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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B?hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Stéphane | 2013 | European Heart Journal2013，，28： | 5 |
| 3 | Prognostic interest of bone turnover markers in the management of postmenopausal osteoporosis显示文摘 | Florence Chopin Emmanuel Biver Thomas Funck-Brentano Béatrice Bouvard Guillaume Coiffier Patrick Garnero Thierry Thomas | 2011 | Joint Bone Spine2011，，1： | 2 |
| 4 | Characterization and genetic mapping of a new blood-flesh trait controlled by the single dominant locus DBF in peach显示文摘 | Zhijun Shen Carole Confolent Patrick Lambert Jean-Luc Po?ssel Bénédicte Quilot-Turion Mingliang Yu Ruijuan Ma Thierry Pascal | 2013 | Tree Genetics & Genomes2013，，6： | 2 |
| 5 | The tail suspension test: A new method for screening antidepressants in mice 显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology1985，85，3： | 1 |
| 6 | A new SURE approach to im- age denoising: interscale othonormal wavelet thresholding 显示文摘 | Flofian L Thierry B Michael U | 2007 | IEEE Transactions on hnage Processing2007，16，3： | 1 |
| 7 | Delivery platform for hydrophobic drugs: prodrug approach combined with self-assembled muhilayers 显示文摘 | THIERRY B KUJAWA P TKACZYK C | 2005 | J Am Chem Soc2005，127，6： | 1 |
| 8 | The tail suspension test:a newmethod for screening antidepressants in mice显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology(Berl)1985，85，3： | 1 |
| 9 | The tail suspension test:a new method for screening antidepressants in mice显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology(Berl)1985，85，3： | 1 |
| 10 | The tail suspension test:a new method for screening antidepressants in Mice显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology1985，85，3： | 1 |
| 11 | 显示文摘 | Thierry B Tabrizian M Trepanier C | 2000 | Journal of Biomedical Materials Research2000，51，： | 1 |
| 12 | The tail suspension test: a new method for screening antidepressants in mice显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology1985，85，3： | 1 |
| 13 | Nucleotide sequence of a cDNA encoding the chicken p53 nuclear oncoprotein显示文摘 | Thierry S Agnes B Michel K | 1988 | Nucleic Acids Res1988，16，11： | 1 |
| 14 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B?hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Stéphane | 2013 | European Heart Journal2013，，28： | 1 |
| 15 | Evaluation of a DNA microarray (check-MDR CT102) for rapid detection of TEM,SHV, and CTX-M extended-spectrum 13-1actamases and of KPC, OXA-48, VIM, IMP, and NDM-1 carbapene- mases显示文摘 | Thierry N GaeIle C Pierre B | 2011 | Clin Microbiol2011，49，4： | 1 |
| 16 | Nitrous Oxide for Early Analgesia in the Emergency Setting: A Randomized, Double‐blind Multicenter Prehospital Trial显示文摘 | Jean‐Louis Ducassé Georges Siksik Manon Durand‐Béchu Sébastien Couarraze Baptiste Vallé Nathalie Lecoules Patrice Marco Thierry Lacombe Vincent Bounes | 2013 | Acad Emerg Med2013，，： | 1 |
| 17 | The tail suspension test:a new method for screening antidepressants in mice显示文摘 | STERU L CHERMAT R THIERRY B | 1985 | Psychopharmacology (Berl)1985，85，3： | 1 |
| 18 | Effect of surface treatment and sterilization processes on the corrosion behavior of NiTi shape memory alloy显示文摘 | Thierry B Tabrization M Savadogo O | 2002 | J Biomed Mater Res2002，51，4： | 1 |
| 19 | The tail suspension test : a new method for screening antidepressants in mice 显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology (Serl)1985，85，3： | 1 |
| 20 | The suspension test:a new method for screening antidepressants in mice显示文摘 | Steru L Chermat R Thierry B | 1985 | Psychopharmacology1985，85，3： | 1 |
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