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| 1 | Small bowel capsule endoscopy in 2007:Indications,risks and limitations显示文摘囊内视镜检查法有 revoluzionized 由提供一个可靠方法评估的小肠的学习,内视镜的联盟者,全部小肠。在最后六年里,几份报纸被出版了处于不同临床的条件探索这考试的可能的角色。在现在的时间囊,内视镜检查法通常被推荐为第三考试,在否定双向内视镜检查法以后,在有阴暗胃肠的流血的病人。证据的成长身体也处于象 Crohn 的疾病,乳糜泻,小肠息肉病症候群或小肠肿瘤那样的另外的临床的条件为这考试建议一个重要角色。这考试的主要复杂并发症是在以前未知的小肠苛评的地点的设备的保留。然而,也由于这个工具的技术限制主要有一些另外的开的问题(它没从遥控被驾驶,是不能的拿活体检视到 insufflate 空气,正确地缩放并且定位损害到 suck 液体或碎片并且到有时) 。最近发达的双汽球肠脓毒病,尽管侵略、耗时,由于它的能力指向了活体检视探索小肠的大部分并且拿,能克服囊内视镜检查法的一些限制。在现在预定,在临床的条件的多数(即阴暗官方补给的流血),赢的策略似乎是联合这二种技术探索小肠在一无痛苦,安全、完全的方法(与囊内视镜检查法)并且识别了定义并且对待损害(与两倍汽球肠寄生物)。 | Emanuele Rondonotti Federica Villa Chris JJ Mulder Maarten AJM Jacobs Roberto de Franchis | 2007 | World Journal of Gastroenterology2007，13，46： | 30 |
| 2 | Capsule endoscopy in neoplastic diseases显示文摘Until recently, diagnosis and management of small-bowel tumors were delayed by the diffi culty of access to the small bowel and the poor diagnostic capabilities of the available diagnostic techniques. An array of new methods has recently been developed, increasing the possibility of detecting these tumors at an earlier stage. Capsule endoscopy (CE) appears to be an ideal tool to recognize the presence of neoplastic lesions along this organ, since it is non-invasive and enables the entire small bowel to be visualized. High- quality images of the small-bowel mucosa may be captured and small and ? at lesions recognized, without exposure to radiation. Recent studies on a large population of patients undergoing CE have reported small-bowel tumor frequency only slightly above that reported in previous surgical series (range, 1.6%-2.4%) and have also confirmed that the main clinical indication to CE in patients with small-bowel tumors is obscure gastrointestinal (GI) bleeding. The majority of tumors identified by CE are malignant; many were unsuspected and not found by other methods. However, it remains difficult to identify pathology and tumor type based on the lesion’s endoscopic appearance. Despite its limitations, CE provides crucial information leading in most cases to changes in subsequent patient management. Whether the use of CE in combination with other new diagnostic (MRI or multidetector CT enterography) and therapeutic (Push- and-pull enteroscopy) techniques will lead to earlier diagnosis and treatment of these neoplasms, ultimately resulting in a survival advantage and in cost savings,remains to be determined through carefully-designed studies. | Marco Pennazio Emanuele Rondonotti Roberto de Franchis | 2008 | World Journal of Gastroenterology2008，14，34： | 17 |
| 3 | Revising consensus in portal hypertension: Report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension显示文摘 | Roberto de Franchis | 2010 | Journal of Hepatology2010，，4： | 15 |
| 4 | 最新门脉高压共识(Baveno V版)显示文摘门脉高压与肝硬化最严重的并发症有关,包括腹水,肝性脑病和胃食管静脉曲张出血。自1986年之后,组织了一系列共识会议,第一次由安德鲁伯勒斯组织在荷兰格罗宁根召开, | 杨力 韩国宏 de Franchis R | 2011 | 临床肝胆病杂志2011，27，2： | 14 |
| 5 | Esophageal testing: What we have so far显示文摘Gastroesophageal reflux disease(GERD) is a common disorder of the gastrointestinal tract. In the last few decades, new technologies have evolved and have been applied to the functional study of the esophagus, allowing for the improvement of our knowledge of the pathophysiology of GERD. High-resolution manometry(HRM) permits greater understanding of the function of the esophagogastric junction and the risks associated with hiatal hernia. Moreover, HRM has been found to be more reproducible and sensitive than conventional water-perfused manometry to detect the presence of transient lower esophageal sphincter relaxation. Esophageal 24-h p H-metry with or without combined impedance is usually performed in patients with negative endoscopy and reflux symptoms who have a poor response to anti-reflux medical therapy to assess esophageal acid exposure and symptom-reflux correlations. In particular, esophageal 24-h impedance and p H monitoring can detect acid and non-acid reflux events. Endo FLIP is a recent technique poorly applied in clinical practice, although it provides a large amount of information about the esophagogastric junction. In the coming years, laryngopharyngeal symptoms could be evaluated with up and coming non-invasive or minimally invasive techniques, such as pepsin detection in saliva or pharyngeal p H-metry. Future studies are required of these techniques to evaluate their diagnostic accuracy and usefulness, although the available data are promising. | Nicola de Bortoli Irene Martinucci Lorenzo Bertani Salvatore Russo Riccardo Franchi Manuele Furnari Salvatore Tolone Giorgia Bodini Valeria Bolognesi Massimo Bellini Vincenzo Savarino Santino Marchi Edoardo Vincenzo Savarino | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 8 |
| 6 | Imaging of the small bowel in Crohn's disease: A review of old and new techniques显示文摘The investigation of small bowel morphology is often mandatory in many patients with Crohn's disease. Traditional radiological techniques (small bowel enteroclysis and small bowel follow-through) have long been the only suitable methods for this purpose. In recent years, several alternative imaging techniques have been proposed. To review the most recent advances in imaging studies of the small bowel, with particular reference to their possible application in Crohn's disease, we conducted a complete review of the most important studies in which traditional and newer imaging methods were performed and compared in patients with Crohn's disease. Several radiological and endoscopic techniques are now available for the study of the small bowel; each of them is characterized by a distinct profile of favourable and unfavourable features. In some cases, they may also be used as complementary rather than alternative techniques. In everyday practice, the choice of the technique to be used stands upon its availability and a careful evaluation of diagnostic accuracy, clinical usefulness, safety and cost. The recent development ofinnovative imaging techniques has opened a new and exciting area in the exploration of the small bowel in Crohn's disease patients. | Simone Saibeni Emanuele Rondonotti Andrea Iozzelli Luisa Spina Gian Eugenio Tontini Flaminia Cavallaro Camilla Ciscato Roberto de Franchis Francesco Sardanelli Maurizio Vecchi | 2007 | World Journal of Gastroenterology2007，13，24： | 6 |
| 7 | Transjugular intrahepatic portosystemic shunt for Budd-Chiari syndrome:A comprehensive review显示文摘Budd-Chiari syndrome(BCS)is a relatively rare clinical condition with a wide range of symptomatology,caused by the obstruction of the hepatic venous outflow.If left untreated,it has got an high mortality rate.Its management is based on a step-wise approach,depending on the clinical presentation,and includes different treatment from anticoagulation therapy up to Interventional Radiology techniques,such as transjugular intrahepatic portosystemic shunt(TIPS).TIPS is today considered a safe and highly effective treatment and should be recommended for BCS patients,including those awaiting orthotopic liver transplantation.In this review the pathophysiology,diagnosis and treatment options of BCS are presented,with a special focus on published data regarding the techniques and outcomes of TIPS for the treatment of BCS.Moreover,unresolved issues and future research will be discussed. | Riccardo Inchingolo Alessandro Posa Martin Mariappan Tiago Kojun Tibana Thiago Franchi Nunes Stavros Spiliopoulos Elias Brountzos | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 8 | Outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy: Report of 100 consecutive cases显示文摘 | Marco Pennazio Renato Santucci Emanuele Rondonotti Carla Abbiati Gizela Beccari Francesco P. Rossini Roberto De Franchis | 2004 | Gastroenterology2004，，3： | 5 |
| 9 | Novel mutation in the ligand-binding domain of the androgen receptor gene (1790p) associated with complete androgen insensitivity syndrome显示文摘在基因在敏感症候群(AIS ) 引起雄激素的 X 连接雄激素受体(AR ) 的变化,在 46 导致损害的胚胎的性区别, XY 基因人。在敏感(CAIS ) 的完全的雄激素生产女外部显型,而有在敏感(白族) 的部分雄激素的盒子有生殖器的各种各样的歧义。在敏感(MAIS ) 的温和雄激素被 undermasculinization 和男子女性型乳房描绘。这里,我们描述 2-month-old 46, XY 女病人,与所有 CAIS 的特征。在睾丸激素(T) 和二氢睾酮(DHT ) 合成背叛被排除。AR 基因定序在 790 上在鳕鱼的第二个库在 6 一 T 上在前显示出存在到 C 转变,核苷酸位置 2369,在 AR 蛋白质的 ligand 有约束力的域引起一个新奇错误感觉 Leu790Pro 变化。在有 CAIS 的一个女孩的一个新奇 AR 变化的鉴定在 AR 的 ligand 有约束力的领域由于错误感觉变化的重要性提供重要信息,它能在雄激素绑定能力,活跃符合构造的稳定,或和激活剂的相互作用导致功能的畸形。 | Florina Raicu Rossella Giuliani Valentina Gatta Chiara Palka Paolo Guanciali Franchi Pierluigi Lelli-Chiesa Stefano Tumini Liborio Stuppia | 2008 | Asian Journal of Andrology2008，10，4： | 4 |
| 10 | Evolving Consensus in Portal Hypertension Report of the Baveno IV Consensus Workshop on methodology of diagnosis and therapy in portal hypertension显示文摘 | Roberto de Franchis | 2005 | Journal of Hepatology2005，，1： | 4 |
| 11 | Revising consensus in portal hypertension: Report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension显示文摘 | Roberto de Franchis | 2010 | Journal of Hepatology2010，，4： | 3 |
| 12 | Outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy: Report of 100 consecutive cases显示文摘 | Marco Pennazio Renato Santucci Emanuele Rondonotti Carla Abbiati Gizela Beccari Francesco P. Rossini Roberto De Franchis | 2004 | Gastroenterology2004，，3： | 3 |
| 13 | A 28-Year Study of the Course of Hepatitis Δ Infection: A Risk Factor for Cirrhosis and Hepatocellular Carcinoma显示文摘 | Raffaella Romeo Ersilio Del Ninno Mariagrazia Rumi Antonio Russo Angelo Sangiovanni Roberto de Franchis Guido Ronchi Massimo Colombo | 2009 | Gastroenterology2009，，5： | 2 |
| 14 | Glucose intolerance and diabetes mellitus in ulcerative colitis: Pathogenetic and therapeutic implications显示文摘Diabetes mellitus is one of the most frequent co-morbidities of ulcerative colitis patients.The epidemiological association of these diseases suggested a genetic sharing and has challenged gene identification.Diabetes co-morbidity in ulcerative colitis has also relevant clinical and therapeutic implications,with potential clinical impact on the follow up and outcome of patients.These diseases share specific complications,such as neuropathy,hepatic steatosis,osteoporosis and venous thrombosis.It is still unknown whether the coexistence of these diseases may increase their occurrence.Diabetes and hyperglycaemia represent relevant risk factors for postoperative complications and pouch failure in ulcerative colitis.Medical treatment of ulcerative colitis in patients with diabetes mellitus may be particularly challenging.Corticosteroids are the treatment of choice of active ulcerative colitis.Their use may be associated with the onset of glucose intolerance and diabetes,with difficult control of glucose levels andwith complications in diabetic patients.Epidemiologic and genetic evidences about diabetes co-morbidity in ulcerative colitis patients and shared complications and treatment of patients with these diseases have been discussed in the present review. | Giovanni Maconi Federica Furfaro Roberta Sciurti Cristina Bezzio Sandro Ardizzone Roberto de Franchis | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 15 | The American Society for Gastrointestinal Endoscopy (ASGE) diagnostic algorithm for obscure gastrointestinal bleeding: Eight burning questions from everyday clinical practice显示文摘 | Emanuele Rondonotti Riccardo Marmo Massimo Petracchini Roberto de Franchis Marco Pennazio | 2012 | Digestive and Liver Disease2012，，： | 2 |
| 16 | Conservative treatment by chemotherapy and uterine arteries embolization of a cesarean scar pregnancy显示文摘 | Fabio Ghezzi Domenico Laganà Massimo Franchi Carlo Fugazzola Pierfrancesco Bolis | 2002 | European Journal of Obstetrics and Gynecology2002，，1： | 2 |
| 17 | Portal Hypertension in Children: Expert Pediatric Opinion on the Report of the Baveno V Consensus Workshop on Methodology of Diagnosis and Therapy in Portal Hypertension显示文摘 | Benjamin L. Shneider Jaime Bosch Roberto de Franchis Sukru H. Emre Roberto J. Groszmann Simon C. Ling Jonathan M. Lorenz Robert H. Squires Riccardo A. Superina Ann E. Thompson George V. Mazariegos | 2012 | Pediatric Transplantation2012，，5： | 2 |
| 18 | Improving strategies for diagnosing ovarian cancer: a summary of the International Ovarian Tumor Analysis ( IOTA ) studies显示文摘 | J. Kaijser T. Bourne L. Valentin A. Sayasneh C. Van Holsbeke I. Vergote A. C. Testa D. Franchi B. Van Calster D. Timmerman | 2012 | Ultrasound Obstet Gynecol2012，，： | 2 |
| 19 | European Society of Gastrointestinal Endoscopy (ESGE): Recommendations (2009) on clinical use of video capsule endoscopy to investigate small-bowel, esophageal and colonic diseases显示文摘 | S. Ladas K. Triantafyllou C. Spada M. Riccioni J.-F. Rey Y. Niv M. Delvaux R. de Franchis G. Costamagna | 2010 | Endoscopy2010，，03： | 2 |
| 20 | B1a lymphocytes in the rectal mucosa of ulcerative colitis patients显示文摘AIM:To assess B1a cell expression in the rectal mucosa of ulcerative colitis (UC) patients in comparison with healthy controls.METHODS:Rectal mucosa biopsies were collected from 15 UC patients and 17 healthy controls.CD5 + B cells were analysed by three colour flow cytometry from rectal mucosal samples after mechanical disaggregation by Medimachine.Immunohistochemical analysis of B and T lymphocytes was also performed.Correlations between,on the one hand,rectal B1a cell concentrations and,on the other,erythrocyte sedimentation rate and C-reactive protein levels and clinical,endoscopic and histological disease activity indices were evaluated.RESULTS:Rectal B-lymphocyte (CD19 + /CD45 +) rate and concentration were higher in UC patients compared with those in healthy controls (47.85% ± 3.12% vs 26.10% ± 3.40%,P=0.001 and 501 ± 91 cells/mm 2 vs 117 ± 18 cells/mm 2,P < 0.001);Rectal B1a cell density (CD5 + CD19 +) was higher in UC patients than in healthy controls (85 ± 15 cells/mm 2 vs 31 ± 6.7 cells/mm 2,P=0.009).Rectal B1a cell (CD5/CD19 +) rate correlated inversely with endoscopic classification (Rs=-0.637,P < 0.05).CONCLUSION:B1a lymphocytes seem to be involved in the pathogenesis of UC,however,the role they play in its early phases and in disease activity,have yet to be defined. | Lino Polese Riccardo Boetto Giuseppe De Franchis Imerio Angriman Andrea Porzionato Lorenzo Norberto Giacomo Carlo Sturniolo Veronica Macchi Raffaele De Caro Stefano Merigliano | 2012 | World Journal of Gastroenterology2012，18，2： | 2 |
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