|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 大量风电引入电网时的频率控制特性显示文摘大量风力发电引入电网时,会对电网的频率控制带来影响。在深入分析异步电动机频率特性的基础上,采用所开发的电力扰动装置对不同转矩特性的异步电动机的频率特性进行了测试。基于加权综合的思路建立了包含异步电动机的综合负荷的频率特性模型。同时分析了风力发电的出力特性。通过对一个包含风力发电的电网进行分析,论证了考虑负荷频率特性以后,在同样电网调频能力的情况下,频率波动的偏差会变小。 | 韩民晓 崔军立 姚蜀军 Lie XU | 2008 | 电力系统自动化2008，32，1： | 64 |
| 2 | Early Oligocene anatexis in the Yardoi gneiss dome,southern Tibet and geological implications显示文摘The Yardoi gneiss dome is located to the easternmost of the North Himalayan Gneiss Dome (NHGD),southern Tibet. It consists of metapelite,garnet amphibolite,granite and leucogranite,and is a key subject to constrain the formation and tectonic evolution of NHGD. SHRIMP zircon U/Pb data on the leucogranite yield an age of 35.3±1.1 Ma,which is substantially older than that of the similar leu-cogranites to the west. Sr and Nd isotope systematics indicate that this leucogranite was derived from partial melting of the mixed garnet amphibolite and metapelite. Our data suggest that (1) during the early stage of Himalayan magmatism,amphibolite dehydration melting overwhelmed that of the metapelite; and (2) such a melting at middle-lower crust might be a major factor that initiated the movement along the Southern Tibetan Detachment System (STDS). | ZENG LingSen LIU Jing GAO LiE XIE KeJia WEN Li | 2009 | Chinese Science Bulletin2009，54，1： | 61 |
| 3 | 不平衡电网电压下双馈感应发电机转子侧变换器的比例–谐振电流控制策略显示文摘为了研究不平衡电网电压条件下双馈感应风力发电机(doubly-fedinduction generator,DFIG)系统增强运行能力的有效控制策略,提出了网侧、转子侧变换器的比例–谐振电流控制方案以及两者之间的协同控制策略。针对电网电压不平衡条件下DFIG转子侧变换器,提出了一种在两相定子静止αβ坐标系中实施的比例–谐振(proportional-resonant,P-R)电流控制方案,以实现对DFIG转子电流无需正、负相序分解的统一调节。采用正序d+轴电网电压定向简化了各种增强运行能力控制目标下的转子正、负序电流指令值算法,设计了相应的DFIG不平衡控制策略。实验研究表明,这种P-R电流控制方案能够实现转子侧变换器选定控制目标,具备优良的动态调节性能,可增强不平衡电网电压故障下DFIG风力发电机系统的不间断运行能力。 | 胡家兵 贺益康 王宏胜 LIE Xu | 2010 | 中国电机工程学报2010，30，6： | 70 |
| 4 | 不平衡电网电压下双馈感应发电机网侧和转子侧变换器的协同控制显示文摘建立了不平衡电网电压下双馈感应发电机(doubly-fed induction generator,DFIG)网侧变换器的数学模型,讨论了交流输入电抗对瞬时有功功率的影响,在此基础上,提出4种可供选择的网侧变换器协同控制目标。为了验证网侧、转子侧变换器协同控制策略的有效性,提出静止αβ坐标系中比例?谐振控制器,使网侧变换器正、负序电流无需分解调节,并构建了DFIG网侧变换器的不平衡控制系统。仿真和实验研究结果表明,所提网侧、转子侧变换器协同控制策略可实现风电机组更为优化的不对称故障穿越(不间断)运行控制;所设计的网侧、转子侧变换器P-R电流控制方案不仅能够在稳态不平衡电网下提供精确的电流调节,而且在瞬态不平衡下体现优良的动态响应特性。 | 胡家兵 贺益康 王宏胜 LIE Xu | 2010 | 中国电机工程学报2010，30，9： | 62 |
| 5 | Adjuvant transcatheter arterial chemoembolization after curative resection for hepatocellular carcinoma patients with solitary tumor and microvascular invasion: a randomized clinical trial of efficacy and safety显示文摘Background:The optimal strategy for adjuvant therapy after curative resection for hepatocellular carcinoma(HCC)patients with solitary tumor and microvascular invasion(MVI)is controversial.This trial evaluated the efficacy and safety of adjuvant transcatheter arterial chemoembolization(TACE)after hepatectomy versus hepatectomy alone in HCC patients with a solitary tumor≥5 cm and MVI.Methods:In this randomized,open-labeled,phase III trial,HCC patients with a solitary tumor≥5 cm and MVI were randomly assigned(1:1)to receive either 1-2 cycles of adjuvant TACE after hepatectomy(Hepatectomy-TACE)or hepatectomy alone(Hepatectomy Alone).The primary endpoint was disease-free survival(DFS);the secondary end-points included overall survival(OS)and adverse events.Results:Between June 1,2009,and December 31,2012,250 patients were enrolled and randomly assigned to the Hepatectomy-TACE group(n=125)or the Hepatectomy Alone group(n=125).Clinicopathological characteristics were balanced between the two groups.The median follow-up time from randomization was 37.5 months[interquartile range 18.3-48.2 months].The median DFS was significantly longer in the Hepatectomy-TACE group than in the Hepatectomy Alone group[17.45 months(95%confidence interval[CI]11.99-29.14)vs.9.27 months(95%CI 6.05-13.70),hazard ratio[HR]=0.70(95%CI 0.52-0.95),P=0.020],respectively.The median OS was also significantly longer in the Hepatectomy-TACE group than in the Hepatectomy Alone group[44.29 months(95%CI 25.99-62.58)vs.22.37 months(95%CI 10.84-33.91),HR=0.68(95%CI 0.48-0.97),P=0.029].Treatment-related adverse events were more frequently observed in the Hepatectomy-TACE group,although these were generally mild and manageable.The most common grade 3 or 4 adverse events in both groups were neutropenia and liver dysfunction.Conclusion:Hepatectomy followed by adjuvant TACE is an appropriate option after radical resection in HCC patients with solitary tumor≥5 cm and MVI,with acceptable toxicity. | Wei Wei Pei-En Jian Shao-Hua Li Zhi-Xing Guo Yong-Fa Zhang Yi-Hong Ling Xiao-Jun Lin Li Xu Ming Shi Lie Zheng Min-Shan Chen Rong-Ping Guo | 2018 | Cancer Communications2018，38，1： | 62 |
| 6 | Characterization and assessment of volatile organic compounds (VOCs) emissions from typical industries显示文摘VOCs play an increasingly important role in affecting air quality and threatening human health in China in recent years,where industry activities show a significant contribution to VOCs emission.In this article we report our long term study of industrial VOCs emissions of six major industries (vehicle manufacturing,printing,equipment coating,electronic manufacturing,furniture manufacturing and bio-pharming) on the aspects of emission characteristics,environmental impact and health risk assessment,and control challenge analysis with the purpose to obtain in-depth understanding of industry VOCs emissions and offer some original basements for national control and management of industry VOCs emissions.This study shows that all these industries give middle or low emission with total VOCs concentration less than 1000 mg/m3 at each exhaust pipe.Benzenes,esters,alcohols,ketones,alkanes,chloroalkanes and alkenes were detected as the major emission components and the most frequently monitored VOCs were benzenes,which varied obviously with different processes and industries.The environmental impact assessments indicate that vehicle manufacturing and benzenes should be prior controlled with the purpose to reduce air pollution.While,health risk assessments suggest that furniture manufacturing and chloroalkanes should be firstly controlled.Control analysis indicates that developing technologies with low cost and high efficiency and establishing and completing specific industry emission standards/regulations are the two key issues in VOCs emission management at present stage. | WANG HaiLin NIE Lie LI Jing WANG YuFei WANG Gang WANG JunHui HAO ZhengPing | 2013 | Science China(Technological Sciences)2013，56，3： | 60 |
| 7 | 黄海环流的分析显示文摘基于近期几次大型调查所获资料,结合有关的历史观测结果,重点分析了冷半年黄海环流的基本状况.与以往类似研究相比,首先以更为丰富的实测资料进一步论述了黄海暖流的起源和路径,并明确指出:黄海暖流并非是对马暖流的直接分支,而是从济州岛邻近水域由对马暖流水和东海陆架水形成的混合水区中衍生出来的.黄海暖流的路径有一定的季节和年际变异.然后,阐明了近期发现的济州暖流的基本特征及其与黄海暖流的关系.分析表明,两支暖流基本同源.济州暖流主流路径大致位于济州岛西北侧近岸80 m以深水域.最后,还以较新的观测资料展示了西朝鲜半岛沿岸流的分布特征.观测显示,这支沿岸流大致沿朝鲜半岛西侧40~50 m等深线附近水域南下,流速则从北向南递增. | 臧家业 汤毓祥 邹娥梅 Lie Heung-Jae | 2001 | 科学通报2001，46，S1： | 47 |
| 8 | Effects of citrus tree-shape and spraying height of small unmanned aerial vehicle on droplet distribution显示文摘In order to explore the droplet penetration of spraying with unmanned aerial vehicle(UAV)on citrus trees with different shapes,the tests were carried out at different working heights.The material was five years old Cocktail grapefruit(Citrus paradisi cv.Cocktail)grafted on Trafoliata(Poncirus trifoliata L.Raf.)and the type of UAV sprayer used was the 3W-LWS-Q60S.A solution of 300 times Ponceau 2R diluents liquid instead of pesticide was used for citrus fields spraying and the droplets were collected by paper cards.Droplets deposition parameters were extracted and analyzed using digital image processing after scanning the cards.The results showed that:1)For the trees with round head shape canopy,the droplet depositions of the upper,middle and lower layers had a significant difference at 0.05 level.The droplet deposition had the best effect when the working height was 1.0 m,where the average droplet deposition densities were 39.97 droplets/cm2 and the average droplet size was 0.30 mm,but the droplet coverage(3.19%)was lower than that at the working height of 1.5 m(4.27%).2)Under three different working heights of UAV,the tree with open center shape can obtain higher droplet deposition density at all three layers than that with the round head shape canopy.It was especially prominent when the working height was 1.0 m,as the middle layer increased by 49.92%.However,the higher range of droplet deposition density meant larger fluctuation and dispersion.3)The open center shape canopy and the 1.0 m working height obviously improved the droplet coverage rate and droplet density in the citrus plant.For these parameters of open center shape citrus tree,there was no obvious difference in the front and rear direction,but in the left and middle part of the tree crown,the difference reached a 0.05 significant level.Considering droplet deposition characteristics and the spray uniformity,the UAV performed better when working on open center shape plants at a 1.0 m working height. | Zhang Pan Deng Lie Lyu Qiang He Shaolan Yi Shilai Liu Yande Yu Yongxu Pan Haiyang | 2016 | International Journal of Agricultural and Biological Engineering2016，9，4： | 37 |
| 9 | 冬至初春黄海暖流的路径和起源显示文摘主要根据近几年来中韩黄海水循环动力学合作调查结果,结合有关观测资料,进一步分析了冬至初春黄海暖流的路径和起源.与以往类似研究不同的主要有两点:(l)初步探讨了黄海暖流路径的季节和年际变异,并指出这种变异与北向风的强弱密切相关;(2)通过分析济州岛西侧海域混合水的去向,进一步确认了部分混合水绕济州岛运行,并进入济州海峡这一事实.同时,初步揭示进入黄海的混合水,即黄海暖流水,含有更多的东海陆架水成分. | 汤毓祥 邹娥梅 LIE Heung-Jae | 2001 | 海洋学报2001，23，1： | 29 |
| 10 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 11 | Jianpi Qingchang decoction alleviates ulcerative colitis by inhibiting nuclear factor-κB activation显示文摘AIM To inve s t igat e t he t he r ape ut ic e f f e c t of Jianpi Qingchang decoction(JPQCD) on dextran sulfate sodium(DSS)-induced ulcerative colitis(UC) in mice.METHODS C57BL/c mice were injected intragastrically with 5% DSS instead of drinking water for 7 d, and their body weight, diarrhea severity and fecal bleeding were monitored, while the mice in the control group were treated with standard drinking water, without DSS. After 7 d, the DSS drinking water was changed to normal water and the DSS group continued with DSS water. The control and DSS groups were given normal saline by intragastric injection. The 5-aminosalicylic acid(5-ASA) group was treated orally with 5-ASA at a dose of 100 mg/kg daily. The JPQCD group was treated orally with JPQCD at a dose of 17.1 g/kg daily. On day 14, the colon length was measured, the colorectalhistopathological damage score was assessed, and protein levels of interleukin(IL)-1β, IL-8 and tumor necrosis factor-alpha(TNF-α) in colon supernatants were measured by enzyme-linked immunosorbent assay. m RNA expression of IL-1β, IL-8, TNF-α and nuclear factor-kappa B(NF-κB) was detected by realtime quantitative polymerase chain reaction. Western blotting was used to detect the protein expression of NF-κB and inhibitor of kappa B. RESULTS Acute inflammation occurred in the mice administered DSS, including the symptoms of losing body weight, loose feces/watery diarrhea and presence of fecal blood; all these symptoms worsened at 7 d. The colons of mice treated with DSS were assessed by histological examination, and the results confirmed that acute inflammation had occurred, as evidenced by loss of colonic mucosa and chronic inflammatory cell infiltration, and these features extended into the deeper layer of the colon walls. The expression levels of IL-1β, IL-8 and TNF-α in the DSS group were higher than those in the control group(P < 0.05), and the expression levels of IL-1β, IL-8 and TNF-α in the JPQCD and 5-ASA groups were lower than those in the DSS group after treating with JPQCD and 5-ASA. Comparing with the DSS group, the mR NA level of IL-1β, IL-8, TNF-α and NF-κB was significantly reduced by 5-ASA and JPQCD. The difference between JPQCD and 5-ASA groups was not statistically significant(P > 0.05). Comparing with the DSS group, due to using JPQCD and 5-ASA, significant suppression of activation in DSSinduced NF-κB and increased phosphorylation of IκB in mice with experimental colitis occurred(P < 0.05). The difference between the JPQCD group and the 5-ASA group was not statistically significant(P > 0.05). CONCLUSION Activation of the NF-κB signaling pathway is inhibited by JPQCD, which shows the potential mechanism by which JPQCD treats UC. | Lie Zheng Ya-Li Zhang Yan-Cheng Dai Xuan Chen De-Liang Chen Yue-Ting Dai Zhi-Peng Tang | 2017 | World Journal of Gastroenterology2017，23，7： | 30 |
| 12 | The PI3K/Akt/m TOR pathway in ovarian cancer: therapeutic opportunities and challenges显示文摘The phosphatidylinositol 3 kinase(PI3K) pathway is frequently altered in cancer, including ovarian cancer(OC). Unfortunately, despite a sound biological rationale and encouraging activity in preclinical models, trials of first-generation inhibitors of mammalian target of rapamycin(m TOR) in OC have demonstrated negative results. The lack of patient selection as well as resistance to selective m TOR complex-1(m TORC1) inhibitors could explain the disappointing results thus far. Nonetheless, a number of novel agents are being investigated, including dual m TORC1/m TORC2, Akt, and PI3 K inhibitors. Although it is likely that inhibition of the PI3K/Akt/m TOR pathway may have little effect in unselected OC patients, certain histological types, such as clear cell or endometrioid OC with frequent phosphatidylinositol-4,5-biphosphate 3-kinase, catalytic subunit alpha(PIK3CA) and/or phosphatase and tensin homolog(PTEN) alterations, may be particularly suited to this approach. Given the complexity and redundancy of the PI3 K signaling network, PI3 K pathway inhibition may be most useful in combination with either chemotherapy or other targeted therapies, such as MEK inhibitors, anti-angiogenic therapy, and hormonal therapy, in appropriately selected OC patients. Here, we discuss the relevance of the PI3 K pathway in OC and provide an up-to-date review of clinical trials of novel PI3 K inhibitors alone or in combination with cytotoxics and novel therapies in OC. In addition, the challenges of drug resistance and predictive biomarkers are addressed. | Bianca Cheaib Aurélie Auguste Alexandra Leary | 2015 | Chinese Journal of Cancer2015，34，1： | 27 |
| 13 | Jianpi Qingchang decoction regulates intestinal motility of dextran sulfate sodium-induced colitis through reducing autophagy of interstitial cells of Cajal显示文摘AIM To investigate the underlying effect of Jianpi Qingchang decoction(JQD) regulating intestinal motility of dextran sulfate sodium(DSS)-induced colitis in mice. METHODS C57BL/6 mice were randomly divided into four groups: the control group, the DSS group, the JQD group, and the 5-aminosalicylic acid group. Except for the control group, colitis was induced in other groups by giving distilled water containing 5% DSS. Seven days after modeling, the mice were administered corresponding drugs intragastrically. The mice were sacrificed on the 15^(th) day. The disease activity index, macroscopic and histopathologic lesions, and ultrastructure of colon interstitial cells of Cajal(ICC) were observed. The levels of tumor necrosis factor-alpha(TNF-α), interleukin(IL)-1β, IL-10 and interferon gamma(IFN-γ), the expression of nuclear factor-kappa B(NF-κB) p65, c-kit, microtubule-associated protein 1 light chain 3(LC3-Ⅱ) and Beclin-l m RNA, and the colonic smooth muscle tension were assessed. RESULTS Acute inflammation occurred in the mice administered DSS. Compared with the control group, the levels of IL-1β, TNF-α, IL-10 and IFN-γ, the expression of LC3-Ⅱ, Beclin-1 and NF-κB p65 m RNA, and the contractile frequency increased(P < 0.05), the expression of c-kit m RNA and the colonic smooth muscle contractile amplitude decreased in the DSS group(P < 0.05). Compared with the DSS group, the levels of IL-10 and IFN-γ, the expression of c-kit m RNA, and the colonic smooth muscle contractile amplitude increased(P < 0.05), the levels of TNF-α and IL-1β, the expression of LC3-Ⅱ, Beclin-1 and NF-κB p65 m RNA, and the contractile frequency decreased in the JQD group(P < 0.05).CONCLUSION JQD can regulate the intestinal motility of DSS-induced colitis in mice through suppressing intestinal inflammatory cascade reaction, reducing autophagy of ICC, and regulating the network path of ICC/smooth muscle cells. | Yan-Cheng Dai Lie Zheng Ya-Li Zhang Xuan Chen De-Liang Chen Li-Juan Wang Zhi-Peng Tang | 2017 | World Journal of Gastroenterology2017，23，26： | 26 |
| 14 | K节点应力集中系数的试验和数值研究方法显示文摘工程中常用的评价海洋平台中管节点疲劳寿命的方法是使用S-N曲线。当管节点承受疲劳载荷作用的时候,可以通过数值或者试验方法得到沿着焊缝处的热点应力幅的大小。然后通过S-N曲线,可以预测此节点在破坏前可以承受疲劳载荷的循环次数。应力幅的大小可以由应力集中系数这个参数来确定。对K型节点在承受基本载荷作用下的应力集中系数进行了数值和试验分析,得到了各种基本载荷作用下K节点沿着焊缝处应力分布情况和极值应力点的位置。 | 邵永波 LIE Seng-Tjhen | 2006 | 工程力学2006，23，A01： | 23 |
| 15 | A Single Active Trehalose-6-P Synthase (TPS) and a Family of Putative Regulatory TPS-Like Proteins in Arabidopsis显示文摘更高的植物典型地不在大数量生产 trehalose,但是他们的染色体序列揭示通常认为的 trehalose 新陈代谢酶的大家庭。在植物生长和开发的一个重要规章的角色也为新陈代谢的中间的 trehalose-6-P (T6P ) 正在出现。这里,我们在场 Arabidopsis trehalose 新陈代谢上的更改和为进一步详细的分析的一个资源。另外,我们提供 Arabidopsis 靠着可能在活跃地种纸巾完成特定的规章的功能的催化地不活跃的象 TPS 一样蛋白质的一个家庭编码单个 trehalose-6-P synthase (TPS ) 的证据。 | Lies Vandesteene Matthew Ramon Katrien Le Roy Patrick Van Dijck Filip Rolland | 2010 | Molecular Plant2010，3，2： | 22 |
| 16 | Eocene high grade metamorphism and crustal anatexis in the North Himalaya Gneiss Domes,Southern Tibet显示文摘Determination of the timing and geochemical nature of early metamorphic and anatectic events in the Himalayan orogen may provide key insights into the physical and chemical behavior of lower crustal materials during the early stage of tectonic evolution in large-scale collisional belts.The Yardoi gneiss dome is the easternmost dome of the North Himalayan Gneiss Domes(NHGD),and contains three types of amphibolites with distinct mineral assemblage,elemental and radiogenic isotope geochemistry,as well as various types of gneisses.SHRIMP zircon U/Pb analyses on the garnet amphibolite and garnet-bearing biotite granitic gneiss yield ages of nearly peak metamorphism at 45.0±1.0 Ma and 47.6±1.8 Ma,respectively,which are 2 to 4 Ma older than the age for partial melting in migmatitic garnet amphibolite(43.5±1.3 Ma).Available data have demonstrated that ultra-high pressure metamorphism in the Tethyan Himalaya occurred at ~55 Ma,and high amphibolite facies to granulite facies metamorphism at 45 to 47 Ma.In addition,partial melting at thickened crustal conditions occurred at 43.5±1.3 Ma,which led to the formation of high Sr/Y ratios two-mica granites.The high-grade metamorphic rocks in the NHGD may represent the subducted front of the Indian continental lithosphere.In large collisional belts,fertile components in crustal materials could melt and form granitic melts with relatively high Na/K and Sr/Y ratios under thickened crustal conditions,significantly different from those formed by decompressional melting during rapid exhumation. | GAO LiE ZENG LingSen XIE KeJia | 2012 | Chinese Science Bulletin2012，57，6： | 23 |
| 17 | Episodic crustal anatexis and the formation of Paiku composite leucogranitic pluton in the Malashan Gneiss Dome, Southern Tibet显示文摘The Paiku composite leucogranitic pluton in the Malashan gneiss dome within the Tethyan Himalaya consists of tourmaline leucogranite,two-mica granite and garnet-bearing leucogranite.Zircon U-Pb dating yields that(1)tourmaline leucogranite formed at28.2±0.5 Ma and its source rock experienced simultaneous metamorphism and anatexis at 33.6±0.6 Ma;(2)two-mica granite formed at 19.8±0.5 Ma;(3)both types of leucogranite contain inherited zircon grains with an age peak at^480 Ma.These leucogranites show distinct geochemistry in major and trace elements as well as in Sr-Nd-Hf isotope compositions.As compared to the two-mica granites,the tourmaline ones have higher initial Sr and zircon Hf isotope compositions,indicating that they were derived from different source rocks combined with different melting reactions.Combined with available literature data,it is suggested that anatexis at^35 Ma along the Himalayan orogenic belt might have triggered the initial movement of the Southern Tibetan Detachment System(STDS),and led to the tectonic transition from compressive shortening to extension.Such a tectonic transition could be a dominant factor that initiates large scale decompressional melting of fertile high-grade metapelites along the Himalayan orogenic belt.Crustal anatexis at^28 Ma and^20 Ma represent large-scale melting reactions associated with the movement of the STDS. | GAO LiE ZENG LingSen HOU KeJun GUO ChunLi TANG SuoHan XIE KeJia HU GuYue WANG Li | 2013 | Chinese Science Bulletin2013，58，28： | 23 |
| 18 | Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells显示文摘瞄准:现在的学习被设计进一步调查结缔组织生长因素反感觉 oligonucleotide 的效果(CTGF -- 作为) 在血管收缩素上, II (Ang II ) 导致了管状的房间上皮的间充质的转变(EMT ) 在试管内。方法:人的近似管状的房间线(HK2 ) 在 Dulbecco 的家被种修改的鹰包含 10% 热的媒介使胎儿的小牛浆液失去活性。在在 24 h 的没有浆液的媒介被放松以后, CTGF 的影响 -- 作为(20 mug/mL ) 在 Ang 上导致 II (0.1 micromol/L ) CTGF mRNA 和蛋白质表示被使用反向的抄写聚合酶链反应和 indirect-immunofluorescence 检验。CTGF 的效果 -- 作为在 Ang 上,导致 II 的细胞的超微结构用一台能送的电子显微镜被观察。alpha 光滑的行动(alpha-SMA ) 的表示是由免疫细胞化学的 assayed。在所有实验,控制组与爬的 oligonucleotide 被对待。结果:Ang II 显著地导致了 CTGF mRNA 和蛋白质的增加的表示,这被显示出(P<0.01,分别地) ,它被处理显著地与 CTGF 废除 -- 作为。在与 Ang II 刺激房间以后,细胞的超微结构显示出间充质的特征。这些效果被 CTGF 部分禁止 -- 作为。Ang II 显著地导致了及时依赖的举止,它是显著地与 CTGF 由处理稀释了的 alpha-SMA 的表示 -- 作为(P<0.01,分别地) 。相反,没有类似的效果在与爬的 oligonucleotide 对待的控制组被观察。结论:在人的近似管状的上皮细胞(PTC ) 的 Ang 导致 II 的 EMT 能被处理与 CTGF 稀释 -- 作为。我们的数据提供 CTGF 可能在 PTC 涉及 Ang 导致 II 的 EMT 的进一步的证据。 | Long CHEN Bi-cheng LIE Xiao-liang ZHANG Jian-dong ZHANG Hong LIU Min-xia LI | 2006 | Acta Pharmacologica Sinica2006，27，8： | 21 |
| 19 | Rotor Strength Analysis of High-speed Permanent Magnet Synchronous Motors显示文摘为了对转子进行有效的冷却,在满足电机电磁性能的前提下,可通过减小保护套的厚度来尽可能增大定转子之间的气隙,因而必须对保护套和永磁体进行强度校核。将转子受力状况简化为平面应变问题,在此基础上推导出了两层过盈配合、三层过盈配合转子的应力场、应变场、位移场的解析公式,并利用有限元方法验证了解析公式的正确性。归纳了高速情况下热套式永磁转子强度设计准则,为转子的优化设计提供了理论依据。以一台额定转速120kr/min、10kW的高速永磁同步电机为例,给出了两种常用过盈配合高速电机转子的强度设计方法。 | CHENG Wenjie GENG Haipeng FENG Sheng YU Lie SUN Yanhua YANG Lihua | 2012 | 中国电机工程学报2012，32，27： | 21 |
| 20 | Immunosuppressive exosomes from TGF-pl gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells显示文摘 | Zhijian Cai Wei Zhang Fei Yang Lei Yu Zhou Yu JihHung Pan Lie Wang Xuetao Cao Jianli Wang | 2012 | Cell Research2012，22，3： | 20 |
您所在的机构暂未开通此部分的功能，请联系管理员