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| 1 | Anthropogenic emission inventories in China:a review显示文摘The development of reliable anthropogenic emission inventories is essential for both understanding the sources of air pollution and designing effective air-pollution-control measures in China. However, it is challenging to quantify emissions in China accurately, given the variety of contributing sources, the complexity of the technology mix and the lack of reliable measurements. Over the last two decades,tremendous efforts have been made to improve the accuracy of emission inventories, and significant improvements have been realized. More reliable statistics and survey-based data have been used to reduce the uncertainties in activity rates and technology distributions. Local emission factors and source profiles covering various sources have been measured and reported. Based on these local databases, improved emission inventory models have been developed for power plants, large industrial plants and the residential,transportation and agricultural sectors. In this paper, we review the progress that has been made in developing inventories of anthropogenic emissions in China. We first highlight the major updates that have been made to emission inventory models and the underlying data by source category. We then summarize the sector-based estimates of emissions of different species contained in current inventories. The progress that has been made in the development of model-ready emissions is also presented. Finally, we suggest future directions for further improving the accuracy of emission inventories in China. | Meng Li Huan Liu Guannan Geng Chaopeng Hong Fei Liu Yu Song Dan Tong Bo Zheng Hongyang Cui Hanyang Man Qiang Zhang Kebin He | 2017 | National Science Review2017，4，6： | 100 |
| 2 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 3 | An Overview on Advanced Grid-connected Inverters Used for Decentralized Renewable Energy Resources显示文摘并网逆变器是分散式可再生能源接入配电网的重要接口,随着分布式可再生能源渗透率的不断提高,并网逆变器在传统配电网中的地位越发突出。为了高效完成可再生能源分散式并网,并有效降低并网逆变器对电网的冲击,一些在装置上、结构上和功能上更加先进的并网逆变器成为了迫切的需求。针对现有的一些先进并网逆变器进行比较、分析和研究,从装置级、功能级和控制级的角度对现有先进并网逆变器进行综述。给出一些在结构上能更加灵活地将可再生能源分散接入配电网的硬件电路。研究一些适用于可再生能源分散接入的,使并网逆变器能虚拟同步发电机完成自治运行、电能质量治理、系统阻抗检测、网络阻抗控制等辅助控制功能。同时还对并网逆变器的并网同步算法和电流跟踪控制策略进行了探讨。最后,提出一个适合于可再生能源分散并网的先进并网逆变器框架。 | ZENG Zheng ZHAO Rongxiang TANG Shengqing YANG Huan LU Zhipeng | 2013 | 中国电机工程学报2013，33，24： | 76 |
| 4 | Injectable hydrogels for cartilage and bone tissue engineering显示文摘Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix(ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed. | Mei Liu Xin Zeng Chao Ma Huan Yi Zeeshan Ali Xianbo Mou Song Li Yan Deng Nongyue He | 2017 | Bone Research2017，5，2： | 54 |
| 5 | Opening and evolution of the South China Sea constrained by studies on volcanic rocks:Preliminary results and a research design显示文摘The South China Sea (SCS) is characterized by abundant seamounts, which provide important information about the evolution of the SCS and related deep processes. Cenozoic volcanism in the SCS and its surroundings comprises three stages relative to the spreading of the SCS:prespreading (>32 Ma), syn-spreading (32-16 Ma), and post-spreading (<16 Ma). The pre-spreading magmatism predominantly occurs on the northern margin of the SCS and in South China coastal areas and shows a bi-modal affinity. The syn-spreading magmatic activity was very limited on the periphery of the SCS, but may be concentrated in the SCS. However, seafloor samples of this stage are not available yet because of overlying thick sedimentary deposits. Post-spreading magmatism is widespread in the central and southwest sub-basins of the SCS, Hainan Island, Leizhou Peninsula, Thailand, and Vietnam. These are mainly alkali basalts with subordinate tholeiites, and display OIB-type geochemical characteristics. The Dupal isotope anomaly and presence of high-magnesian olivine phenocrysts suggests their possible derivation from the Hainan mantle plume. The temporal and spatial distribution of Cenozoic volcanism in the SCS and its surroundings may be accounted for either by plate stress re-organization before and after SCS spreading, or by ridge suction of plume flow during opening of the SCS. If the latter is the case, the volcanic rocks within the SCS basin may not be typical mid-ocean ridge basalts (MORB). It remains puz-zling, however, that the transition between the South China continental margin and the SCS basin does not have features typical of a volcanic rifted margin. Clearly, the relationship between mantle plume and SCS opening needs further evaluation. A better un-derstanding of the link between deep processes and opening of the SCS not only requires enhanced studies on igneous petrogene-sis, but also is heavily dependent on systematic sampling of seafloor rocks. | XU YiGang WEI JingXian QIU HuaNing ZHANG HuiHuang HUANG XiaoLong | 2012 | Chinese Science Bulletin2012，57，24： | 43 |
| 6 | The Critical Rainfall Characteristics for Torrents and Debris Flows in the Wenchuan Earthquake Stricken Area显示文摘Critical rainfall assessment is a very important tool for hazard management of torrents and debris flows in mountainous areas. The Wenchuan Earthquake 2008 caused huge casualties and property damages in the earthquake-stricken area,which also generated large quantities of loose solid materials and increased occurrence probabilities of debris flows. There is an urgent need to quantify the critical rainfall distribution in the area so that better hazard management could be planned and if real time rainfall forecast is available,torrent and debris flow early-warning could be issued in advance. This study is based on 49-year observations (1954-2003) of up to 678 torrent and debris flow events. Detailed contour maps of 1 hour and 24 hour critical rainfalls have been generated (Due to the data limitation,there was insufficient 10 minute critical rainfall to make its contour map). Generally,the contour maps from 1 hour and 24 hours have similar patterns. Three zones with low,medium and high critical rainfalls have been identified. The characteristics of the critical rainfall zones are linked with the local vegetation cover and land forms. Further studies and observations are needed to validate the finding and improve the contour maps. | CHEN Ningsheng YANG Chenglin ZHOU Wei HU Guisheng LI Huan David Han | 2009 | Journal of Mountain Science2009，6，4： | 35 |
| 7 | MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines显示文摘迷走神经神经能通过“一条胆碱能的反煽动性的小径”控制煽动性的反应,它被 α 调停; 7-nicotinic 醋胆素受体(α 7nAChR ) 在巨噬细胞上。然而,连接 α 的细胞内部的机制; 7nAChR 激活和支持 inflammatory cytokine 生产遗体不好理解。在这研究,我们发现 miR-124 是由在暴露 LPS 的房间和老鼠的胆碱能的收缩筋的 upregulated。利用 miR-124 模仿并且 siRNA 击倒,我们证明 miR-124 是为胆碱能的反煽动性的行动的一个批评调停人。而且,我们的数据显示 miR-124 由指向信号变换器和抄写 3 的使活跃之物(STAT3 ) 到减少 IL-6 生产和 TNF-α 调制导致 LPS 的 cytokine 生产;变换酶(不作声) 减少 TNF-α版本。这些结果也显示 miR-124 是为煽动性的疾病的处理的一个潜在的治疗学的目标。 | Yang Sun Qi Li Huan Gui Dong-Ping Xu Yi-LiYang Ding-Feng Su Xia Liu | 2013 | Cell Research2013，23，11： | 35 |
| 8 | Gd-EOB-DTPA-enhanced magnetic resonance imaging for focal liver lesions in Chinese patients:a multicenter,open-label,phase Ⅲ study显示文摘BACKGROUND:Contrast agents help to improve visibility in magnetic resonance(MR)imaging.However,owing to the large interstitial spaces of the liver,there is a reduction in the natural contrast gradient between lesions and healthy tissue.This study was undertaken to evaluate the efficacy and safety of the liverspecific MR imaging contrast agent gadoxetate disodium(GdEOB-DTPA)in Chinese patients.METHODS:This was a single-arm,open-label,multicenter study in patients with known or suspected focal liver lesions referred for contrast-enhanced MR imaging.MR imaging was performed in 234 patients before and after a single intravenous bolus of Gd-EOB-DTPA(0.025 mmol/kg body weight).Images were evaluated by clinical study investigators and three independent,blinded radiologists.The primary efficacy endpoint was sensitivity in lesion detection.RESULTS:Gd-EOB-DTPA improved sensitivity in lesion detection by 9.46%compared with pre-contrast imaging for the average of the three blinded readers(94.78%vs 85.32%for Gd-EOB-DTPA vs pre-contrast,respectively).Improvements in detection were more pronounced in lesions less than 1cm.Gd-EOB-DTPA improved diagnostic accuracy in lesion classification.CONCLUSIONS:This open-label study demonstrated that Gd-EOB-DTPA improves diagnostic sensitivity in liver lesions,particularly in those smaller than 1 cm.Gd-EOB-DTPA also significantly improves the diagnostic accuracy in lesion classification,and furthermore,Gd-EOB-DTPA is safe in Chinese patients with liver lesions. | Meng-Su Zeng Hui-Yi Ye Liang Guo Wei-Jun Peng Jian-Ping Lu Gao-Jun Teng Josy Breuer Yi Huan Ping Li Jian-Rong Xu Chang-Hong Liang | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 31 |
| 9 | Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma显示文摘Sorafenib is the first-line medication for advanced hepatocellular carcinoma(HCC),but it can only extend limited survival.It is imperative to find a combination strategy to increase sorafenib efficacy.Artesunate is such a preferred candidate,because artesunate is clinically well-tolerated and more importantly both drugs can induce ferroptosis through different mechanisms.In this study we investigated the combined effect of sorafenib and artesunate in inducing ferroptosis of HCC and elucidated the involved molecular mechanisms.We showed that artesunate greatly enhanced the anticancer effects of low dose of sorafenib against Huh7,SNU-449,and SNU-182 HCC cell lines in vitro and against Huh7 cell xenograft model in Balb/c nude mice.The combination index method confirmed that the combined effect of sorafenib and artesunate was synergistic.Compared with the treatment with artesunate or sorafenib alone,combined treatment induced significantly exacerbated lipid peroxidation and ferroptosis,which was blocked by N-acetyl cysteine and ferroptosis inhibitors liproxstatin-1 and deferoxamine mesylate,but not by inhibitors of other types of cell death(z-VAD,necrostatin-1 and belnacasan).In Huh7 cells,we demonstrated that the combined treatment induced oxidative stress and lysosome-mediated ferritinophagy,two essential aspects of ferroptosis.Sorafenib at low dose mainly caused oxidative stress through mitochondrial impairments and SLC7A11-invovled glutathione depletion.Artesunate-induced lysosome activation synergized with sorafenib-mediated pro-oxidative effects by promoting sequential reactions including lysosomal cathepsin B/L activation,ferritin degradation,lipid peroxidation,and consequent ferroptosis.Taken together,artesunate could be repurposed to sensitize sorafenib in HCC treatment.The combined treatment can be easily translated into clinical applications. | Zhong-jie Li Hui-qi Dai Xiao-wei Huang Ji Feng Jing-huan Deng Zi-xuan Wang Xiao-mei Yang Yu-jia Liu Yong Wu Pan-hong Chen Huan Shi Ji-gang Wang Jing Zhou Guo-dong Lu | 2021 | Acta Pharmacologica Sinica2021，42，2： | 31 |
| 10 | Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway显示文摘 | Mei-qi ZHANG Yue-liang ZHENG Huan CHEN Jian-feng TU Ye SHEN Jun-ping GUO Xiang-hong YANG Shu-ren YUAN Liang-zhong CHEN Jing-jie CHAI Jian-hong LU Chang-lin ZHAI | 2013 | Acta Pharmacologica Sinica2013，34，11： | 30 |
| 11 | Morphological study on colonic pathology in ulcerative colitis treated by moxibustion显示文摘AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P<0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P<0.001).The goblet cells significantlyincreased(P<0.001);crypt paracrypt abscessor mucosal ulceration was seen(P<0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. | Huan Gan Wu Li Bin Zhou Da Ren Shi Shi Min Liu Hui Rong Liu Bi Meng Zhang Han Ping Chen Lin Shan Zhang | 2000 | World Journal of Gastroenterology2000，6，6： | 28 |
| 12 | Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review显示文摘Background:The coronavirus disease(COVID-19)has been identified as the cause of an outbreak of respiratory illness in Wuhan,Hubei Province,China beginning in December 2019.As of 31 January 2020,this epidemic had spread to 19 countries with 11791 confirmed cases,including 213 deaths.The World Health Organization has declared it a Public Health Emergency of International Concern.Methods:A scoping review was conducted following the methodological framework suggested by Arksey and O'Malley.In this scoping review,65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology,causes,clinical diagnosis,prevention and control of this virus.The research domains,dates of publication,journal language,authors'affiliations,and methodological characteristics were included in the analysis.All the findings and statements in this review regarding the outbreak are based on published information as listed in the references.Results:Most of the publications were written using the English language(89.2%).The largest proportion of published articles were related to causes(38.5%)and a majority(67.7%)were published by Chinese scholars.Research articles initially focused on causes,but over time there was an increase of the articles related to prevention and control.Studies thus far have shown that the virus7 origination is in connection to a seafood market in Wuhan,but specific animal associations have not been confirmed.Reported symptoms include fever,cough,fatigue,pneumonia,headache,diarrhea,hemoptysis,and dyspnea.Preventive measures such as masks,hand hygiene practices,avoidance of public contact,case detection,contact tracing,and quarantines have been discussed as ways to reduce transmission.To date,no specific antiviral treatment has proven effective;hence,infected people primarily rely on symptomatic treatment and supportive care.Conclusions:There has been a rapid surge in research in response to the outbreak of COVID-19.During this early period,published research primarily explored the epidemiology,causes,clinical manifestation and diagnosis,as well as prevention and control of the novel coronavirus.Although these studies are relevant to control the current public emergency,more high-quality research is needed to provide valid and reliable ways to manage this kind of public health emergency in both the short-and long-term. | Sasmita Poudel Adhikari Sha Meng Yu-Ju Wu Yu-Ping Mao Rui-Xue Ye Qing-Zhi Wang Chang Sun Sean Sylvia Scott Rozelle Hein Raat Huan Zhou | 2020 | Infectious Diseases of Poverty2020，9，2： | 28 |
| 13 | Ant Colony System Algorithm for Real-Time Globally Optimal Path Planning of Mobile Robots显示文摘为活动机器人计划的即时全球性最佳的路径的一个新奇方法基于蚂蚁殖民地系统(交流) 被建议算法。这个方法包括三步:第一步正在利用 MAKLINK 图理论建立活动机器人的空间模型,第二步正在利用 Dijkstra 算法发现一条非最优的没有碰撞的路径,并且第三步正在利用 ACS 算法优化非最优的路径的地点以便产生全球性最佳的路径。建议方法是有效的并且能在即时路径被使用活动机器人计划的计算机模拟实验表演的结果。建议方法比与优秀人材模型一起基于基因算法计划方法的路径处于集中速度,答案变化,动态集中行为,和计算效率有更好的性能,这被验证了。 | TAN Guan-Zheng HE Huan SLOMAN Aaron | 2007 | 自动化学报2007，33，3： | 26 |
| 14 | Effect of Sancaijiangtang on plasma nitric oxide and endothelin-1 levels in patients with type 2 diabetes mellitus and vascular dementia:a single-blind randomized controlled trial显示文摘OBJECTIVE: To observe the effect of Sancaijiangtang powders on plasma nitric oxide and endothelin-1 levels. We sought to identify the common pathological link and mechanism of action for Traditional Chinese medicine in type 2 diabetes mellitus and vascular dementia,and to explicate the material basis for treating the different diseases with the same method in Traditional Chinese Medicine.METHODS: In total,168 patients with type 2 diabetes mellitus and vascular dementia were enrolled in the study,and randomly divided into two groups by simple randomization. Patients in the treatment group received oral Sancaijiangtang powders with pioglitazone hydrochloride three times daily,while patients in the control group received pioglitazone hydrochloride alone. The treatment course was for12 weeks. Mini-mental state examinations(Chinese version) and Montreal Cognitive Assessments(Beijing version) were performed,and fasting plasma glucose,fasting insulin,hemoglobin A1 c,homeostasis model assessment of insulin resistance,plasma nitric oxide and endothelin-1 levels were measured before and after the treatment.RESULTS: The post-treatment levels for all measurements in both groups were better than pre-treatment levels(P < 0.05). The post-treatment levels for all measurements in the treatment group were better than the levels measured in the control group(P < 0.05).CONCLUSION: Type 2 diabetes mellitus and vascular dementia have common pathological mechanisms for insulin resistance and endothelium dysfunction. Sancaijiangtang powders could improve the release of nitric oxide and inhibit the secretion of endothelin-1. Therefore,the material basis exists for treating the different diseases with the same method in Traditional Chinese Medicine. | Guo Qiang Cao Wenzhai Zhao Huan Zhu Yuxia Yang Dongdong Zhong Sen Chen Qiu | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 24 |
| 15 | Hemorrhagic cystitis following hematopoietic stem cell transplantation:incidence,risk factors and association with CMV reactivation and graft-versus-host disease显示文摘背景在 allogenic 以后的出血性的膀胱炎(HC ) 的明确的致病造血的干细胞移植(allo-HSCT ) 一直不好阐明。在 HC 遗体的发展的复活和 graft-versus-host 疾病(GVHD ) 遮住的 cytomegalovirus (CMV ) 的角色。这研究在 allo-HSCT 以后为 HC 决定了发生和风险因素并且与 CMV 复活和 GVHD 分析了它的协会。我们回顾地在高度学习了 250 个病人的方法为 CMV 冒险疾病都基于 busulfan/cyclophosphamide (BU/CY ) 经历了 allo-HSCT myloablative 政体。发生,病原学,风险因素和 HC 的临床的管理是在 180 天以内开发的 investigated.Results HC 在 72 移植病人与28.8%的全面发生和在有 匹配HLA 的相关施主( MRD )的病人的12.6%的发生,34.38%在那些与 匹配HLA 的无关的施主(泥),49.45%在那些与错配的相关施主( MMRD )。CMV-viremia 显著地增加了以后的发作 HC (LOHC ) 的发生;然而,仅仅, 9 实际上从有 CMV viruria 的 15 个病人开发了 LOHC。多重回归分析识别了等级 - 尖锐 GVHD (RR=2.75;95% CI 1.63-4.66;P0.01 ) 并且从泥或 MMRD 的接枝(RR=2.60;95% CI 1.52-5.20;P0.01 ) 为 HC 的同样独立的风险因素。事件顺序分析显示事件在 GVHD initiation.Conclusions CMV-viremia 附近开始了的 HC 的一个多数是为 LOHC 的一个高风险因素。我们的数据也显示出在尖锐 GVHD 和 HC 之间的关联,它建议 alloimmunity 可以涉及 HC 的致病。 | XU Lan-ping ZHANG Hong-yu HUANG Xiao-jun LIU Kai-yan LIU Dai-hong HAN Wei CHEN Huan CHEN Yu-hong GAO Zhi-yong ZHANG Yao-chen LU Dao-pei | 2007 | Chinese Medical Journal2007，，19： | 22 |
| 16 | Administration of imatinib in the first 90 days after allogeneic hematopoietic cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia显示文摘背景恶化在 allogeneic 以后经常发生在有费城染色体积极的尖锐成淋巴细胞的白血病的病人的造血的房间移植( allo-HCT )(Ph+所有)在 allo-HCT 前后的最小的剩余疾病( MRD )的 .Detection rate.Early 与更高的恶化被联系在 allo-HCT 以后的 imatinib 的管理可以阻止周期性的Ph+ ALL.The 目的这研究是当时,在阻止 hematological 恶化评估 imatinib 的安全和功效 imatinib | CHEN Huan LIU Kai-yan XU Lan-ping LIU Dai-hong CHEN Yu-hong SHI Hong-xia HAN Wei ZHAN Xiao-hui WANG Yu ZHAO Ting HUANG Xiao-jun | 2011 | Chinese Medical Journal2011，，2： | 23 |
| 17 | Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability显示文摘The integrity of the endothelial barrier is a determinant of the prognosis of lipopolysaccharide (LPS)-induced acute lung injury (ALI). In this study, we investigated whether and how Sirtuin 1 (SIRT1) maintained the vascular integrity during ALI. An experimental model of ALI was established in mice through intratracheal administration of LPS (10 mg/kg). LPS stimulation significantly increased the pulmonary permeability and decreased the expression of SIRT1 and tight junction proteins (TJs), including occludin, claudin-5, tight junction protein 1 and tight junction protein 2. Morphological studies showed that LPS induced obvious lung injury with inammatory cell infiltration in the interstitial and alveolar space, hemorrhage, edema, and the thickened alveolar wall compared to the control mice. Intratracheal administration of the selective SIRT1 activator SRT1720 (6.25 mg/kg) significantly attenuated LPS- induced lung injury, lung hyper-permeability and increased TJs expression, whereas intratracheal administration of the selective SIRT1 inhibitor EX527 (6.25 mg/kg) aggravated LPS-induced ALI. Similar protective effects of SIRT1 on pulmonary cellular permeability were observed in primary human pulmonary microvascular endothelial cells treated with LPS (2 mg/mL) in vitro. We further demonstrated that the RhoA/ROCK signaling pathway was activated in SIRT1 regulation of tight junction permeability. The RhoA/ROCK inhibitor Y-27632 (10 μM) increased the expression of TJs and reversed LPS- or EX527-induced hyper-permeability. In conclusion, SIRT1 ameliorates LPS-induced lung injury via decreasing endothelial tight junction permeability, possibly via RhoA/ ROCK signaling pathway. This finding may contribute to the development of new therapeutic approaches for lung injury. | Cui-ping Fu Sheng-yu Hao Xiao-bo Xu Jian Zhou Zi-long Liu Huan Lu Li-min Wang Wei-zhong Jin Shan-qun Li | 2019 | Acta Pharmacologica Sinica2019，40，5： | 22 |
| 18 | Effect of neutrophil CD64 for diagnosing sepsis in emergency department显示文摘BACKGROUND:The aim of this study is to investigate the diagnostic and prognostic value of neutrophil CD64(nCD64)as a novel biomarker in sepsis patients.METHODS:One hundred fifty-one adult patients diagnosed with sepsis and 20 age-matched healthy controls were enrolled in the study.Patients with sepsis were further subdivided into a sepsis group and a septic shock group.nCD64 expression,serum procalcitonin(PCT)level,C-reactive protein(CRP)level,and white blood cell(WBC)count were obtained for each patient,and Sequential Organ Failure Assessment(SOFA)scores were calculated.RESULTS:nCD64 expression was higher in the sepsis group with confirmed infection than in the control group.The receiver operating characteristic(ROC)curve of nCD64 was higher than those of SOFA score,PCT,CRP and WBC for diagnosing infection.The area under the curve(AUC)of nCD64 combined with SOFA score was the highest for all parameters.The AUC of nCD64 for predicting 28-day mortality in sepsis was signifi cantly higher than those of PCT,CRP,and WBC,but slightly lower than that of SOFA score.The AUC of nCD64 or PCT combined with SOFA score was signifi cantly higher than that of any single parameter for predicting 28-day mortality.CONCLUSION:nCD64 expression and SOFA score are valuable parameters for early diagnosis of infection and prognostic evaluation of sepsis patients. | Wen-peng Yin Jia-bao Li Xiao-fang Zheng Le An Huan Shao Chun-sheng Li | 2020 | World Journal of Emergency Medicine2020，11，2： | 23 |
| 19 | Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation显示文摘Glucagon-like peptide1(GLP-1)is secreted from Langerhans cells in response to oral nutrient intake.Glucagon-like peptide-1 receptor agonists(GLP-1RAs)are a new class of incretin-based anti-diabetic drugs.They function to stimulate insulin secretion while suppressing glucagon secretion.GLP-1-based therapies are now well established in the management of type 2 diabetes mellitus(T2DM),and recent literature has suggested potential applications of these drugs in the treatment of obesity and for protection against cardiovascular and neurological diseases.As we know,along with change in lifestyles,the prevalence of non-alcoholic fatty liver disease(NAFLD)in China is rising more than that of viral hepatitis and alcoholic fatty liver disease,and NAFLD has become the most common chronic liver disease in recent years.Recent studies further suggest that GLP-1RAs can reduce transaminase levels to improve NAFLD by improving blood lipid levels,cutting down the fatcontent to promote fat redistribution,directly decreasing fatty degeneration of the liver,reducing the degree of liver fibrosis and improving inflammation.This review shows the NAFLD-associated effects of GLP-1RAs in animal models and in patients with T2DM or obesity who are participants in clinical trials. | Xing-Chun Wang Aaron M Gusdon Huan Liu Shen Qu | 2014 | World Journal of Gastroenterology2014，20，40： | 23 |
| 20 | Early kidney injury during long-term adefovir dipivoxil therapy for chronic hepatitis B显示文摘AIM: To evaluate urine β2-microglobulin(β2-M), retinol-binding protein(RBP) excretion, and renal impairment with adefovir dipivoxil(ADV) for chronic hepatitis B. METHODS: We enrolled 165 patients with chronic hepatitis B infection who were treated with ADV monotherapy(n = 90) or ADV plus lamivudine combination therapy(n = 75). An additional 165 chronic hepatitis B patients treated with entecavir were recruited as controls. We detected serum creatinine, urine β2-M, and RBP levels, and estimated the glomerular filtration rate(e GFR) at the initiation of antiviral therapy and every 6 mo for a period of five years. RESULTS: Urine β2-M abnormalities were observed in patients during the first(n = 3), second(n = 7), third(n = 11), fourth(n = 16), and fifth(n = 21) year of ADV treatment. Urinary RBP abnormalities were observed in patients during the first(n = 2), second(n = 8), third(n = 12), fourth(n = 15), and fifth(n = 22) year of ADV treatment. e GFR decreased 20%-30% from baseline in 20 patients, 30%-50% in 12 patients, and > 50% in 3 patients during the five years of treatment. Further analysis indicated that decreases in e GFR of ≥ 30% relative to the baseline level correlated significantly with urine RBP and β2-M abnormalities. In contrast, both serum creatinine and e GFR remained stable in patients treated with entecavir, and only one of these patients developed a urine β2-M abnormality, and two developed urine RBP abnormalities during the five years of treatment. CONCLUSION: Urine RBP and β2-M are biomarkers of renal injury during long-term ADV treatment for chronic hepatitis B, and indicate when treatment should be switched to entecavir. | Hong-Yu Jia Feng Ding Jian-Yang Chen Jiang-Shan Lian Yi-Min Zhang Lin-Yan Zeng Dai-Rong Xiang Liang Yu Jian-Hua Hu Guo-Dong Yu Huan Cai Ying-Feng Lu Lin Zheng Lan-Juan Li Yi-Da Yang | 2015 | World Journal of Gastroenterology2015，21，12： | 22 |
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