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| 1 | Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases显示文摘AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific probes.RESULTS:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy population.In NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver disease.However,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory alterations.The linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of NAFLD.CONCLUSION:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis. | Johannes W Rey Andrea Noetel Aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans Peter Dienes Uta Drebber Margarete Odenthal | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 2 | Liver tumor infiltrating lymphocytes: Comparison of hepatocellular and cholangiolar carcinoma显示文摘AIM: To investigate the role of tumor inf iltrating lym-phocytes (TIL) in primary hepatocellular and cholangio-lar carcinomas of the liver.METHODS: Immunohistochemical analysis was per-formed including antibodies to CD3, CD4, CD8, CD20, CD56 and TIA-1 in formalin-f ixed and paraff in-embed-ded tissue of 35 liver resection specimens of hepatocel-lular or cholangiocellular carcinomas. Semiquantitative evaluation was performed with emphasis on the area of the tumor itself and of the tumor/liver interface.RESULTS: All hepatocellular carcinomas showed in-filtration of lymphocytes predominantly around the tumor in the tumor/liver interface consisting mainly of CD3+ CD4+ T lymphocytes [164.3/10 high power f ields (HPF)] and in the tumor itself of CD8+ cells (54.9/10 HPF). Cholangiocarcinomas contained a heterogeneous amount of TIL, composed mainly of CD3+ T cells with a predominance of CD8+ cells in the tumor tissue (52.6/10 HPF) and of CD4+ cells in the interface region (223.1/10 HPF). CD56+ cells of the innate immune system were scarce. There was no significant difference between hepatocellular or cholangiolar carcinoma. No correlation with the clinicopathological data was seen. CONCLUSION: Liver TIL consists of intratumoral CD8+ T cells and peritumoral CD4+ T cells indepen-dent of histogenetic origin. Different functions of lym-phocytes in these regions seem possible. | Hans-Udo Kasper Uta Drebber Dirk Ludger Stippel Hans Peter Dienes Anton Gillessen | 2009 | World Journal of Gastroenterology2009，15，40： | 8 |
| 3 | Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases显示文摘AIM: To investigate the expression of nucleoporin 88 (Nup88) in hepatitis B virus (HBV) and C virus (HCV)-related liver diseases. METHODS: We generated a new monoclonal Nup88 antibody to investigate the Nup88 protein expression by immunohistochemistry (IHC) in 294 paraffin-embedded liver specimens comprising all stages of hepatocellular carcinogenesis. In addition, in cell culture experiments HBV-positive (HepG2.2.15 and HB611) and HBV-negative (HepG2) hepatoma cell lines were tested for the Nup88 expression by Western-immunoblotting to test data obtained by IHC.RESULTS: Specific Nup88 expression was found in chronic HCV hepatitis and unspecific chronic hepatitis, whereas no or very weak Nup88 expression was detected in normal liver. The Nup88 expression was markedly reduced or missing in mild chronic HBV infection and inversely correlated with HBcAg expression. Irrespective of the HBV- or HCV-status, increasing Nup88 expression was observed in cirrhosis and dysplastic nodules, and Nup88 was highly expressed in hepatocellular carcinomas. The intensity of Nup88 expression significantly increased during carcinogenesis (P < 0.0001) and correlated with dedifferentiation (P < 0.0001). Interestingly, Nup88 protein expression was significantly downregulated in HBV-positive HepG2.2.15 (P < 0.002) and HB611 (P < 0.001) cell lines as compared to HBV-negative HepG2 cells. CONCLUSION: Based on our immunohistochemical data, HBV and HCV are unlikely to influence the expression of Nup88 in cirrhotic and neoplastic liver tissue, but point to an interaction of HBV with the nuclear pore in chronic hepatitis. The expression of Nup88 in nonneoplastic liver tissue might reflect enhanced metabolic activity of the liver tissue. Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. | Martina Knoess Anna Kordelia Kurz Olga Goreva Nuran Bektas Kai Breuhahn Magarethe Odenthal Peter Schirmacher Hans Peter Dienes C Thomas Bock Hanswalter Zentgraf Axel zur Hausen | 2006 | World Journal of Gastroenterology2006，12，36： | 4 |
| 4 | 越南传统医药概况显示文摘传统医药在越南的医疗卫生系统中发挥着重要作用。越南传统医药(VTM)是以东方哲学和康复理论为基础的,其受到中医药的巨大影响,但是有一定程度的差异。VTM大多不是以科学证据为基础的临床视角看问题,而是基于草药多年使用经验提供的亚临床数据。为了提高用药安全性,传统草药的不良反应和相互作用的研究十分必要。越南政府十分支持传统医药的深入科学研究及其与西药之间的联用。现从VTM的历史进程、规范管理、与中药的对比、哲学背景等方面进行概述。 | Herman J Woerdenbag Tuyen Manh Nguyen Dien Van Vu | 2013 | 亚太传统医药2013，9，11： | 3 |
| 5 | 汉语复合词视觉识别的时间进程:基于同形语素的行为与ERP证据显示文摘基于同形语素抑制效应,本研究探讨了汉语复合词视觉识别中的形音义激活进程。结果发现:(1)同形异音、同形同音、相同条件相对于控制条件都产生了语素启动效应;(2)在P2、晚期N400成分上,同形同音条件与控制条件更为接近,但与同形异音及相同条件差别显著;(3)在早期N400成分上,同形同音条件与相同条件更为接近,但与同形异音条件差别显著。研究表明,汉语复合词的视觉识别的早期阶段可能为基于词位的形态−正字法加工,字形匹配与音位信息是首要影响因素,但语义是否介入仍未可知;而晚期阶段则可能为基于词条的形态−语义加工,主要涉及语义竞争与选择。本研究结果支持了McClelland等学者提出的“平行分布加工模型”。 | 吴建设 常嘉宝 邱寅晨 Joseph Dien | 2020 | 心理学报2020，52，2： | 2 |
| 6 | Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis显示文摘 | Jonel Trebicka Evrim Anadol Natalia Elfimova Ingo Strack Michael Roggendorf Sergei Viazov Inga Wedemeyer Uta Drebber Jürgen Rockstroh Tilman Sauerbruch Hans-Peter Dienes Margarete Odenthal | 2012 | Journal of Hepatology2012，，： | 2 |
| 7 | Histomorphologic Tumor Regression and Lymph Node Metastases Determine Prognosis Following Neoadjuvant Radiochemotherapy for Esophageal Cancer: Implications for Response Classification显示文摘 | Paul M. Schneider Stephan E. Baldus Ralf Metzger Martin Kocher Rudolf Bongartz Elfriede Bollschweiler Hartmut Schaefer Juergen Thiele Hans P. Dienes Rolf P. Mueller Arnulf H. Hoelscher | 2005 | Annals of Surgery2005，，5： | 2 |
| 8 | Simultaneous occurrence of a hepatocellular carcinoma and a hepatic non-Hodgkin's lymphoma infi ltration显示文摘To investigate the simultaneous occurrence of hepatocellular carcinoma and non-Hodgkin's lymphoma, we report the case of a 70 year old patient with a primary diagnosis of non-Hodgkin's lymphoma in 2002. In a routine follow up investigation of his chronic lymphocytic leukemia a newly detected mass in the Couinaud's segments 2 and 3 was found. No hepatitis C virus or hepatitis B virus infection or cirrhosis was evident. After laparoscopic segmentectomy the histological examination revealed a hepatocellular carcinoma. While the relation between liver parenchyma damages and hepatocellular carcinoma or non-Hodgkin's lymphoma is well known, only a few publications have focused on the coexistence of hepatocellular carcinoma and non-Hodgkin's lymphoma. With this case we demonstrate the coexistence of these diseases without having a pre- damaged liver parenchyma. | Sabine Heidecke Dirk L Stippel Arnulf H Hoelscher Inga Wedemeyer Hans-Peter Dienes Uta Drebber | 2010 | World Journal of Hepatology2010，2，6： | 2 |
| 9 | 樟子松天然林土壤碳氮含量与水解酶活性坡位差异及月动态显示文摘【目的】研究大兴安岭地区樟子松天然林土壤的碳氮含量与水解酶活性的坡位差异和月份动态,探究土壤碳氮含量与水解酶活性的关系,以期为阐明土壤碳氮转化酶学机制及森林土壤可持续利用提供理论依据。【方法】2018年5—10月每月中旬,在大兴安岭漠河地区樟子松天然林坡地设置试验地。分别在试验地上、中、下坡位各设置3块20 m×30 m的樟子松林试验样地,每样地选3个取样点,每取样点清除枯枝落叶层后,记录不同土深(2.5、7.5、15、25 cm)处土壤温度。同时采集每个取样点不同土层(0~5、5~10、10~20和20~30 cm)的土壤样品测定土壤含水率、碳氮含量(有机碳、全氮)及水解酶(脲酶、蛋白酶、蔗糖酶、纤维素酶)活性。【结果】土壤的有机碳及全氮含量随土层加深而降低,随坡位升高而减少,但坡位差异不显著(P>0.05);0~5、5~10、10~20和20~30 cm土层的有机碳含量分别为68.53~80.38、40.28~46.66、15.86~21.08和11.91~13.79 g·kg-1,土壤全氮含量分别为5.34~5.96、2.98~3.68、2.35~2.61和1.54~1.75 g·kg-1;土壤脲酶、蛋白酶、蔗糖酶及纤维素酶活性随土层加深而降低;随坡位降低,土壤脲酶及蔗糖酶活性增高,蛋白酶与纤维素酶活性降低;月动态分析显示,土壤有机碳和全氮含量高峰期均为9月,酶活性高峰期集中在7—8月;相关分析表明,土壤碳氮(有机碳、全氮)含量与水解酶(脲酶、蔗糖酶、纤维素酶、蛋白酶)活性和含水率均极显著正相关(P<0.01),土壤温度与有机碳含量显著正相关(P>0.05)、与全氮含量显著负相关(P<0.05)。【结论】大兴安岭地区樟子松天然林土壤碳氮含量与水解酶活性随土层加深而降低,土壤碳氮含量与酶活性的坡位差异不显著(P>0.05),有机碳和全氮含量高峰期为9月,土壤水解酶活性高峰期集中在7—8月。土壤碳氮含量与水解酶活性极显著相关(P<0.01),土壤温湿度对碳氮含量与酶活性具有显著影响(P<0.05)。 | Vuong Thi Minh Dien 曾健勇 满秀玲 | 2020 | 林业科学2020，56，2： | 2 |
| 10 | Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy显示文摘 | Uta Drebber Max Lay Inga Wedemeyer Daniel Vallb?hmer Elfriede Bollschweiler Jan Brabender Stefan M?nig Arnulf H?lscher Hans Dienes Margarete Odenthal | 2011 | International Journal of Oncology2011，，： | 2 |
| 11 | AN ECONOMIC MODEL-BASED MATCHING APPROACH BETWEEN BUYERS AND SELLERS THROUGH A BROKER IN AN OPEN E- MARKETPLACE显示文摘 | Dien Tuan LE Minjie ZHANG Fenghui REN | 2018 | Journal of Systems Science and Systems Engineering2018，27，2： | 2 |
| 12 | Frequency and diagnostic patterns of lymphomas in liver biopsies with respect to the WHO classification显示文摘 | Christoph Loddenkemper Thomas Longerich Michael Hummel Karen Ernestus Ioannis Anagnostopoulos Hans-Peter Dienes Peter Schirmacher Harald Stein | 2007 | Virchows Archiv2007，，5： | 2 |
| 13 | Nitrogen source and minerial optimization enhance D-xylose conversion to ethanol by yeast Pichia stipitis NRRL Y-TI24显示文摘 | Slininger PJ Dien BS Gorsich SW Liu ZL | 2006 | Applied microbiology and biolechnology2006，72，： | 1 |
| 14 | Activity and structure of hydrotreating Ni,Mo,and Ni-Mo sulfide catalysts supported on γ-Al2O3-USY zeolite 显示文摘 | Dien L Nishijima A Morris D E | 1999 | J Catalysis1999，188，： | 1 |
| 15 | Maximal function on generalized Lebesgue spaces Lp ( · )显示文摘 | Diening L | 2004 | Math Inequal Appl2004，7，： | 1 |
| 16 | Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease显示文摘 | Tannapfel A Denk H Dienes HP | 2011 | Virchows Arch2011，458，5： | 1 |
| 17 | Isolation of microorganisms ror biological dctoxification of lignocellulosic hydrolysates显示文摘 | Lopez MJ Nichols NN Dien BS | 2004 | Appl Microbiol Biotechnol2004，64，1： | 1 |
| 18 | Granulocyte - macrophage - colony - stimulating factor enhances immune re-sponses to melanoma- associated peptides in vivo 显示文摘 | Jager E Ringhoffer M Dienes H P | 1996 | Int J Cancer1996，67，1： | 1 |
| 19 | Fault diagnosis in gears operating under non-stationary rotational speed using polar wavelet amplitude maps 显示文摘 | Mehzer G Nguyen Phong Dien | 2004 | Mechanical Systems and Signal Processing2004，18，： | 1 |
| 20 | Application of Polyphosphate Metabolism to Environmental and Biotechnological Problems 显示文摘 | KEASKING J D VAN DIEN S J TRELSTAD P | 2000 | Biochemistry (Moscow)2000，65，： | 1 |
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