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| 1 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008显示文摘 | R. Phillip Dellinger Mitchell M. Levy Jean M. Carlet Julian Bion Margaret M. Parker Roman Jaeschke Konrad Reinhart Derek C. Angus Christian Brun-Buisson Richard Beale Thierry Calandra Jean-Francois Dhainaut Herwig Gerlach Maurene Harvey John J. Marini Joh | 2008 | Intensive Care Medicine2008，，1： | 7 |
| 2 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008显示文摘 | R Phillip Dellinger Mitchell M. Levy Jean M. Carlet Julian Bion Margaret M. Parker Roman Jaeschke Konrad Reinhart Derek C. Angus Christian Brun-Buisson Richard Beale Thierry Calandra Jean-Francois Dhainaut Herwig Gerlach Maurene Harvey John J. Marini John | 2008 | Critical Care Medicine2008，，1： | 4 |
| 3 | Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock显示文摘 | R. Phillip Dellinger Jean M. Carlet Henry Masur Herwig Gerlach Thierry Calandra Jonathan Cohen Juan Gea-Banacloche Didier Keh John C. Marshall Margaret M. Parker Graham Ramsay Janice L. Zimmerman Jean-Louis Vincent M. M. Levy | 2004 | Intensive Care Medicine2004，，4： | 3 |
| 4 | Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock显示文摘 | R. Phillip Dellinger Jean M. Carlet Henry Masur Herwig Gerlach Thierry Calandra Jonathan Cohen Juan Gea-Banacloche Didier Keh John C. Marshall Margaret M. Parker Graham Ramsay Janice L. Zimmerman Jean-Louis Vincent Mitchell M. Levy | 2004 | Critical Care Medicine2004，，3： | 2 |
| 5 | Folate targeted coated SPIONs as efficient tool for MRI显示文摘The development of more sensitive diagnostic tools allowing an early-stageand highly efficient medical imaging of tumors remains a challenge. Magneticnanoparticles seem to be the contrast agents with the highest potential, if properlyconstructed. Therefore, in this study, hybrid magnetic nanoarchitectures weredeveloped using a new amphiphilic inulin-based graft copolymer (INU-LA-PEG-FA) as coating material for 10-nm spinel iron oxide (magnetite, Fe304)superparamagnetic nanoparticles (SPION). Folic acid (FA) covalently linked tothe coating copolymer in order to be exposed onto the nanoparticle surface waschosen as the targeting agent because folate receptors are upregulated in manycancer types. Physicochemical characterization and in vitro biocompatibilitystudy was then performed on the prepared magnetic nanoparticles. The improvedtargeting and imaging properties of the prepared FA-SPIONs were furtherevaluated in nude mice using 7-Tesla magnetic resonance imaging (MRI).FA-SPIONs exhibited the ability to act as efficient contrast agents in conventionalMRI, providing a potential nanoplatform not only for tumor diagnosis but alsofor cancer treatment, through the delivery of anticancer drug or locoregional magnetic hvverthermia. | Cinzia Scialabba Roberto Puleio Davide Peddis Gaspare Varvaro Pietro Calandra Giovanni Cassata Luca Cicero Mariano Licciardi Gaetano Giammona | 2017 | Nano Research2017，10，9： | 2 |
| 6 | Angiopoietin-like protein 3 (ANGPTL3) deficiency and familial combined hypolipidemia显示文摘Three members of the angiopoietin-like(ANGPTL) protein family-ANGPTL3, ANGPTL4 and ANGPTL8-are important regulators of plasma lipoproteins. They inhibit the enzyme lipoprotein lipase, which plays a key role in the intravascular lipolysis of triglycerides present in some lipoprotein classes. This review focuses on the role of ANGPTL3 as emerged from the study of genetic variants of Angptl3 gene in mice and humans. Both loss of function genetic variants and inactivation of Angptl3 gene in mice are associated with a marked reduction of plasma levels of triglyceride and cholesterol and an increased activity of lipoprotein lipase and endothelial lipase. In humans with ANGPTL3 deficiency, caused by homozygous loss of function(LOF) variants of Angptl3 gene, the levels of all plasma lipoproteins are greatly reduced. This plasma lipid disorder referred to as familial combined hypolipidemia(FHBL2) does not appear to be associated with distinct pathological manifestations. Heterozygous carriers of LOF variants have reduced plasma levels of total cholesterol and triglycerides and are at lower risk of developing atherosclerotic cardiovascular disease, as compared to non-carriers. These observations have paved the way to the development of strategies to reduce the plasma level of atherogenic lipoproteins in man by the inactivation of ANGPTL3, using either a specific monoclonal antibody or anti-sense oligonucleotides. | Patrizia Tarugi Stefano Bertolini Sebastiano Calandra | 2019 | The Journal of Biomedical Research2019，33，2： | 2 |
| 7 | Purification,bioactivity,and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF)显示文摘 | Bernhagen J Mitchell R A Calandra T | 1994 | Biochemistry1994，33，14： | 1 |
| 8 | MIF is a pituitary derived cytokine that potentiates lethal endotoxemia显示文摘 | Bernhagen J Calandra T Mitchell RA | 1993 | Nature1993，365，： | 1 |
| 9 | Voriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomes 显示文摘 | Pascual A Calandra T Bolay S | 2008 | Clin lnfect Dis2008，46，2： | 1 |
| 10 | Cyclooxygenase and prostaglandins in somatic cell populations of the testis显示文摘 | FRUNGIERI M B CALANDRA R S MAYERHOFER A | 2015 | Reproduction2015，149，： | 1 |
| 11 | Macrophage migration inhibitory factor:a regulator of innate immunity显示文摘 | Calandra T Roger T | 2003 | Nat Rev Immunol2003，13，10： | 1 |
| 12 | Macrophage migration inhibitory factor (MIF):mechanisms of action and role in disease显示文摘 | Lue H Kleemann R Calandra T | 2000 | Microbes Infect2000，4，4： | 1 |
| 13 | Macrophage migration inhibitory factor (MIF): a glucocorticoid counter-regulator within the immune system显示文摘 | Calandra T Bucala R | 1997 | Crit Rev Immunol1997，17，1： | 1 |
| 14 | Macrophage migration inhibitory factor and host innate immune responses to microbes显示文摘 | Calandra T | 2003 | Scand J Infect Dis2003，35，： | 1 |
| 15 | MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia 显示文摘 | Bernhagen J Calandra T Mitchell RA | 1993 | Nature1993，365，6448： | 1 |
| 16 | MIF as a glucocorticoid-induced modulator of cytokine production显示文摘 | Calandra T Bernhagen J Metz CN | 1995 | Nature1995，377，6544： | 1 |
| 17 | Protection from septic shock by neutralization of macrophage migration inhibitory factor 显示文摘 | Calandra T Echtenacher B Roy D L | 2000 | Nat Med2000，6，2： | 1 |
| 18 | Purification, bioactivity and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF) 显示文摘 | Berhagen J Mitchell RA Calandra T | 1994 | Biochemisty1994，33，14： | 1 |
| 19 | Macrophage migration inhibitory factor:a regulator of innate immunity显示文摘 | Calandra T Roger T | 2003 | Nat Rev Immunol2003，13，10： | 1 |
| 20 | The macrophage migration inhibitory factor - glucocorticoid dyad:regulation of inflammation and immunity 显示文摘 | Flaster H Bemhagen J Calandra T | 2007 | Mol Endocrirnol2007，21，6： | 1 |
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