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| 1 | Autonomous vehicles: challenges, opportunities, and future implications for transportation policies显示文摘This study investigates the challenges and opportunities pertaining to transportation policies that may arise as a result of emerging autonomous vehicle(AV)technologies. AV technologies can decrease the transportation cost and increase accessibility to low-income households and persons with mobility issues. This emerging technology also has far-reaching applications and implications beyond all current expectations. This paper provides a comprehensive review of the relevant literature and explores a broad spectrum of issues from safety to machine ethics. An indispensable part of a prospective AV development is communication over cars and infrastructure(connected vehicles). A major knowledge gap exists in AVtechnology with respect to routing behaviors. Connectedvehicle technology provides a great opportunity to implement an efficient and intelligent routing system. To this end, we propose a conceptual navigation model based on a fleet of AVs that are centrally dispatched over a network seeking system optimization. This study contributes to the literature on two fronts:(i) it attempts to shed light on future opportunities as well as possible hurdles associated with AV technology; and(ii) it conceptualizes a navigation model for the AV which leads to highly efficient traffic circulations. | Saeed Asadi Bagloee Madjid Tavana Mohsen Asadi Tracey Oliver | 2016 | Journal of Modern Transportation2016，24，4： | 14 |
| 2 | Role of endoscopic ultrasonography in the loco-regional staging of patients with rectal cancer显示文摘The prognosis of rectal cancer(RC) is strictly related to both T and N stage of the disease at the time of diagnosis. RC staging is crucial for choosing the best multimodal therapy: patients with high risk locally advanced RC(LARC) undergo surgery after neoadjuvant chemotherapy and radiotherapy(NAT); those with low risk LARC are operated on after a preoperative short-course radiation therapy; finally, surgery alone is recommended only for early RC. Several imaging methods are used for staging patients with RC: computerized tomography, magnetic resonance imaging, positron emission tomography, and endoscopic ultrasound(EUS). EUS is highly accurate for the loco-regional staging of RC, since it is capable to evaluate precisely the mural infiltration of the tumor(T), especially in early RC. On the other hand, EUS is less accurate in restaging RC after NAT and before surgery. Finally, EUS is indicated for follow-up of patients operated on for RC, where there is a need for the surveillance of the anastomosis. The aim of this review is to highlight the impact of EUS on the management of patients with RC, evaluating its role in both preoperative staging and follow-up of patients after surgery. | Pietro Marone Mario de Bellis Valentina D'Angelo Paolo Delrio Valentina Passananti Elena Di Girolamo Giovanni Battista Rossi Daniela Rega Maura Claire Tracey Alfonso Mario Tempesta | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 11 |
| 3 | Colorectal cancer in patients under 50 years of age:A retrospective analysis of two institutions' experience显示文摘AIM:To investigate the epidemiological characteristics of colorectal cancer(CRC)in patients under 50 years of age across two institutions.METHODS:Records of patients under age 50 years of age who had CRC surgery over a 16 year period were assessed at two institutions.The following documents where reviewed:admission notes,operative notes,and discharge summaries.The main study variables included:age,presenting symptoms,family history,tumor location,operation,stage/differentiation of disease,and post operative complications.Stage of disease was classified according to the American Joint Committee on Cancer TNM staging system:tumor depth;node status;and metastases.RESULTS:CRC was found in 180 patients under age50 years(87 females,93 males;mean age 41.4±6.2years).Young patients accounted for 11.2%of cases during a 6 year period for which the full data set wasavailable.Eight percent had a 1stdegree and 12%a 2nd degree family CRC history.Almost all patients(94%)were symptomatic at diagnosis;common symptoms included:bleeding(59%),obstruction(9%),and abdominal/rectal pain(35%).Evaluation was often delayed and bleeding frequently attributed to hemorrhoids.Advanced stage CRC(Stage 3 or 4)was noted in 53%of patients.Most tumors were distal to the splenic flexure(77%)and 39%involved the rectum.Most patients(95%)had segmental resections;6 patients had subtotal/total colectomy.Poorly differentiated tumors were noted in 12%and mucinous lesions in 19%of patients of which most had Stage 3 or 4 disease.Twenty-two patients(13%)developed recurrence and/or progression of disease to date.Three patients(ages 42,42and 49 years)went on to develop metachronous primary colon cancers within 3 to 4 years of their initial resection.CONCLUSION:CRC was common in young patients with no family history.Young patients with symptoms merit a timely evaluation to avoid presentation with late stage CRC. | Elizabeth A Myers Daniel L Feingold Kenneth A Forde Tracey Arnell Joon Ho Jang Richard L Whelan | 2013 | World Journal of Gastroenterology2013，19，34： | 9 |
| 4 | 旅游地居民对旅游业发展认知及影响因素研究显示文摘方差分析结果表明,居民的年龄、月收入、受教育程度均影响了居民对旅游业发展所持的态度。典型相关分析的结果显示,居民对旅游业发展带来正面影响的认知与支持旅游业发展之间存在正相关关系。但研究也发现,居民对旅游业发展带来负面影响的认知与居民支持旅游业发展之间不存在显著相关关系。 | 刘静艳 Bruce Tracey 颜亮 | 2006 | 学术研究2006，，4： | 9 |
| 5 | 武汉市养老院老年人生活质量及其影响因素显示文摘目的了解武汉市养老院老年人的生活质量状况及其影响因素。方法采用一般资料问卷和长期照顾生活质量量表对武汉市5所养老院107位老年人进行调查。结果武汉市养老院老人生活质量平均分偏低,为(6.22±1.42)分;得分最低的是'参加社会活动'和'与家人或朋友进行支持性沟通'。多因素分析显示影响养老院老年人生活质量的因素为自理能力、养老院居住的满意度、健康状况及养老院性质。结论武汉市养老院老年人生活质量有待提高。改善其生活质量应该鼓励老年人参加更多的社会活动;帮助建立较好的家庭社会支持系统;另外老年人的自理能力、养老院居住的满意度及健康状况应予关注。 | 裴先波 高莹 张青 Tracey McDonald | 2016 | 中国老年学杂志2016，36，17： | 8 |
| 6 | Tim-3 promotes cell aggressiveness and paclitaxel resistance through NF-κB/STAT3 signalling pathway in breast cancer cells显示文摘Objective:Although T-cell immunoglobulin and mucin-domain containing molecule-3(Tim-3)has been recognized as a promising target for cancer immunotherapy,its exact role in breast cancer has not been fully elucidated.Methods:Tim-3 gene expression in breast cancer and its prognostic significance were analyzed.Associated mechanisms were then explored in vitro by establishing Tim-3-overexpressing breast cancer cells.Results:In a pooled analysis of The Cancer Genome Atlas(TCGA)database,Tim-3 gene expression levels were significantly higher(P<0.001)in breast cancer tissue,compared with normal tissues.Tim-3 was a prognosis indicator in breast cancer patients[relapse-free survival(RFS),P=0.004;overall survival(OS),P=0.099].Tim-3 overexpression in Tim-3 low breast cancer cells promoted aggressiveness of breast cancer cells,as evidenced by enhanced proliferation,migration,invasion,tight junction deterioration and tumor-associated tubal formation.Tim-3 also enhanced cellular resistance to paclitaxel.Furthermore,Tim-3 exerted its function by activating the NF-κB/STAT3 signalling pathway and by regulating gene expression[cyclin D1(CCND1),C-Myc,matrix metalloproteinase-1(MMP1),TWIST,vascular endothelial growth factor(VEGF)upregulation,concomitant with Ecadherin downregulation).Lastly,Tim-3 downregulated tight junction-associated molecules zona occludens(ZO)-2,ZO-1 and occludin,which may further facilitate tumor progression.Conclusions:Tim-3 plays an oncogenic role in breast cancer and may represent a potential target for antitumor therapy. | Yizi Cong Yuxin Cui Shiguang Zhu Jianqiao Cao Haidong Zou Tracey AMartin Guangdong Qiao Wenguo Jiang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 7 |
| 7 | Lipid dysregulation in hepatitis C virus, and impact of statin therapy upon clinical outcomes显示文摘The hepatitis C virus(HCV) is one of the most common causes of chronic liver disease and the leading indication for liver transplantation worldwide. Every aspect of the HCV life cycle is closely tied to human lipid metabolism. The virus circulates as a lipid-rich particle, utilizing lipoprotein cell receptors to gain entry into the hepatocyte. It has also been shown to upregulate lipid biosynthesis and impair lipid degradation, resulting in significant intracellular lipid accumulation and circulating hypocholesterolemia. Patients with chronic hepatitis C(CHC) are at increased risk of hepatic steatosis, fibrosis, and cardiovascular disease including accelerated atherosclerosis. HMG Co A Reductase inhibitors, or statins, have been shown to play an important role in the modulation of hepatic steatosis and fibrosis, and recent attention has focused upon their potential therapeutic role in CHC. This article reviews the hepatitis C viral life cycle as it impacts host lipoproteins and lipid metabolism. It then describes the pathogenesis of HCV-related hepatic steatosis, hypocholesterolemia and atherosclerosis, and finally describes the promising anti-viral and anti-fibrotic effects of statins, for the treatment of CHC. | Tracey G Simon Adeel A Butt | 2015 | World Journal of Gastroenterology2015，21，27： | 5 |
| 8 | Plastid genome sequences of legumes reveal parallel inversions and multiple losses of rps16 in papilionoids显示文摘迄今为止,荚的公开可得到的质体染色体通常被限制了到亚科 Papilionoideae。这里,我们报导跨越所有三个亚科的荚的 13 个新质体染色体。代表 Caesalpinioideae 和 Mimosoideae 的染色体高度在基因内容和基因顺序被保存,类似于祖先的被子植物染色体组织。然而,在 Papilionoideae 以内的染色体首先在大单个拷贝区域在九个 intergenic 分隔符由于删除减少了尺寸。我们的学习也显示 rps16 独立地在荚被失去了至少五次,与在 papilionoids 之中散布的另外的基因和 intron 损失。另外,从在 papilionoids, Lupinus 和 Robinia 以内的二个不同的系的类,分别地有 36 和 39 kb 的平行倒置。当它看起来被 29 bp 重复在二 trnS 基因以内引起,这平行倒置是新奇的。这次重复在显示为在更多的种类在场的这倒置有潜力的所有可得到的荚质体染色体是在场的。homoplasious 倒置的这个案例也是一些倒置事件不能是可靠种系发生的标记的证据。 | Erika N. Schwarz Tracey A. Ruhlman Jamal S. M. Sabir Nahid H. Hajrah Njud S. Alharbi Abdulrahman L. AI-Malki C. Donovan Bailey Robert K. Jansen | 2015 | Journal of Systematics and Evolution2015，53，5： | 5 |
| 9 | Expression of the Transcription Factors Snail, Slug, and Twist and Their Clinical Significance in Human Breast Cancer显示文摘 | Tracey A. Martin Amit Goyal Gareth Watkins Wen G. Jiang | 2005 | Annals of Surgical Oncology2005，，6： | 3 |
| 10 | Calling underwater is a costly signal: size-related differences in the call rates of Antarctic leopard seals显示文摘 | Tracey L. ROGERS | 2017 | Current Zoology2017，63，4： | 3 |
| 11 | Review of direct-acting antiviral agents for the treatment of chronic hepatitis C显示文摘 | Nihar Shah Tracey Pierce Kris V Kowdley | 2013 | Expert Opinion on Investigational Drugs2013，，9： | 3 |
| 12 | 重组人类生长激素治疗儿童X-连锁低血磷性佝偻病显示文摘目的评价重组人类生长激素rhGH治疗儿童X-连锁低血磷性佝偻病(XLH)的临床疗效与安全性。方法检查Cochrane囊性纤维化及遗传性疾病工作组建立的先天性代谢缺陷数据库。手检相关骨和矿物质代谢的杂志和会议摘要。纳入所有单独采用重组人类生长激素或联合传统疗法与安慰剂或单用传统疗法治疗儿童XLH作比较的随机对照试验或半随机对照试验。2个评价员独立选择纳入的试验、评价试验的方法学质量及提取数据。结果只有1个研究符合该系统评价的纳入标准,且样本量小。rhGH治疗可能改善XLH患儿身高增长,并可因暂时减少尿磷的排出而提高血磷水平。结论尚没有足够的证据显示rhGH是否对患儿的身高增长、矿物质代谢、内分泌、肾功能、骨矿密度和上下部量比例有影响。 | 杨慧明 万朝敏 Tracey Remmington | 2004 | 临床儿科杂志2004，22，8： | 3 |
| 13 | Gastric adenocarcinoma in patients 40 years of age or younger显示文摘 | Charles P. Theuer Christian de Virgilio Greg Keese Samuel French Tracey Arnell Jorge Tolmos Stanley Klein William Powers Tony Oh Bruce E. Stabile | 1996 | The American Journal of Surgery1996，，5： | 2 |
| 14 | Statin Use is Associated with a Reduced Risk of Fibrosis Progression in Chronic Hepatitis C显示文摘 | Tracey G. Simon Lindsay Y. King Hui Zheng Raymond T. Chung | 2014 | Journal of Hepatology2014，，： | 2 |
| 15 | Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock显示文摘 | Jonas Sundén-Cullberg Anna Norrby-Teglund Ari Rouhiainen Heikki Rauvala Gunilla Herman Kevin J. Tracey Martin L. Lee Jan Andersson Leif Tokics Carl Johan Treutiger | 2005 | Critical Care Medicine2005，，3： | 2 |
| 16 | Epidemiology of neuroendocrine cancers in an Australian population显示文摘 | Colin Luke Timothy Price Amanda Townsend Christos Karapetis Dusan Kotasek Nimit Singhal Elizabeth Tracey David Roder | 2010 | Cancer Causes & Control2010，，6： | 2 |
| 17 | Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice显示文摘 | Rui Kang Qiuhong Zhang Wen Hou Zhenwen Yan Ruochan Chen Jillian Bonaroti Preeti Bansal Timothy R. Billiar Allan Tsung Qingde Wang David L. Bartlett David C. Whitcomb Eugene B. Chang Xiaorong Zhu Haichao Wang Ben Lu Kevin J. Tracey Lizhi Cao Xue-Gong Fan M | 2013 | Gastroenterology2013，，： | 2 |
| 18 | Passiflora plastome sequencing reveals widespread genomic rearrangements显示文摘Although past studies have included Passiflora among angiosperm lineages with highly rearranged plastid genomes (plastomes),knowledge about plastome organization in the genus is limited.So far only one draft and one complete plastome have been published.Expanded sampling of Passiflora plastomes is needed to understand the extent of the genomic rearrangement in the genus,which is also unusual in having biparental plastid inheritance and plastome-genome incompatibility.We sequenced 15 Passiflora plastomes using either Illumina paired-end or shotgun cloning and Sanger sequencing approaches.Assembled plastomes were annotated using Dual Organellar GenoMe Annotator (DOGMA)and tRNAscan-SE.The Populus trichocarpa plastome was used as a reference to estimate genomic rearrangements in Passifloru by performing whole genome alignment in progressiveMauve.The phylogenetic distribution of rearrangements was plotted on the maximum likelihood tree generated from 64 plastid encoded protein genes.Inverted repeat (IR)expansion/contraction and loss of the two largest hypothetical open reading frames,ycf1 and ycf2,account for most plastome size variation,which ranges from 139 262 base pairs (bp)in P.biflora to 161 494 bp in P.pittieri.Passifloru plastomes have experienced numerous inversions,gene and intron losses along with multiple independent IR expansions and contractions resulting in a distinct organization in each of the three subgenera examined.Each Passiflora subgenus has a unique plastome structure in terms of gene content,order and size.The phylogenetic distribution of rearrangements shows that Passiflora has experienced widespread genomic changes,suggesting that such events may not be reliable phylogenetic markers. | Samar O.Rabah Bikash Shrestha Nahid H.Hajrah Mumdooh J.Sabir Hesham F.Alharby Mernan J.Sabir Alawiah M.Alhebshi Jamal S.M.Sabir Lawrence E.Gilbert Tracey A.Ruhlman Robert K.Jansen | 2019 | Journal of Systematics and Evolution2019，57，1： | 2 |
| 19 | Hepatic artery pseudoaneurysm following laparoscopic cholecystectomy显示文摘 | Caroline A. Yao Tracey D. Arnell | 2010 | The American Journal of Surgery2010，，： | 2 |
| 20 | ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO显示文摘 | Marieke A.D. van Zoelen Huan Yang Sandrine Florquin Joost C.M. Meijers Shizuo Akira Bernd Arnold Peter P. Nawroth Angelika Bierhaus Kevin J. Tracey Tom van der Poll | 2009 | Shock2009，，3： | 2 |
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