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| 1 | Management of necrotizing pancreatitis显示文摘Infection complicating pancreatic necrosis leads to persisting sepsis, multiple organ dysfunction syndrome and accounts for about half the deaths that occur following acute pancreatitis. Severe cases due to gallstones require urgent endoscopic sphincterotomy. Patients with pancreatic necrosis should be followed with serial contrast enhanced computed tomography (CE-CT) and if infection is suspected fine needle aspiration of the necrotic area for bacteriology (FNAB) should be undertaken. Treatment of sterile necrosis should initially be non-operative. In the presence of infection necrosectomy is indicated. Although traditionally this has been by open surgery, minimally invasive procedures are a promising new alternative. There are many unresolved issues in the management of pancreatic necrosis. These include, the use of antibiotic prophylaxis, the precise indications for and frequency of repeat CE-CT and FNAB,and the role of enteral feeding. | John Slavin Paula Ghaneh Robert Sutton Mark Hartley Peter Rowlands Conall Garvey Mark Hughes John Neoptolemos | 2001 | World Journal of Gastroenterology2001，7，4： | 21 |
| 2 | Elevated blood pressure: Our family's fault?The genetics of essential hypertension显示文摘AIM: To provide an updated review on current genetic aspects possibly affecting essential hypertension(EH), and to further elucidate their role in EH. METHODS: We searched for genetic and epigenetic factors in major studies associated with EH between Jan 2008-Oct 2013 using PubMed. We limited our search to reviews that discussed mostly human studies, and were accessible through the university online re-source. We found 11 genome wide association studies(GWAS), as well as five methylation and three miRNA studies that fit our search criteria. A distinction was not made between genes with protective effects or nega-tive effects, as this article is only meant to be a sum-mary of genes associated with any aspect of EH.RESULTS: We found 130 genes from the studies that met our inclusion/exclusion criteria. Of note, genes withmultiple study references include: STK39, CYP17A1, MTHFR-NPPA, MTHFR-NPPB, ATP2B1, CSK, ZNF652, UMOD, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3, ATXN2, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, and HFE. The following genes overlapped between the genetic studies and epigenetic studies: WNK4 and BDKRB2. Several of the identified genes were found to have functions associated with EH. Many epigenetic factors were also correlated with EH. Of the epigenetic factors, there were no articles discussing siRNA and its effects on EH that met the search criteria, thus the topic was not included in this review. Among the miRNA tar-gets found to be associated with EH, many of the genes involved were also identified in the GWAS studies.CONCLUSION: Genetic hypertension risk algorithms could be developed in the future but may be of limited benefit due to the multi-factorial nature of EH. With emerging technologies, like next-generation sequenc-ing, more direct causal relationships between genetic and epigenetic factors affecting EH will likely be discov-ered creating a tremendous potential for personalized medicine using pharmacogenomics. | Aniket Natekar Randi L Olds Meghann W Lau Kathleen Min Karra Imoto Thomas P Slavin | 2014 | World Journal of Cardiology2014，6，5： | 7 |
| 3 | Adjuvant therapy in pancreatic cancer显示文摘The outlook for patients with pancreatic cancer has been grim. There have been major advances in the surgical treatment of pancreatic csncer, leading to a drsmatic reduction in post-operative mortality from the development of high volume specialized centres. This stimulated the study of adjuvant and neoadjuvant treatments in pancreatic cancer including chemoradiotherapy and chemotherapy. Initial protocols have been based on the original but rather small GITSG study first reported in 1985. There have been two large European trials totalling over 600 patients (EORTC and ESPAC-1) that do not support the use of chemoradiation as adjuvant therapy. A second major finding from the ESPAC-1 trial (541 patients randomized) was some but not conclusive evidence for a survival benefit associated with chemotherapy. A third major finding from the ESPAC-1 trial was that the quality of life was not affected by the use of adjuvant treatments compared to surgery alone.The ESPAC-3 trial aims to assess the definitive use of adjuvant chemotherapy in a randomized controlled trial of 990 patients. | Paula Ghaneh John Slavin Robert Sutton Mark Hartley John P Neoptolemos | 2001 | World Journal of Gastroenterology2001，7，4： | 3 |
| 4 | Current management of intraventricular hemorrhage显示文摘 | Herbert H Engelhard Carlota O Andrews Konstantin V Slavin Fady T Charbel | 2003 | Surgical Neurology2003，，1： | 2 |
| 5 | Assessment of Intermediate Severity Coronary Lesions in the Catheterization Laboratory显示文摘 | Jonathan Tobis Babak Azarbal Leo Slavin | 2007 | Journal of the American College of Cardiology2007，，8： | 2 |
| 6 | Skin--sparing mastectomy and immediate reconstruction: oncologic risks and aesthetic resuits in patients with early--stage breast cancer显示文摘 | Slavin SA Schnitt SJ Duda RB | 1998 | Plast Reconstr Surg1998，102，1： | 1 |
| 7 | Guidelines for the use of antifungal agents in the treatment of invasive Candida and mould infections 显示文摘 | Slavin M A Szer J Grigg A P | 2004 | Intern Med J2004，34，2： | 1 |
| 8 | Efficacy and safety of fluconazole prophylaxis for fungal infections after marrow transplantation--aprospective,randomized,double-blind study显示文摘 | Slavin MA Osborne B Adams R | 1995 | J Infect Dis1995，171，6： | 1 |
| 9 | Suppression ofcollagen-induced arthritis by oral or nasal administration of type IIcollagen显示文摘 | GARCIA G KOMAGATA Y SLAVIN A J | 1999 | Journal of Autoimmunity1999，13，3： | 1 |
| 10 | Current management of intraventricular hemorrhage显示文摘 | Engelhard HH Andrews CO Slavin KV | 2003 | Surg Neurol2003，60，1： | 1 |
| 11 | Nonmyeloablative stem cell transplanation and cell therapy as a alternative to conventional bone marrow transplanation with lethal cytoreduction for the treatment of malignant and nonmalignant hematopoietic diseases显示文摘 | Slavin S Nagler A Naparstek A | 1998 | Blood1998，91，2： | 1 |
| 12 | Dietary fiber and body weight显示文摘 | Slavin JL | 2005 | Nutrition2005，21，3： | 1 |
| 13 | Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases显示文摘 | Slavin S Nagler A Naparstek E | | 0，，： | 1 |
| 14 | Co-operation显示文摘 | Slavin R E | | 0，，50： | 1 |
| 15 | Cooperative Learning显示文摘 | Slavin R E | 1980 | Review of Educational Research1980，，50： | 1 |
| 16 | Serum amyloid A is a better early predictor of severity than C-reactive protein in acute pancreatitis显示文摘 | Mayer JM Raraty M Slavin J | 2002 | Br J Surg2002，89，2： | 1 |
| 17 | optic canal:microanatomic study显示文摘 | Dujovny M Soeira G | 1994 | Skull Base Surgery1994，4，3： | 1 |
| 18 | Epithelioid sarcoma with extensive chondroid differentiation显示文摘 | Chetty R Slavin JL | 1994 | Histopathology1994，24，4： | 1 |
| 19 | Dietary fiber and body weight 显示文摘 | Slavin J L | 2005 | Nutrition2005，21，3： | 1 |
| 20 | Lack of correlation- between clinical disease activity and erythrocyte sedimentation rate, acute phase proteins or protease inhibitors in ankylosing spondylitis显示文摘 | Sheehan NJ Slavin BM Donovan MP | 1986 | Br J Rheumatol1986，25，： | 1 |
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