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38篇 您的检索式：作者名="Petzold GC"

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	题名	作者	年代	出处	被引量
1	星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。	Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊	2019	神经损伤与功能重建2019，14，6：	2
2	The NALP3 inflamma- some is involved in the innate immune response to amyloid - be- ta显示文摘	Halle A Hornung V Petzold GC	2008	Nat Immuno12008，9，8：	1
3	Role of astroeytes in neurovascular cou- pling显示文摘	Petzold GC Murthy VN	2011	Neuron2011，71，5：	1
4	The NALP3 inflammasome is involved in the innate immune response to amyloid-beta显示文摘	Halle A Hornung V Petzold GC	2008	Nat Immunol2008，9，8：	1
5	Repetitive spreading depression-like events result in cell damage in juvenile hippocampal slice cultures maintained in normoxia显示文摘	Pomper JK Haack S Petzold GC	2006	J Neurophysiol2006，95，：	1
6	The NALP3 inflammasome is involved in the innate immune response to amyloid-β显示文摘	Halle A Hornung V Petzold GC		0，，08：	1
7	The NALP3 inflammasome is involved in the innate immune response to amyloid-beta 显示文摘	Halle A Homung V Petzold GC	2008	Nat Immunol2008，9，8：	1
8	The NALP3 inflammasome is involved in the innate immune response to amyloid-~ 显示文摘	Halle A Hornung V Petzold GC	2008	Nat Immunol2008，9，8：	1
9	The NALP3 inflammassome is involved in the innate immune reponse to amyloid-beta显示文摘	Halle A Hornung V Petzold GC	2008	Nat Immunol2008，9，8：	1
10	The NALP3 inflamma-some is involved in the innate immune response to amyloid-beta显示文摘	Halle A Homung V Petzold GC	2008	Nat Immunol2008，9，8：	1
11	Experience-dependent modification of primary sensory synapses in the mammalian olfactory bulb显示文摘	TYLER W J PETZOLD GC PAL SK	2007	J Neurosci2007，27，：	1
12	The NALP3 inflamma-some is involved in the innate immune response to amyloid-beta显示文摘	Haile A Homung V Petzold GC	2008	Nat Immunol2008，9，8：	1
13	Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type Ⅱ显示文摘	Dreier JP Jurkat-Rott K Petzold GC	2005	Neurology2005，64，：	1
14	The NALP3inflammasome is involved in the innate immune response to amyloid-beta显示文摘	Halle A Hornung V Petzold GC	2008	Nat Immunol2008，9，8：	1
15	Role of astrocytes in neurovascular coupling显示文摘	Petzold GC Murthy VN		0，，05：	1
16	Role of astrocytes in neurovascular coupling 显示文摘	Petzold GC Murthy VN	2011	Neuron2011，71，5：	1
17	The NALP3 inflammasome is involved in the innate immune response to amyloid-β 显示文摘	Halle A Homung V Petzold GC	2008	Nat Im-munol2008，9，8：	1
18	Ischemia triggered by spreading neuronal activation is induced by endothelin-1 and he- moglobin in the subarachnoid space 显示文摘	Petzold GC Einhaupl KM Dirnagl U	2003	Ann Neurol2003，54，5：	1
19	The NALP3 inflammasome is involved in the innate immune response to amyloid-beta显示文摘	Halle A Hornung V Petzold GC		0，，8：	1
20	The NALP3 inflammasome is involved in the innate immune response to amyloid-b显示文摘	Halle A Hornung V Petzold GC	2008	Nat Immunol2008，9，8：	1

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