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| 1 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008显示文摘 | R Phillip Dellinger Mitchell M. Levy Jean M. Carlet Julian Bion Margaret M. Parker Roman Jaeschke Konrad Reinhart Derek C. Angus Christian Brun-Buisson Richard Beale Thierry Calandra Jean-Francois Dhainaut Herwig Gerlach Maurene Harvey John J. Marini John | 2008 | Critical Care Medicine2008，，1： | 4 |
| 2 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 3 | Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial显示文摘 | Christian Récher Bertrand Coiffier Corinne Haioun Thierry Jo Molina Christophe Fermé Olivier Casasnovas Catherine Thiéblemont André Bosly Guy Laurent Franck Morschhauser Hervé Ghesquières Fabrice Jardin Serge Bologna Christophe Fruchart Bernadette Corront | 2011 | 2011 (9806)2011，，9806： | 2 |
| 4 | Pandemic influenza 2009: Impact of vaccination coverage on critical illness in children, a Canada and France observational study显示文摘AIM To study the impact of vaccination critical illness due to H1N1pdm09, we compared the incidence and severity of H1N1pdm09 infection in Canada and France.METHODS We studied two national cohorts that included children with documented H1N1pdm09 infection, admitted to a pediatric intensive care unit(PICU) in Canada and in France between October 1, 2009 and January 31, 2010.RESULTS Vaccination coverage prior to admission to PICUs was higher in Canada than in France(21% vs 2% of children respectively, P < 0.001), and in both countries, vaccination coverage prior to admission of these critically ill patients was substantially lower than in the general pediatric population(P < 0.001). In Canada, 160 children(incidence = 2.6/100000 children) were hospitalized in PICU compared to 125 children(incidence = 1.1/100000) in France(P < 0.001). Mortality rates were similar in Canada and France(4.4% vs 6.5%, P = 0.45, respectively), median invasive mechanical ventilation duration and mean PICU length of stay were shorter in Canada(4 d vs 6 d, P = 0.02 and 5.7 d vs 8.2 d, P = 0.03, respectively). H1N1pdm09 vaccination prior to PICU admission was associated with a decreased risk of requiring invasive mechanical ventilation(OR = 0.30, 95%CI: 0.11-0.83, P = 0.02).CONCLUSION The critical illness due to H1N1pdm09 had a higher incidence in Canada than in France. Critically ill children were less likely to have received vaccination prior to hospitalization in comparison to general population and children vaccinated had lower risk of ventilation. | Olivier Fléchelles Olivier Brissaud Robert Fowler Thierry Ducruet Philippe Jouvet the Pediatric Canadian Critical Care Trials Group H1N1 Collaborative and Groupe Francophone de Réanimation et Urgences Pédiatriques | 2016 | World Journal of Clinical Pediatrics2016，5，4： | 2 |
| 5 | The tail suspension test: A new method for screening antidepressants in mice 显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology1985，85，3： | 1 |
| 6 | The tail suspension test:a newmethod for screening antidepressants in mice显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology(Berl)1985，85，3： | 1 |
| 7 | The tail suspension test:a new method for screening antidepressants in mice显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology(Berl)1985，85，3： | 1 |
| 8 | The tail suspension test:a new method for screening antidepressants in Mice显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology1985，85，3： | 1 |
| 9 | The tail suspension test: a new method for screening antidepressants in mice显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology1985，85，3： | 1 |
| 10 | Complications of Scoliosis Surgery in Prader-Willi Syndrome显示文摘 | Franck Accadbled Thierry Odent Alexandre Moine Edouard Chau Christophe Glorion Gwenaelle Diene Jér?me Sales de Gauzy | 2008 | Spine2008，，4： | 1 |
| 11 | Image fusion-the ARSIS concept and some successful implementation schemes显示文摘 | Thierry R Bruno A Luciano A | 2003 | ISPRS Journal of Photogrammetry & Remote Sensing2003，，58： | 1 |
| 12 | The tail suspension test:a new method for screening antidepressants in mice显示文摘 | STERU L CHERMAT R THIERRY B | 1985 | Psychopharmacology (Berl)1985，85，3： | 1 |
| 13 | DNA damage and DNA adduct formation in rat tissues following oral administration of acrylamide显示文摘 | Isabelle Manierea Thierry Godardb Daniel R | 2005 | Mutation Research2005，580，： | 1 |
| 14 | The tail suspension test : a new method for screening antidepressants in mice 显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology (Serl)1985，85，3： | 1 |
| 15 | The suspension test:a new method for screening antidepressants in mice显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology1985，85，3： | 1 |
| 16 | Endothelial cell responses to hypoxia:initiation of a cascade of cellular interactions显示文摘 | Carine M Thierry A Jose R | 2000 | Biochimica et Biophysica Acta2000，1497，4： | 1 |
| 17 | Hybrid simulation of scatter intensity in industrial cone-beam computed tomography显示文摘 | THIERRY R MICELI A HOFMANN J | 2009 | Nuclear Instruments and Methods in Physics Research Section A2009，598，2： | 1 |
| 18 | The tail suspension test: a new method for screening antidepressants in mice 显示文摘 | Stem L Chermat R Thierry B | 1985 | Psychoparmacology1985，85，3： | 1 |
| 19 | The tail suspen- sion test: a new method for screening antidepressants in mice显示文摘 | STERU L CHERMAT R THIERRY B | 1985 | Psychopharmaeology ( Bed)1985，85，3： | 1 |
| 20 | The tail suspension test:a new method for sceening antidepressants in mice 显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology ( Berl)1985，85，3： | 1 |
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