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| 1 | Depression and chronic heart failure in the elderly: an intriguing relationship显示文摘长期的心失败和压抑的混乱有高流行和发生在老。几研究显示出消沉怎么趋于加重共存的长期的心失败和它的临床的结果并且反过来也如此,在特别老。在长期的心失败和消沉在之间的否定协同老可以被接近仅仅考虑位于两个这些条件下面的 multifaceted pathophysiological 特征,例如行为因素, neurohormonal 激活,煽动性的调停人, hypercoagulability 和脉管的损坏。不过,在这二个条件之间的 pathophysiological 连接还很好没被建立。尽管有在长期的心失败的消沉的高流行老病人和它的否定预示的价值,因为分享的症状,它特别经常是未被认出的。用可靠问询表,屏蔽心情混乱因此与长期的心失败在老病人被推荐,就算不能由心理健康职业运动员代替诊断会见。在这个背景,消沉的治疗要求包括的一条多学科的途径:心理疗法,抗抑郁剂,锻练训练和 electroconvulsive 治疗。尽管有冲突结果,有选择血清素举起禁止者的药理学治疗改进生活的质量但是不保证更好的结果。锻练训练在改进生活和预后的质量是有效的,但是同时心脏的康复服务是极大地 underutilized。 | Ilaria Liguori Gennaro Russo Francesco Curcio Giuseppe Sasso David Della-Morte Gaetano Gargiulo Flora Pirozzi Francesco Cacciatore Domenico Bonaduce Pasquale Abete Gianluca Testa | 2018 | Journal of Geriatric Cardiology2018，15，6： | 16 |
| 2 | A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome显示文摘AIM:To test the efficacy of a proprietary nutraceutical combination in reducing insulin resistance associated with the metabolic syndrome(MetS).METHODS:Sixty-four patients with MetS followed at a tertiary outpatient clinic were randomly assigned to receive either placebo or a proprietary nutraceutical combination(AP)consisting of berberine,policosanol and red yeast rice,in a prospective,double-blind,placebo-controlled study.Evaluations were performed at baseline and after 18 wk of treatment.The homeostasis model assessment of insulin resistance(HOMAIR)index was the primary outcome measure.Secondary endpoints included lipid panel,blood glucose and insulin fasting,after a standard mixed meal and after an oral glucose tolerance test(OGTT),ow-mediated dilation(FMD),and waist circumference.RESULTS:Fifty nine patients completed the study,2 withdrew because of adverse effects.After 18 wk there was a signif icant reduction in the HOMA-IR index in the AP group compared with placebo(ΔHOMA respectively-0.6 ± 1.2 vs 0.4 ± 1.9;P < 0.05).Total and low density lipoprotein cholesterol also significantly decreased in the treatment arm compared with placebo(Δlow density lipoprotein cholesterol-0.82 ± 0.68 vs-0.13 ± 0.55 mmol/L;P < 0.001),while triglycerides,high density lipoprotein cholesterol,and the OGTT were not affected.In addition,there were significant reductions in blood glucose and insulin after the standard mixed meal,as well as an increase in FMD(ΔFMD 1.9 ± 4.2 vs 0 ± 1.9 %;P < 0.05)and a significant reduction in arterial systolic blood pressure in the AP arm.CONCLUSION:This short-term study shows that AP has relevant beneficial effects on insulin resistance and many other components of MetS. | Flora Affuso Valentina Mercurio Antonio Ruvolo Concetta Pirozzi Filomena Micillo Guido Carlomagno Fabrizia Grieco Serafino Fazio | 2012 | World Journal of Cardiology2012，4，3： | 7 |
| 3 | Mitral peak early diastolic filling velocity to deceleration time ratio as a predictor of prognosis in patients with chronic heart failure and preserved or reduced ejection fraction显示文摘ObjectiveDoppler 导出僧帽形的山峰到减速时间比率(E/DT ) 的早心脏舒张的充满速度为在一般人口预言预后作为参数被建议了。这研究有希望地在就医的病人在临床的、常规 echocardiographic 和 mitral-Doppler 变量上调查 E/DT 的增长的预示的值因为患心脏代偿失调的心失败(HF ).MethodsWe 分析了 95 个 HF 病人(吝啬的年龄 64.8 ±12.2 年) 从 2010 年 1 月在我们的机构就医了到 2012 年 3 月。主要端点是心脏的死亡或住院,无论哪个首先发生了。考克斯回归分析被执行识别 outcomes.ResultsDuring 后续的重要预言者(中部 37.7 个月) 13 个病人死了, 44 为一个心脏的事件被就医。在 univariable 分析,纽约心协会(NYHA ) 功能的班, furosemide 剂量,侧面的有三尖的环形的飞机收缩旅行,减速时间和 E/DT 结果是预兆的。在 multivariable 分析, E/DT 是预后的唯一的预言者(危险比率 = 1.02, P = 0.018 ) ,把增长预示的信息给临床并且另外的 echocardio 图形的措施(从 15.4 ~ 25.2 的全球 chi 平方;P = 0.032 ).ConclusionsE/DT 在 HF 病人给独立、增长的预示的信息。 | Flora Pirozzi AntoneUa Paglia Laura Sasso Pasquale Abete Angelo Carlomagno Carlo G Tocchetti Domenico Bonaduce Mario Petretta | 2015 | Journal of Geriatric Cardiology2015，12，4： | 2 |
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