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| 1 | Epigenetic effects of ethanol on liver and gastrointestinal injury显示文摘Alcohol consumption causes cellular injury. Recent developments indicate that ethanol induces epigenetic alterations, particularly acetylation, methylation of histones, and hypo- and hypermethylation of DNA. This has opened up a new area of interest in ethanol research and is providing novel insight into actions of ethanol at the nucleosomal level in relation to gene expression and patho-physiological consequences. The epigenetic effects are mainly attributable to ethanol metabolic stress (Emess), generated by the oxidative and non-oxidative metabolism of ethanol, and dysregulation of methionine metabolism. Epigenetic changes are important in ethanol-induced hepatic steatosis, fibrosis, carcinoma and gastrointestinal injury. This editorial highlights these new advances and its future potential. | Shivendra D Shukla Annayya R Aroor | 2006 | World Journal of Gastroenterology2006，12，33： | 12 |
| 2 | Management of hypersplenism in non-cirrhotic portal hypertension:a surgical series显示文摘BACKGROUND:Hypersplenism is commonly seen in patients with non-cirrhotic portal hypertension(NCPH).While a splenectomy alone can effectively relieve the hypersplenism,it does not address the underlying portal hypertension.The present study was undertaken to analyze the impact of shunt and non-shunt operations on the resolution of hypersplenism in patients with NCPH.The relationship of symptomatic hypersplenism,severe hypersplenism and number of peripheral cell line defects to the severity of portal hypertension and outcome was also assessed.METHODS:A retrospective analysis of NCPH patients with hypersplenism managed surgically between 1999 and 2009 at our center was done.Of 252 patients with NCPH,64(45 with extrahepatic portal vein obstruction and 19 with non-cirrhotic portal fibrosis) had hypersplenism and constituted the study group.Statistical analysis was done using GraphPad InStat.Categorical and continuous variables were compared using the chi-square test,ANOVA,and Student's t test.The MannWhitney U test and Kruskal-Wallis test were used to compare non-parametric variables.RESULTS:The mean age of patients in the study group was 21.81±6.1 years.Hypersplenism was symptomatic in 70.3% with an incidence of spontaneous bleeding at 26.5%,recurrent anemia at 34.4%,and recurrent infection at 29.7%.The mean duration of surgery was 4.16±1.9 hours,intraoperative blood loss was 457±126(50-2000) mL,and postoperative hospital stay 5.5±1.9 days.Following surgery,normalization of hypersplenism occurred in all patients.On long-term followup,none of the patients developed hepatic encephalopathy and 4 had a variceal re-bleeding(2 after a splenectomy alone,1 each after an esophago-gastric devascularization and proximal splenorenal shunt).Patients with severe hypersplenism and those with defects in all three peripheral blood cell lineages were older,had a longer duration of symptoms,and a higher incidence of variceal bleeding and postoperative morbidity.In addition,patients with triple cell line defects had elevated portal pressure(P=0.001),portal biliopathy(P=0.02),portal gastropathy(P=0.005) and intraoperative blood loss(P=0.001).CONCLUSIONS:Hypersplenism is effectively relieved by both shunt and non-shunt operations.A proximal splenorenal shunt not only relieves hypersplenism but also effectively addresses the potential complications of underlying portal hypertension and can be safely performed with good long-term outcome.Patients with hypersplenism who have defects in all three blood cell lineages have significantly elevated portal pressures and are at increased risk of complications of variceal bleeding,portal biliopathy and gastropathy. | Rajesh Rajalingam Amit Javed Dharmanjay Sharma Puja Sakhuja Shivendra Singh Hirdaya H Nag Anil K Agarwal | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 7 |
| 3 | Molecular targets of cancer chemoprevention by garlic-derived organosulfides显示文摘瞀或蒜之类蔬菜的药用的好处,特别大蒜,在整个记录历史被注意了。瞀或蒜之类蔬菜和他们的成分的已知的健康好处包括心血管的保护的效果,有免疫力的功能的刺激,血葡萄糖水平的减小,辐射防护,记忆损失的改进,对微生物引起、病毒、真菌的感染的保护,象反癌症一样, 基于effects.Population 的盒子控制研究包括大蒜建议了在瞀或蒜之类蔬菜的饮食的吸入和瞀或蒜之类蔬菜的不同类型 ofcancers.The anticarcinogenic 效果的风险之间的反的关联被归因 toorganosulfur 混合物(振荡),它在在许多化学致癌物劝诱的动物模特儿对癌症负担得起保护是高度有效的。更最近的研究证明了某些自然地发生的振荡类似物能在文化并且在在房间经常是的癌症的增长的导致振荡的变化在房间周期前进和 G2/M 阶段拘捕的正式就职与不安联系了的 vivo.The 压制癌症房间的增长。振荡也被表明了由在房间文化并且在改变蛋白质的 Bc1-2 家庭的比率经由内在的小径导致 apoptosis 在 vivo models.Anti-angiogenic,为 garlic-derivedOSC 的活动也被记录了。这篇文章由振荡在癌症 chemoprevention 的分子的目标上总结当前的知识。 | Anna HERMAN-ANTOSIEWICZ Anna A POWOLNY Shivendra V SINGH | 2007 | Acta Pharmacologica Sinica2007，28，9： | 6 |
| 4 | A GFP-based bacterial biosensor with chromosomally integrated sensing cassette for quantitative detection of Hg(Ⅱ) in environment显示文摘A mercury biosensor was constructed by integrating biosensor genetic elements into E. coli JM109 chromosome in a single copy number, using the attP/attB recombination mechanism of λ phage. The genetic elements used include a regulatory protein gene (merR) along with operator/promoter (O/P) derived from the mercury resistance operon from pDU1358 plasmid of Serratia marcescens. The expression of reporter gene gfp is also controlled by merR/O/P. Integration of the construct into the chromosome was done to increase the stability and precision of the biosensor. This biosensor could detect Hg(Ⅱ) ions in the concentration range of 100–1700 nmol/L, and manifest the result as the expression of GFP. The GFP expression was significantly different (P 0.05) for each concentration of inducing Hg(Ⅱ) ions in the detection range, which reduces the chances of misinterpretation of results. A model using regression method was also derived for the quantification of the concentration of Hg(Ⅱ) in water samples. | Himanshu Priyadarshi Absar Alam Gireesh-Babu P Rekha Das Pankaj Kishore Shivendra Kumar Aparna Chaudhari | 2012 | Journal of Environmental Sciences2012，24，5： | 6 |
| 5 | Multimodality management of gallbladder cancer can lead to a better outcome:Experience from a tertiary care oncology centre in North India显示文摘BACKGROUND Surgical resection is a treatment of choice for gallbladder cancer(GBC)patients but only 10%of patients have a resectable disease at presentation.Even after surgical resection,overall survival(OS)has been poor due to high rates of recurrence.Combination of surgery and systemic therapy can improve outcomes in this aggressive disease.AIM To summarize our single-center experience with multimodality management of resectable GBC patients.METHODS Data of all patients undergoing surgery for suspected GBC from January 2012 to December 2018 was retrieved from a prospectively maintained electronic database.Information extracted included demographics,operative and perioperative details,histopathology,neoadjuvant/adjuvant therapy,follow-up,and recurrence.To know the factors associated with recurrence and OS,univariate and multivariate analysis was done using log rank test and cox proportional hazard analysis for categorical and continuous variables,respectively.Multivariate analysis was done using multiple regression analysis.RESULTS Of 274 patients with GBC taken up for surgical resection,172(62.7%)were female and the median age was 56 years.On exploration,102 patients were found to have a metastatic or unresectable disease(distant metastasis in 66 and locally unresectable in 34).Of 172 patients who finally underwent surgery,93(54%)underwent wedge resection followed by anatomical segment IVb/V resection in 66(38.4%)and modified extended right hepatectomy in 12(7%)patients.The postoperative mortality at 90 d was 4.6%.During a median follow-up period of 20 mo,71(41.2%)patients developed recurrence.Estimated 1-,3-,and 5-years OS rates were 86.5%,56%,and 43.5%,respectively.Estimated 1-and 3-year disease free survival(DFS)rates were 75%and 49.2%,respectively.On multivariate analysis,inferior OS was seen with pT3/T4 tumor(P=0.0001),perineural invasion(P=0.0096),and R+resection(P=0.0125).However,only pT3/T4 tumors were associated with a poor DFS(P<0.0001).CONCLUSION Multimodality treatment significantly improves the 5-year survival rate of patients with GBC up to 43%.R+resection,higher T stage,and perineural invasion adversely affect the outcome and should be considered for systemic therapy in addition to surgery to optimize the outcomes.Multimodality treatment of GBC has potential to improve the survival of GBC patients. | Shaifali Goel Abhishek Aggarwal Assif Iqbal Vineet Talwar Swarupa Mitra Shivendra Singh | 2021 | World Journal of Gastroenterology2021，27，45： | 5 |
| 6 | Palliative surgical bypass for unresectable periampullary carcinoma显示文摘BACKGROUND:Around 60%to 80%of patients with periampullary carcinoma are unresectable either due to distant metastasis or local vascular invasion.With the advancement of endoscopic interventional procedures,the role of surgical bypass has diminished.However,surgical bypass is still appropriate in patients with unresectable disease discovered at the time of surgery.This study was conducted to assess the results of palliative surgical bypass for patients with unresectable periampullary carcinoma at our hospital,a tertiary referral center of Northern India. METHOD:The study group comprised 204 patients who had undergone surgical bypass for advanced periampullary carcinoma over the last 15 years. RESULTS:Between January 1990 and December 2004,204 patients(128 males,76 females)consisting of 179 patients with carcinoma of head of the pancreas,14 patients with ampullary carcinoma,8 patients with lower end cholangiocarcinoma and 3 patients with duodenal carcinoma underwent surgical bypass.Their average age was 51 years (range 20-78 years).Both biliary and gastric bypasses were done in 158(77.45%),biliary bypass alone in 37(18.13%) and gastric bypass alone in 9(4.32%).Biliary bypass was done by Roux-en-Y hepaticojejunostomy,and gastric bypass by retrocolic gastrojejunostomy.The overall postoperative mortality and morbidity were 0.98%and 26.9%,respectively The patients who died had undergone previously endoscopic intervention.Complications included wound infection in 12.25%of the patients,bile leak in 5.12%,delayed gastric emptying in 5.38%,ascitic leak from drains in 8.8%,and upper gastrointestinal bleeding in 1.96%.The incidences of wound infection and bile leak both were significantly higher in patients who had had preoperative biliary stenting None of the patients who had undergone Roux-en-Y hepati cojejunostomy+retrocolic gastrojejunostomy required any intervention later in their life.CONCLUSIONS:Surgical bypass is a safe procedure with negligible mortality and minimal morbidity.It has not lost its relevance and is an appropriate treatment in patients deemed unresectable on peroperative assessment. | Shivendra Singh Ajay Kumar Sachdev Adarsh Chaudhary Anil Kumar Agarwal | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 3 |
| 7 | 铬解毒机制诱导香根草的生长和抗氧化反应(英文)显示文摘本文研究了铬(Cr)对香根草(Chrysopogon zizanioides)生长以及抗氧化防御酶活性的影响,探讨其对Cr的解毒机制。在50 mg/L Cr处理条件下,植物地上部分和地下部分的生长量分别降低了36.8%和45.0%;Cr在植物地下部分的积累量(9807μg/g干重)大于地上部分的积累量(8730μg/g干重)。随着Cr添加量的增加,光合色素和丙二醛含量增加,在30 mg/L Cr处理条件下含量达到最高,之后,随着Cr处理浓度的增加略有下降;同时,抗氧化防御酶(超氧化物歧化酶、过氧化氢酶和过氧化物酶)的活性显著提高,在较高浓度Cr处理下略有下降。同工酶结果显示在高浓度Cr处理下,超氧化物歧化酶、过氧化氢酶和过氧化物酶的条带强度降低。目前研究结果表明,高浓度Cr导致活性氧过量产生,从而增加了对香根草的氧化损伤,而光合色素、丙二醛、抗氧化酶含量的增加表明香根草对Cr有潜在的耐性机制。结果表明,香根草具有对Cr的解毒机制,并可以积累高浓度的Cr。本文为更深入地研究根草对Cr的解毒机制提供了依据。 | Manikdanan RAJENDRAN 安文慧 李伟展 Venkatachalam PERUMAL 吴川 Shivendra Vikram SAHI Santosh Kumar SARKAR | 2019 | Journal of Central South University2019，26，2： | 3 |
| 8 | Designing a Mini-Core Collection Effectively Representing 3004 Diverse Rice Accessions显示文摘Genetic diversity provides the foundation for plant breeding and genetic research.Over 3000 rice genomes were recently sequenced as part of the 3K Rice Genome(3KRG)Project.We added four additional Indian rice accessions to create a panel of 3004 accessions.However,such a large collection of germplasm is difficult to preserve and evaluate.The construction of core and mini-core collections is an efficient method for the management of genetic resources.In this study,we developed a mini-core comprising 520 accessions that captured most of the SNPs and represented all of the phenotypes and geographic regions from the original panel.The mini-core was validated using different statistical analyses and contained representatives from all major rice groups,including japonica,indica,aus/boro,and aromatic/basmati.Genomewide association analyses of the mini-core panel efficiently reproduced the marker–trait associations identified in the original panel.Haplotype analysis validated the utility of the mini-core panel.In the current era with many ongoing large-scale sequencing projects,such a strategy for mini-core design should be useful in many crops.The rice mini-core collection developed in this study would be valuable for agronomic trait evaluation and useful for rice improvement via marker-assisted molecular breeding. | Angad Kumar Shivendra Kumar Kajol B.M.Singh Manoj Prasad Jitendra K.Thakur | 2020 | Plant Communications2020，1，5： | 3 |
| 9 | Choledochal cyst with large stone cast and portal hypertension显示文摘BACKGROUND:Choledochal cysts in adults are more commonly associated with complications such as cystolithiasis,recurrent cholangitis,portal hypertension and malignancy,than in the pediatric age group.METHOD:We report a case of adult choledochal cyst with long-term complication of large stone cast and portal hypertension due to secondary biliary cirrhosis.RESULTS:A 50-year-old patient presented with obstructive jaundice and hepatosplenomegaly.On investigation,she was diagnosed as having a choledochal cyst with large stone cast and portal hypertension.Single stage resection of the choledochal cyst with Roux-en-Y hepaticojejunostomy was done by meticulous dissection and ligation of collaterals.CONCLUSION:Single stage resection of a choledochal cyst is possible in spite of associated portal hypertension,if the portal vein is patent. | Shivendra Singh Laxman Singh Kheria Sunil Puri Amrinder S Puri Anil K Agarwal | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 2 |
| 10 | Comparison of extramedullary and intramedullary devices for treatment of subtrochanteric femoral fractures at tertiary level center显示文摘破裂正在质问的 subtrochanteric 和治疗形式的 ObjectiveThe 治疗并且植入常常正在演变。这研究试图与 subtrochanteric 破裂在相对年轻的 population.MethodsThirty 病人重游并且比较 extramedullary 对 intramedullary 设备与设备和后续继续的 extramedullary 或 intramedullary 被注册并且对待一个为病人的 clinico 放射学的 assessment.ResultsThe 平均数年龄的年是 37.53 年。最是在 21-40 岁之间的男性。损害的主导的模式是交通事故(66%) 。破裂根据 Russell-Taylor 分类被分类。百分之四十是 Russell-Taylor 类型 IA, 37% 类型 IB 和 23% 类型 IIA。外科的平均时间是从到医院的承认的时间的 3.6 天。外科的吝啬的持续时间是为 intramedullary 设备(组 A ) 的 45 分钟, 105 为 extramedullary 纪录设备(组 B ) 。平均的血损失是 100 在组 A 和 200 的 ml;在组 B 的 ml。意味着放射暴露的持续时间为组 A 和 B 是 130 秒和 140 秒,当医院停留的平均持续时间分别地是 12 天和 16 天时。优秀结果在组 A 在 47% 盒子中被看见,在组 B.ConclusionIntramedullary 设备的 33% 盒子是一可靠为 subtrochanteric 植入破裂。它与最小的软织物的损坏有联合的高率。Intramedullary 固定有生物并且 biomechanical 优点,而是手术技术上正在要求。渐渐的学习和耐心被需要做真正奖励的这个方法。 | Sanjay Yadav Shivendra Sinha Edwin Luther Naresh Chander Arora Manish Prasad Rohit Varma | 2014 | Chinese Journal of Traumatology2014，17，3： | 2 |
| 11 | Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds显示文摘 | Anna A. Powolny Shivendra V. Singh | 2008 | Cancer Letters2008，，2： | 2 |
| 12 | Nutritional aspects of food extrusion: a review 显示文摘 | SHIVENDRA Singh SHIRANI Gamlath LARA Wakeling | 2007 | International Journal of Food Science and Technology2007，42，8： | 1 |
| 13 | Neem(Azadirachta indica) seed kernel extracts and azadirachtin as oviposition deterrents against the melon fly (Bactrocera cucurbitae) and the oriental fruit fly (Bactrocera dorsalis)显示文摘 | SHIVENDRA S SINGH R P | 1998 | Phytoparasitica1998，26，3： | 1 |
| 14 | Nutritional aspects of food extrusion:a review显示文摘 | Shivendra Singh Shirani Gamlath Lara Wakeling | 2007 | International Journal of Food Science and Technology2007，42，： | 1 |
| 15 | Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells显示文摘 | Dhanir Tailor Eun-Ryeong Hahm Raosaheb K. Kale Shivendra V. Singh Rana P. Singh | 2013 | Mitochondrion2013，，： | 1 |
| 16 | To Forward or not to For-ward-That is the Question显示文摘 | Sathya Narayanan Shivendra S Panwar | 2007 | Wireless Personal Communica-tions2007，43，： | 1 |
| 17 | Impact of garlic organosulfides on p21 H-ras processing显示文摘 | Shivendra VS | 2001 | J Nutr2001，131，3： | 1 |
| 18 | Nutritional aspects of food extrusion: a review显示文摘 | Shivendra Singh Shirani Gamlath Lara Wakeling | 2007 | International Journal of Food Science and Technology2007，42，： | 1 |
| 19 | The influence of polymer structure on melt strength behavior of PE resins显示文摘 | Shivendra K Goyal | 1995 | Plastics Engineering1995，51，2： | 1 |
| 20 | Response surface methodology-based approach to CNC drilling operations显示文摘 | Godfrey C. Onwubolu Shivendra Kumar | 2005 | Journal of Materials Processing Tech2005，，1： | 1 |
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