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| 1 | Gut microbiome,liver immunology,and liver diseases显示文摘The gut microbiota is a complex and plastic consortium of microorganisms that are intricately connected with human physiology.The liver is a central immunological organ that is particularly enriched in innate immune cells and constantly exposed to circulating nutrients and endotoxins derived from the gut microbiota.The delicate interaction between the gut and liver prevents accidental immune activation against otherwise harmless antigens.Work on the interplay between the gut microbiota and liver has assisted in understanding the pathophysiology of various liver diseases.Of immense importance is the step from high-throughput sequencing(correlation)to mechanistic studies(causality)and therapeutic intervention.Here,we review the gut microbiota,liver immunology,and the interaction between the gut and liver.In addition,the impairment in the gut-liver axis found in various liver diseases is reviewed here,with an emphasis on alcohol-associated liver disease(ALD),nonalcoholic fatty liver disease(NAFLD),and autoimmune liver disease(AILD).On the basis of growing evidence from these preclinical studies,we propose that the gut-liver axis paves the way for targeted therapeutic modalities for liver diseases. | Rui Wang Ruqi Tang Bo Li Xiong Ma Bernd Schnabl Herbert Tilg | 2021 | Cellular & Molecular Immunology2021，18，1： | 23 |
| 2 | 2016年欧洲粪菌移植共识介绍显示文摘粪菌移植(fecal microbiota transplantation,FMT)是治疗艰难梭菌感染的一个重要选择。研究表明,FMT也可能在管理与肠道微生物群变化相关的其他疾病方面发挥作用。虽然医疗界正在用最新的观点评估FMT,且患者正在变得越来越了解FMT,但在将非标准化的治疗方案转化为安全和管理恰当的临床实践中存在技术和后勤问题。鉴于此,需要一个基于证据的指南来推动FMT的实际实施。在这个欧洲共识会议上,来自10个国家的28名专家,分成多个小组并通过循证过程对以下事项提供了指南:FMT适应证、供体选择、粪便材料的准备、临床管理和移植实施,以及建立一个FMT中心的基本要求。每个小组提出的指南经过全体成员的评估和投票,首先通过Delphi电子流程,随后经过全体共识会议。指南根据现有最佳证据提出,目的是为计划进行FMT的医师提供指导,以期支持这种疗法的广泛适用性,探讨与FMT有关的其他事项并促进未来在肠道菌群操作领域的临床研究。共识报告强烈建议建立治疗艰难梭菌感染的FMT中心,并提供技术、标准、管理和实验室相关要求。 | 李超 谈路轩 张馨梅 汪志兵 张振玉 Cammarota G Ianiro G Tilg H | 2017 | 胃肠病学和肝病学杂志2017，26，9： | 10 |
| 3 | Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis显示文摘 | Herbert Tilg Alexander R. Moschen | 2010 | Hepatology2010，，： | 5 |
| 4 | Inflammatory Bowel Disease Is a Risk Factor for Recurrent Venous Thromboembolism显示文摘 | Gottfried Novacek Ansgar Weltermann Anna Sobala Herbert Tilg Wolfgang Petritsch Walter Reinisch Andreas Mayer Thomas Haas Arthur Kaser Thomas Feichtenschlager Harry Fuchssteiner Peter Knoflach Harald Vogelsang Wolfgang Miehsler Reingard Platzer Wolfgang T | 2010 | Gastroenterology2010，，3： | 4 |
| 5 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
| 6 | European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease显示文摘 | J.F. Rahier S. Ben-Horin Y. Chowers C. Conlon P. De Munter G. D’Haens E. Domènech R. Eliakim A. Eser J. Frater M. Gassull M. Giladi A. Kaser M. Lémann T. Moreels A. Moschen R. Pollok W. Reinisch M. Schunter E.F. Stange H. Tilg G. Van Assche N. Viget B. Vu | 2009 | Journal of Crohn’s and Colitis2009，，2： | 3 |
| 7 | Clinical presentation of venous thromboembolism in inflammatory bowel disease显示文摘 | Pavol Papay Wolfgang Miehsler Herbert Tilg Wolfgang Petritsch Walter Reinisch Andreas Mayer Thomas Haas Arthur Kaser Thomas Feichtenschlager Harry Fuchssteiner Peter Knoflach Harald Vogelsang Reingard Platzer Wolfgang Tillinger Bernhard Jaritz Alfons Schm | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 8 | Cytokines in alcoholic and nonalcoholic steatohepatitis显示文摘 | Tilg H Diehl AM | | 0，，： | 2 |
| 9 | Progressive Fibrosis in Nonalcoholic Steatohepatitis: Association With Altered Regeneration and a Ductular Reaction显示文摘 | Michelle M. Richardson Julie R. Jonsson Elizabeth E. Powell Elizabeth M. Brunt Brent A. Neuschwander–Tetri Prithi S. Bhathal John B. Dixon Martin D. Weltman Herbert Tilg Alexander R. Moschen David M. Purdie Anthony J. Demetris Andrew D. Clouston | 2007 | Gastroenterology2007，，1： | 2 |
| 10 | Inflammation, Cytokines and Insulin Resistance: A Clinical Perspective显示文摘 | Verena Wieser Alexander R. Moschen Herbert Tilg | 2013 | Archivum Immunologiae et Therapiae Experimentalis2013，，2： | 2 |
| 11 | Role of adiponectin and PBEF/ visfatin as regulators of inflammation:involvement in obesity-associated diseases显示文摘 | Tilg H Moschen AR | 2008 | Clin Sci(Lond)2008，114，4： | 1 |
| 12 | Obesity and the microbiota显示文摘 | TILG H MOSCHEN A R KASER A | 2009 | Gastroenterology2009，136，5： | 1 |
| 13 | Adipocytokines:Mediators linking adipose tissue,inflammation and immunity显示文摘 | Tilg H Moschen AR | | 0，，10： | 1 |
| 14 | Inflammatory mechanisms in the regulation of insulin resistance显示文摘 | Tilg H Moschen AR | 2008 | Mol Med2008，14，34： | 1 |
| 15 | Cytokines in alcoholic and nonalcoholic steatohepatitis显示文摘 | Tilg H Diehl AM | 2000 | N Engl J Med2000，343，20： | 1 |
| 16 | IL-6 and APPs:anti- inflammatory and immunosuppressive mediators显示文摘 | TILG H DINARELLO C A MIER J W | 1997 | Immunol Today1997，18，9： | 1 |
| 17 | Circulating serum levels of interleukin 6 and C-reactive protein after liver transplantation显示文摘 | NORDBERG J VOGEL W | 1992 | Transplantation1992，54，： | 1 |
| 18 | Mechanism of disease Cytokines in alcoholic and monalcoholic steatohopatitis显示文摘 | Tilg H Diehl A M | 2000 | N Engl J Med2000，343，： | 1 |
| 19 | Pharmacological and non-pharmacological treatment of non-alcoholic fatty liver disease显示文摘 | Kaser S Ebenbichler C F Tilg H | | 0，，07： | 1 |
| 20 | Anti - tumor necrosis factor- alpha monoclonal antibody therapy in severe alcoholic hepatitis显示文摘 | Tilg H Jalan R Kaser A | 2003 | J Hepatol2003，38，： | 1 |
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