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| 1 | 中国芝麻资源核心收集品研究显示文摘对中国收集编目的4251份芝麻种质资源材料,依据来源、品种类别、生态类型3层分成14个组。应用计算机系统对随机小样本的14个性状数据进行聚类分析,选择确定了离差平方和法是芝麻资源聚类的适宜方法。通过组内聚类分析并结合随机选取和预选比例20%的原则,预选出核心收集品材料884份,对其14个性状的6个特征值的初步研究结果表明,基本代表了总收集品的遗传变异范围。对预选核心收集品在中国3个生态试验点两年的农艺性状鉴定表明:6个质量性状的5304性状次与原评价资料之间完全一致的为97.85%,3个数量性状呈良好的显著正相关。对决选的核心收集品代表性测验表明,14个性状的平均值符合率达97%以上,标准差符合率在90%以上,表明核心收集品良好地代表了预选核心收集品。 | 张秀荣 郭庆元 赵应忠 冯祥运 周明德 Toby Hodgkin | 1998 | 中国农业科学1998，31，3： | 50 |
| 2 | 美国早期特殊教育师资培养体系反思及启示显示文摘早期特殊教育不仅在促进每个障碍儿童的发展和提高其家庭生活质量方面起着至关重要的作用,而且有着巨大的社会效益和经济效益,是和谐社会的重要组成部分。美国法律规定0-21岁的所有障碍儿童有权获得免费和适当的教育,由具有专业化水平的相关人员为这些儿童提供服务和支持。本文从政策层面到实践层面对美国的早期特殊教育师资培养体系进行了系统、全面地分析,了解其现状和存在的挑战,以及未来发展的趋势,以期为促进我国早期特殊教育师资培养体系的发展提供一些理论和实践上的参考。 | 苏雪云 Toby Long Lorelei Emma Marian Jarrett | 2010 | 中国特殊教育2010，，5： | 13 |
| 3 | 控制新型冠状病毒肺炎的长期影响:对NICE、SIGN和RCGP快速指南的总结显示文摘对于一部分人来说,新型冠状病毒肺炎(COVID-19)的长期效应可能对生活质量产生重大影响。根据国家统计局的数据,约五分之一的COVID-19阳性患者的症状可持续5周及以上。这给确定最佳照护标准带来了挑战。目前,尚无公认的COVID-19长期影响的定义及其明确治疗途径的说明。为了协助临床工作者,英国国家健康与临床优选研究所(NICE)、苏格兰校际指南网络(SIGN)和皇家全科医师学院(RCGP)发布了'COVID-19快速指南:控制COVID-19的长期影响'。 | Waqaar Shah Toby Hillman E Diane Playford Lyth Hishmeh 陈镜伊(译) 梁志欣(校) | 2021 | 英国医学杂志中文版2021，24，6： | 10 |
| 4 | Metabolic Engineering of Plant-derived (E)-β-farnesene Synthase Genes for a Novel Type of Aphid-resistant Genetically Modified Crop Plants显示文摘Aphids are major agricultural pests that cause significant yield losses of crop plants each year.Excessive dependence on insec-ticides for long-term aphid control is undesirable because of the development of insecticide resistance,the potential negative effects on non-target organisms and environmental pollution.Transgenic crops engineered for resistance to aphids via a non-toxic mode of action could be an efficient alternative strategy.(E)-β-Farnesene (EβF) synthases catalyze the formation of EβF,which for many pest aphids is the main component of the alarm pheromone involved in the chemical communication within these species.EβF can also be synthesized by certain plants but is then normally contaminated with inhibitory compounds.Engineering of crop plants capable of synthesizing and emitting EβF could cause repulsion of aphids and also the attraction of natural enemies that use EβF as a foraging cue,thus minimizing aphid infestation.In this review,the effects of aphids on host plants,plants' defenses against aphid herbivory and the recruitment of natural enemies for aphid control in an agricultural setting are briefly introduced.Furthermore,the plant-derived EβF synthase genes cloned to date along with their potential roles in generating novel aphid resistance via genetically modified approaches are discussed. | Xiu-Dao Yu John Pickett You-Zhi Ma Toby Bruce Johnathan Napier Huw D.Jones Lan-Qin Xia | 2012 | Journal of Integrative Plant Biology2012，54，5： | 10 |
| 5 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 6 | Autophagy in dendritic cells显示文摘Autophagy and immunity share the property of being auto-protective for the organism.Autophagy is an important degradation pathway that buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man.Perturbations in autophagy are associated with inflammation and cancer development.Emerging studies have characterized the molecular details regarding how autophagy is controlled by immune cells.Among these,dendritic cells(DCs)are one of the most potent professional antigen-presenting cells critical for the activation of naïve T cells to maintain immune tolerance and drive protective immunity to infection and cancer.DCs undergo functional maturation that can either lead to an immunostimulatory phenotype,as in the context of infection,or to a tolerogenic phenotype associated with immunosuppression to self-antigens,as well as to cancer.An increasing number of recent studies has characterized the involvement of autophagy in DC functions in various physiological and pathological contexts.Here,we provide a comprehensive review of these outcomes and discuss the limitation of the models used and the forefront of the knowledge concerning the crosstalk between autophagy and DC biology. | Ghita Ghislat Toby Lawrence | 2018 | Cellular & Molecular Immunology2018，15，11： | 8 |
| 7 | 花曲柳窄吉丁在中国的分布与危害的调查研究显示文摘花曲柳窄吉丁是木犀科梣属树木毁灭性的蛀干害虫,2003年已被列入我国林业危险性有害生物名单中.本研究对中国黑龙江、吉林、辽宁、河北和山东省及天津和北京市16个梣属树木分布区进行了花曲柳窄吉丁的调查.结果显示:除在北京市和山东省滨州市以及辽宁省的一个地区未发现花曲柳窄吉丁危害外,在其它省市的13个地区都发现有该害虫,而且在部分地区其危害已较为严重,有虫株率最高达90%以上,虫口密度最高达230头/株,并已出现部分白蜡树死亡.另外,在花曲柳窄吉丁自然种群中发现有幼虫被真菌感染致死和茧蜂科天敌寄生现象,并对害虫的种群发展显示了较好的控制作用. | 高瑞桐 赵同海 Houping Liu Leah S. Bauer Toby R. Petrice | 2004 | 中国造纸学报2004，19，z1： | 7 |
| 8 | 曹保平 好电影一定要说些什么显示文摘6月21日晚,第18届上海国际电影节在上海大剧院举办闭幕式暨颁奖礼。曹保平凭借《烈日灼心》拿下最佳导演奖,《烈日灼心》一片也帮助郭涛、段奕宏和邓超三人拿下了最佳男演员奖,可谓本届电影节最大赢家。在发表获奖感言时,曹保平说:"三年前,自己拿着剧本去找投资人,聊了十分钟对方就表示会投拍,后来开拍时,才发现人家压根都没看剧本。"曹保平回忆起投资人的信任,以及影片立项和拍摄期间的种种不易,坦言非常感谢陪伴自己一起走过最艰难时光的该影片出品方和剧组。最后,曹保平深情说道:"我一直觉得,好电影一定要说些什么。" | Toby | 2015 | 东方电影2015，0，7： | 5 |
| 9 | Civil and structural engineering applications,recent trends,research and developments on pultruded fiber reinforced polymer closed sections:a review显示文摘The objectives of this study are to review and evaluate the developments and applications of pultruded fiber-reinforced polymer composites in civil and structural engineering and review advances in research and developments.Several case applications are reviewed.The paper presents a state-of-the-art review of fundamental research on the behavior of pultruded fiber reinforced polymer closed sections and highlights gaps in knowledge and areas of potential further research. | Alfred Kofi GAND Tak-Ming CHAN James Toby MOTTRAM | 2013 | Frontiers of Structural and Civil Engineering2013，7，3： | 4 |
| 10 | On the relation between NDVI, fractional vegetation cover, and leaf area index显示文摘 | Toby N. Carlson David A. Ripley | 1997 | Remote Sensing of Environment1997，，3： | 3 |
| 11 | Immune profiling and cancer post transplantation显示文摘Half of all long-term(> 10 year) australian kidney transplant recipients(KTR) will develop squamous cell carcinoma(SCC) or solid organ cancer(SOC), making cancer the leading cause of death with a functioning graft. At least 30% of KTR with a history of SCC or SOC will develop a subsequent SCC orSOC lesion. Pharmacological immunosuppression is a major contributor of the increased risk of cancer for KTR, with the cancer lesions themselves further adding to systemic immunosuppression and could explain, in part, these phenomena. Immune profiling includes; measuring immunosuppressive drug levels and pharmacokinetics, enumerating leucocytes and leucocyte subsets as well as testing leucocyte function in either an antigen specific or non-specific manner. Outputs can vary from assay to assay according to methods used. In this review we define the rationale behind post-transplant immune monitoring assays and focus on assays that associate and/or have the ability to predict cancer and rejection in the KTR. We find that immune monitoring can identify those KTR of developing multiple SCC lesions and provide evidence they may benefit from pharmacological immunosuppressive drug dose reductions. In these KTR risk of rejection needs to be assessed to determine if reduction of immunosuppression will not harm the graft. | Christopher Martin Hope Patrick Toby H Coates Robert Peter Carroll | 2015 | World Journal of Nephrology2015，4，1： | 3 |
| 12 | Geological mapping and mining prospecting in the Aouli inlier(Eastern Meseta,Morocco)based on remote sensing and geographic information systems(GIS)显示文摘Landsat 8 Oli,ASTER,and Sentinel 2A satellite images processing was used to map geological formations,lineaments and hydrothermal alteration minerals in the Aouli inlier,as a case study to illustrate the application of digital images processing and Geographic Information System(GIS)in geological mapping and mining prospecting.Principal Component Analysis(PCA)applied to the Landsat images allowed good lithological discrimination and contributed to the updating of available geological maps.The Automatic lineament extraction from Sentinel images revealed the main tectonic structures affecting Aouli inlier.The ratio bands(b5+b7)/b6 and the false color composite(b4/b6,b2/b1,b3/b2)allowed the hydrothermal alteration minerals mapping from Aster images.Combined with available geological data and field observations,the satellite derived data were integrated and analyzed in a GIS software to establish mining prospecting guides.The results showed that the anomaly zones are intimately linked to NNE-SSW and NW-SE oriented faults and to highly fractured areas developing argillic and Fe rich alterations.Verified via field survey,this approach was successfully applied to the Aouli inlier to rapidly target potential areas to be explored in the tactical phase.This provides a model for future prospecting efforts for similar mineral deposits in other areas. | Lakhlifa Benaissi Amraoui Tarek Adnane Tobi Hassan Ibouh Khadra Zaid Khalid Elamari Mohamed Hibti | 2022 | China Geology2022，5，4： | 3 |
| 13 | Hyaline Globules in Neuroendocrine and Solid-pseudopapillary Neoplasms of the Pancreas: A Clue to the Diagnosis显示文摘 | Zina Meriden Chanjuan Shi Barish H. Edil Trevor Ellison Christopher L. Wolfgang Toby C. Cornish Richard D. Schulick Ralph H. Hruban | 2011 | The American Journal of Surgical Pathology2011，，： | 2 |
| 14 | SJES14110700383743显示文摘 | Peter J. Murray Judith E. Allen Subhra K. Biswas Edward A. Fisher Derek W. Gilroy Sergij Goerdt Siamon Gordon John A. Hamilton Lionel B. Ivashkiv Toby Lawrence Massimo Locati Alberto Mantovani Fernando O. Martinez Jean-Louis Mege David M. Mosser Gioacchin | 2014 | Immunity2014，，1： | 2 |
| 15 | GENCODE: The reference human genome annotation for The ENCODE Project显示文摘 | Jennifer Harrow Adam Frankish Jose M. Gonzalez Electra Tapanari Mark Diekhans Felix Kokocinski Bronwen L. Aken Daniel Barrell Amonida Zadissa Stephen Searle If Barnes Alexandra Bignell Veronika Boychenko Toby Hunt Mike Kay Gaurab Mukherjee Jeena Rajan Glo | 2012 | Genome Research2012，，9： | 2 |
| 16 | On the relation between NDVI, fractional vegetation cover, and leaf area index显示文摘 | Toby N. Carlson David A. Ripley | 1997 | Remote Sensing of Environment1997，，3： | 2 |
| 17 | Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair显示文摘Macrophage plasticity is critical for normal tissue repair following injury.In pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are unknown.Here,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJD3 in diabetic wound macrophages,resulting in increased inflammatory gene expression.Mechanistically,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 signaling.However,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 mechanism.Interestingly,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound macrophages.STING limits inflammatory cytokine production by wound macrophages during healing.However,in diabetic mice,its role changes to limit wound repair and enhance inflammation.This finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time points.Finally,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and STING.Taken together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds. | Christopher O.Audu William J.Melvin Amrita D.Joshi Sonya J.Wolf Jadie Y.Moon Frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer James Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher | 2022 | Cellular & Molecular Immunology2022，19，11： | 2 |
| 18 | Real-time human pose recognition in parts from single depth images显示文摘 | Jamie Shotton Toby Sharp Alex Kipman Andrew Fitzgibbon Mark Finocchio Andrew Blake Mat Cook Richard Moore | 2013 | Communications of the ACM2013，，1： | 2 |
| 19 | Assessment of Intermediate Severity Coronary Lesions in the Catheterization Laboratory显示文摘 | Jonathan Tobis Babak Azarbal Leo Slavin | 2007 | Journal of the American College of Cardiology2007，，8： | 2 |
| 20 | Expert and Non-expert Opinion About Technological Unemployment显示文摘There is significant concern that technological advances, especially in robotics and artificial intelligence(AI), could lead to high levels of unemployment in the coming decades. Studies have estimated that around half of all current jobs are at risk of automation.To look into this issue in more depth, we surveyed experts in robotics and AI about the risk, and compared their views with those of nonexperts. Whilst the experts predicted a significant number of occupations were at risk of automation in the next two decades, they were more cautious than people outside the field in predicting occupations at risk. Their predictions were consistent with their estimates for when computers might be expected to reach human level performance across a wide range of skills. These estimates were typically decades later than those of the non-experts. Technological barriers may therefore provide society with more time to prepare for an automated future than the public fear. In addition, public expectations may need to be dampened about the speed of progress to be expected in robotics and AI. | Toby Walsh | 2018 | International Journal of Automation and computing2018，15，5： | 2 |
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