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| 1 | Clinical algorithms for the prevention of variceal bleeding and rebleeding in patients with liver cirrhosis显示文摘Portal hypertension(PH),a common complication of liver cirrhosis,results in development of esophageal varices.When esophageal varices rupture,they cause significant upper gastrointestinal bleeding with mortality rates up to 20%despite state-of-the-art treatment.Thus,prophylactic measures are of utmost importance to improve outcomes of patients with PH.Several high-quality studies have demonstrated that non-selective beta blockers(NSBBs)or endoscopic band ligation(EBL)are effective for primary prophylaxis of variceal bleeding.In secondary prophylaxis,a combination of NSBB+EBL should be routinely used.Once esophageal varices develop and variceal bleeding occurs,standardized treatment algorithms should be followed to minimize bleeding-associated mortality.Special attention should be paid to avoidance of overtransfusion,early initiation of vasoconstrictive therapy,prophylactic antibiotics and early endoscopic therapy.Pre-emptive transjugular intrahepatic portosystemic shunt should be used in all Child C10-C13 patients experiencing variceal bleeding,and potentially in Child B patients with active bleeding at endoscopy.The use of carvedilol,safety of NSBBs in advanced cirrhosis(i.e.with refractory ascites)and assessment of hepatic venous pressure gradient response to NSBB is discussed.In the present review,we give an overview on the rationale behind the latest guidelines and summarize key papers that have led to significant advances in the field. | Nikolaus Pfisterer Lukas W Unger Thomas Reiberger | 2021 | World Journal of Hepatology2021，13，7： | 11 |
| 2 | Angiotensin Type 1 Receptor Blockers Induce Peroxisome Proliferator–Activated Receptor-γ Activity显示文摘 | Michael Schupp Jürgen Janke Ronald Clasen Thomas Unger Ulrich Kintscher | 2004 | Circulation: Journal of the American Heart Association2004，，17： | 3 |
| 3 | Effects of endothelin ET_A receptor blocker LU 135252 on cardiac remod-eling and survival in a hypertensive rat model of chronic heart failure显示文摘瞄准:调查 endothelin 希腊语字母的第七字受体阻滞物是否在在长期的心力衰竭(CHF ) 的一个高血压的老鼠模型的心脏的改变和幸存上提供类似的利益。方法:男性击容易自发地, hypertensive (SHR-SP ) 老鼠受到左冠的动脉的永久结扎并且与 endothelin 希腊语字母的第七字受体阻滞物 LU 135252 被对待 6 个星期(30 mg.kg (在结扎或 untreatment 以后开始 24 h 的 -1).d(-1)) 。假冒操作老鼠用作正常控制。吝啬的动脉的血压(地图),心搏率( HR ),左室的结束心脏舒张的压力( LVEDP ),左室的收缩性( LV dp/dt (最大)),左室的内部直径( LVD )和圆周( LVC ),氏族的厚度,左室的空隙的骨胶原内容(国际计算中心)和心重量( HW )在处理的结束被测量。结果:与未经治疗的组相比, LU 135252 趋于增加 HW (1.43 +/-0.03 对 1.38 +/-0.04 g;P> 0.05 ) ,增加的 LVD (7.65+/-0.24 公里对 6.58+/-0.14 公里;P<0.05 ) ,显著地增加的 LVC (30.11+/-0.83 公里对 24.82+/-0.85 公里;P< 0.01 ) 并且减少的左室的国际计算中心(3.79%+/-0.09% 对 6.71%+/-0.11% ;P< 0.01 ) ,稍微降低的地图(132+/-6 毫米汞柱对 142+/-4 毫米汞柱;P>0.05 ) ,减少的 LVEDP (14 4 毫米汞柱对 27+/-4 毫米汞柱;P<0.05 ) 并且改进 LV dp/dtmax (4230+/-450 mmHg/s 对 1950+/-400 mmHg/s;P<0.05 ) ;幸存没显著地被延长(13% 对 11% ;P=NS ) 。结论:在 CHF 的这个高血压的老鼠模型,然而,有 LU 135252 的长期的 endothelin 希腊语字母的第七字受体封锁改进心脏的血液动力学它不影响长期的幸存并且变得更坏心脏的改变。因此, endothelin 希腊语字母的第七字受体对手是不大可能的与 CHF 在病人的管理有一个重要角色。 | Qin-gui XIA Alexander REINECKE Marc DORENKAMP Mat Jap DAEMEN Reichiger SIMON Thomas UNGER | 2006 | Acta Pharmacologica Sinica2006，27，11： | 3 |
| 4 | The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke显示文摘 | Christa Th?ne-Reineke Christian Neumann Pawel Namsolleck Kristin Schmerbach Maxim Krikov Jan H Schefe Kristin Lucht Heide H?rtnagl Michael Godes Susanne Müller Kay Rumschüssel Heiko Funke-Kaiser Arno Villringer U Muscha Steckelings Thomas Unger | 2008 | Journal of Hypertension2008，，12： | 2 |
| 5 | 缓激肽在ACE抑制剂改善心肌梗塞后缺血边缘区血供中的作用显示文摘目的 研究血管紧张素转换酶抑制剂 (ACEⅠ )介导的缓激肽 (bradykinin)对急性心肌梗塞后缺血边缘区组织血流量的影响。方法 ♂Wistar大鼠被随机分成 4组 :雷米普利、雷米普利加icatibant、络沙坦以及喂水对照组。用药 1wk后结扎冠状动脉左前降支 ,在结扎前后分别测定心率、血2 0 0 1 0 2 0 6收稿 ,2 0 0 1 0 5 17再修回1 复旦大学基础医学院生理学教研室·肾脏与高血压研究中心 ,上海 2 0 0 0 322 上海市岳阳医院内科 ,上海 2 0 0 4373德国基尔大学药理系作者简介 :茅建春 ,男 ,主治医师 ,Tel:0 2 1 64 0 4190 2 198压、缺血边缘区组织血流量的变化 ,成活的大鼠饲养 3wk后测定心肌梗死面积。结果 用雷米普利预处理 1wk能改善急性心梗心脏缺血边缘带的组织血流量并缩小心肌梗死面积 ,icatibant能使以上作用明显减弱 ,而单用络沙坦则无效。结论 ACEI类药物可改善急性心梗心脏缺血区边缘的血供并使梗塞面积缩小 。 | 茅建春 金莹 朱依纯 仰礼真 Thomas Unger | 2001 | 中国药理学通报2001，17，5： | 2 |
| 6 | Quantitative real-time RT-PCR data analysis: current concepts and the novel “gene expression’s C T difference” formula显示文摘 | Jan H. Schefe Kerstin E. Lehmann Ivo R. Buschmann Thomas Unger Heiko Funke-Kaiser | 2006 | Journal of Molecular Medicine2006，，11： | 1 |
| 7 | Vascular endothelial growth factor receptor tyro- sine kinase inhibitors : PTIC787/ZK 222584 显示文摘 | Thomas AL Morgan B Drevs J Unger C Wiedenmann B Van- hoefer U | 2003 | Semin Oncol2003，30，6： | 1 |
| 8 | Agglomerated non-porous silica nanoparticles as model carriers in polyethylene synthesis 显示文摘 | UNGER KLAUS K THOMAS EBERLE | 2004 | Journal of Molecular Catalysis A:Chemical2004，221，12： | 1 |
| 9 | Evaluation of a Porous Tantalum Uncemented Acetabular Cup in Revision Total Hip Arthroplasty显示文摘 | Anthony S. Unger Randall J. Lewis Thomas Gruen | 2005 | The Journal of Arthroplasty2005，，8： | 1 |
| 10 | Angiotensin Ⅱ and its AT2 receptor: new insights into an old system 显示文摘 | Monika Stoll Thomas Unger | 2001 | Regul Pept2001，99，1： | 1 |
| 11 | Significance of timing of angiotensin AT1 receptor blockade in rats with myocardial infarction-induced heart failure 显示文摘 | Xia QG Oliver Chung Thomas Unger | 2001 | Cardiovasc Res2001，49，1： | 1 |
| 12 | Therapeutic app lications of lipid-coated microbubbles显示文摘 | UNGER E C THOMAS P WILLIAM C | 2004 | Advanced Drug Delivery Reviews2004，56，9： | 1 |
| 13 | Sol–gel derived TiO2 wood composites显示文摘 | Thomas Hübert Brita Unger Michael Bücker | 2010 | Journal of Sol - Gel Science and Technology2010，，2： | 1 |
| 14 | Pressurized flow electrochromatography with reversed phase capillary columns显示文摘 | Thomas Eimer Klaus K. Unger Takao Tsuda | 1995 | Fresenius’ Journal of Analytical Chemistry (-)1995，，7： | 1 |
| 15 | Estrogen receptor α supports cardiomyocytes indirectly through post-infarct cardiac c-kit+ cells显示文摘 | Marie Brinckmann Elena Kaschina Wassim Altarche-Xifró Caterina Curato Melanie Timm Aleksandra Grzesiak Jun Dong Kai Kappert Ulrich Kintscher Thomas Unger Jun Li | 2009 | Journal of Molecular and Cellular Cardiology2009，，1： | 1 |
| 16 | Growth and aggregation behavior of representative phytoplankton as affected by the environmental contaminant di-n-butyl phthalate显示文摘 | Roger Acey Patricia Healy Thomas F. Unger Carolyn E. Ford Richard A. Hudson | 1987 | Bulletin of Environmental Contamination and Toxicology1987，，1： | 1 |
| 17 | Angiotensin Type 2 Receptor Stimulation Ameliorates Left Ventricular Fibrosis and Dysfunction via Regulation of Tissue Inhibitor of Matrix Metalloproteinase 1/Matrix Metalloproteinase 9 Axis and Transforming Growth Factor β1 in the Rat Heart显示文摘 | Dilyara Lauer Svetlana Slavic Manuela Sommerfeld Christa Th?ne-Reineke Yuliya Sharkovska Anders Hallberg Bjorn Dahl?f Ulrich Kintscher Thomas Unger Ulrike Muscha Steckelings Elena Kaschina | 2014 | Hypertension2014，，3： | 1 |
| 18 | Biomedical Implications of a Thrombus-Specific US Contrast Agent显示文摘 | Evan C Unger Terry O Matsunaga Thomas P McCreery Robert H Sweitzer | 2002 | Academic Radiology2002，，1： | 1 |
| 19 | Mesenchymal stem cell proliferation and differentiation on load-bearing trabecular Nitinol scaffolds显示文摘 | Irena Gotman Dror Ben-David Ronald E. Unger Thomas B?se Elazar Y. Gutmanas C. James Kirkpatrick | 2013 | Acta Biomaterialia2013，，： | 1 |
| 20 | Cardiovascular drug delivery with ultrasound and microbubbles显示文摘 | Evan Unger Thomas Porter Jonathan Lindner Paul Grayburn | 2014 | Advanced Drug Delivery Reviews2014，，： | 1 |
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