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| 1 | Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation:Effects on virus replication and recurrent hepatitis显示文摘瞄准:决定 calcineurin 禁止者, cyclosporine 和 tacrolimus 的效果,在丙肝上,在病人的周期性的丙肝的病毒(HCV ) 复制和活动张贴肝移植。方法:在我们的中心为在 1999 和 2003 之间的联系 HCV 的肝肝硬化收到了肝移植的 107 个病人的一个队的数据回顾地被分析。浆液 HCV-RNA 的水平和周期性的肝炎的活动在作为主要抑制免疫力的代理人和没在移植以后在开始的 12 瞬间以内导致胆汁的复杂并发症的不那样类似的抑制免疫力的政体收到了 cyclosporine 或 tacrolimus 的 47 个病人之间被比较。结果:HCV-RNA 在移植以后在 3 瞬间以内增加了,但是 cyclosporine 组和 tacrolimus 组之间的差别是不足道的(在 12 瞬间的 P=0.49 ) 。另外,由浆液 transaminases 决定了的周期性的肝炎并且门发炎和纤维变性的组织学的分级没在 12 瞬间(P=0.34 ) 以后显示出有效差量。结论:一个主要抑制免疫力的代理人不在肝移植以后在感染 HCV 的病人影响周期性的肝炎的正式就职或严厉的 Cyclosporine 或 tacrolimus。 | Philip Hilgard Alisan Kahraman Nils Lehmann Cornelia Seltmann Susanne Beckebaum R Stefan Ross Hideo A Baba Massimo Malago Christoph E Broelsch Guido Gerken | 2006 | World Journal of Gastroenterology2006，12，5： | 235 |
| 2 | Endoscopic ultrasound guided radiofrequency ablation,for pancreatic cystic neoplasms and neuroendocrine tumors显示文摘AIM: To outline the feasibility, safety, adverse events and early results of endoscopic ultrasound(EUS)-radiofrequency ablation(RFA) in pancreatic neoplasms using a novel probe. METHODS: This is a multi-center, pilot safety feasibility study. The intervention described was radiofrequency ablation(RF) which was applied with an innovative monopolar RF probe(1.2 mm Habib EUS-RFA catheter) placed through a 19 or 22 gauge fine needle aspiration(FNA) needle once FNA was performed in patients with a tumor in the head of the pancreas. The HabibTM EUSRFA is a 1 Fr wire(0.33 mm, 0.013') with a working length of 190 cm, which can be inserted through the biopsy channel of an echoendoscope. RF power is applied to the electrode at the end of the wire to coagulate tissue in the liver and pancreas.RESULTS: Eight patients [median age of 65(range 27-82) years; 7 female and 1 male] were recruited in a prospective multicenter trial. Six had a pancreatic cysticneoplasm(four a mucinous cyst, one had intraductal papillary mucinous neoplasm and one a microcystic adenoma) and two had a neuroendocrine tumors(NET) in the head of pancreas. The mean size of the cystic neoplasm and NET were 36.5 mm(SD ± 17.9 mm) and 27.5 mm(SD ± 17.7 mm) respectively. The EUSRFA was successfully completed in all cases. Among the 6 patients with a cystic neoplasm, post procedure imaging in 3-6 mo showed complete resolution of the cysts in 2 cases, whilst in three more there was a 48.4% reduction [mean pre RF 38.8 mm(SD ± 21.7 mm) vs mean post RF 20 mm(SD ± 17.1 mm)] in size. In regards to the NET patients, there was a change in vascularity and central necrosis after EUS-RFA. No major complications were observed within 48 h of the procedure. Two patients had mild abdominal pain that resolved within 3 d. CONCLUSION: EUS-RFA of pancreatic neoplasms with a novel monopolar RF probe was well tolerated in all cases. Our preliminary data suggest that the procedure is straightforward and safe. The response ranged from complete resolution to a 50% reduction in size. | Madhava Pai Nagy Habib Hakan Senturk Sundeep Lakhtakia Nageshwar Reddy Vito R Cicinnati Iyad Kaba Susanne Beckebaum Panagiotis Drymousis Michel Kahaleh William Brugge | 2015 | World Journal of Gastrointestinal Surgery2015，7，4： | 23 |
| 3 | Paclitaxel-eluting balloon dilation of biliary anastomotic stricture after liver transplantation显示文摘AIM:To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon(PEB) for biliary anastomotic stricture(AS) after liver transplantation(LT).METHODS:This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT at the University Hospital of Münster between January 2011 and March 2014.The patients were treated by endoscopic therapy with a PEB and followed up every 8 wk by endoscopic retrograde cholangiopancreatography(ERCP).In cases of re-stenosis,further balloon dilation with a PEB was performed.Follow-up was continued until 24 mo after the last intervention.RESULTS:Initial technical feasibility,defined as successful balloon dilation with a PEB during the initial ERCP procedure,was achieved in 100% of cases.Long-term clinical success(LTCS),defined as no need for further endoscopic intervention for at least 24 mo,was achieved in 12 of the 13 patients(92.3%).The mean number of endoscopic interventions required to achieve LTCS was only 1.7 ± 1.1.Treatment failure,defined as the need for definitive alternative treatment,occurred in only one patient,who developed recurrent stenosis with increasing bile duct dilatation that required stent placement.CONCLUSION:Endoscopic therapy with a PEB is very effective for the treatment of AS after LT,and seems to significantly shorten the overall duration of endoscopic treatment by reducing the number of interventions needed to achieve LTCS. | Anna Hüsing Holger Reinecke Vito R Cicinnati Susanne Beckebaum Christian Wilms Hartmut H Schmidt Iyad Kabar | 2015 | World Journal of Gastroenterology2015，21，3： | 4 |
| 4 | Optimized endoscopic treatment of ischemic-type biliary lesions after liver transplantation显示文摘 | Thomas Zoepf Evelyn J. Maldonado de Dechêne Alexander Dechêne Massimo Malágo Susanne Beckebaum Andreas Paul Guido Gerken Philip Hilgard | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 5 | MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity显示文摘 | Leibo Xu Susanne Beckebaum Speranta Iacob Gang Wu Gernot M. Kaiser Arnold Radtke Chao Liu Iyad Kabar Hartmut H. Schmidt Xiaoyong Zhang Mengji Lu Vito R. Cicinnati | 2013 | Journal of Hepatology2013，，： | 2 |
| 6 | Effects of mycophenolate mofetil introduction in liver transplant patients: results from an observational, non‐interventional, multicenter study ( LOBSTER )显示文摘 | Hans J. Schlitt Sven Jonas Tom M. Ganten Gerrit Grannas Christian Moench Falk Rauchfuss Aiman Obed Giuseppe Tisone Antonio D. Pinna Giorgio E. Gerunda Susanne Beckebaum | 2013 | Clin Transplant2013，，3： | 1 |
| 7 | Major bile duct injuries after laparoscopic cholecystectomy: A tertiary center experience显示文摘 | Andrea Frilling M.D. Ph.D. Jun Li M.D. Frank Weber M.D. Nils Roman Frühauf M.D. Jennifer Engel Susanne Beckebaum M.D. Andreas Paul M.D. Thomas Z?pf M.D. Massimo Malago M.D. Ph.D. Christoph Erich Broelsch M.D. Ph.D | 2004 | Journal of Gastrointestinal Surgery2004，，6： | 1 |
| 8 | Increased levels of interleukin-10 in serum from patients with hepatocellular carcinoma correlate with profound numerical deficiencies and immature phenotype of circulating dendritic cell subsets 显示文摘 | Susanne Beckebaum Xia Zhang Xiao Chen | 2004 | Clinical Cancer Research2004，10，21： | 1 |
| 9 | 351 Endoscopic Ultrasound Guided Radiofrequency Ablation (EUS-RFA) for Cystic Neoplasms and Neuroendocrine Tumors of the Pancreas显示文摘 | Madhava Pai Hakan Senturk Sundeep Lakhtakia D. Nageshwar Reddy Vito Cicinnati Iyad Kabar Susanne Beckebaum Zhendong Jin Dong Wang Jianfeng Yang Xiaofeng Zhang Michel Kahaleh Nagy Habib William R. Brugge | 2013 | Gastrointestinal Endoscopy2013，，5： | 1 |
| 10 | Calcineurin inhibitors in liver transplantation – still champions or threatened by serious competitors?显示文摘 | Susanne Beckebaum Vito R. Cicinnati Arnold Radtke Iyad Kabar | 2013 | Liver Int2013，，5： | 1 |
| 11 | Neurologic complications in adult living donor liver transplant patients: an underestimated factor?显示文摘 | Fuat Hakan Saner Julia Gensicke Steven W. M. Olde Damink Goran Pavlakovi? Juergen Treckmann Marc Dammann Gernot M. Kaiser Georgios C. Sotiropoulos Arnold Radtke Susanne Koeppen Susanne Beckebaum Vito Cicinnati Silvio Nadalin Massimo Malagó Andreas Paul Ch | 2010 | Journal of Neurology2010，，2： | 1 |
| 12 | Introducing Paclitaxel-Eluting Balloons as a New Treatment Option of Biliary-Enteric Anastomotic Stricture After Liver Transplantation显示文摘 | Iyad Kabar Vito R. Cicinnati Susanne Beckebaum Stefanie Cordesmeyer Holger Reinecke Hartmut H. Schmidt | 2012 | Transplantation Journal2012，，1： | 1 |
| 13 | Major bile duct injuries after laparoscopic cholecystectomy: A tertiary center experience显示文摘 | Andrea Frilling M.D. Ph.D. Jun Li M.D. Frank Weber M.D. Nils Roman Frühauf M.D. Jennifer Engel Susanne Beckebaum M.D. Andreas Paul M.D. Thomas Z?pf M.D. Massimo Malago M.D. Ph.D. Christoph Erich Broelsch M.D. Ph.D | 2004 | Journal of Gastrointestinal Surgery2004，，6： | 1 |
| 14 | Optimized endoscopic treatment of ischemic-type biliary lesions after liver transplantation显示文摘 | Thomas Zoepf Evelyn J. Maldonado de Dechêne Alexander Dechêne Massimo Malágo Susanne Beckebaum Andreas Paul Guido Gerken Philip Hilgard | 2012 | Gastrointestinal Endoscopy2012，，3： | 1 |
| 15 | Major bile duct injuries after laparoscopic cholecystectomy: a tertiary center experience显示文摘 | Andrea Frilling Jun Li Frank Weber Nils Roman Frühauf Jennifer Engel Susanne Beckebaum Andreas Paul Thomas Z?pf Massimo Malago Christoph Erich Broelsch | 2004 | Journal of Gastrointestinal Surgery2004，，6： | 1 |
| 16 | Patient Outcomes in Two Steroid-Free Regimens Using Tacrolimus Monotherapy After Daclizumab Induction and Tacrolimus With Mycophenolate Mofetil in Liver Transplantation显示文摘 | Thomas Becker Daniel Foltys Itxarone Bilbao Davide D’Amico Michele Colledan Angel Bernardos Susanne Beckebaum Helena Isoniemi Jacques Pirenne Jen? Jaray | 2008 | Transplantation2008，，12： | 1 |
| 17 | Risk of venous congestion in live donors of extended right liver graft显示文摘AIM: To investigate middle hepatic vein(MHV)management in adult living donor liver transplantation and safer remnant volumes(RV).METHODS: There were 59 grafts with and 12 grafts without MHV(including 4 with MHV-5/8 reconstructions).All donors underwent our five-step protocol evaluation containing a preoperative protocol liver biopsy Congestive vs non-congestive RV, remnantvolumebody-weight ratios(RVBWR) and postoperative outcomes were evaluated in 71 right graft living donors. Dominant vs non-dominant MHV anatomy in total liver volume(d-MHV/TLV vs nd-MHV/TLV) was constellated with large/small congestion volumes(CVindex).Small for size(SFS) and non-SFS remnant considerations were based on standard cut-off- RVBWR and RV/TLV. Non-congestive RVBWR was based on non-congestive RV.RESULTS: MHV and non-MHV remnants showed no significant differences in RV, RV/TLV, RVBWR, total bilirubin, or INR. SFS-remnants with RV/TLV < 30%and non-SFS-remnants with RV/TLV ≥ 30% showedno significant differences either. RV and RVBWR for non-MHV(n = 59) and MHV-containing(n = 12)remnants were 550 ± 95 ml and 0.79 ± 0.1 ml vs568 ± 97 ml and 0.79 ± 0.13, respectively(P = 0.423 and P = 0.919. Mean left RV/TLV was 35.8% ± 3.9%.Non-MHV(n = 59) and MHV-containing(n = 12)remnants(34.1% ± 3% vs 36% ± 4% respectively,P = 0.148. Eight SFS-remnants with RVBWR < 0.65 had a significantly smaller RV/TLV than 63 non-SFSremnants with RVBWR ≥ 0.65 [SFS: RV/TLV 32.4%(range: 28%-35.7%) vs non-SFS: RV/TLV 36.2%(range: 26.1%-45.5%), P < 0.009. Six SFS-remnants with RV/TLV < 30% had significantly smaller RVBWR than 65 non-SFS-remnants with RV/TLV ≥ 30%(0.65(range: 0.6-0.7) vs 0.8(range: 0.6-1.27), P < 0.01.Two(2.8%) donors developed reversible liver failure.RVBWR and RV/TLV were concordant in 25%-33%of SFS and in 92%-94% of non-SFS remnants. MHV management options including complete MHV vs MHV-4A selective retention were necessary in n = 12 vs n =2 remnants based on particularly risky congestive and non-congestive volume constellations.CONCLUSION: MHV procurement should consider individual remnant congestive- and non-congestive volume components and anatomy characteristics,RVBWR-RV/TLV constellation enables the identification of marginally small remnants. | Arnold Radtke George Sgourakis Ernesto P Molmenti Susanne Beckebaum Vito R Cicinnati Hartmut Schmidt Heinz-Otto Peitgen Christoph E Broelsch Massimo Malagó Tobias Schroeder | 2015 | World Journal of Gastroenterology2015，21，19： | 1 |
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