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| 1 | A Modified Plate Assay for Rapid Screening of Potassium-Solubilizing Bacteria显示文摘The utility of microorganisms for solubilizing the unavailable forms of potassium(K) from soil has led to renewed interest in fabrication of rapid and sensitive plate assays for their isolation and screening. The present study developed a modified plate assay and compared it with previously reported methods for the isolation and screening of K-solubilizing bacteria. The newly developed plate assay is based on improved visualization of halo zone formation around the colonies on agar plates, through inclusion of an acid-base indicator dye, bromothymol blue(BTB), to modify the previously reported Aleksandrov medium. The halo zone exhibited a significant correlation(R = 0.939) with K released in liquid medium. The visualization of potential K solubilizers was improved using this method, which would help in detection of weak/non-acid producers based on secretion of organic acids in the medium. Organic acids in plate diffuse radially and form halo zones in response to reaction with the acid-base indicator dye BTB. Furthermore, K solubilization on plates with this method can be observed within 48–72 h, against the incubation time of 4–5 d needed in the earlier method. Therefore, the newly developed protocol for the plate assay was time saving, more sensitive, and beneficial in comparison to the previously reported Aleksandrov plate assay. | Mahendra Vikram Singh RAJAWAT Surender SINGH Satya Prakash TYAGI Anil Kumar SAXENA | 2016 | Pedosphere2016，26，5： | 6 |
| 2 | Helicobacter pylori eradication in patients with chronic immune thrombocytopenic purpura显示文摘AIM:To assess the effect of Helicobacter pylori(H.pylori)eradication on platelet counts in patients with chronic immune thrombocytopenic purpura(cITP).METHODS:A total of 36 cITP patients were included in the study.The diagnosis of H.pylori was done by rapid urease test and Giemsa staining of the gastric biopsy specimen.All H.pylori positive patients received standard triple therapy for 14 d and were subjected for repeat endoscopy at 6 wk.Patients who continued to be positive for H.pylori on second endoscopyreceived second line salvage therapy.All the patients were assessed for platelet response at 6 wk,3rd and 6th months.RESULTS:Of the 36 patients,17 were positive for H.pylori infection and eradication was achieved in16 patients.The mean baseline platelet count in the eradicated patients was 88615.38±30117.93/mm3and platelet count after eradication at 6 wk,3 mo and6 mo was 143230.77±52437.51/mm3(P=0.003),152562.50±52892.3/mm3(P=0.0001),150187.50±41796.68/mm3(P=0.0001)respectively and in the negative patients,the mean baseline count was71000.00±33216.46/mm3 and at 6 wk,3rd and 6th month follow up was 137631.58±74364.13/mm3(P=0.001),125578.95±71472.1/mm3(P=0.005),77210.53±56892.28/mm3(P=0.684)respectively.CONCLUSION:Eradication of H.pylori leads to increase in platelet counts in patients with cITP and can be recommended as a complementary treatment with conventional therapy. | Ravinder Naik Noonavath Chandrasekharan Padma Lakshmi Tarun Kumar Dutta Vikram Kate | 2014 | World Journal of Gastroenterology2014，20，22： | 6 |
| 3 | Predictors of fifty days in-hospital mortality in decompensated cirrhosis patients with spontaneous bacterial peritonitis显示文摘AIM: To determine the predictors of 50 d in-hospital mortality in decompensated cirrhosis patients with spontaneous bacterial peritonitis(SBP).METHODS: Two hundred and eighteen patients admitted to an intensive care unit in a tertiary care hospital between June 2013 and June 2014 with the diagnosis of SBP(during hospitalization) and cirrhosis were retrospectively analysed. SBP was diagnosed by abdominal paracentesis in the presence of polymorphonuclear cell count ≥ 250 cells/mm3 in the peritoneal fluid. Student's t test, multivariate logistic regression, cox proportional hazard ratio(HR), receiver operating characteristics(ROC) curves and Kaplan-Meier survival analysis were utilized for statistical analysis. Predictive abilities of several variables identified by multivariate analysis were compared using the area under ROC curve. P < 0.05 were considered statistical significant. RESULTS: The 50 d in-hospital mortality rate attributable to SBP is 43.11%(n = 94). Median survival duration for those who died was 9 d. In univariate analysis acute kidney injury(AKI), hepatic encephalopathy, septic shock, serum bilirubin, international normalized ratio, aspartate transaminase, and model for end-stage liver disease- sodium(MELD-Na) were significantly associated with in- hospital mortality in patients with SBP(P ≤ 0.001). Multivariate coxproportional regression analysis showed AKI(HR = 2.16, 95%CI: 1.36-3.42, P = 0.001) septic shock(HR = 1.73, 95%CI: 1.05-2.83, P = 0.029) MELD-Na(HR = 1.06, 95%CI: 1.02-1.09, P ≤ 0.001) was significantly associated with 50 d in-hospital mortality. The prognostic accuracy for AKI, MELD-Na and septic shock was 77%, 74% and 71% respectively associated with 50 d inhospital mortality in SBP patients.CONCLUSION: AKI, MELD-Na and septic shock were predictors of 50 d in-hospital mortality in decompensated cirrhosis patients with SBP. | Chinmaya Kumar Bal Ripu Daman Vikram Bhatia | 2016 | World Journal of Hepatology2016，8，12： | 5 |
| 4 | Risk factors for the development of colorectal carcinoma:A case control study from South India显示文摘AIM:To study the association of colorectal carcinoma(CRC) with diet,smoking,alcohol,physical activity,body mass index,family history and diabetes.METHODS: All consecutive patients with CRC confirmed by histopathology diagnosis were included. Age(±5 years) and gender matched controls were selected among the patients admitted in surgery ward for various conditions without any co-existing malignancy. Food frequency questionnaire(FFQ) was developed and validated after pretesting by investigator trained in data col ection techniques. Cases and controls were interviewed ensuring privacy,in similar interview setting,with same duration of time for both cases and controls without any leading question. Biological variables like family history of CRC in first degree relatives,history of diabetes mellitus; behavioral factors like tobacco use both smoking and smokeless form,alcohol consumption and physical activity were recorded. Dietary details were recorded using a FFQ consisting 29 food items with seven categories. Analysis was done using appropriate statistical methods.RESULTS: Ninety-four histopathologically confirmed cases of CRC and equal number of age and gender matched controls treated over a period of two years were studied. Age distribution,mean age,male to female ratio,education level and socioeconomic status were similar in cases and controls. Intake of food items was categorized into tertile due to skewed distribution of subjects as per recommended cut off for consumption of food item. On univariate analysis red meat [OR=7.4(2.935-18.732)],egg [OR=5.1(2.26-11.36)],fish,fried food and oil consumption were found to be risk factors for CRC. On multivariate analysis red meat consumption of more than 2-3 times a month(OR=5.4; 95%CI:1.55-19.05) and egg consumption of more than 2-3 times a week(OR = 3.67; 95%CI:1.23-9.35) were found to be independent risk factors for the development of CRC.CONCLUSION: Egg and red meat consumption found to be independent risk factors for CRC. Smoking,alcohol,physical activity and family history were not associated with increased risk. | Santhana Krishnan Iswarya Kariyarath Cheriyath Premarajan Sitanshu Sekhar Kar Sathasivam Suresh Kumar Vikram Kate | 2016 | World Journal of Gastrointestinal Oncology2016，8，2： | 3 |
| 5 | 铬解毒机制诱导香根草的生长和抗氧化反应(英文)显示文摘本文研究了铬(Cr)对香根草(Chrysopogon zizanioides)生长以及抗氧化防御酶活性的影响,探讨其对Cr的解毒机制。在50 mg/L Cr处理条件下,植物地上部分和地下部分的生长量分别降低了36.8%和45.0%;Cr在植物地下部分的积累量(9807μg/g干重)大于地上部分的积累量(8730μg/g干重)。随着Cr添加量的增加,光合色素和丙二醛含量增加,在30 mg/L Cr处理条件下含量达到最高,之后,随着Cr处理浓度的增加略有下降;同时,抗氧化防御酶(超氧化物歧化酶、过氧化氢酶和过氧化物酶)的活性显著提高,在较高浓度Cr处理下略有下降。同工酶结果显示在高浓度Cr处理下,超氧化物歧化酶、过氧化氢酶和过氧化物酶的条带强度降低。目前研究结果表明,高浓度Cr导致活性氧过量产生,从而增加了对香根草的氧化损伤,而光合色素、丙二醛、抗氧化酶含量的增加表明香根草对Cr有潜在的耐性机制。结果表明,香根草具有对Cr的解毒机制,并可以积累高浓度的Cr。本文为更深入地研究根草对Cr的解毒机制提供了依据。 | Manikdanan RAJENDRAN 安文慧 李伟展 Venkatachalam PERUMAL 吴川 Shivendra Vikram SAHI Santosh Kumar SARKAR | 2019 | Journal of Central South University2019，26，2： | 3 |
| 6 | Evaluation of potential landslide damming: Case study of Urni landslide,Kinnaur, Satluj valley, India显示文摘This work aims to understand the process of potential landslide damming using slope failure mechanism,dam dimension and dam stability evaluation. The Urni landslide, situated on the right bank of the Satluj River, Himachal Pradesh(India) is taken as the case study. The Urni landslide has evolved into a complex landslide in the last two decade(2000-2016) and has dammed the Satluj River partially since year 2013,damaging ~200 m stretch of the National Highway(NH-05). The crown of the landslide exists at an altitude of ~2180-2190 m above msl, close to the Urni village that has a human population of about 500.The high resolution imagery shows ~50 m long landslide scarp and ~100 m long transverse cracks in the detached mass that implies potential for further slope failure movement. Further analysis shows that the landslide has attained an areal increase of 103,900 ± 1142 m^2 during year 2004-2016. About 86% of this areal increase occurred since year 2013. Abrupt increase in the annual mean rainfall is also observed since the year 2013. The extreme rainfall in the June, 2013; 11 June(~100 mm) and 16 June(~115 mm),are considered to be responsible for the slope failure in the Urni landslide that has partially dammed the river. The finite element modelling(FEM) based slope stability analysis revealed the shear strain in the order of 0.0-0.16 with 0.0-0.6 m total displacement in the detachment zone. Further, kinematic analysis indicated planar and wedge failure condition in the jointed rockmass. The debris flow runout simulation of the detached mass in the landslide showed a velocity of ~25 m/s with a flow height of ~15 m while it(debris flow) reaches the valley floor. Finally, it is also estimated that further slope failure may detach as much as 0.80 ±0.32 million m^3 mass that will completely dam the river to a height of 76±30 m above the river bed. | Vipin Kumar Vikram Gupta Imlirenla Jamir Shovan Lal Chattoraj | 2019 | Geoscience Frontiers2019，10，2： | 2 |
| 7 | Risk factors of thrombosis in abdominal veins显示文摘AIM: To estimate the prevalence of inherited and acquired thrombophilic risk factors in patients with abdominal venous thrombosis and to compare the risk factor profiles between Budd-Chiari syndromes (BCS) and splanchnic vein thrombosis (SVT). METHODS: In this retrospective study, 36 patients with abdominal venous thrombosis were studied. The patients were divided into Budd-Chiari group (hepatic vein, IVC thrombosis) and splanchnic venous thrombosis group (portal, splenic, superior mesenteric veins) based on the veins involved. Hereditary and acquired thrombophilic risk factors were evaluated in all patients. RESULTS: Twenty patients had SVT, 14 had BCS, and 2 had mixed venous thrombosis. Ten patients (28%) had hereditary and 10 patients (28%) acquired thrombophilic risk factors. The acquired risk factors were significantly more common in the SVT group (SVT vs BCS: 45% vs 7%, χ2 = 5.7, P = 0.02) while hereditary risk factors did not show significant differences between the two groups (SVT vs BCS: 25% vs 36%, χ2 = 0.46, P = 0.7). Multiple risk factors were present in one (7%) patient with BCS and in 3 patients (15%) with SVT. No risk factors were identified in 57% of patients with BCS and in 45% of patients with SVT. CONCLUSION: Hereditary and acquired risk factors play an important role in the etiopathogenesis of abdominal venous thrombosis. Acquired risk factorsare significantly more common in SVT patients while hereditary factors are similar in both groups. | Amit Kumar Dutta Ashok Chacko Biju George Joseph Anjilivelil Joseph Sukesh Chandran Nair Vikram Mathews | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 8 | Evaluation of potential surface instability using finite element method in Kharsali Village,Yamuna Valley,Northwest Himalaya显示文摘Kharsali village, located in the Northwest Himalaya near the confluence of the Yamuna River and Unta Gad, is situated on a thick(>150 m) paleolandslide deposit. The village is continuously being eroded at its base by the two rivers. Cracks are noted in most houses while the ancient Shani Temple lying to the south of the village has tilted ~5° towards the northeast. Three slope sections(S-1, S-2, S-3) were modelled and analysed to determine the displacement and shear strain patterns of the slopes. Based on surface failure conditions, potential slope instability of the Kharsali village was evaluated from 2D Finite Element Method(FEM) using Shear Strain Reduction(SSR) analysis in the Phase2 software. Results indicate a critical Stress Reduction Factor(SRF) of 1.5 for the southern edge of the village(S-1) housing the Shani Temple. The development of failure surfaces at its lower portion signifies the propagating, progressive nature of the slope. The S-2 slope section is most vulnerable to slope failure, with a critical SRF of 1.08. This has been inferred by the formation of failure surfaces with displacements of 0.05-0.08 m. The S-3 section in the northern part of the Kharsali shows highest critical SRF of 2.76. The un-metalled road section in the north of the village near S-3 hasdeveloped a failure surface with displacement of 0.003-0.004 m, and a zone of subsidence. The S-3 section is relatively stable, whereas the S-2 section is the most vulnerable portion of the village. | Imlirenla JAMIR Vikram GUPTA Vipin KUMAR Glenn T.THONG | 2017 | Journal of Mountain Science2017，14，8： | 2 |
| 9 | Long-Term Cultured Human Term Placenta-Derived Mesenchymal Stem Cells of Maternal Origin Displays Plasticity显示文摘 | Vikram Sabapathy Saranya Ravi Vivi Srivastava Alok Srivastava Sanjay Kumar Rajarshi Pal | 2012 | Stem Cells International2012，，： | 1 |
| 10 | The role of lipids in the development of diabetic microvascular complications:implications for therapy显示文摘 | Misra A Kumar S Kishore Vikram | 2003 | Am J Cardiovasc Drugs2003，3，5： | 1 |
| 11 | Using likely invariants for automated software fault localization显示文摘 | Swarup Kumar Sahoo John Criswell Chase Geigle Vikram Adve | 2013 | ACM SIGARCH Computer Architecture News2013，41，1： | 1 |
| 12 | A recent review on phytochemical constituents and medicinal properties of kesum(Polygonum minus Huds.)显示文摘Medicinal plants and herbal preparations are gaining renowned interest in scientific communities nowadays due to their reliable pharmacological actions and affordability to common people which makes them effective in control of various diseases.Polygonum minus(Polygonaceae)locally known as kesuni is an aromatic plant commonly used in Malay delicacies.The plant is having potential applications due to its high volatile oil constituents in perfumes and powerful antioxidant activity.It has been used traditionally to treat various ailments including dandruff.The research has been carried out by various researchers using different in vitro and in vivo models for biological evaluations to support these claims.This review paper may help upcoming research activities on Polygonum minus by giving up to date information on the phytochemical constituents and medicinal properties of kesum to a possible extent with relevant data. | Paritala Vikram Kishore Kumar chiruvella Ilfah Husna Abdullah Ripain Mohammed Arifullah | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，6： | 1 |
| 13 | Controlled attenuation parameter for non‐invasive assessment of hepatic steatosis: Does etiology affect performance?显示文摘 | Manoj Kumar Archana Rastogi Tarandeep Singh Chhagan Behari Ekta Gupta Hitendra Garg Ramesh Kumar Vikram Bhatia Shiv K Sarin | 2013 | J Gastroenterol Hepatol2013，，7： | 1 |
| 14 | Spectrum of pulmonary infections in renal transplant recipients in the tropics: a single center study显示文摘 | Vikram Kalra Sanjay Kumar Agarwal Gopi Chand Khilnanil | 2005 | Internationnal Urology and Nephrology2005，37，3： | 1 |
| 15 | Liver Stiffness Measurements in Patients with Different Stages of Nonalcoholic Fatty Liver Disease: Diagnostic Performance and Clinicopathological Correlation显示文摘 | Ramesh Kumar Archana Rastogi Manoj Kumar Sharma Vikram Bhatia Pankaj Tyagi Praveen Sharma Hitendra Garg K. N. Chandan Kumar Chhagan Bihari Shiv Kumar Sarin | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
| 16 | The role of lipids in the development of diabetic mierovascular complications: implications for therapy显示文摘 | Misra A Kumar S Kishore Vikram N | 2003 | Am J Cardiovasc Drugs2003，3，： | 1 |
| 17 | Nonalcoholic fatty liver disease is associated with subclinical atherosclerosis independent of obesity and metabolic syndrome in Asian Indians显示文摘 | Manik Lal Thakur Sanjay Sharma Atin Kumar Surya Prakash Bhatt Kalpana Luthra Randeep Guleria Ravindra M. Pandey Naval K. Vikram | 2012 | Atherosclerosis2012，，2： | 1 |
| 18 | Cytogenetic analysis of acute myeloid leukemia with t(8;21) from a tertiary care center in India with correlation between clinicopathologic characteristics and molecular analysis显示文摘 | Mayur Parihar J. Ashok Kumar Usha Sitaram Poonkuzhali Balasubramanian Aby Abraham Auro Viswabandya Biju George Vikram Mathews Alok Srivastava Vivi M. Srivastava | 2012 | Leukemia & Lymphoma2012，，1： | 1 |
| 19 | Evaluation of Helicobacter pylori infection and other risk factors in patients with benign peptic ulcer disease显示文摘 | Depender Kumar Timshina SS Pankaja Himagirish K Rao Vikram Kate | 2011 | Asian Pacific Journal of Tropical Disease2011，，1： | 1 |
| 20 | Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: Role of adipokines显示文摘 | Parmanand Malvi Balkrishna Chaube Vimal Pandey Maleppillil Vavachan Vijayakumar Purushotham Reddy Boreddy Naoshad Mohammad Shivendra Vikram Singh Manoj Kumar Bhat | 2014 | Molecular Oncology2014，，： | 1 |
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