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| 1 | Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells显示文摘Artemisinin 对药抵抗的疟疾的寄生虫是高度有效的,它将近影响全球人口和杀死的一半 > 500 000 个人每年。artemisinin 的主要费用是过去常从 Artemisia annua 提取并且净化这药的昂贵的过程。这显然不必要的步的消除将在地方性的区域使这有势力抗疟药药买得起到全球人口生活。这里,我们报导了非蛋白质药 artemisinin biosynthesized 的口头的交货(0.8 mg/g 干燥重量) 在在由设计二的烟草的临床上有意义的层次,新陈代谢的小径指向了到三不同细胞的分隔空间(叶绿体,原子核,和线粒体) 。二倍地转基因的线显示出 isopentenyl 焦磷酸盐的三方面的改进,并且指向 AACPR, DBR2,和 CYP71AV1 到叶绿体导致了更高的表示和 dihydroartemisinic 酸的有效相片氧化到 artemisinin。从转基因的烟草植物的叶子的部分净化的摘录在变形体感染 falciparum 的红血房间的 vitro 生长前进禁止了。artemisinin 减少了的整个未经触动的植物房间 bioencapsulating 的口头的喂在与商业药比较的质问老鼠的 parasitemia 层次。如此的新奇 synergistic 途径应该通过可食的植物的新陈代谢的工程便于 artemisinin 和另外的药的便宜生产和交货。 | Karan Malhotra Mayavan Subramaniyan Khushboo Rawat Md. Kalamuddin M. Irfan Qureshi Pawan Malhotra Asif Mohmmed Katrina Cornish Henry Daniell Shashi Kumar1 | 2016 | Molecular Plant2016，9，11： | 14 |
| 2 | Probiotic Bacteria Enhance Murine and Human Intestinal Epithelial Barrier Function显示文摘 | Karen Madsen Anthony Cornish Paul Soper Conor McKaigney Humberto Jijon Christine Yachimec Jason Doyle Lawrence Jewell Claudio De Simone | 2001 | Gastroenterology2001，，3： | 2 |
| 3 | Hyaline Globules in Neuroendocrine and Solid-pseudopapillary Neoplasms of the Pancreas: A Clue to the Diagnosis显示文摘 | Zina Meriden Chanjuan Shi Barish H. Edil Trevor Ellison Christopher L. Wolfgang Toby C. Cornish Richard D. Schulick Ralph H. Hruban | 2011 | The American Journal of Surgical Pathology2011，，： | 2 |
| 4 | A Meta-Analysis of Quality of Life for Abdominoperineal Excision of Rectum versus Anterior Resection for Rectal Cancer显示文摘 | Julie A. Cornish MBBCh MRCS Henry S. Tilney MBBS MRCS Alexander G. Heriot MD FRCS Ian C. Lavery MD Victor W. Fazio MD Paris P. Tekkis MD FRCS | 2007 | Annals of Surgical Oncology2007，，7： | 2 |
| 5 | Quantitative Gas-Chromatographic Determination of Pentaerythritol and its By-Products by Direct Oximation and then Silyation of Aqueous Solutions显示文摘 | Simon C D Comninos H Cornish L | 1993 | Journal of Chromatographic Science1993，31，6： | 2 |
| 6 | Simvastatin normalizes autonomic neural control in experimental heart failure显示文摘 | Pliquett RU Cornish KG Peuler JD | 2003 | Circulation2003，107，： | 1 |
| 7 | Mechanistic and toxicity studies of the photocatalytic oxidation of microcystin-LR 显示文摘 | Liu I Lawton L A Cornish B | 2002 | Journal of Photochemistry and Photobiology A: Chemistry2002，148，123： | 1 |
| 8 | Sirovastatin normalizes autonomic neural control in experimental heart failure显示文摘 | Pliquett RU Cornish KG Peuler JD | 2003 | Circula- tion2003，107，19： | 1 |
| 9 | Frequency,type and clinical importance of medication history errors at admission to hospital:a systematic review显示文摘 | Tam VC Knowles SR Cornish PL | 2005 | CMAJ2005，173，5： | 1 |
| 10 | A meta-analysis on the influ- ence of inflammatory bowel disease on pregnancy显示文摘 | Cornish J Tan E Teare J | 2007 | GUT2007，56，6： | 1 |
| 11 | Probioticbacteria enhancemurine and human intestinal epithelial barrierfunction显示文摘 | Anthony Cornish Paul Soper | 2001 | Gastroentrology2001，121，3： | 1 |
| 12 | Hydrogen peroxide enhanced photocatalytic oxidation of microcystin-LR using titanium dioxide 显示文摘 | Cornish B J P A Lawton L A Robertson P K J | 2000 | Applied Catalysis B: Environmental2000，25，1： | 1 |
| 13 | Genetics and biochemistry of anthocyanin biosynthesis 显示文摘 | HOLTON T A CORNISH E C | 1995 | Plant Cell1995，7，7： | 1 |
| 14 | Farm-scalestorm water losses of sediment and nutrients from a market gardennear Sydney,Australia显示文摘 | HOLLINGER E CORNISH P SiBAGINSKA B | 2001 | Agricultural Water Management2001，47，3： | 1 |
| 15 | A neuropsychological profile of attention deficits in young males with fragile X syndrome显示文摘 | Munir F Cornish KM Wilding J | | 0，，09： | 1 |
| 16 | IEEE 1641 supports test and design显示文摘 | Cornish M | 2007 | Test & Measurement World2007，，2： | 1 |
| 17 | Alteration of NMDA NR1 receptors within the paraventricular nucleus of hypothala musin rats with heart failure显示文摘 | LI Y F CORNISH K G PATEL K P | 2003 | CircRes2003，93，10： | 1 |
| 18 | Simvastatin normalizes autonomic neural control in experimental heart failure显示文摘 | Pliquett RU Cornish KG Peuler JD | 2003 | Circulation2003，107，19： | 1 |
| 19 | Cloning of cDNA for a stylar glycoprotein associated with expression of self- incompatibility in Nicotiana alata显示文摘 | Cornish E C Mau S- L | 1986 | Nature1986，321，： | 1 |
| 20 | Aluminium-lithium based alloys for aerospace application显示文摘 | Cornish A J Miller W S | 1985 | Metals and Materials1985，1，6： | 1 |
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