure,defined as the need for definitive alternative treatment,occurred in only one patient,who developed recurrent stenosis with increasing bile duct dilatation that required stent placement.CONCLUSION:Endoscopic therapy with a PEB is very effective for the treatment of AS after LT,and seems to significantly shorten the overall duration of endoscopic treatment by reducing the number of interventions needed to achieve LTCS. | Anna Hüsing Holger Reinecke Vito R Cicinnati Susanne Beckebaum Christian Wilms Hartmut H Schmidt Iyad Kabar | 2015 | World Journal of Gastroenterology2015，21，3： | 4 |
| 8 | Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels 显示文摘 | Shevchenko A Wilm M Vorm O | 1996 | Anal Chem1996，68，： | 2 |
| 9 | Controlling and regulation of integrated aquaponic production systems – An approach for a management execution system (MES)显示文摘Manufacturing execution systems(MESs)play a significant role in the manufacturing paradigm.MES is there to link between the Enterprise Resource Planning(ERP)systems and the plant equipment control or Supervisory Control and Data Acquisition(SCADA)applications.In this paper the MES of the INAPRO aquaponics system which was developed to support and advise the aquaponics managers in operating the complex aquaponic farms,will be presented.One important feature of the INAPRO aquaponics system is to minimize fresh water<3%,energy and nutrient supplies.This can only be achieved by appropriate design of the fish and crop mixture,considering the fish to crop ratio,when to sow the crops etc.and to monitor the system to see whether it performing as designed or not.Therefore,the MES has a view to show the designed system with all the material flow(water,energy and nutrients)balances and also how the system will be performing for a given predictive horizon.Knowing the future developments of the system,the operator can taking corrective measures to make sure that the system is behaving as required.An example of water balance of a system with 40 m3 fish tanks coupled with a hydroponic NFT system with 1,000 m2 which can produce five tons of Tilapia and 75 tons of tomato yearly is given. | Olaf Witzel Stefan Wilm Divas Karimanzira Daniela Baganz | 2019 | Information Processing in Agriculture2019，6，3： | 2 |
| 10 | Fluid Therapy in Acute Pancreatitis: Anybody?s Guess显示文摘 | Matthew D. Haydock Anubhav Mittal Heath R. Wilms Anthony Phillips Maxim S. Petrov John A. Windsor | 2013 | Annals of Surgery2013，，2： | 2 |
| 11 | Effect of growth factors on cell proliferation by human nasal septal chondrocytes cultured in monolayer显示文摘 | Sittinger M Wilmes E | 1994 | Acta Otolaryngol( Stockh )1994，114，： | 1 |
| 12 | Intracranial meningiomast correlation between MR imaging and histology in fifty patients显示文摘 | DEMAEREL P WILMS G LAMMENS M | 1991 | J Comput Assist Tomogr1991，15，1： | 1 |
| 13 | The murine homologue of HIRA,a DiGeorge syndrome candidate gene,is expressed in embryonic structures affected in human CATCH22 patients显示文摘 | Wilming L G Snoeren C A van Rijswijk A | 1997 | Hum Mol Genet1997，6，2： | 1 |
| 14 | Impact of implant design on primary stability of orthodontic mini-implants显示文摘 | Wilmes B Ottenstreuer S Su YY | | 0，，1： | 1 |
| 15 | Postoprative retroperitoneal hemorrhage due to a bleeding ureteric artery:treatment by transcatheter embolization显示文摘 | Maleux G Stockx L Wilms G | 2001 | European Radiology2001，11，： | 1 |
| 16 | Mechanisms of retention and flux decline for the nanofiltration of dye baths from the textile industry 显示文摘 | Bruggen B V Daems B Wilms D | 2001 | Separation and Purification Technology2001，2223，： | 1 |
| 17 | Influence of molecular size, polarity and charge on the retension of organic molecules by nanofiltration 显示文摘 | Van der Bruggen B Schaep J Wilms D | 1999 | J Membr Sci1999，156，： | 1 |
| 18 | Coexpression of PMP22 gene with MBP and P0 during de novo myelination and nerve repair显示文摘 | Kuhn G Lie A Wilms S | | 0，，： | 1 |
| 19 | Long-term outcome of split liver transplantation using right extended grafts in adulthood:a matched pair analysis显示文摘 | Wilms C Walter J Kaptein M | | 0，，06： | 1 |
| 20 | High- resolution diffusion-weighted imaging for monitoring breast cancer treatment response显示文摘 | Wilmes L J McLaughlin RL Newitt DC | 2013 | Acad Radiol2013，20，5： | 1 |
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