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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | ImmunostimulatoryRNA oligonucleotides induce an effective antitumoral NK cellresponse through the TLR7显示文摘 | Bourquin C Schmidt L Lanz A L | 2009 | J Immunol2009，183，3： | 1 |
| 3 | Magnetic resonance imaging of coronary arteries and heart valves in a living mouse:techniques and preliminary results显示文摘 | Ruff J Wiesmann F Lanz T | 2000 | J Magn Reson2000，，146： | 1 |
| 4 | Differential regulation of genes for resveratrol synthase in cell cultures of Arachis hypogaea L显示文摘 | Thomas Lanz Gudrun Schroder Joachim Schroder | 1990 | Planta1990，181，2： | 1 |
| 5 | Receptor modeling of C2-C7 hydrocarbon sources at an urban background site in Zurich, Switzerland : Changes between 1993-1994 and 2005-2006显示文摘 | Lanz V A Hueglin C Buchmann B | 2008 | Atmos Chem Phys2008，8，： | 1 |
| 6 | Comparion of exhaled nitric oxide,serum eosinopilic cationic protein,and soluble interleukin-2 receptor in exacerbations of pediatric asthma显示文摘 | Lanz M J Leung DY McCormick DR | 1997 | Pediatric Pulmonology1997，24，： | 1 |
| 7 | The role of cysteines in polyketide synthases 显示文摘 | Lanz T Tropf S Mamer F J | 1991 | J Biol Chem1991，266，15： | 1 |
| 8 | Solid-phase extraction enhances detection of beta-amyloid peptides in plasma and enables Abeta quantification following passive immunization with Abeta antibodies显示文摘 | Lanz TA Schachter JB | | Journal of Neuroscience Methods0，，： | 1 |
| 9 | Combined in situ Raman and IR microscopy at the interface of a single graphite particle with ethylene carbonate/dimethyl carbonate显示文摘 | Lanz P Novak P | 2014 | Journal of the Electrochemical Society2014，161，10： | 1 |
| 10 | Corrective osteotomy of the distal radius through volar approach 显示文摘 | Prommersberger KJ Lanz UB | 2004 | Tech Hand Up Extrem Surg2004，8，2： | 1 |
| 11 | Arthroscopic suprascap- ular nerve release: indications and technique 显示文摘 | LAFOSSE L PIPER K LANZ U | 2011 | J Shoul- der Elbow Surg2011，20，2： | 1 |
| 12 | Differentiation of cytotoxic and vasogenic edema in a patient with reversible posterior leukoencephalopathy syndrome using diffusion-weighted MRI显示文摘 | Doelken M Lanz S Rennert J | 2007 | Diagn Interv Radiol2007，13，3： | 1 |
| 13 | Evaluation and optimization of capillary zone electrophoresis with different dynamic capillary coatings for the determination of carbohydrate-deficient transferrin in human serum显示文摘 | Kuhn M Bortolotti F | 2002 | J Chromatogr A2002，979，： | 1 |
| 14 | Outcome after corrective osteotomy for malunited fractures of the distal end of the radius显示文摘 | Prommersberger KJ Van Schoonhoven J Lanz UB | 2002 | J Hand Surg Br2002，27，1： | 1 |
| 15 | Evidence that stilbene synthases have developed from ehaleone synthases several times in the course of evolution 显示文摘 | Tropf S Lanz T Rensing S A | 1994 | Journal of Molecular Evolution1994，38，6： | 1 |
| 16 | The extent of blockade following various techiques of brachial plexus block显示文摘 | Lanz E Thiss D Jankovic D | 1983 | Anesth Analg1983，62，1： | 1 |
| 17 | Rac-3 is a NF-kappa B coactivator显示文摘 | WERBAJH S NOJEK I LANZ R | 2000 | FEBS Lett2000，485，23： | 1 |
| 18 | Photocatalytic oxidation of water to O2 on AgCl-coated electrodes显示文摘 | Lanz M Schürch D Calzaferri G | 1999 | Journal of Photochemistry and Photobiology A:Chemistry1999，120，2： | 1 |
| 19 | Mechanisms of neuropathic pain显示文摘 | Nickel F T Seifert F Lanz S | 2012 | Eur Neuropsychopharmacol2012，22，2： | 1 |
| 20 | Angiotensin II sustains brain inflammation in mice via TGF-[Beta]显示文摘 | Lanz Tobias V Ding Zhaoqing Ho Peggy P Luo Jian Agrawal Ankur N Srinagesh Hrishikesh Axtell Robert Zhang Hui Platten Michael Wyss-Coray Tony Steinman Lawrence | 2010 | Journal of Clinical Investigation2010，，8： | 1 |
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