|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Depression and chronic heart failure in the elderly: an intriguing relationship显示文摘长期的心失败和压抑的混乱有高流行和发生在老。几研究显示出消沉怎么趋于加重共存的长期的心失败和它的临床的结果并且反过来也如此,在特别老。在长期的心失败和消沉在之间的否定协同老可以被接近仅仅考虑位于两个这些条件下面的 multifaceted pathophysiological 特征,例如行为因素, neurohormonal 激活,煽动性的调停人, hypercoagulability 和脉管的损坏。不过,在这二个条件之间的 pathophysiological 连接还很好没被建立。尽管有在长期的心失败的消沉的高流行老病人和它的否定预示的价值,因为分享的症状,它特别经常是未被认出的。用可靠问询表,屏蔽心情混乱因此与长期的心失败在老病人被推荐,就算不能由心理健康职业运动员代替诊断会见。在这个背景,消沉的治疗要求包括的一条多学科的途径:心理疗法,抗抑郁剂,锻练训练和 electroconvulsive 治疗。尽管有冲突结果,有选择血清素举起禁止者的药理学治疗改进生活的质量但是不保证更好的结果。锻练训练在改进生活和预后的质量是有效的,但是同时心脏的康复服务是极大地 underutilized。 | Ilaria Liguori Gennaro Russo Francesco Curcio Giuseppe Sasso David Della-Morte Gaetano Gargiulo Flora Pirozzi Francesco Cacciatore Domenico Bonaduce Pasquale Abete Gianluca Testa | 2018 | Journal of Geriatric Cardiology2018，15，6： | 16 |
| 2 | Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotectionJrepair in Parkinson's disease显示文摘 | Francesca L'Episcopo Cataldo Tirolo Salvo Caniglia Nuccio Testa Maria Concetta Moral~ Maria Francesca Serapide: Stefano Pluchino Bianca Marchetti | 2014 | Journal of Molecular Cell Biology2014，8，1： | 8 |
| 3 | Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity显示文摘Breast cancer(BC) is the most common cancer among women worldwide. The aetiology and carcinogenesis of BC are not clearly defined, although genetic, hormonal, lifestyle and environmental risk factors have been established. The most common treatment for BC includes breast-conserving surgery followed by a standard radiotherapy(RT) regimen. However, radiation hypersensitivity and the occurrence of RT-induced toxicity in normal tissue may affect patients' treatment. The role of DNA repair in cancer has been extensively investigated, and an impaired DNA damage response may increase the risk of BC and individual radiosensitivity. Single nucleotide polymorphisms(SNPs) in DNA repair genes may alter protein function and modulate DNA repair efficiency, influencing the development of various cancers, including BC. SNPs in DNA repair genes have also been studied as potential predictive factors for the risk of RT-induced side effects. Here, we review the literature on the association between SNPs in base excision repair(BER) genes and BC risk. We focusedon X-ray repair cross complementing group 1(XRCC1), which plays a key role in BER, and on 8-oxoguanine DNA glycosylase 1, apurinic/apyrimidinic endonuclease 1 and poly(ADP-ribose) polymerase-1, which encode three important BER enzymes that interact with XRCC1. Although no association between SNPs and radiation toxicity has been validated thus far, we also report published studies on XRCC1 SNPs and variants in other BER genes and RT-induced side effects in BC patients, emphasising that large well-designed studies are needed to determine the genetic components of individual radiosensitivity. | Clarice Patrono Silvia Sterpone Antonella Testa Renata Cozzi | 2014 | World Journal of Clinical Oncology2014，5，5： | 8 |
| 4 | ISI数据库——学术期刊及网站的选择显示文摘ISI(美国科学信息研究所)的基本任务是向其用户提供所需要的世界最重要、最有影响的期刊收录信息,ISI 数据库不仅可以检索当年而且可追溯以往。现有数据库收录自然科学、社会科学、艺术与人文科学的国际期刊8500余种。ISI 能完整地检索它所收录的任何一条文献数据。期刊的评估与选择是动态过程,每年 ISI 数据库的来源期刊都会有所增加或删减。每种期刊在被录用或被淘汰前都经过内容广泛的评估过程。ISI 数据库期刊评估要考虑多种因素,评估范围从质到量标准不同,包括基本出版标准、学术内容、作者的国际化程度,及其与之相关的引文数据;出版时限、国际编辑规范是必要因素,因为 ISI数据库是英语数据库,所有论文的标题、摘要、关键词都必须是英语。引证的文献也须经过英文翻译或拼写形式发表,以便能收录进数据库。近几个月 ISI 开始为 Current Contents(现刊目录)订户收录学术网址。Current web Contents (现刊网址目录)的收录要求进一步完善特殊的选择标准。可以预见,与学术期刊文献一样,对学术机构来说相对少量的网站将被证明发挥最大的作用。 | James Testa 郑晓南 | 2000 | 中国科技期刊研究2000，11，6： | 7 |
| 5 | Aetiology of Legg-Calvé-Perthes disease:A systematic review显示文摘BACKGROUND Legg-Calvé-Perthes disease(LCPD) is a clinical condition affecting the femoral head of children during their growth. Its prevalence is set to be between 0.4/100000 to 29.0/100000 children less than 15 years of age with a peak of incidence in children aged from 4 years to 8 years. LCPD aetiology has been widely studied, but it is still poorly understood.AIM To analyse the available literature to document the up-to-date evidence on LCPD aetiology.METHODS A systematic review of the literature was performed regarding LCPD aetiology,using the following inclusion criteria: studies of any level of evidence, reporting clinical or preclinical results and dealing with the aetiology or pathogenesis of LCPD. Two reviewers searched the PubMed and Science Direct databases from their date of inception to the 20th of May 2018 in accordance with the Preferred Reporting Items for Systemic Reviews and Meta-Analyses guidelines. To achieve the maximum sensitivity of the search strategy, we combined the terms: ‘‘Perthes disease OR LCPD OR children avascular femoral head necrosis' with 'pathology OR aetiology OR biomechanics OR genetics' as either key words or MeSH terms.RESULTS We include 64 articles in this review. The available evidence on LCPD aetiology is still debated. Several hypotheses have been researched, but none of them was found decisive. While emerging evidence showed the role of environmental risk factors and evidence from twin studies did not support a major role for genetic factors, a congenital or acquired predisposition cannot be excluded in disease pathogenesis. One of the most supported theories involved mechanical induced ischemia that evolved into avascular necrosis of the femoral head in sensible patients.CONCLUSION The literature available on the aetiology of LCPD presents major limitations in terms of great heterogeneity and a lack of high-profile studies. Although a lot of studies focused on the genetic, biomechanical and radiological background of the disease, there is a lack of consensus on one or multiple major actors of the etiopathogenesis. More studies are needed to understand the complex and multifactorial genesis of the avascular necrosis characterizing the disease. | Vito Pavone Emanuele Chisari Andrea Vescio Claudio Lizzio Giuseppe Sessa Gianluca Testa | 2019 | World Journal of Orthopedics2019，10，3： | 7 |
| 6 | SEDIMENT RETENTION AND WATER QUALITY ENHANCEMENT IN DISTURBED WATERSHEDS`显示文摘Globally, water quality and quantity issues are alarming. Water quality problems generally result from past and present large-scale land uses. Continuing deterioration of water quality and use/reuse issues place the responsibility on agriculture for water quality improvement. Research on agricultural management practices in the United States shows that production agriculture can use measures that improve water quality.Instream suspended sediments and bedload are, by volume, the largest category of pollutant, sediments also carry many compounds that adhere to them in transport. Thus, reducing sediments must play a major role in improving water quality. Innovative management practices can reduce sediments and nutrients by 70 percent or more. If broadly applied, agricultural management and stream stabilization practices can significantly reduce non-point source contamination and have the extra benefit of improving terrestrial and aquatic habitat. | C. M. Cooper(Supervisory Ecologist, USDA-ARS National Sedimentation Laboratory, Oxford, Mississippi, USA.)F. D. Shields, Jr(Research Hydraulic Engineer, USDA-ARS National Sedimentation Laboratory, Oxford, Mississippi, USA.)S. Testa, Ⅲ (Biologist Ⅲ, USDA | 2000 | International Journal of Sediment Research2000，15，1： | 6 |
| 7 | Marine propellers performance and flow-field prediction by a free-wake panel method显示文摘A Boundary Element Method(BEM) hydrodynamics combined with a flow-alignment technique to evaluate blades shed vorticity is presented and applied to a marine propeller in open water. Potentialities and drawbacks of this approach in capturing propeller performance, slipstream velocities, blade pressure distribution and pressure disturbance in the flow-field are highlighted by comparisons with available experiments and RANSE results. In particular, correlations between the shape of the convected vortexsheet and the accuracy of BEM results are discussed throughout the paper. To this aim, the analysis of propeller thrust and torque is the starting point towards a detailed discussion on the capability of a 3-D free-wake BEM hydrodynamic approach to describe the local features of the flow-field behind the propeller disk, in view of applications to propulsive configurations where the shed wake plays a dominant role. | GRECO Luca MUSCARI Roberto TESTA Claudio DI MASCIO Andrea | 2014 | Journal of Hydrodynamics2014，26，5： | 4 |
| 8 | Are metabolic factors still important in the era of direct antiviral agents in patients with chronic hepatitis C?显示文摘The high rate of sustained viral response(SVR)to boceprevir or telaprevir-based triple therapy in hepatitis C(HCV)-related,non-cirrhotic na ve patients or relapsers to previous antiviral treatment leads clinicians to believe that the impact of metabolic host factors on SVR is minimal when triple therapy is used,unlike what is observed with the peginterferon and ribavirin schedules.This concept is strongly expressed by some opinion leaders on the basis of the data derived from subanalyses of registrative trials as well as from a post-hoc analysis of the phaseⅡC208 clinical trial.The perception of unrestrainable therapeutic success with the use of newer,more powerful antivirals is now reinforced by the brilliant results obtained with sofosbuvir,an HCV NS5B polymerase inhibitor,as well as by the data from the phaseⅡandⅢstudies on the various combinations of second-generation NS3/4A inhibitors and NS5A and/or NS5B inhibitors.However,a great deal of concern has emerged from the real world scenario in which patients are often older and have more comorbidities than patients in the'world of trials'.Furthermore,many of them have advanced fibrosis and previous failure with peginterferon and ribavirin treatment.Some data from the recent literature suggest that the host metabolic factors may play a minor but non-negligible role in these difficult-to-treat patients,an issue that will hopefully be investigated in further studies.This editorial aims to provide a detailed analysis of the role that host metabolic factors played in the past and what role they may play in the era of direct antiviral agents. | Alessandro Grasso Federica Malfatti Roberto Testa | 2013 | World Journal of Gastroenterology2013，19，41： | 4 |
| 9 | Arthroereisis in juvenile flexible flatfoot:Which device should we implant?A systematic review of literature published in the last 5 years显示文摘BACKGROUND Flexible flatfoot(FFF)is a very common condition in children,characterized by the loss of the medial arch and by an increase in the support base with valgus of the hindfoot.Arthroereisis(AR)procedures are widely performed corrective surgeries and are classified as subtalar AR and calcaneo-stop(CS).AIM We investigated the literature published in the last 5 years with the aim of providing an update on the evidence related to AR treatment in FFF patients.We report the principal findings of subtalar AR and CS procedures concerning clinical and radiological outcomes and complication rates in the general population,young athletes,and obese people according to material device.METHODS Following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses,a systematic review of studies published in the past 5 years and included the PubMed and Science Direct databases was performed on May 6,2020.The research string used was(pediatric OR children OR Juvenile NOT adult)AND(flexible NOT rigid)AND(flat foot OR pes planus)AND(calcaneo-Stop OR arthroereisis OR subtalar extra-articular screw OR SESA OR subtalar arthroereisis OR endosinotarsal).The risk of bias assessment was performed using the Dutch checklist form for prognosis.RESULTS A total of 47 articles were found.Ultimately,after reading the full text and checking reference lists,we selected 17 articles that met the inclusion and exclusion criteria.A total of 1864 FFFs were identified.Eight studies concerned the subtalar AR(47.1%)and nine concerning CS(52.9%).The average age of patients at start of treatment was 11.8 years,the average follow-up of the studies was 71.9 mo(range 29.1-130).Globally,complications occurred in 153 of the 1864 FFF treated,with a rate of 8.2%.CONCLUSION Both AR procedures are valid surgical techniques for treating FFF.Surgeon experience,implant cost,and cosmetic correction are the most common considerations included in the orthopedic device decision-making process.In obese patients,the subtalar AR is not recommended.In adolescents who need to improve sports performance,the CS screw had better results compared with other implants. | Andrea Vescio Gianluca Testa Mirko Amico Claudio Lizzio Marco Sapienza Piero Pavone Vito Pavone | 2021 | World Journal of Orthopedics2021，12，6： | 3 |
| 10 | Application of the platelet count/spleen diameter ratio to rule out the presence of oesophageal varices in patients with cirrhosis: A validation study based on follow-up显示文摘 | E.G. Giannini F. Botta P. Borro P. Dulbecco E. Testa C. Mansi V. Savarino R. Testa | 2005 | Digestive and Liver Disease2005，，10： | 3 |
| 11 | Usefulness of myocardial positron emission tomography/nuclear imaging in Takotsubo cardiomyopathy显示文摘AIM:To analyse and summarize all the articles related to positron emission tomography and Takotsubo cardiomyopathy(TTC).METHODS:We performed a systematic review of the existing literature on positron emission tomography/nuclear imaging and Takotsubo cardiomyopathy using PUBMED database.We combined search terms such as'takotsubo','takotsubo syndrome','myocardial positron emission tomography','positron emission tomography'.All case reports were excluded.The list included only four articles which were reviewed by two independent investigators.It was not possible to undertake a formal meta-analysis because of the heterogeneity of the studies;therefore,we made a narrative synthesis of the collected data.RESULTS:Nuclear medicine techniques can be useful employed in the differential diagnosis of TTC from an acute coronary syndrome(ACS).In fact,transient left ventricular(LV)apical ballooning is a syndrome frequently misdiagnosed as an ACS and can mimic symptoms of myocardial infarction with ST-T segments changes on electrocardiography(ECG),a limited re-lease of myocardial enzyme,mainly reported after sudden emotional or physical stress,and an akinesis or dyskinesis of the left ventricle apex which are completely reversible in a few weeks.In the studies included in this review,nuclear medicine techniques have demonstrated a discrepancy between normal perfusion and a reduced glucose utilization in TTC,commonly known as'inverse flow metabolism mismatch'.This suggests that apical ballooning represents a transient metabolic disorder on the cellular level,rather than a structural contractile disease of the myocardium,due to a transient decrease of glucose metabolism that might be related to a coronary microcirculation impairment followed by prolonged myocardial stunning.CONCLUSION:Nuclear medicine techniques can be usefully used for the diagnosis of TTC and can increase our knowledge of the pathophysiological mechanisms of TTC. | Marzia Testa Mauro Feola | 2014 | World Journal of Radiology2014，6，7： | 3 |
| 12 | Mutation analysis of the RPGR gene reveals novel mutations in south European patients with X-linked retinitis pigmentosa显示文摘 | Miano MG Testa F Strazzullo M Trujillo M De Bernardo C Grammatico B | | 0，，： | 2 |
| 13 | The vision- guide robot grows up Industrial robot显示文摘 | Justin Testa | 1999 | An Industrial Journal1999，26，5： | 2 |
| 14 | Right Living Donor Liver Transplantation: An Option for Adult Patients: Single Institution Experience With 74 Patients显示文摘 | Massimo Malagó Giuliano Testa Andrea Frilling Silvio Nadalin Camino Valentin-Gamazo Andreas Paul Hauke Lang Ulrich Treichel Vito Cicinnati Guido Gerken Christoph Erich Broelsch | 2003 | Annals of Surgery2003，，6： | 2 |
| 15 | Laboratory Diagnosis and Nonoperative Management of Biliary Complications in Living Donor Liver Transplant Patients显示文摘 | Mukund Venu Russell D. Brown Rita Lepe Jamie Berkes Scott J. Cotler Enrico Benedetti Giuliano Testa Rama P. Venu | 2007 | Journal of Clinical Gastroenterology2007，，5： | 2 |
| 16 | Enhancement of the photocatalytic activity of various TiO2 materials by platinisation显示文摘 | Hufschmidt D Bahnemann D Testa J J | 2002 | J Photochem Photobio A:Chem2002，148，： | 2 |
| 17 | Improving strategies for diagnosing ovarian cancer: a summary of the International Ovarian Tumor Analysis ( IOTA ) studies显示文摘 | J. Kaijser T. Bourne L. Valentin A. Sayasneh C. Van Holsbeke I. Vergote A. C. Testa D. Franchi B. Van Calster D. Timmerman | 2012 | Ultrasound Obstet Gynecol2012，，： | 2 |
| 18 | Complications of Biliary Tract in Liver Transplantation显示文摘 | Giuliano Testa Massimo Malagò Christoph E. Broelsch | 2001 | World Journal of Surgery2001，，10： | 2 |
| 19 | Gender differences in the efficacy of cardiovascular rehabilitation in patients after cardiac surgery procedures显示文摘 | Mauro Feola Sonia Garnero Beatrice Daniele Claudia Memo Fabio Dell'Aira Giuliana Chizzolini Marzia Testa | 2015 | Journal of Geriatric Cardiology2015，12，5： | 2 |
| 20 | Hormetic effect(s) of tetracyclines as environmental contaminant on Zea mays显示文摘 | Luciana Migliore Feliciana Godeas Stefania Paola De Filippis Paolo Mantovi Davide Barchi Cecilia Testa Nicolino Rubattu Gianfranco Brambilla | 2009 | Environmental Pollution2009，，1： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员