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9篇 您的检索式：作者名="Toby Lawrence"

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		题名	作者	年代	出处	被引量
	1	Autophagy in dendritic cells显示文摘Autophagy and immunity share the property of being auto-protective for the organism.Autophagy is an important degradation pathway that buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man.Perturbations in autophagy are associated with inflammation and cancer development.Emerging studies have characterized the molecular details regarding how autophagy is controlled by immune cells.Among these,dendritic cells(DCs)are one of the most potent professional antigen-presenting cells critical for the activation of naïve T cells to maintain immune tolerance and drive protective immunity to infection and cancer.DCs undergo functional maturation that can either lead to an immunostimulatory phenotype,as in the context of infection,or to a tolerogenic phenotype associated with immunosuppression to self-antigens,as well as to cancer.An increasing number of recent studies has characterized the involvement of autophagy in DC functions in various physiological and pathological contexts.Here,we provide a comprehensive review of these outcomes and discuss the limitation of the models used and the forefront of the knowledge concerning the crosstalk between autophagy and DC biology.	Ghita Ghislat Toby Lawrence	2018	Cellular & Molecular Immunology2018，15，11：	8
	2	SJES14110700383743显示文摘	Peter J. Murray Judith E. Allen Subhra K. Biswas Edward A. Fisher Derek W. Gilroy Sergij Goerdt Siamon Gordon John A. Hamilton Lionel B. Ivashkiv Toby Lawrence Massimo Locati Alberto Mantovani Fernando O. Martinez Jean-Louis Mege David M. Mosser Gioacchin	2014	Immunity2014，，1：	2
	3	The Nuclear Factor NF-kB Pathway in Inflammation显示文摘	TOBY LAWRENCE	2009	Cold Spring Harb Perspect Biol2009，1651，：	1
	4	The nuclear factor NF-kB pathway in inflammation显示文摘	Toby Lawrence		0，，6：	1
	5	The resolution of inflammation: Anti-inflammatory roles for NF-κB显示文摘	Toby Lawrence Carol Fong	2010	International Journal of Biochemistry and Cell Biology2010，，4：	1
	6	The Effects of System Parameters on In Vivo Injection Performance of a Needle-Free Injector in Human Volunteers显示文摘	Lawrence Linn Brooks Boyd Hristo Iontchev Toby King Stephen J. Farr	2007	Pharmaceutical Research2007，，8：	1
	7	An inducible model for specific neutrophil depletion by diphtheria toxin in mice显示文摘Neutrophils are crucial for immunity and play important roles in inflammatory diseases;however,mouse models selectively deficient in neutrophils are limited,and neutrophil-specific diphtheria toxin(DT)-based depletion system has not yet been established.In this study,we generated a novel knock-in mouse model expressing diphtheria toxin receptor(DTR)under control of the endogenous Ly6G promoter.We showed that DTR expression was restricted to Ly6G+neutrophils and complete depletion of neutrophils could be achieved by DT treatment at 24-48 h intervals.We characterized the effects of specific neutrophil depletion in mice at steady-state,with acute inflammation and during tumor growth.Our study presents a valuable new tool to study the roles of neutrophils in the immune system and during tumor progression.	Tianzhu Chao Liaoxun Lu Lichen Zhang Rong Huang Zhuangzhuang Liu Binhui Zhou Eryan Kong Zhongjian Zhang Toby Lawrence Yinming Liang	2021	Science China(Life Sciences)2021，64，8：	1
	8	The nuclear factor NF-KB pathway inflammation 显示文摘	Toby Lawrence	2009	Cold Spring Harbor Perspect Biol2009，1，00：	1
	9	Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer显示文摘	Michael Karin Toby Lawrence Victor Nizet	2006	Cell2006，，：	1

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