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| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | High-performance silicon−graphene hybrid plasmonic waveguide photodetectors beyond 1.55μm显示文摘Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm wavelength band.In this work,we propose and realize high-performance waveguide photodetectors based on bolometric/photoconductive effects by introducing an ultrathin wide silicon−graphene hybrid plasmonic waveguide,which enables efficient light absorption in graphene at 1.55μm and beyond.When operating at 2μm,the present photodetector has a responsivity of ~70 mA/W and a setup-limited 3 dB bandwidth of >20 GHz.When operating at 1.55μm,the present photodetector also works very well with a broad 3 dB bandwidth of >40 GHz(setup-limited)and a high responsivity of ~0.4 A/W even with a low bias voltage of−0.3 V.This work paves the way for achieving highresponsivity and high-speed silicon-graphene waveguide photodetection in the near/mid-infrared ranges,which has applications in optical communications,nonlinear photonics,and on-chip sensing. | Jingshu Guo Jiang Li Chaoyue Liu Yanlong Yin Wenhui Wang Zhenhua Ni Zhilei Fu Hui Yu Yang Xu Yaocheng Shi Yungui Ma Shiming Gao Limin Tong Daoxin Dai | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 3 | Effect of Preheating Temperature on Surface Cracking of High Nitrogen CrMn Austenitic Stainless Steel显示文摘18Mn18Cr0.5N steel specimens were preheated at the temperatures from 1100 to 1250°C for 5 min,and then cooled to 950°C and compressed.The cracking behaviors were investigated using optical microscopy and scanning electron microscopy.The results showed that the hot workability of 18Mn18Cr0.5N steel gradually decreased with increasing preheating temperature between 1100 and 1200°C,and quickly deteriorated up to 1250°C.Above 1200°C,delta ferrite particles appeared in 18Mn18Cr0.5N steel,promoted cavity coalescence on grain boundary,and accelerated surface crack formation during the hot working process. | Zhenhua Wang Wantang Fu Shuhua Sun Zhiqing Lv Wenhui Zhang | 2010 | Journal of Materials Science & Technology2010，26，9： | 4 |
| 4 | Fibrinolytic Evaluation of Compounds Isolated from a Marine Fungus Stachybotrys Iongispora FG216显示文摘 | Ruihua Guo Yiting Zhang Dong Duan Qiang Fu Xiangyu Zhang Xiaowei Yu Shujun Wang Bin Bao Wenhui Wu | 2016 | Chinese Journal of Chemistry2016，34，11： | 4 |
| 5 | Integrated treatment for lower-limb stage Ⅱ thromboangiitis obliterans by interventional therapy and oral administration of Chinese medicine: a randomized controlled clinical trial显示文摘OBJECTIVE: To observe if integrated treatment is better than other therapies for lower-limb stage thromboangiitis obliterans(TAO).ⅡMETHODS: Ninety lower-limb stage randomly dividedⅡ i or worse TAO patients werento three groups: group A(30 cases) treated by intervention and oral administration of Chinese medicine; groupB(30 cases) treated by intervention alone; and group C(30 cases) treated only with oral administration of Chinese medicine. Therapeutic effects were observed, including the cure rate; the recurrence rate after one month, three months, six months, nine months, and one year; the ankle brachial indexes; the incidence of complications; and the level of C-reactive protein and erythrocyte sedimentation rate.RESULTS: Group A had significantly better clinically curative effects, related indexes, and outcomes during the long-term follow-up survey, than that of groups B and C.CONCLUSION: Integrated treatment is more effective for treating lower-limb stage Ⅱ or worse TAO. | Chang Yaowen Li Fenqiang Wang Wenhui Song Laichang Li Li Li Zhengfei Su Dongjun Fu Zhaoliang | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 3 |
| 6 | Identification and Fibrinolytic Evaluation of an Isoindolone Derivative Isolated from a Rare Marine Fungus Stachybotrys Iongispora FG216显示文摘isoindolone 衍生物,真菌 fibrinolytic 混合物(R)-2,5-bis((2R,3R)-2-((E)-4,8-dimethylnona-3,7-dien-1-yl)-3,5-dihydroxy-2-methyl-7-oxo-3,4,7,9-tetrahydropyrano[2,3-e]isoindol-8(2H)-yl)pentanoic 酸(FGFC1,真菌 fibrinolytic 化合物 1 ) ,从稀罕海洋的微生物种类 Stachybotrys longispora FG216 被孤立。FGFC1 的结构被 1 H NMR, 13 C NMR,红外,和 MS 数据;而且,它也在 vitro 并且在 vivo 为 fibrinolytic 活动被评估。结果证明 FGFC1 的 0.1-0.4 mmol/L 能刺激胞质素活动的产生(由 2.05-11.44 褶层增加了) 由在 vitro 测量 Glu-plasminogen 和 Lys-plasminogen 激活。荧光黄 isothiocyanate (FITC ) 的实验纤维蛋白原降级显示在 fibrinolytic 活动的 FGFC1 的效果被 plasminogen 和 scuPA 调停。另外, FGFC1 (10 mg/kg ) 能在 vivo 溶解大多数 Wistar 老鼠的肺的血栓。FGFC1 以后是一个潜在的 thrombolytic 代理人,是可能的。 | Ge Wang Wenhui Wu Quangang Zhu Shiqing Fu Xiaoyu Wang Shaotong Hong Ruihua Guo Bin Bao | 2015 | Chinese Journal of Chemistry2015，33，9： | 2 |
| 7 | The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis显示文摘PH20 is a member of the human hyaluronidase family that degrades hyaluronan in the extracellular matrix and controls tumor progression.Inhibition of DNA methyltransferases(DNMTs)leads to elevated hyaluronan levels;however,whether DNMT inhibitors control PH20 remains unclear.Here,we report that the DNMT1 inhibitor,decitabine,suppresses PH20 expression by activating the long non-coding RNA PHACTR2-AS1(PAS1).PAS1 forms a tripartite complex with the RNA-binding protein vigilin and histone methyltransferase SUV39H1.The interaction between PAS1 and vigilin maintains the stability of PAS1.Meanwhile,PAS1 recruits SUV39H1 to trigger the H3K9 methylation of PH20,resulting in its silencing.Functionally,PAS1 inhibits breast cancer growth and metastasis,at least partially,by suppressing PH20.Combination therapy of decitabine and PAS1-30nt-RNA,which directly binds to SUV39H1,effectively blocked breast cancer growth and metastasis in mice.Taken together,DNMT1,PAS1,and PH20 comprise a regulatory axis to control breast cancer growth and metastasis.These findings reveal that the DNMT1-PAS1-PH20 axis is a potential therapeutic target for breast cancer. | Yenan Fu Xi Zhang Xiao Liu Peng Wang Wenhui Chu Wei Zhao Yunling Wang Guangbiao Zhou Yu Yu Hongquan Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 8 | Capacitive Properties of the Binder-Free Electrode Prepared from Carbon Derived from Cotton and Reduced Graphene Oxide显示文摘减少的 graphene 氧化物(rGO ) 和从棉花(aCFC ) 导出的激活的碳的没有文件夹的合成电影被制作了并且用作电极让电气化学的电容器(EC ) 在另外的文件夹引起的传统的过程避免电容的性能的减少。最佳的 aCFC 在 850 | Wenhui Ma Yunzhen Chang Gaoyi Han Yaoming Xiao Dongying Fu Yahui Chang | 2017 | Chinese Journal of Chemistry2017，35，12： | 2 |
| 9 | Effects of Bacillus preparations on immunity and antioxidant activities in grass carp ( Ctenopharyngodon idellus )显示文摘 | Li Weifen Zhang Xiaoping Song Wenhui Deng Bin Liang Quan Fu Luoqin Zheng Jiajia Wang yue Yu Dongyou | 2012 | Fish Physiology and Biochemistry2012，，6： | 1 |
| 10 | Cascade Classifier Using Combination of Histograms of Oriented Gradients for Rapid Pedestrian Detection显示文摘 | Li Wenhui Lin Yifeng Fu Bo | 2013 | Journal of Software2013，8，1： | 1 |
| 11 | Synthesis and Enhanced Electrochemical Catalytic Performance of Monolayer WS2(1– x )Se2 x with a Tunable Band Gap显示文摘 | Qi Fu Lei Yang Wenhui Wang Ali Han Jian Huang Pingwu Du Zhiyong Fan Jingyu Zhang Bin Xiang | 2015 | Adv. Mater2015，，32： | 1 |
| 12 | Hot deformation behavior of a Nb-containing 316LN stainless steel显示文摘 | Zhang Wenhui Sun Shuhua Zhao Deli Wang Baozhong Wang Zhenhua Fu Wantang | 2011 | Materials and Design2011，，8： | 1 |
| 13 | High-entropy alloy stabilized and activated Pt clusters for highly efficient electrocatalysis显示文摘Although Pt and other noble metals are the state-of-the-art catalysts for various energy conversion applications,their low reserve,high cost,and instability limit their large-scale utilization.Herein,we report a hybrid catalysts design featuring noble metal clusters(e.g.,Pt)uniformly dispersed and stabilized on high-entropy alloy nanoparticles(HEA,e.g.,FeCoNiCu),denoted as HEA@Pt,which is prepared via ultra-fast shock synthesis(∼300 ms)for HEA alloying combined with Pt galvanic replacement for surface anchoring.In our design,the HEA core critically ensures high dispersity,stability,and tunability of the surface Pt clusters through high entropy stabilization and core-shell interactions.As an example in the hydrogen evolution reaction,HEA@Pt achieved a significant mass activity of 235 A/gPt,which is 9.4,3.6,and 1.9-times higher compared to that of homogeneous FeCoNiCuPt(HEA-Pt),Pt,and commercial Pt/C,respectively.We also demonstrated noble Ir stabilized on FeCoNiCrMn nanoparticles(HEA-5@Ir),achieving excellent anodic oxygen evolution performance and highly efficient overall water splitting when combined with the cathodic HEA@Pt.Therefore,our work developed a general catalysts design strategies by using high entropy nanoparticles for effective dispersion,stabilization,and modulation of surface active sites,achieving a harmonious combination of high activity,stability,and low cost. | Wenhui Shi Hanwen Liu Zezhou Li Chenghang Li Jihan Zhou Yifei Yuan Feng Jiang (Kelvin)Kun Fu Yonggang Yao | 2022 | SusMat2022，2，2： | 1 |
| 14 | Cascade Classifier Using Combination of Histograms of Oriented Gradients for Rapid Pedestrian Detection显示文摘 | Li Wenhui Lin Yifeng Fu Bo | 2013 | Journal of Software2013，8，1： | 1 |
| 15 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 16 | Effect of composite pore-former on the fabrication and performance of anode-supported membranes for SOFCs显示文摘 | Jinyan Hu Zhe Lü Kongfa Chen Xiqiang Huang Na Ai Xiaobo Du Chengwei Fu Jiaming Wang Wenhui Su | 2008 | Journal of Membrane Science2008，，1： | 1 |
| 17 | Changes in wheat protein digestibility and allergenicity: role of Pediococcus acidilactici XZ31 and yeast during dough fermentation显示文摘Wheat flour,as the most important source of food globally,is one of the most common causative agents of food allergy.This study aimed to investigate the effects of fermentation on wheat protein digestibility and allergenicity.Protein digestibility were evaluated using the sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis and enzyme-linked immunosorbent assay.The effect of protein on intestinal permeability was investigated by Caco-2 cell monolayers.Co-culture fermentation with Pediococcus acidilactici XZ31 and yeast leads to improvement in digestibility of wheat protein compared to single strain fermentation.Fermentation leads to a decrease in albumin/globulin antigenicity and an increase in gluten R5 reactivity,with the most significant changes in the co-culture group.Digestion strengthen the decrease of protein antigenicity and counteracts the difference in antigenicity induced by fermentation between groups.However,pretreatment with P.acidilactici XZ31 reduces the amount of allergens across Caco-2 monolayer and attenuates the gluten-induced increase in permeability of Caco-2 cell monolayer by reducing actin polymerization and villous atrophy.Co-culture fermentation reduces gluten-induced cell monolayer damage to a greater extent than P.acidilactici XZ31 monoculture.These results gives valuable insight into the effects of P.acidilactici XZ31 fermentation on the allergenicity and toxicity of wheat proteins,which contribute to promoting the application of multi-strain leavening agent in hypoallergenic and gluten-free wheat products. | Wenhui Fu Chen Chen Chenglong Liu Sha Tao Wentong Xue | 2023 | Food Science and Human Wellness2023，12，6： | 0 |
| 18 | Target-activated and ratiometric photochromic probe for “double-check” detection of toxic thiols in live cells显示文摘Photochromic molecules can achieve reversible isomerization upon alternate light irradiations, which offers a great opportunity to improve the precision of analytes detection and imaging in complicated biological environments. Previous reported photochromic probe exhibited only mono-color switching and an initially fluorescence-ON state that may cause high background signal and impose an adverse impact on the desired sensing precision. To overcome this set-back, we developed a novel photochromic probe with an analyte-activation mode for ratiometric sensing of toxic thiols in both real water samples and live cells. The dynamic dual-fluorescence signal is released only after the fast and selective cleavage of the 2,4-dinitrophenyl sulfonate by the targeted thiophenol derivatives. Consequently, a 'double-check' with synchronized dual-fluorescence blinking for analyte detection is successfully employed upon alternate light triggers with rapid response(k=7.2×10^(-2) s^(-1)), high sensitivity(LOD=6.1 nM) as well as selectivity of thiophenol derivatives over other common thiol species(e.g., GSH, Cys and Hcy). The photochromic probe was successfully introduced to the fast and on-site detection of highly toxic thiophenols in real waste water samples. Moreover, by using confocal laser-scanning microscopy(CLSM) and flow cytometric analysis, the potential applications of this ratiometric photochromic probe for trace toxic thiol sensing in live cells are examined. | Youxin Fu Xing Zhang Feng Cao Wenhui Wang Guangren Qian Junji Zhang | 2019 | Science China Chemistry2019，62，9： | 0 |
| 19 | Numerical simulation of granular silicon growth and silicon fines formation process in polysilicon fluidized bed显示文摘Operating conditions strongly affect the yield and quality of polysilicon in a polysilicon fluidized bed.In this study,a new model of polysilicon fluidized bed was established using the Euler-Euler model coupled with population balance model(PBM),which was combined with fluid flow,heat,and mass transfer models,while considering the scavenging effect of silicon fines.The effects of different operating conditions on the deposition and formation rates of silicon fines were investigated.Results show that the model can correctly describe the particle growth process in the fluidized bed of polysilicon.The silicon fines and the interphase velocity difference show'N'-and'M'-shaped distributions along the axial direction,respectively.The particle temperature and concentration near the wall are higher than those in the central region.The decomposition of silane in the bottom region of the bed is dominated by het-erogeneous deposition.The scavenging of silicon fines occurs in the dilute-phase region.The effects of operating conditions,i.e.inlet gas temperature,silane composition,and gas velocity,on the reactor performance were also explored comprehensively.Increasing the inlet gas composition and velocity enhances the formation rates of solid silicon and fines.Increasing the inlet gas temperature promotes the growth of solid silicon and inhibits the formation of silicon fines.High fluidization ratio,low inlet silane concentration,and high inlet gas temperature enhance the selectivity of silicon growth. | Guangkai Gu Guoqiang Lv Wenhui Ma Shanlin Du Boqiang Fu | 2024 | Particuology2024，87，4： | 0 |
| 20 | Neural stem cell-derived exosomes regulate cell proliferation,migration,and cell death of brain microvascular endothelial cells via the miR-9/Hes1 axis under hypoxia显示文摘Background:Our previous study found that mouse embryonic neural stem cell(NSC)-derived exosomes(EXOs)regulated NSC differentiation via the miR-9/Hes1 axis.However,the effects of EXOs on brain microvascular endothelial cell(BMEC)dysfunction via the miR-9/Hes1 axis remain unknown.Therefore,the current study aimed to determine the effects of EXOs on BMEC proliferation,migration,and death via the miR-9/Hes1 axis.Methods:Immunofluorescence,quantitative real-time polymerase chain reaction,cell counting kit-8 assay,wound healing assay,calcein-acetoxymethyl/propidium iodide staining,and hematoxylin and eosin staining were used to determine the role and mechanism of EXOs on BMECs.Results:EXOs promoted BMEC proliferation and migration and reduced cell death under hypoxic conditions.The overexpression of miR-9 promoted BMEC prolifera-tion and migration and reduced cell death under hypoxic conditions.Moreover,miR-9 downregulation inhibited BMEC proliferation and migration and also promoted cell death.Hes1 silencing ameliorated the effect of amtagomiR-9 on BMEC proliferation and migration and cell death.Hyperemic structures were observed in the regions of the hippocampus and cortex in hypoxia-induced mice.Meanwhile,EXO treatment improved cerebrovascular alterations.Conclusion:NSC-derived EXOs can promote BMEC proliferation and migra-tion and reduce cell death via the miR-9/Hes1 axis under hypoxic conditions.Therefore,EXO therapeutic strategies could be considered for hypoxia-induced vascular injury. | Xiaojun Deng Xiaoyi Hu Shang Wang Hui Zhao Yaqin Wei Jiaqi Fu Wenhui Wu Jinming Liu Caicai Zhang Lili Wang Ping Yuan | 2024 | Animal Models and Experimental Medicine2024，7，1： | 0 |
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