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| 1 | Clinical outcome and predictors of survival after TIPS insertion in patients with liver cirrhosis显示文摘AIM:To determine the clinical outcome and predictors of survival after transjugular intrahepatic portosystemic stent shunt (TIPS) implantation in cirrhotic patients. METHODS:Eighty-one patients with liver cirrhosis and consequential portal hypertension had TIPS implantation (bare metal) for either refractory ascites (RA) (n= 27) or variceal bleeding (VB) (n = 54). Endpoints for the study were:technical success, stent occlusion and stent stenosis, rebleeding, RA and mortality. Clinical records of patients were collected and analysed. Baseline characteristics [e.g., age, sex, CHILD score and the model for end-stage liver disease score (MELD score), underlying disease] were retrieved. The Kaplan-Meier method was employed to calculate survival from the time of TIPS implantation and comparisons were made by log rank test. A multivariate analysis of factors influencing survival was carried out using the Cox proportional hazards regression model. Results were expressed as medians and ranges. Comparisons between groups were performed by using the Mann-Whitney Utest and the χ 2 test as appropriate. RESULTS:No difference could be seen in terms of age, sex, underlying disease or degree of portal pressure gradient (PPG) reduction between the ascites and the bleeding group. The PPG significantly decreased from 23.4 ± 5.3 mmHg (VB) vs 22.1 ± 5.5 mmHg (RA) before TIPS to 11.8 ± 4.0 vs 11.7 ± 4.2 after TIPS implantation (P = 0.001 within each group). There was a tendency towards more patients with stage CHILD A in the bleeding group compared to the ascites group (24 vs 6, P = 0.052). The median survival for the ascites group was 29 mo compared to > 60 mo for the bleeding group (P = 0.009). The number of radiological controls for stent patency was 6.3 for bleeders and 3.8 for ascites patients (P = 0.029). Kaplan-Meier calculation indicated that stent occlusion at first control (P = 0.027), ascites prior to TIPS implantation (P = 0.009), CHILD stage (P = 0.013), MELD score (P = 0.001) and those patients not having undergone liver transplantation (P = 0.024) were significant predictors of survival. In the Cox regression model, stent occlusion (P = 0.022), RA (P = 0.043), CHILD stage (P = 0.015) and MELD score (P = 0.004) turned out to be independent prognostic factors of survival. The anticoagulation management (P = 0.097), the porto-systemic pressure gradient (P= 0.460) and rebleeding episodes (P = 0.765) had no significant effect on the overall survival. CONCLUSION:RA, stent occlusion, initial CHILD stage and MELD score are independent predictors of survival in patients with TIPS, speaking for a close follow-up in these circumstances. | Hauke S Heinzow Philipp Lenz Michael Khler Frank Reinecke Hansjrg Ullerich Wolfram Domschke Dirk Domagk Tobias Meister | 2012 | World Journal of Gastroenterology2012，18，37： | 17 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | In silieo predictions of the temperature-dependent viscosities and electrical conductivities of functionalized and nonfunctionalized ionic liquids 显示文摘 | PHILIPP E SAFAK B TOBIAS K | 2011 | J Phys Chem B2011，115，： | 1 |
| 4 | Dexmedetomidine for the treatment of postanesthesia shivering in children显示文摘 | BLAINE EASLEY R BRADY K M TOBIAS J D | 2007 | Paediatr Anaesth2007，17，4： | 1 |
| 5 | Dexmedetomidine for the treatment of postanesthesia shivering in children显示文摘 | Blaine Easley R Brady K M Tobias J D | | 0，，4： | 1 |
| 6 | A comprehensive urinary metabolomie approach for identifying kidney cancer显示文摘 | VLADIMIR T OLIVER F | 2007 | Anal Biochem2007，363，2： | 1 |
| 7 | Effect of irrigated rice agriculture on Japanese encephalitis, including challenge and opportunities for integrated vector management 显示文摘 | Jennifer K Michael FM Tobias EE | 2005 | Acta Tropica2005，95，： | 1 |
| 8 | 2010,Regu-lation of liver regeneration by growth factors and cytokines显示文摘 | Friederike B(o)hm Ulrike A K(o)hler Tobias Speicher | 2010 | EMBOMolecular Medicine2010，2，8： | 1 |
| 9 | Antagonistic regulation of convergent extension movements in Xenopus by Wnt/β-catenin and Wnt/Ca 2+ signaling显示文摘 | Michael Kühl Karin Geis Laird C Sheldahl Tobias Pukrop Randall T Moon Doris Wedlich | 2001 | Mechanisms of Development2001，，1： | 1 |
| 10 | High-throughput pro tein and DNA analysis based on microfluidic on-chip electrophoresis 显示文摘 | MEIKE K CARSTEN B TOBIAS P | 2005 | Journal of the Association for Laboratory Automation2005，10，5： | 1 |
| 11 | Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial显示文摘 | Thomas K?hnlein Wolfram Windisch Dieter K?hler Anna Drabik Jens Geiseler Sylvia Hartl Ortrud Karg Gerhard Laier-Groeneveld Stefano Nava Bernd Sch?nhofer Bernd Schucher Karl Wegscheider Carl P Criée Tobias Welte | 2014 | The Lancet Respiratory Medicine2014，，9： | 1 |
| 12 | Estimating the Monetary Conditions Index for South Africa 显示文摘 | Tobias K | 2005 | Paper to be Presented at the 'Exchange Rate Econometrics'Conference Luxembourg2005，4，： | 1 |
| 13 | Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants显示文摘 | Degenhardt J Tobias G K Gershenzon J | 2009 | Phytochemistry2009，70，： | 1 |
| 14 | Lipopolysaccharide (LPS) -binding proteins BPI and LBP for different types of complexes with LPS 显示文摘 | Tobias PS Soldau K Weiss J | 1997 | J Biol Chem1997，272，18： | 1 |
| 15 | The Pelation between the Static and the Dynamic Cutting of Metals显示文摘 | Das M K Tobias S A | 1967 | Inter- national Journal of Machince Tools and Manufac- ture1967，7，： | 1 |
| 16 | Thematic review series:the immune system and atherogenesis,paying the price for pathogen protection:toll receptors in atherogenesis显示文摘 | Tobias P Curtiss L K | 2005 | J Lipid Res2005，46，3： | 1 |
| 17 | Transfection of CD14 into70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide(LPS)and LPS binding protein显示文摘 | Lee JD Kato K Tobias PS | 1992 | J Exp Med1992，175，6： | 1 |
| 18 | Density and kinetics of Ikr and Iks inguinea pig and rabbit ventrictular myocytes explain different efficacy of Iks blockade at high heart rate in guinea pig and rabbit显示文摘 | Zhibo Lu Kaichiro K Tobias O | 2001 | Circulation2001，21，： | 1 |
| 19 | CT Angiography and Doppler sonography for Emergency Assessment in acute basilar artery ischemia 显示文摘 | Tobias B Michael K Susanne W | 1999 | Stroke1999，30，7： | 1 |
| 20 | In Vitro Evaluation of Ureteral Perforation Forces显示文摘 | Renato N. Pedro Kari Hendlin Derek Weiland Anup Ramani Tobias S. K?hler J. Kyle Anderson Manoj Monga | 2007 | Urology2007，，3： | 1 |
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