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| 1 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 2 | Evolution of the Yellow River delta, China: Impacts of channel avulsion and progradation显示文摘The evolution of the Yellow River delta is characterized by heavy sediment load,rapid seaward migration,frequent avulsions,and intense anthropogenic disturbances.Evolution of the delta channel following avulsions is very complex and has not yet been thoroughly understood.In the research presented by this paper,we conducted comprehensive analyses of the changes in the water stages,slopes,longitudinal profiles,and the erosion and deposition in the Yellow River delta channels during a time period of over five decades.Results showed that,following each avulsion,channels migrated seaward at decaying rates and the slopes at the downstream of the avulsion point decreased exponentially with time and completed its major adjustment within about four to five years.A generalized geometric model was proposed to describe the changes in the longitudinal profiles of the delta channels.A calculation method to determine the characteristic water stages at the delta was proposed based on the geometric model and the delayed response model for the morphological responses of fluvial rivers to perturbations.Water stages corresponding to a discharge of 3000 m^3/s at Lijin and Xihekou during 1954 through 2012 were calculated by using the proposed method.The proposed method may be used to predict the evolution of the delta channels in response to artificial avulsions at the Yellow River delta in the future. | Shan Zheng Baosheng Wu Kairong Wang Guangming Tan Shasha Han Colin R. Thorne | 2017 | International Journal of Sediment Research2017，32，1： | 9 |
| 3 | A Subpopulation of CD26 + Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer显示文摘 | Roberta Pang Wai Lun Law Andrew C.Y. Chu Jensen T. Poon Colin S.C. Lam Ariel K.M. Chow Lui Ng Leonard W.H. Cheung Xiao R. Lan Hui Y. Lan Victoria P.Y. Tan Thomas C. Yau Ronnie T. Poon Benjamin C.Y. Wong | 2010 | Cell Stem Cell2010，，6： | 4 |
| 4 | 肿瘤免疫治疗时代的多重免疫组织化学/免疫荧光技术显示文摘常规免疫组织化学(immunohistochemistry,IHC)是组织病理学中广泛应用的诊断技术。但该技术存在诸多局限性,包括观察者间的变异性高,每张组织切片仅能标记一个标志物。本文详细描述了各种多重检测技术,这些技术克服了上述局限性,可在单张切片上同时检测多个标志物,可对细胞组成、细胞功能和细胞间相互作用进行整合研究。在这些技术中,多重免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)已成为最具应用前景的技术。mIHC/IF为开展高重复性、高效、高性价比的组织研究提供了高通量多重染色技术和标准化的定量分析。该技术在转化研究和临床实践中,尤其是肿瘤免疫治疗中极具应用价值。 | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2021 | 癌症2021，40，9： | 2 |
| 5 | Nonlinear Finite Element Simulations to Elucidate the Determinants of Perforator Patency in Propeller Flaps显示文摘 | Chin-Ho Wong Fangsen Cui Bien-Keem Tan Zhuangjian Liu Heow-Pueh Lee C Lu Chee-Liam Foo Colin Song | 2007 | Annals of Plastic Surgery2007，，6： | 2 |
| 6 | A study of air pollution of city clusters显示文摘 | Huiwang Gao Jing Chen Bin Wang Sai-Chun Tan Colin M. Lee Xiaohong Yao Han Yan Jinhui Shi | 2011 | Atmospheric Environment2011，，： | 1 |
| 7 | A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects显示文摘 | Jinqiu Zhang Qizhou Lian Guili Zhu Fan Zhou Lin Sui Cindy Tan Rafidah Abdul Mutalif Raju Navasankari Yuelin Zhang Hung-Fat Tse Colin L. Stewart Alan Colman | 2011 | Cell Stem Cell2011，，1： | 1 |
| 8 | Eventual Positivity of Hermitian Polynomials and Integral Operators显示文摘Quillen proved that if a Hermitian bihomogeneous polynomial is strictly positive on the unit sphere, then repeated multiplication of the standard sesquilinear form to this polynomial eventually results in a sum of Hermitian squares. Catlin-D'Angelo and Varolin deduced this positivstellensatz of Quillen from the eventual positive-definiteness of an associated integral operator. Their arguments involve asymptotic expansions of the Bergman kernel. The goal of this article is to give an elementary proof of the positive-definiteness of this integral operator. | Colin TAN | 2016 | Chinese Annals of Mathematics,Series B2016，37，1： | 1 |
| 9 | Phacoemuisification versus manual small-incision cataract surgery for white cataract显示文摘 | Renraj Venkatesh colin Tan Sabyasachi Sengupta | 2010 | J Cataract Refract Surg2010，36，： | 1 |
| 10 | 地质力学分析新方法显示文摘应力与压力对任何油藏、井筒及完井装置都会产生影响。钻井、开采及注入过程都会使应力和压力发生变化,有时会给作业者带来不利影响。随着地质力学测量、模拟和监测技术的不断发展,在油气田从评价到废弃的整个生命期内,勘探与生产公司都能够预测应力及压力的变化情况,并降低这些变化所造成的不利影响。 | JohnCook ReneA.Frederiksen KlausHasbo Sidney Green Arnis Judzis J.Wesley Martin Roberto Suarez-Rivera Jorg Herwanger Patrick Hooyman Don Lee Sheila Noeth Colin Sayers Nick Koutsabeloulis Robert Marsden Morten G.Stage Chee Phuat Tan | 2009 | 国外测井技术2009，，1： | 1 |
| 11 | Circulating leukocyte TBET and GATA3 mRNA in patients with acute coronary syndrome显示文摘 | Timothy H. Rainer Rebecca W.Y. Chan Colin A. Graham Cangel P.Y. Chan Patrick C.F. Tan Gabriel W.K. Yip Cheuk-Man Yu | 2012 | International Journal of Cardiology2012，，2： | 1 |
| 12 | Five-year review of infections in a burn intensive care unit: High incidence of Acinetobacter baumannii in a tropical climate显示文摘 | Harvey Chim Ban Hock Tan Colin Song | 2007 | Burns2007，，8： | 1 |
| 13 | Visual Experiences During Vitreous Surgery Under Regional Anesthesia: A Multicenter Study显示文摘 | Colin S.H. Tan Usman Mahmood Paul D. O’Brien Stephen Beatty Alvin K.H. Kwok Vincent Y.W. Lee Kah-Guan Au Eong | 2005 | American Journal of Ophthalmology2005，，6： | 1 |
| 14 | Factors affecting visual outcome of myopic choroidal neovascularization treated with verteporfin photodynamic therapy显示文摘AIM: To evaluate the visual outcomes of choroidal neovascularization (CNV) secondary to pathological myopia and the impact of novel risk factors affecting the final visual outcome. ·METHODS: Interventional case series of 18 consecutive patients with pathological myopia treated with photodynamic therapy (PDT). Inclusion criteria were spherical equivalent -6D or worse or features of pathological myopia on retinal examination. The main outcome measure was final best -corrected visual acuity (BCVA). ·RESULTS: Of 18 eyes, 13 (72.2%) avoided moderate visual loss (≥3 lines of LogMAR BCVA) and 5 eyes (27.8%) improved by at least 1 line after 1 year. Patients with LogMAR BCVA ≤0.3 (Snellen equivalent 20/40) at one year were younger than those with BCVA >0.3 (mean age 39.0 vs 61.6 years, P =0.001). A higher proportion of eyes with greatest linear dimension (GLD) of ≤1 000μm avoided moderate visual loss (100% vs 50%, P =0.026). Among patients who were treated within 2 weeks of visual symptoms, 88.9% avoided the loss of 3 or more lines compared to 55.6% for those who presented later. The mean improvement in LogMAR BCVA of those with GLD ≤1 000μm was +0.12 compared to a loss of 0.55 LogMAR units for those with GLD >1 000μm (P =0.02). Visual outcomes were not associated with gender or refractive error.·CONCLUSION: Good visual outcome in myopic CNV is associated with younger age, smaller lesion size and earlier initiation of treatment. These factors are relevant for ophthalmologists considering treatment options for myopic CNV. | Colin S. Tan Milton C. Chew Kai-Hung Lim Tock-Han Lim | 2013 | International Journal of Ophthalmology(English edition)2013，6，3： | 0 |
| 15 | 诗家董百货旗舰店显示文摘本案获得了多个享誉盛名的专业奖项,其中包括“新加坡2013年度最佳购物体验奖”以及由新加坡零售协会颁发的“2013年度最佳零售概念奖”。MOD设计团队与新加坡的知名百货公司“诗家董”共同合作完成了此次“诗家董”店庆80周年的改造项目。 | Colin Seah Kevin Leong Ron Sim Joyce Low Don Washington Castaneda Dennis Cheok Tan Qingling Julie Djohan Dora Tokai Joanne Pang Charissa Ho Bryan Law Allan Veloso Lolleth Alejandro Edward Hendricks 姜敏华 | 2014 | 现代装饰2014，，4： | 0 |
| 16 | 北京侨福芳草地显示文摘2000年岁末,北京市中心,来自香港的侨福集团为一座地标性建筑提出了一项挑战性的策划,旨在改变大型综合商业开发项目的成规。它所引得的回应,也是一项时尚、节能且环保的设计,由徐腾(Winston Shu)领衔的香港建筑事务所IDA一手命制。整个开发项目有微气候调节,运用与北京季候变化相一致的可持续自然手段,实现了水准空前的热舒适度与灵活的使用空间。 | 徐腾 Ulrich Blum Nicole Ip Alicia Tan Pusey Chan Stephane Lacroix Moses Tan Kin Choy Christa Lange Jochen Tombers Howard Chung Peter Liu Louisa Williams Colin Foster Rosita Nicknafs Patrick Yue Simon Griffiths Ed Peter Connie Ho William Tam | 2013 | 城市环境设计2013，，8： | 0 |
| 17 | Eventual Positivity of Hermitian Algebraic Functions and Associated Integral Operators显示文摘Quillen proved that repeated multiplication of the standard sesquilinear form to a positive Hermitian bihomogeneous polynomial eventually results in a sum of Hermitian squares,which was the first Hermitian analogue of Hilbert s seventeenth problem in the nondegenerate case.Later Catlin-D’Angelo generalized this positivstellensatz of Quillen to the case of Hermitian algebraic functions on holomorphic line bundles over compact complex manifolds by proving the eventual positivity of an associated integral operator.The arguments of Catlin-D’Angelo involve subtle asymptotic estimates of the Bergman kernel.In this article,the authors give an elementary and geometric proof of the eventual positivity of this integral operator,thereby yielding another proof of the corresponding positivstellensatz. | Colin TAN Wing-Keung TO | 2020 | Chinese Annals of Mathematics,Series B2020，41，6： | 0 |
| 18 | 新加坡UOL Edge画廊显示文摘近年来,新加坡正在经历一场住宅公寓开发的热潮。因此,建筑师一直呼吁设计一个临时性的展示建筑,用来展示这些建筑,并促进其出售。很多展示空间的设计显然并不能引发丰富的想象,反而呈现出一种程式化的相似——与建筑表皮完全无关的笨拙、匀称的立方体玻璃、石膏、木材与室内设计的表现形式,典型的毫无节制的奢华和一成不变的排场。顺应这一潮流,MOD设计的这座画廊探讨并重新定义了象征新加坡公共管理能力的展示空间的类型。 | Colin Seah Tulsi Grover Joyce Low Angie Ng Anita Shewchuk Ron Sim David Tan Marcin Skolimowski Noel Banta Aliza Suarez Lolleth Alejandro Allan Veloso Pauline Pan | 2012 | 设计家2012，，4： | 0 |
| 19 | 冷酷“脚手架”——新加坡Durasafe零售商店显示文摘Durasafe是新加坡一家供应安全装备的品牌商,此次旗舰店的设计,商家希望可以打造一个独特的商品展示和零售的空间,既能加强已有的品牌形象,又能为该品牌主要的男性客户群提供一个兴奋的购物体验。项目位于一个6米高的现代仓库,于是设计师试图创造一个多层次的空间体验,为整个购物过程增添一点戏剧化的效果。 | Colin Seah Tan Qing Ling Lolleth Alejandro Don Washington Castaneda Ron Sim Charissa Ho 张妍钰 | 2013 | 设计家2013，，6： | 0 |
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