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| 1 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 2 | Fungal diversity notes 111-252-taxonomic and phylogenetic contributions to fungal taxa显示文摘This paper is a compilation of notes on 142 fungal taxa,including five new families,20 new genera,and 100 new species,representing a wide taxonomic and geographic range.The new families,Ascocylindricaceae,Caryosporaceae and Wicklowiaceae(Ascomycota)are introduced based on their distinct lineages and unique morphology.The new Dothideomycete genera Pseudomassariosphaeria(Amniculicolaceae),Heracleicola,Neodidymella and Pseudomicrosphaeriopsis(Didymellaceae),Pseudopithomyces(Didymosphaeriaceae),Brunneoclavispora,Neolophiostoma and Sulcosporium(Halotthiaceae),Lophiohelichrysum(Lophiostomataceae),Galliicola,Populocrescentia and Vagicola(Phaeosphaeriaceae),Ascocylindrica(Ascocylindricaceae),Elongatopedicellata(Roussoellaceae),Pseudoasteromassaria(Latoruaceae)and Pseudomonodictys(Macrodiplodiopsidaceae)are introduced.The newly described species of Dothideomycetes(Ascomycota)are Pseudomassariosphaeria bromicola(Amniculicolaceae),Flammeascoma lignicola(Anteagloniaceae),Ascocylindrica marina(Ascocylindricaceae),Lembosia xyliae(Asterinaceae),Diplodia crataegicola and Diplodia galiicola(Botryosphaeriaceae),Caryospora aquatica(Caryosporaceae),Heracleicola premilcurensis and Neodidymella thailandicum(Didymellaceae),Pseudopithomyces palmicola(Didymosphaeriaceae),Floricola viticola(Floricolaceae),Brunneoclavispora bambusae,Neolophiostoma pigmentatum and Sulcosporium thailandica(Halotthiaceae),Pseudoasteromassaria fagi(Latoruaceae),Keissleriella dactylidicola(Lentitheciaceae),Lophiohelichrysum helichrysi(Lophiostomataceae),Aquasubmersa japonica(Lophiotremataceae),Pseudomonodictys tectonae(Macrodiplodiopsidaceae),Microthyrium buxicola and Tumidispora shoreae(Microthyriaceae),Alloleptosphaeria clematidis,Allophaeosphaeria cytisi,Allophaeosphaeria subcylindrospora,Dematiopleospora luzulae,Entodesmium artemisiae,Galiicola pseudophaeosphaeria,Loratospora luzulae,Nodulosphaeria senecionis,Ophiosphaerella aquaticus,Populocrescentia forlicesenensis and Vagicola vagans(Phaeosphaeriaceae),Elongatopedicellata lignicola,Roussoella magnatum and Roussoella angustior(Roussoellaceae)and Shrungabeeja longiappendiculata(Tetraploasphaeriaceae).The new combinations Pseudomassariosphaeria grandispora,Austropleospora archidendri,Pseudopithomyces chartarum,Pseudopithomyces maydicus,Pseudopithomyces sacchari,Vagicola vagans,Punctulariopsis cremeoalbida and Punctulariopsis efibulata Dothideomycetes.The new genera Dictyosporella(Annulatascaceae),and Tinhaudeus(Halosphaeriaceae)are introduced in Sordariomycetes(Ascomycota)while Dictyosporella aquatica(Annulatascaceae),Chaetosphaeria rivularia(Chaetosphaeriaceae),Beauveria gryllotalpidicola and Beauveria loeiensis(Cordycipitaceae),Seimatosporium sorbi and Seimatosporium pseudorosarum(Discosiaceae),Colletotrichum aciculare,Colletotrichum fusiforme and Colletotrichum hymenocallidicola(Glomerellaceae),Tinhaudeus formosanus(Halosphaeriaceae),Pestalotiopsis subshorea and Pestalotiopsis dracaenea(Pestalotiopsiceae),Phaeoacremonium tectonae(Togniniaceae),Cytospora parasitica and Cytospora tanaitica(Valsaceae),Annulohypoxylon palmicola,Biscogniauxia effusae and Nemania fusoideis(Xylariaceae)are introduced as novel species to order Sordariomycetes.The newly described species of Eurotiomycetes are Mycocalicium hyaloparvicellulum(Mycocaliciaceae).Acarospora septentrionalis and Acarospora castaneocarpa(Acarosporaceae),Chapsa multicarpa and Fissurina carassensis(Graphidaceae),Sticta fuscotomentosa and Sticta subfilicinella(Lobariaceae)are newly introduced in class Lecanoromycetes.In class Pezizomycetes,Helvella pseudolacunosa and Helvella rugosa(Helvellaceae)are introduced as new species.The new families,Dendrominiaceae and Neoantrodiellaceae(Basidiomycota)are introduced together with a new genus Neoantrodiella(Neoantrodiellaceae),here based on both morphology coupled with molecular data.In the class Agaricomycetes,Agaricus pseudolangei,Agaricus haematinus,Agaricus atrodiscus and Agaricus exilissimus(Agaricaceae),Amanita melleialba,Amanita pseudosychnopyramis and Amanita subparvipantherina(Amanitaceae),Entoloma calabrum,Cora barbulata,Dictyonema gomezianum and Inocybe granulosa(Inocybaceae),Xerocomellus sarnarii(Boletaceae),Cantharellus eucalyptorum,Cantharellus nigrescens,Cantharellus tricolor and Cantharellus variabilicolor(Cantharellaceae),Cortinarius alboamarescens,Cortinarius brunneoalbus,Cortinarius ochroamarus,Cortinarius putorius and Cortinarius seidlii(Cortinariaceae),Hymenochaete micropora and Hymenochaete subporioides(Hymenochaetaceae),Xylodon ramicida(Schizoporaceae),Colospora andalasii(Polyporaceae),Russula guangxiensis and Russula hakkae(Russulaceae),Tremella dirinariae,Tremella graphidis and Tremella pyrenulae(Tremellaceae)are introduced.Four new combinations Neoantrodiella gypsea,Neoantrodiella thujae(Neoantrodiellaceae),Punctulariopsis cremeoalbida,Punctulariopsis efibulata(Punctulariaceae)are also introduced here for the division Basidiomycota.Furthermore Absidia caatinguensis,Absidia koreana and Gongronella koreana(Cunninghamellaceae),Mortierella pisiformis and Mortierella formosana(Mortierellaceae)are newly introduced in the Zygomycota,while Neocallimastix cameroonii and Piromyces irregularis(Neocallimastigaceae)are introduced in the Neocallimastigomycota.Reference specimens or changes in classification and notes are provided for Alternaria ethzedia,Cucurbitaria ephedricola,Austropleospora,Austropleospora archidendri,Byssosphaeria rhodomphala,Lophiostoma caulium,Pseudopithomyces maydicus,Massariosphaeria,Neomassariosphaeria and Pestalotiopsis montellica. | Hiran A.Ariyawansa Kevin D.Hyde Subashini C.Jayasiri Bart Buyck K.W.Thilini Chethana Dong Qin Dai Yu Cheng Dai Dinushani A.Daranagama Ruvishika S.Jayawardena Robert Lücking Masoomeh Ghobad-Nejhad Tuula Niskanen Kasun M.Thambugala Kerstin Voigt Rui Lin Zhao Guo-Jie Li Mingkwan Doilom Saranyaphat Boonmee Zhu L.Yang Qing Cai Yang-Yang Cui Ali H.Bahkali Jie Chen Bao Kai Cui Jia Jia Chen Monika C.Dayarathne Asha J.Dissanayake Anusha H.Ekanayaka Akira Hashimoto Sinang Hongsanan E.B.Gareth Jones Ellen Larsson Wen Jing Li Qi-Rui Li Jian Kui Liu Zong Long Luo Sajeewa S.N.Maharachchikumbura Ausana Mapook Eric H.C.McKenzie Chada Norphanphoun Sirinapa Konta Ka Lai Pang Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Umpava Pinruan Emile Randrianjohany Chonticha Singtripop Kazuaki Tanaka Cheng Ming Tian Saowaluck Tibpromma Mohamed A.Abdel-Wahab Dhanushka N.Wanasinghe Nalin N.Wijayawardene Jin-Feng Zhang Huang Zhang Faten A.Abdel-Aziz Mats Wedin Martin Westberg Joseph F.Ammirati Timur S.Bulgakov Diogo X.Lima Tony M.Callaghan Philipp Callac Cheng-Hao Chang Luis F.Coca Manuela Dal-Forno Veronika Dollhofer Kateřina Fliegerová Katrin Greiner Gareth W.Griffith Hsiao-Man Ho Valerie Hofstetter Rajesh Jeewon Ji Chuan Kang Ting-Chi Wen Paul M.Kirk Ilkka Kytövuori James D.Lawrey Jia Xing Hong Li Zou Yi Liu Xing Zhong Liu Kare Liimatainen H.Thorsten Lumbsch Misato Matsumura Bibiana Moncada Salilaporn Nuankaew Sittiporn Parnmen AndréL.C.M.de Azevedo Santiago Sujinda Sommai Yu Song Carlos A.F.de Souza Cristina M.de Souza-Motta Hong Yan Su Satinee Suetrong Yong Wang Syuan-Fong Wei Ting Chi Wen Hai Sheng Yuan Li Wei Zhou Martina Réblová Jacques Fournier Erio Camporesi J.Jennifer Luangsa-ard Kanoksri Tasanathai Artit Khonsanit Donnaya Thanakitpipattana Sayanh Somrithipol Paul Diederich Ana M.Millanes Ralph S.Common Marc Stadler Ji Ye Yan XingHong Li Hye Won Lee Thi T.T.Nguyen Hyang Burm Lee Eliseo Battistin Orlando Marsico Alfredo Vizzini Jordi Vila Enrico Ercole Ursula Eberhardt Giampaolo Simonini Hua-An Wen Xin-Hua Chen Otto Miettinen Viacheslav Spirin Hernawati | 2015 | Fungal Diversity2015，，6： | 2 |
| 3 | 肿瘤免疫治疗时代的多重免疫组织化学/免疫荧光技术显示文摘常规免疫组织化学(immunohistochemistry,IHC)是组织病理学中广泛应用的诊断技术。但该技术存在诸多局限性,包括观察者间的变异性高,每张组织切片仅能标记一个标志物。本文详细描述了各种多重检测技术,这些技术克服了上述局限性,可在单张切片上同时检测多个标志物,可对细胞组成、细胞功能和细胞间相互作用进行整合研究。在这些技术中,多重免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)已成为最具应用前景的技术。mIHC/IF为开展高重复性、高效、高性价比的组织研究提供了高通量多重染色技术和标准化的定量分析。该技术在转化研究和临床实践中,尤其是肿瘤免疫治疗中极具应用价值。 | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2021 | 癌症2021，40，9： | 2 |
| 4 | Angiotensin II sustains brain inflammation in mice via TGF-[Beta]显示文摘 | Lanz Tobias V Ding Zhaoqing Ho Peggy P Luo Jian Agrawal Ankur N Srinagesh Hrishikesh Axtell Robert Zhang Hui Platten Michael Wyss-Coray Tony Steinman Lawrence | 2010 | Journal of Clinical Investigation2010，，8： | 1 |
| 5 | Sequential argon-YAG laser iridotomies in dark irides显示文摘 | Tony HO Richard F | 1992 | Br J Ophthalmol1992，76，： | 1 |
| 6 | Long-Term Prognosis of Patients with Biliary Atresia: A 25 Year Summary显示文摘 | Pei-Yin Hung Chiu-Chiang Chen Wei-Jao Chen Hong-Shiee Lai Wen-Ming Hsu Po-Hung Lee Ming-Chih Ho Tony H. H Chen Yen-Hsuan Ni Huey-Ling Chen Hong-Yuan Hsu Mei-Hwei Chang | 2006 | Journal of Pediatric Gastroenterology and Nutrition2006，，2： | 1 |
| 7 | Sequential argon-YAG laser iridotomies in dark irids 显示文摘 | Tony Ho Richard F | 1992 | Br J Ophthalmol1992，76，： | 1 |
| 8 | Comparison of the efficacy and tolerability of preservative-free and preservative-containing formulations of the dorzolamide/timolol fixed combination (COSOPT?) in patients with elevated intraocular pressure in a randomized clinical trial显示文摘 | Arthur Shedden Ingrid A. Adamsons Albert J. Getson Jean K. Laurence Christopher R. Lines David J. Hewitt Tony W. Ho | 2010 | Graefe’s Archive for Clinical and Experimental Ophthalmology2010，，12： | 1 |
| 9 | Behavioral models of managerial decision-making显示文摘 | Avi Goldfarb Teck-Hua Ho Wilfred Amaldoss Alexander Brown Yan Chen Tony Cui Alberto Galasso Tanjim Hossain Ming Hsu Noah Lim Mo Xiao Botao Yang | 2012 | Marketing Letters2012，，2： | 1 |
| 10 | Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non–Small-Cell Lung Cancer显示文摘 | Victor H.F. Lee Vicky P.C. Tin Tim-shing Choy Ka-on Lam Cheuk-wai Choi Lap-ping Chung Janice W.H. Tsang Patty P.Y. Ho Dennis K.C. Leung Edmond S.K. Ma Jing Liu Tony W.H. Shek Dora L.W. Kwong To-wai Leung Maria P. Wong | 2013 | Journal of Thoracic Oncology2013，，： | 1 |
| 11 | Liver resection after irinotccan 5-fluorourac and folinic acid for patients with unresectahle colorectal liver metastases: a muhicenter phase II study by the Cancer Therapeutic Research Group显示文摘 | WingM Ho Ma B Tony Mok | 2005 | Med Oncol2005，22，3： | 1 |
| 12 | Prader-Willi Syndrome:16-Year Experience in Hong Kong显示文摘Prader-Willi syndrome(PWS) is an important,wellrecognized syndromic form of neurodevelopmental disorder. The incidence is about 1 in 15,000-25,000 live births,and it affects both males and females(Vogels et al.,2004).The underlying genetic defects occur at an imprinted region on chromosome 15q11-13.Within this region,some genes only express on the maternally inherited chromosome 15,like UBE3A and ATP10C;while other genes only express on the paternally inherited chromosome 15,like MKRN3,MAGEL2, NDN,C15orf2,SNURF-SNRPN,and a number of | Ivan F.M. Lo Ho Ming Luk luksite@gmail.com Tony M.F. Tong Kent K.S. Lai Daniel H.C. Chan Albert C.F. Lam David K.H. Chan Edgar W.L. Hau Connie O.Y. Fung Stephen T.S. Lam | 2012 | Journal of Genetics and Genomics2012，39，4： | 1 |
| 13 | Sequential argon-YAG laser iridotomies in dark irises显示文摘 | Tony HO Richard F | 1992 | Br J Ophthalmol1992，76，： | 1 |
| 14 | Sequential argon-YAG laser iridotomies in darkirides显示文摘 | Tony HO Richard F | 1992 | Br J Ophthalmol1992，76，3： | 1 |
| 15 | 豪车周年纪念显示文摘一个世纪可以发生很多事情,科技、文化、医疗、战争、疾病等等,当然最重要的莫过于发明。无论是电灯、电话亦或是电脑,都是改变人类生活方式的发明,汽车出现后的一百多年中,也改变了这个星球的出行方式,而不同的汽车品牌有着各自的经典和传奇,甚至可以说,汽车已然成为人类进化史的一部分。在跨越了2012的'末日危机'后,很多品牌在2013年周年庆之际推出了纪念款车型,这些车型与品牌的诞生不仅有着千丝万缕的联系,并且传承了纯正的品牌DNA。沉稳大气的路虎、动力强劲的保时捷以及雍容高贵的劳斯莱斯,不同品牌的豪车,为我们打造了一场奢华的视觉盛宴。 | Tony Ho | 2013 | 明日风尚2013，0，7： | 0 |
| 16 | 关于数据战略,管理层应思考四个问题显示文摘亚马逊创始人兼CEO杰夫·贝索斯曾在致股东信中评论了数据、数据库和机器学习。我们把这封信视为一个“号召”,表明数据和数据管理能力将是未来几年大多数企业成功的关键,我们认为:数据和数据管理能力将成为各类公司之间的关键差距。数据技术提供商将大幅提升数据和分析工具的可用性,降低其成本。对于任何企业来说,人工智能、机器学习和其他强大的工具都将成为其筹码。根据具体数据定制的方案会激增.通用方法将丧失竞争力。 | Antonio Castro Tony Ho Jorge Machado Allen Weinberg | 2020 | 销售与管理2020，0，1： | 0 |
| 17 | 遇见移动的家显示文摘从第一辆汽车诞生开始,人类赋予汽车的想象越来越宽泛,从邦德在《007》中拥有的多功能座驾到影响了几代人的《变形金刚》,直至印度电影《大篷车》中那且行且住的大篷车的出现,房车开始走进人们的视线。在玩家眼里,房车是个移动的家,随意停靠在远离城市的沙滩、湖岸、草地、山坡、森林中,同时又拥有城市的生活方式,享受窗外移动的风景才是真正的乐趣。 | Tony Ho | 2013 | 明日风尚2013，0，8： | 0 |
| 18 | Seagrass Meadows under the Changing Climate:A Review of the Impacts of Climate Stressors显示文摘Seagrass meadows provide important ecological functions,particularly by serving as carbon sinks and breeding grounds for marine species.Climate change has threatened seagrass communities,causing their replacement,loss and increased vulnerability.This review examined scholarly articles published between 2010-2021 to comprehensively present the impacts of climate change on seagrass meadows.It shows that ocean warming negatively affects seagrass communities by favouring communities of lower structuring capacities,thus reducing the effectiveness of their ecological functions.Ocean warming also promotes the propagation and spread of invasive species,and changes the trophic structures leading to further loss of seagrasses of value.Higher seawater temperature is associated with shoot mortality and retarded growth of certain seagrasses.Sea level rise causes more wave energy to be received by coastal seagrass communities,thus,creating more damage to the communities.Deepening sea limits light penetration and alters distribution of seagrass meadows.Carbon dioxide enrichment of seawater increases photosynthetic rate of seagrasses but ocean warming and acidification counteract this beneficial effect.Carbon dioxide enrichment affects different seagrass species and different parts of a seagrass species differently,and,where beneficial to seagrass communities,could enhance their ecological services.Temperature extremes could kill seagrasses while marine heatwaves and flooding could act synergistically to increase carbon demand of certain seagrasses and unfavourably change their biomass.These impacts are often aggravated by anthropogenic activities.This review calls for more studies and conservation efforts to understand the impacts of climate change on seagrass communities and future-proof them against the changing climate. | Kuok Ho Daniel Tang Tony Hadibarata | 2022 | Research in Ecology2022，4，1： | 0 |
| 19 | 第二家居室显示文摘面积:72平方米(建筑面积)间隔:二室一厅无论是厅、厨房、房间,设计师通过线条的美感来扩宽空间感和强调家具的独特设计。 | Tony Ho | 1997 | 城市住宅1997，，2： | 0 |
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